Nucléosides
3569 produits trouvés pour "Nucléosides"
Adenosine-5'-O-(1-thiotriphosphate) lithium salt - 100 mM aqueous solution
CAS :Adenosine-5'-O-(1-thiotriphosphate) lithium salt is an inhibitor of the guanine nucleotide-binding protein that is reversibly inhibited by adenosine triphosphate. It has been shown to inhibit HIV infection by binding to the Ryanodine receptor and blocking the release of calcium ions from intracellular stores. This prevents the activation of caspases, which are enzymes that cause cell lysis. Adenosine-5'-O-(1-thiotriphosphate) lithium salt also blocks transcription and polymerase chain reactions, and may inhibit the growth of cancer cells by inhibiting epidermal growth factor receptors on the cell surface.Formule :C10H12Li4N5O12P3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :546.98 g/molL-Thymidine
CAS :L-Thymidine is an antiviral drug that is used in the treatment of chronic hepatitis. It has been shown to be active against a range of viruses, including HIV, HSV, and HBV. L-Thymidine can also be used to treat patients with cancer as an anti-cancer agent. L-Thymidine is a prodrug that is converted into thymidine triphosphate (TTP), which inhibits viral DNA polymerase by competitive inhibition. The antiviral activity of L-Thymidine may be due to its ability to inhibit the synthesis of viral proteins required for viral replication by interfering with the protein production process or by inhibiting the formation of dsDNA during reverse transcription.Formule :C10H14N2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :242.23 g/mol1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt is an Activator for the synthesis of DNA and RNA. It is a novel synthetic nucleoside that has anticancer activity. 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt is used as an antiviral agent, inhibiting viral replication by blocking the RNA polymerase enzyme.Formule :C9H13FN2O14P3·C6H16NDegré de pureté :Min. 95%Masse moléculaire :587.32 g/mol8-Chloro-2'-deoxyguanosine
CAS :8-Chloro-2'-deoxyguanosine is a reactive oxygen species that can cause oxidative damage to DNA. This compound is generated by the hypochlorous acid (HOCl) in cells and can be found in human tissues. 8-Chloro-2'-deoxyguanosine can also be generated by the HOCl in diabetic patients, where it has been shown to cause oxidative damage to DNA. 8-Chloro-2'-deoxyguanosine is a product of the reaction between hydrogen peroxide and catalase, and it is activated by HOCl. It has been shown to be carcinogenic in animal models, where it causes DNA damage that leads to cancer.Formule :C10H12ClN5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :301.69 g/mol4-Hydroxy-6-methylpyrimidine
CAS :4-Hydroxy-6-methylpyrimidine (4-OHMP) is a metabolite of trimethyltin. It is formed in the liver by methylation of 4,6-dimethylpyrimidine (4,6-DMPU). The levels of 4-OHMP in urine samples are used to monitor exposure to this agent. The median values for urinary concentrations of 4-OHMP are typically 10 times higher than those found in blood samples. The metabolite can be detected in urine up to 2 weeks after an individual’s last contact with trimethyltin. This compound has been shown to inhibit the synthesis of glycol dimethyl ethers and carbamates.
Formule :C5H6N2ODegré de pureté :Min. 95%Masse moléculaire :110.11 g/mol3'-O-Allylguanosine
3'-O-Allylguanosine is a antiviral agent that belongs to the group of synthetic nucleosides. It is a monophosphate analog of guanosine and an activator of ribonucleotide reductase. 3'-O-Allylguanosine has been shown to be effective against cancer cells in vitro. It has also been shown to inhibit DNA synthesis and promote DNA degradation in human leukemia cells, suggesting its potential use for the treatment of leukemia.
Formule :C13H17N5O5Degré de pureté :Min. 95%Masse moléculaire :323.3 g/mol2'-O-Acetyl-3'-deoxy-3'-fluoro-5-methoxy-5'-O-toluoyluridine
CAS :2'-O-Acetyl-3'-deoxy-3'-fluoro-5-methoxy-5'-O-toluoyluridine is a modified nucleoside that has antiviral, anticancer and antimalarial activities. This compound has been synthesized as a monophosphate derivative of the natural nucleoside uridine. It is an activator of DNA polymerase, which helps to synthesize DNA in cells. 2'-O-Acetyl-3'-deoxy-3'-fluoro-5-methoxy-5'-O-toluoyluridine also has anticancer activity due to its ability to inhibit the replication of the human tumor virus KSHV.Degré de pureté :Min. 95%N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite
N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite is a novel nucleoside that has antiviral and anticancer properties. It is an analog of adenosine and inhibits the action of ribonucleotide reductase, which is an enzyme that converts ribonucleotides to deoxyribonucleotides. N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite also inhibits the synthesis of DNA, which may be due to its inhibition of DNA polymerase. This compound has been shown to inhibit the growth of leukemia cells in culture and induce apoptosis in human tumor cells.
Formule :C47H51FN7O7PDegré de pureté :Min. 95%Masse moléculaire :875.92 g/mol2'-Deoxy-5'-O-DMT-5-iodouridine
CAS :2'-Deoxy-5'-O-DMT-5-iodouridine is an intercalating agent that binds to DNA and RNA. It can be used as a probe for the detection of specific sequences in human cells. The fluorophore attached to the molecule allows it to be detected by fluorescence microscopy, while the chromophore is responsible for its ability to emit light at a wavelength of 535 nm. 2'-Deoxy-5'-O-DMT-5-iodouridine has been shown to enhance nucleotide excision repair and increase the sensitivity of cancer cells to chemotherapy drugs such as cisplatin. The molecule can also be used as a fluorescent protein marker in her-2 gene amplification and overexpression studies.Formule :C30H29IN2O7Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :656.48 g/mol5'-Amino-5'-deoxyguanosine
CAS :5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.Formule :C10H14N6O4Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :282.26 g/molN6-Benzoyl-2’-chloro-2’-deoxy-5’-O-DMT-adenosine
N6-Benzoyl-2’-chloro-2’-deoxy-5’-O-DMT-adenosine is a novel nucleoside that has been shown to have anti-cancer, antiviral, and antiinflammatory activities. It is structurally related to 2’,3’,5’triphosphate adenine (TPAD) and inhibits the synthesis of DNA by competitive inhibition of ribonucleotide reductase. TPAD also induces apoptosis in tumor cells. N6BzCdA has an IC50 value of 0.5 μM for TPAD synthetase from Escherichia coli and rat liver, indicating that it is a potent inhibitor of this enzyme. The purity level of this product is greater than 98%, with a CAS number of 67972-83-1.Degré de pureté :Min. 95%Uridine-5-oxyacetic acid methyl ester
CAS :Uridine-5-oxyacetic acid methyl ester is a modified nucleotide that is an intermediate in the biosynthesis of uridine. This molecule can be synthesized from 5-hydroxymethyluridine and malonic acid by a methyltransferase. Uridine-5-oxyacetic acid methyl ester can also be obtained from the metabolism of deoxyribose. Analysis of this molecule is possible with spectrometric, mass spectrometric, and chemical structures methods. It has been shown to have a function in translation and protein synthesis. The chemical structure of uridine-5-oxyacetic acid methyl ester has been determined to be guanosine-3',5'-bis(2'-carboxyethyl)phosphate, which is different from that found in DNA or RNA.Formule :C12H16N2O9Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :332.26 g/mol2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-methoxyuridine
CAS :2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-methoxyuridine is a modified nucleoside that is used as an anticancer drug. It is synthesized from 2’,3’,5’triphosphate and 2’C-methyl-5-methoxyuridine. This compound is used to treat leukemia and other cancers by inhibiting the synthesis of DNA. Inhibiting DNA synthesis prevents the reproduction of cancer cells. The chemical structure of this compound was first published in 2007.Degré de pureté :Min. 95%2',3'-Dideoxy-5-methylcytidine
CAS :2',3'-Dideoxy-5-methylcytidine is a synthetic nucleoside analog based on cytidine, a natural building block of DNA and RNA. This molecule is chemically modified to interfere with nucleic acid synthesis, making it a potential tool in antiviral or anticancer therapy, or for studying epigenetics.Formule :C10H15N3O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :225.25 g/mol2,2'-Anhydrothymidine
CAS :2,2'-Anhydrothymidine is an anhydro version of thymidine. As 2,2'-Anhydrothymidine is a modified version of thymidine it can help researchers understand what happens when DNA is changed or damaged. Other possible uses as in research related to antiviral drug creation.Formule :C10H12N2O5Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :240.21 g/mol8-Allyloxy-9-(b-D-xylofuranosyl)guanine
8-Allyloxy-9-(b-D-xylofuranosyl)guanine is a novel nucleoside that is an activator of ribonucleotide reductase. It is a deoxyribonucleoside and monophosphate, and it has been shown to be active against cancer cells and viruses. 8-Allyloxy-9-(b-D-xylofuranosyl)guanine inhibits the growth of cancer cells by inhibiting DNA synthesis and protein synthesis, which may be due to its inhibition of ribonucleotide reductase. This drug also has antiviral activity against HIV, herpes simplex virus type 1 (HSV1), and herpes simplex virus type 2 (HSV2).Degré de pureté :Min. 95%3'-O-Propargylcytidine
3'-O-Propargylcytidine is a monophosphate nucleoside that belongs to the group of synthetic, novel nucleosides and deoxyribonucleosides. It is a modified form of cytidine with an extra methyl group attached to the 3' position of the ribose sugar. 3'-O-Propargylcytidine has been shown to inhibit cancer cells by binding to DNA and preventing transcription and replication. This compound also inhibits virus replication and has antiviral properties. 3'-O-Propargylcytidine is highly pure and high quality, which makes it a good candidate for use in pharmaceuticals or other applications requiring high purity.
Formule :C12H15N3O5Degré de pureté :(%) Min. 97%Couleur et forme :PowderMasse moléculaire :281.26 g/mol2',3'-Di-O-acetyl-D-uridine
CAS :2',3'-Di-O-acetyl-D-uridine is a nucleoside for use in research applicationsFormule :C13H16N2O8Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :328.27 g/molN6-Benzoyl-2',3'-isopropylideneadenosine
CAS :N6-Benzoyl-2',3'-isopropylideneadenosine is a nucleoside that is structurally related to the natural nucleosides adenosine, deoxyadenosine, and deoxyguanosine. It is an antiviral agent that has been shown to be an activator of the enzyme ribonucleotide reductase. N6-Benzoyl-2',3'-isopropylideneadenosine is a modified nucleoside with high purity and high quality. The CAS number for this compound is 39947-04-1. This compound has not been found in nature, but it can be synthesized by modifying nucleosides or by using phosphoramidites.
Formule :C20H21N5O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :411.41 g/mol5-Methylcytidine-5'-monophosphate
CAS :5-Methylcytidine-5'-monophosphate is a nucleotide that is an intermediate in the synthesis of DNA. It is a neutral form and has been sequenced. 5-Methylcytidine-5'-monophosphate is found in cellular components, such as mitochondria and nuclei. The biochemical properties of this molecule are dependent on its methylation state. This molecule also plays a role in mitochondrial functions and nuclear DNA modifications.
Formule :C10H16N3O8PDegré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :337.22 g/mol
