Inhibiteurs

Spiratisanin A is a natural product from Spiraea japonica.

N-Deacetyllapaconitine is a useful organic compound for research related to life sciences and the catalog number is T131546.

MCAAD-3, a near-infrared Aβ imaging probe, exhibits blood-brain barrier permeability and strong affinity for Aβ polymers (Ki >106 nM).

Spirolingzhine D is a useful organic compound for research related to life sciences. The catalog number is T125689 and the CAS number is 1612239-54-9.

AS-604850: PI3Kγ inhibitor, ATP-competitive, IC50=2.5μM, 30x> PI3Kδ/β, 18x> PI3Kα.

mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases

PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells.

1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone is a useful organic compound for research related to life sciences and the catalog number is T125250.

ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.

10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126303.

Yimitasvir, an oral NS5A inhibitor, treats chronic hepatitis C. Used for research.

Questiomycin A derivatives 12 is a Questiomycin A derivative.

RdRP-IN-3, a potential anti-influenza drug candidate, functions by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.

Firefly Luciferase circRNA, originally isolated from Photinus pyralis (Firefly), expresses a luciferase protein and serves as an optimal marker for monitoring

HX103: Fluorogenic EGFR-TKI probe; inhibits various EGFR mutations; predicts NSCLC treatment response. IC50: 1.3-977 nM.

Potent PROTAC ER Degrader-10 for cancer research; from patent WO2021133886, example 36.

BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.

Cap-dependent endonuclease-IN-22 is a powerful inhibitor of cap-dependent endonuclease (CEN) [1].

Mitoquinone is a TPP-based, mitochondrially targeted antioxidant .

Gynosaponin V is a useful organic compound for research related to life sciences. The catalog number is T126218 and the CAS number is 1207861-73-1.

Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

Gd-NMC-3, a bimodal imaging probe, exhibits high resolution and sensitivity for tumor imaging with favorable biocompatibility, demonstrating significant

PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2).

Questiomycin A derivatives 20 is a Questiomycin A derivative.

Antitumor agent-109 (compound 6) is a dual-function inhibitor that targets hyaluronic acid and CD44, which are involved in tumor progression and invasion.

Moxetumomab pasudotox (CAT 8015), an anti-CD22 immunotoxin for researching hairy cell leukemia.

C.I. Pigment Yellow 14 is a yellow dye.

CYH33 methanesulfonate is a PI3Kα inhibitor with IC50 of 5.9 nM; halts breast and NSCLC cell growth, effective against solid tumors.

LH1306 inhibits PD-1/PD-L1 interaction, IC50: 25 nM (HTRF assay); boosts Jurkat cell activation, EC50: 334-4,214 nM.

PD-1/PD-L1 binder, Kd 0.51 μM; blocks interaction in flow cytometry at 1 mg/mL; inhibits tumors, extends mouse survival.

Antiviral agent 8, surpassing lead compounds crocin-1 and crocin-2, has been identified as a potent and promising candidate with enhanced antiviral activities.

rel-(11S,31S)-16,36,37,54-Tetramethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane is a useful organic compound for research related to life sciences and the catalog number is T64548.

2', 3'-cGAMP-C2-SH is a ADC cytotoxin.

Compound N060-0121 is a useful organic compound for research related to life sciences and the catalog number is T131219.

Phototherapeutic agent-1: a light-activated, ROS-generating cancer cell killer with aggregation-induced emission.

Mca-Ala-Pro-Lys(Dnp)-OH, a specific quenched fluorogenic substrate for ACE2, enables the detection of ACE2 activity in various tissues including urinary, heart

Immuno-Oncology Screening Library with 90+ cancer/immunology compounds in 96-well format, 10 mM DMSO solutions, including various target modulators.

gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.

Activates Notch pathway, boosts NSC self-renewal and neurogenesis, enhances mice memory.

1-Hydroxybisabola-2,10-dien-4-one is a natural product for research related to life sciences. The catalog number is TN5398 and the CAS number is 124898-71-1.

CAY10735: Anticancer agent; inhibits growth/migration in various cancer cells; reduces tumor in mouse models. IC50=0.674-11.56μM.

OVA Peptide (323-339) is an Ovalbumin epitope crucial for hypersensitivity in BALB/c mice.

Thalidomide-O-amido-PEG3-C2-NH2 TFA, a cereblon ligand-PEG linker for PROTAC, is synthesized.

GEM-5, a gemcitabine conjugate with HIF-1α inhibitor YC-1 (IC50=30 nM), down-regulates HIF-1α, up-regulates p53, and induces A2780 cell apoptosis.

SIAIS117: A Brigatinib-VHL-1 ALK PROTAC; degrades ALK G1202R, inhibits SR/H2228 cells, may fight small cell lung cancer.

1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity.

SH379, a 2-methylpyrimidine diterpene derivative, boosts testosterone synthesis enzymes and autophagy via AMPK/mTOR.

N2S2-CBMBC, a bromo-benzyl ether, binds to 99mTc for PD-L1 tumor imaging, offering a real-time alternative to immunohistochemistry.

Sirtratumab vedotin (ASG15-ME) is an antibody-drug conjugate (ADC) that links a SLITRK6-specific human gamma 2 antibody (Igγ2) to the microtubule disruption agent monomethyl auristatin E (MMAE) through a protease-cleavable linker [1].

Cap-dependent endonuclease-IN-15: potent CEN inhibitor, halts influenza virus replication, aids viral research.

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.

HDAC3/6-IN-2 inhibits HDAC6/3 with IC50s 0.368/0.635 μM; promotes cancer cell apoptosis and histone acetylation.

Aflatoxin M1, a toxic metabolite of Aflatoxin B1, is produced by Aspergillus fungi, with a toxicity order: B1 > M1 > G1 > B2 > M2 > G2.