Inhibiteurs

VH032-PEG3-acetylene: a VHL ligand-linker for PROTACs, combines VH032 with PEG3-acetylene.

Spirolingzhine D is a useful organic compound for research related to life sciences. The catalog number is T125689 and the CAS number is 1612239-54-9.

2', 3'-cGAMP-C2-SH is a ADC cytotoxin.

Cap-dependent endonuclease-IN-12 (EXP-35) is a potent inhibitor with low toxicity, active against H1N1.

Antitumor agent-109 (compound 6) is a dual-function inhibitor that targets hyaluronic acid and CD44, which are involved in tumor progression and invasion.

Gd-NMC-3, a bimodal imaging probe, exhibits high resolution and sensitivity for tumor imaging with favorable biocompatibility, demonstrating significant

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor and E3 ligase ligand.

PROTAC MDM2 Degrader-2: A potent MDM2-targeting compound with PROTAC tech for E3 ligase-mediated degradation.

AT-1002 TFA, a 6-mer synthetic peptide, functions as a tight junction regulator and absorption enhancer.

Sirtratumab vedotin (ASG15-ME) is an antibody-drug conjugate (ADC) that links a SLITRK6-specific human gamma 2 antibody (Igγ2) to the microtubule disruption agent monomethyl auristatin E (MMAE) through a protease-cleavable linker [1].

TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.

m-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

rel-(11S,31S)-16,36,37,54-Tetramethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane is a useful organic compound for research related to life sciences and the catalog number is T64548.

Yimitasvir, an oral NS5A inhibitor, treats chronic hepatitis C. Used for research.

PROTAC PARP/EGFR ligand 1 enables dual PARP EGFR degrader synthesis via PROTAC.

Mitoquinone-cyclodextrin is a mitochondria-targeted, 1:1 mix of Mitoquinone mesylate and cyclodextrin, aiming to combat oxidative damage.

Compound 13i is a potent PROTAC BRD4 degrader with IC50s: 29.54 nM (BD1), 3.82 nM (BD2), impedes G2/M progression, and induces apoptosis in MV-4-11 cells.

Potent PROTAC ER Degrader-10 for cancer research; from patent WO2021133886, example 36.

Elamipretide TFA (RX-31 TFA) is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide[1].

Microcystin-LF, a phenylalanine variant of Microcystin-LR, is a bacterial metabolite that exhibits cellular toxicity in Caco-2 cells [1] [2].

KHS 101 hydrochloride is a neuronal differentiation inducer

Spiratisanin A is a natural product from Spiraea japonica.

Gynosaponin V is a useful organic compound for research related to life sciences. The catalog number is T126218 and the CAS number is 1207861-73-1.

Stephalonine L is a natural product for research related to life sciences. The catalog number is TN6290 and the CAS number is 2379277-60-6.

Mca-Ala-Pro-Lys(Dnp)-OH, a specific quenched fluorogenic substrate for ACE2, enables the detection of ACE2 activity in various tissues including urinary, heart

Thalidomide-O-amido-PEG3-C2-NH2 TFA, a cereblon ligand-PEG linker for PROTAC, is synthesized.

1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity.

Cap-dependent endonuclease-IN-22 is a powerful inhibitor of cap-dependent endonuclease (CEN) [1].

gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.

Thalidomide-based cereblon ligand-linker for selective dBRD9 synthesis, enabling BAF complex study.

Taragarestrant (D-0502) is an oral SERD with potent activity against ER+ breast cancer.

PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM).

Antiviral agent 8, surpassing lead compounds crocin-1 and crocin-2, has been identified as a potent and promising candidate with enhanced antiviral activities.

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

ER degrader 2: Potent estrogen receptor disruptor; key for cancer research.

Mouse IgG3 kappa Isotype Control is a monoclonal antibody serving as an isotype control specifically for mouse IgG3κ antibodies.

BRD73842 is an inhibitor of Plasmodium PI4K .

Podoblastin A (D-mannitol) is a useful organic compound for research related to life sciences and the catalog number is TSP-41077145.

FGFR-IN-1 targets FGFR1-3 with IC50 <100 nM. (US20130338134A1, ex 219)

CAY10735: Anticancer agent; inhibits growth/migration in various cancer cells; reduces tumor in mouse models. IC50=0.674-11.56μM.

Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.

Questiomycin A derivatives 14 is a Questiomycin A derivative.

TL4830031 (8i), quinolone derivative, Axl inhibitor, IC50: 26 nM, blocks Axl phosphorylation, cell invasion & migration; for cancer research.

STING agonist-9 (Compound 45): potent, EC50 1.2 nM h-STING, 32.82 μM m-STING; antitumor [1].

OVA Peptide (323-339) is an Ovalbumin epitope crucial for hypersensitivity in BALB/c mice.

Oroxin A, a partial PPARγ agonist, activates PPARγ, inhibits α-glucosidase, and has antioxidant properties.

3'-O-Angeloylhamaudol is a useful organic compound for research related to life sciences and the catalog number is T124112.

Ephedrine levulinate: alkaloid, stimulates alpha/beta-adrenergic receptors, boosts norepinephrine release.

Melarsonyl dipotassium, also known as melarsonic acid dipotassium, is a potent anthelmintic agent with the ability to effectively inhibit parasites.

Anticancer agent 11 suppresses angiogenesis and induces DNA cross-links for broad-spectrum efficacy.

MCAAD-3, a near-infrared Aβ imaging probe, exhibits blood-brain barrier permeability and strong affinity for Aβ polymers (Ki >106 nM).

Mitoquinone is a TPP-based, mitochondrially targeted antioxidant .

9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.

Glabralide A is a natural product from plants

N2S2-CBMBC, a bromo-benzyl ether, binds to 99mTc for PD-L1 tumor imaging, offering a real-time alternative to immunohistochemistry.

Microcystin-LY, from Microcystis aeruginosa, is a heptapeptide toxin that triggers oxidative stress by activating the Nrf2 pathway, most effective at 3μM.

eGFP circRNA, originally isolated from the jellyfish Aequorea victoria, is a reporter widely utilized for direct detection in mammalian cell culture due to its

SK-575-NEG is a methylated form of SK-575, binds PARP1 (IC50: 2.64 nM), but doesn't induce PARP1 degradation up to 1 μM in cells.

Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.

Fungicide5 is a fungicide candidate targeting succinate dehydrogenase ( K i = 0.095 μM).

Yimitasvir (Emitasvir) diphosphate，一种针对丙型肝炎病毒(HCV)非结构蛋白5A (NS5A)的口服活性抑制剂，适用于慢性丙型肝炎病毒感染的研究。

10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126303.