Inhibiteurs

Questiomycin A derivatives 14 is a Questiomycin A derivative.

Phototherapeutic agent-1: a light-activated, ROS-generating cancer cell killer with aggregation-induced emission.

GEM-5, a gemcitabine conjugate with HIF-1α inhibitor YC-1 (IC50=30 nM), down-regulates HIF-1α, up-regulates p53, and induces A2780 cell apoptosis.

TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。

Thalidomide-NH-PEG4-Ms: cereblon ligand + linker, for PROTAC BCL-XL degrader XZ739.

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

Microcystin-LY, from Microcystis aeruginosa, is a heptapeptide toxin that triggers oxidative stress by activating the Nrf2 pathway, most effective at 3μM.

PROTAC PARP/EGFR ligand 1 enables dual PARP EGFR degrader synthesis via PROTAC.

Compound 13i is a potent PROTAC BRD4 degrader with IC50s: 29.54 nM (BD1), 3.82 nM (BD2), impedes G2/M progression, and induces apoptosis in MV-4-11 cells.

BRD73842 is an inhibitor of Plasmodium PI4K .

A031: PROTAC AR degrader, IC50 < 0.25 μM, inhibits prostate cancer growth in zebrafish.

Potent PROTAC ER Degrader-10 for cancer research; from patent WO2021133886, example 36.

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

KHS 101 hydrochloride is a neuronal differentiation inducer

PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM).

HX103: Fluorogenic EGFR-TKI probe; inhibits various EGFR mutations; predicts NSCLC treatment response. IC50: 1.3-977 nM.

Ephedrine levulinate: alkaloid, stimulates alpha/beta-adrenergic receptors, boosts norepinephrine release.

(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.

Darobactin is an antibiotic effective against critical Gram-negative pathogens, demonstrating activity both in vitro and in animal infection models [1].

Lupinine hydrochloride is a bioactive chemical.

m-PEG11-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

C.I. Pigment Yellow 14 is a yellow dye.

PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells.

Ppack HCl is a peptide that binds thrombin, inhibiting platelet activation (Ki: 0.24 nM). Used as an anticoagulant and to research clotting and inflammation.

TL4830031 (8i), quinolone derivative, Axl inhibitor, IC50: 26 nM, blocks Axl phosphorylation, cell invasion & migration; for cancer research.

FGFR-IN-1 targets FGFR1-3 with IC50 <100 nM. (US20130338134A1, ex 219)

Cap-dependent endonuclease-IN-22 is a powerful inhibitor of cap-dependent endonuclease (CEN) [1].

m-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.

1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone is a useful organic compound for research related to life sciences and the catalog number is T125250.

M-PEG1-acid, a soluble PEG derivative, has a terminal carboxylic acid for forming amide bonds with primary amines using activators like EDC, DCC.

BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.

Mitoquinone-cyclodextrin is a mitochondria-targeted, 1:1 mix of Mitoquinone mesylate and cyclodextrin, aiming to combat oxidative damage.

CYH33 methanesulfonate is a PI3Kα inhibitor with IC50 of 5.9 nM; halts breast and NSCLC cell growth, effective against solid tumors.

Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.

IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

OVA Peptide (323-339) is an Ovalbumin epitope crucial for hypersensitivity in BALB/c mice.

Stephalonine L is a natural product for research related to life sciences. The catalog number is TN6290 and the CAS number is 2379277-60-6.

Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants ( IC 50 = 0.2-0.7 nM).

STING agonist-9 (Compound 45): potent, EC50 1.2 nM h-STING, 32.82 μM m-STING; antitumor [1].

Sinoporphyrin sodium hinders cell growth, induces early apoptosis, disrupts F-actin, impairs movement, and may treat cancer; it's a photosensitizer.

2', 3'-cGAMP-C2-SH is a ADC cytotoxin.

Immuno-Oncology Screening Library with 90+ cancer/immunology compounds in 96-well format, 10 mM DMSO solutions, including various target modulators.

Taragarestrant (D-0502) is an oral SERD with potent activity against ER+ breast cancer.

AT-1002 TFA, a 6-mer synthetic peptide, functions as a tight junction regulator and absorption enhancer.

PROTAC MDM2 Degrader-4 targets MDM2 for degradation with E3 ligase via a linked inhibitor.

(3,4-Dihydroxy-5-methoxybenzoyl)taraxerol is a natural products from plants

Compound 32a: PROTAC BRD4 Degrader-6, IC50 = 2.7 nM, degrades BRD4, halts BxPC3 pancreatic cancer cell growth, induces apoptosis for research.

LH1306 inhibits PD-1/PD-L1 interaction, IC50: 25 nM (HTRF assay); boosts Jurkat cell activation, EC50: 334-4,214 nM.

Questiomycin A derivatives 12 is a Questiomycin A derivative.

Compound N060-0121 is a useful organic compound for research related to life sciences and the catalog number is T131219.

CAY10735: Anticancer agent; inhibits growth/migration in various cancer cells; reduces tumor in mouse models. IC50=0.674-11.56μM.

Antitumor agent-109 (compound 6) is a dual-function inhibitor that targets hyaluronic acid and CD44, which are involved in tumor progression and invasion.

Firefly Luciferase circRNA, originally isolated from Photinus pyralis (Firefly), expresses a luciferase protein and serves as an optimal marker for monitoring

Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.

Diacetoxyscirpenol: a fungal mycotoxin causing blood disorders in humans/animals.

ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.

Activates Notch pathway, boosts NSC self-renewal and neurogenesis, enhances mice memory.

Azido-PEG12-t-butyl ester, a soluble PEG with azide/reactive t-butyl, forms triazoles via Click Chemistry; deprotectable in acid.