Inhibiteurs

Thalidomide-NH-PEG4-Ms: cereblon ligand + linker, for PROTAC BCL-XL degrader XZ739.

ER degrader 3 targets estrogen receptor, key in cell regulation, potential for cancer research.

Questiomycin A derivatives 13 is a Questiomycin A derivative.

Contezolid acefosamil (MRX-4), oral prodrug of Contezolid (MRX-I), treats multidrug-resistant Gram-positive bacteria, including MRSA.

Compound 17h is a potent antibacterial against VRE and MRSA, reduces MRSA biofilms, and is stable in liver microsomes.

Cap-dependent endonuclease-IN-15: potent CEN inhibitor, halts influenza virus replication, aids viral research.

mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases

α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine

CYH33 methanesulfonate is a PI3Kα inhibitor with IC50 of 5.9 nM; halts breast and NSCLC cell growth, effective against solid tumors.

PROTAC MDM2 Degrader-3 uses PROTAC tech to efficiently break down MDM2 with a potent inhibitor and E3 ligase ligand.

PROTAC PARP/EGFR ligand 1 enables dual PARP EGFR degrader synthesis via PROTAC.

M-PEG1-acid, a soluble PEG derivative, has a terminal carboxylic acid for forming amide bonds with primary amines using activators like EDC, DCC.

IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

Spirolingzhine D is a useful organic compound for research related to life sciences. The catalog number is T125689 and the CAS number is 1612239-54-9.

1-Hydroxybisabola-2,10-dien-4-one is a natural product for research related to life sciences. The catalog number is TN5398 and the CAS number is 124898-71-1.

Glabralide A is a natural product from plants

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

ER degrader 2: Potent estrogen receptor disruptor; key for cancer research.

Azido-PEG12-t-butyl ester, a soluble PEG with azide/reactive t-butyl, forms triazoles via Click Chemistry; deprotectable in acid.

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

Compound 32a: PROTAC BRD4 Degrader-6, IC50 = 2.7 nM, degrades BRD4, halts BxPC3 pancreatic cancer cell growth, induces apoptosis for research.

Microcystin-LF, a phenylalanine variant of Microcystin-LR, is a bacterial metabolite that exhibits cellular toxicity in Caco-2 cells [1] [2].

Aflatoxin M1, a toxic metabolite of Aflatoxin B1, is produced by Aspergillus fungi, with a toxicity order: B1 > M1 > G1 > B2 > M2 > G2.

Darobactin is an antibiotic effective against critical Gram-negative pathogens, demonstrating activity both in vitro and in animal infection models [1].

Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.

SIAIS117: A Brigatinib-VHL-1 ALK PROTAC; degrades ALK G1202R, inhibits SR/H2228 cells, may fight small cell lung cancer.

AS-604850: PI3Kγ inhibitor, ATP-competitive, IC50=2.5μM, 30x> PI3Kδ/β, 18x> PI3Kα.

Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand; used with a linker to create PROTACs.

Sinoporphyrin sodium hinders cell growth, induces early apoptosis, disrupts F-actin, impairs movement, and may treat cancer; it's a photosensitizer.

PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2).

Mitoquinone is a TPP-based, mitochondrially targeted antioxidant .

Phototherapeutic agent-1: a light-activated, ROS-generating cancer cell killer with aggregation-induced emission.

1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity.

Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.

(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.