Inhibiteurs

Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.

Questiomycin A derivatives 20 is a Questiomycin A derivative.

PROTAC MDM2 Degrader-1 uses PROTAC tech to break down MDM2 with an inhibitor, linker, and E3 ligase ligand.

Neuraminic acid: acidic amino sugar, 9 carbon chain, from pyruvic acid + D-mannosamine, in active mucoproteins.

Arsenazo I is a calcium-sensitive, metallochromic dye used as reagent.

NT 2 Toxin is a useful organic compound for research related to life sciences. The catalog number is T124258 and the CAS number is 76348-84-0.

PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 > 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 > 100μM).

SIAIS164018, a PROTAC-derived ALK/EGFR degrader from Brigatinib, has IC50s of 2.5 & 6.6 nM; it hinders cancer cell movement and promotes apoptosis.

C.I. Pigment Yellow 14 is a yellow dye.

PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2).

PROTAC PARP/EGFR ligand 1 enables dual PARP EGFR degrader synthesis via PROTAC.

Taragarestrant (D-0502) is an oral SERD with potent activity against ER+ breast cancer.

Chol-N3 is a bioorthogonal chol probe capable of integrating with super-resolution fluorescence microscopy (SRM) to enable direct nanoscale imaging of lipid

Nutlin carboxylic acid is a Nutlin 3-based MDM2 ligand; used with a linker to create PROTACs.

Lupinine hydrochloride is a bioactive chemical.

Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.

Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants ( IC 50 = 0.2-0.7 nM).

Sirtratumab vedotin (ASG15-ME) is an antibody-drug conjugate (ADC) that links a SLITRK6-specific human gamma 2 antibody (Igγ2) to the microtubule disruption agent monomethyl auristatin E (MMAE) through a protease-cleavable linker [1].

Compound 13i is a potent PROTAC BRD4 degrader with IC50s: 29.54 nM (BD1), 3.82 nM (BD2), impedes G2/M progression, and induces apoptosis in MV-4-11 cells.

Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.

Cap-dependent endonuclease-IN-15: potent CEN inhibitor, halts influenza virus replication, aids viral research.

Cereblon Ligand-Linker 22: A pomalidomide-based E3 ligase conjugate with a PEG3 linker for PROTACs.

HDAC3/6-IN-2 inhibits HDAC6/3 with IC50s 0.368/0.635 μM; promotes cancer cell apoptosis and histone acetylation.

(Rac)-IBT6A HCl: racemic Ibrutinib impurity; for IBT6A dimers/adducts; Ibrutinib is a Btk inhibitor (IC50=0.5nM).

gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.

Ppack HCl is a peptide that binds thrombin, inhibiting platelet activation (Ki: 0.24 nM). Used as an anticoagulant and to research clotting and inflammation.

1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone is a useful organic compound for research related to life sciences and the catalog number is T125250.

HJM-561 is a potent and selective EGFR PROTAC with oral bioavailability, capable of overcoming osimertinib-resistant EGFR triple mutations and demonstrating

Spirolingzhine D is a useful organic compound for research related to life sciences. The catalog number is T125689 and the CAS number is 1612239-54-9.

PROTAC MDM2 Degrader-2: A potent MDM2-targeting compound with PROTAC tech for E3 ligase-mediated degradation.

MCAAD-3, a near-infrared Aβ imaging probe, exhibits blood-brain barrier permeability and strong affinity for Aβ polymers (Ki >106 nM).