Dérivés de Quinazoline et de Quinoléine
Les quinazolines et les quinoléines sont des composés hétérocycliques azotés à structure aromatique qui jouent un rôle clé dans la synthèse de médicaments à activité anticancéreuse, antimicrobienne et anti-inflammatoire. Leurs dérivés présentent des modifications structurelles qui optimisent leur biodisponibilité et leur sélectivité, permettant ainsi le développement de nouveaux principes actifs pour diverses applications thérapeutiques. Ces composés sont utilisés dans la fabrication d’API destinés au traitement du cancer, des infections, des maladies neurodégénératives et cardiovasculaires. De plus, les dérivés de quinazoline et de quinoléine sont essentiels dans la recherche d’inhibiteurs enzymatiques et dans la conception de molécules bioactives innovantes.
Chez CymitQuimica, nous proposons des dérivés de quinazoline et de quinoléine de haute pureté pour des applications en synthèse chimique, développement pharmaceutique et biotechnologie.
65578 produits trouvés pour "Dérivés de Quinazoline et de Quinoléine"
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Ivacaftor (4-tertbutyl-d9) (Major)
CAS :Produit contrôléFormule :C24H19D9N2O3Couleur et forme :NeatMasse moléculaire :401.55Fingolimod Hydrochloride
CAS :Formule :C19H33NO2·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :343.93N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl Lansoprazole
CAS :Produit contrôlé<p>Applications Lansoprazole (L175000) impurity.<br>References Wallmark, B., et al.: J. Gastroenterol., 20, 37 (1985), Barradell, L., et al.: Drugs, 44, 225 (1992), Reddy, K., et al.: Pharmazie, 65, 994 (2006),<br></p>Formule :C25H22F6N4O3SCouleur et forme :Beige To Light BrownMasse moléculaire :572.52Pizotyline
CAS :Produit contrôlé<p>Applications Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.<br>References Geraud, G., et al.: Clin. Ther., 26, 1305 (2004), Bolay, H., et al.: Nat. Med., 8, 136 (2002), Scher, A., et al.: Pain, 106, 81 (2003), Richter, F., et al.: J. Cereb. Blood Flow Metab., 25, 1225 (2005),<br></p>Formule :C19H21NSCouleur et forme :NeatMasse moléculaire :295.44Pimozide-d5 (Major)
CAS :Produit contrôlé<p>Applications Labelled analogue of Pimozide, a D2 dopamine receptor antagonist. Pimozide binds with high affinity to the cloned 5-HT7 receptor. Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.<br>References Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999); Richelson, E., et al.: Life Sci., 68, 29 (2000); Santi, C., et al.: J. Neurosci., 22, 396 (2002); Mariot, P., et al.: J. Biol. Chem., 277, 10824 (2002); Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2005);<br></p>Formule :C28H24D5F2N3OCouleur et forme :White To Light BeigeMasse moléculaire :466.58Aripiprazole N,N-Dioxide
CAS :<p>Applications Aripiprazole N,N-Dioxide is a metabolite of anti-psychotic drug, Aripiprazole (A771000).<br>References Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998), Rowley, M., et al.: J. Med. Chem., 44, 477 (2001), McGavin, J., et al.: CNS Drugs, 16, 779 (2002),<br></p>Formule :C23H27Cl2N3O4Couleur et forme :Off White SolidMasse moléculaire :480.387-Hydroxy Amoxapine
CAS :Produit contrôlé<p>Applications A metabolite of Amoxapine.<br>References Hansen, E., et al.: Drug Metab. Dispos.,15, 97 (1987), Hansen, E., et al.: Xenobiotica, 25, 1081 (1995), Moody, J., et al.: Drug Metab. Dispos., 27, 1157 (1999),<br></p>Formule :C17H16ClN3O2Couleur et forme :NeatMasse moléculaire :329.78t-Butylnorsynephrine
CAS :<p>Impurity Salbutamol EP Impurity B<br>Applications t-Butylnorsynephrine (Salbutamol EP Impurity B) is a derivative of norsynephrine, an endogenous biogenic amine that is closely related to norepinephrine, which has effects on the adrenergic and dopaminergic system. Structure and activity tudies have shown that t-Butylnorsynephrine may also exhibit effects towards β-adrenergic receptors and β-adrenergic receptor-coupled adenylate cyclase.<br>References Wong, A., et al.: Molec. Pharmacol., 31, 368 (1987); Constanzi, S., et al.: J. Comp. Chem., 33, 561, (2012);<br></p>Formule :C12H19NO2Couleur et forme :YellowMasse moléculaire :209.28A 77-1726
CAS :<p>Impurity Leflunomide EP Impurity B<br>Applications A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formule :C12H9F3N2O2Couleur et forme :White To Off-WhiteMasse moléculaire :270.21Deschloro Dasatinib
CAS :Produit contrôléFormule :C22H27N7O2SCouleur et forme :BrownMasse moléculaire :453.56rac Metanephrine-d3 Hydrochloride Salt
CAS :Produit contrôlé<p>Applications A labelled metabolite of Epinephrine (E588585). A naturraly occurring derivative of Epinephrine, found in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Formule :C102H3H12NO3·ClHCouleur et forme :BeigeMasse moléculaire :236.71Ticagrelor Acetonide
CAS :<p>Stability Hygroscopic<br>Applications 2-[[(3aS,4R,6S,6aa)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol is an intermediate in the synthesis of Ticagrelor (T437700) which is an anticoagulant.<br>References Qiao, D., et al.: Preparation of anticoagulant Ticagrelor, China Patent 104592237, May 6, 2015;<br></p>Formule :C26H32F2N6O4SCouleur et forme :NeatMasse moléculaire :562.63Tezacaftor-D4
CAS :Produit contrôléFormule :C26D4H23F3N2O6Couleur et forme :NeatMasse moléculaire :524.52(2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester
CAS :Produit contrôlé<p>Stability Light Sensitive<br>Applications (2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester is an impurity of Nifedipine (N457000); a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal.<br>References Karancsi, T., et al.: Acta Pharm. Hung., 66, 21 (1996); Poetter, H., et al.: J. Pharmaceut. Biomed., 6, 115 (1988); Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989); Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991); Brown, M.J., et al.: Lancet, 356, 366 (2000)<br></p>Formule :C19H18N4O6Couleur et forme :NeatMasse moléculaire :398.37Gabapentin-d4 (100 μg/mL in Methanol)
CAS :Produit contrôléFormule :C9D4H13NO2Couleur et forme :Single SolutionMasse moléculaire :175.26Cabozantinib N-oxide
CAS :Produit contrôlé<p>Applications Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.<br>References Jaeger, S., et al.: Cancer Res, 77, 459-469 (2017)<br></p>Formule :C28H24FN3O6Couleur et forme :Off-WhiteMasse moléculaire :517.51Dermofungin
CAS :Produit contrôlé<p>Applications Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.<br>References Hongchao, J., et al.: Cancer Lett., 312, 11 (2011); LeVine, H., et al.: Neuroscience Lett., 465, 99 (2009);<br></p>Formule :C9H6ClNOCouleur et forme :NeatMasse moléculaire :179.60N-Hydroxy Norfloxacin
CAS :<p>Applications A metabolite of Norfloxacin (N681000).<br>References Uno, T., et al.: J. Med. Chem., 33, 2929 (1990),<br></p>Formule :C16H18FN3O4Couleur et forme :NeatMasse moléculaire :335.33Dehydro Nisoldipine
CAS :Produit contrôlé<p>Applications A metabolite of Nisoldipine (N489125).<br>References Grossi, P., et al.: Xenobiotica, 22, 899 (1992), Hayase, N., et al.: J. Pharm. Sci., 83, 532 (1994), Barlett, M., et al.: J. Pharm. Biomed. Anal., 18, 335 (1998), Nayler, W., et al.: J. Clin. Basic Cardiol., 2, 155 (1999), Mielcarek, J., et al.: J. Pharm. Biomed. Anal., 24, 71 (2000),<br></p>Formule :C20H22N2O6Couleur et forme :NeatMasse moléculaire :386.40(3R,4R,3’R)-Ezetimibe
CAS :Produit contrôlé<p>Applications (3’R,3R,4R)-Ezetimibe is a structural analog of Ezetimibe (E975000); an antihyperlipoproteinemic and a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formule :C24H21F2NO3Couleur et forme :NeatMasse moléculaire :409.43Ethyl 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylate
CAS :Produit contrôlé<p>Impurity Dutateride EP Impurity C<br>Applications Ethyl 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylate (Dutateride EP Impurity C) is a compound synthesized in the production of azasteroids. Used in the inhibition of 5α-reductase and of androgen receptor binding, both major effecters in the male hormonal system.<br>References Ramusson, G. et al.: J. Med. Chem., 29, 2298 (1986);<br></p>Formule :C21H31NO3Couleur et forme :White To Off-WhiteMasse moléculaire :345.481-Bis(4-fluorophenyl)methyl Piperazine
CAS :Produit contrôlé<p>Impurity Flumazenil EP Impurity A<br>Stability Hygroscopic<br>Applications 1-Bis(4-fluorophenyl)methyl Piperazine (Flumazenil EP Impurity A) is a chemical reagent used in the synthesis of novel tubulin polymerization inhibitors. Also used in the synthesis of novel benzhydrylpiperazine carboxamide derivatives. Impurity of F455200<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yin, Y. et al.: Bioorg. Med. Chem., 22, 2409 (2014); Gurdal, E. et al.: J. Enz. Inhib. Med. Chem., 29, 205 (2014);<br></p>Formule :C17H18F2N2Couleur et forme :White To Light YellowMasse moléculaire :288.345-Desbromo, 5-Chloro Brimonidine
CAS :Produit contrôlé<p>Impurity Brimonidine EP Impurity H<br>Applications UK 14819 is a quinoxalinyl imidazolidine α2-adrenoceptor agonist and is structurally related to Brimonidine (B677520).<br>References Thaina, P., et al.: J. Auton. Pharmacol., 19, 185 (1999)<br></p>Formule :C11H10ClN5Couleur et forme :Light Yellow To YellowMasse moléculaire :247.6836Bupivacaine N-Oxide Hydrochloride Salt
CAS :Produit contrôlé<p>Applications The N-oxide of the local anesthetic Bupivacaine (B689546).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formule :C18H29ClN2O2Couleur et forme :White To BeigeMasse moléculaire :340.891,4-bis[3,4-dihydro-2(1H)-quinolinon-7-oxy]butane
CAS :Produit contrôlé<p>Impurity Aripiprazole Diquinoline Butanediol Impurity (USP)<br>Applications An impurity found in the process for the preparation of Aripiprazole (A771000). Aripiprazole Diquinoline Butanediol Impurity (USP).<br>References Burris, K., et al.: J. Pharmacol. Exp. Ther., 302, 381 (2002), Harrison, T., et al.: Drugs, 64, 1715 (2004),<br></p>Formule :C22H24N2O4Couleur et forme :Off-WhiteMasse moléculaire :380.44(-)-trans-Phenothrin
CAS :<p>Applications (-)-trans-Phenothrin is used in exhaustive parallel conformational search of pyrethroids and structural similarity study. Also used as an active compound combination having insecticidal properties, a synthetic reagent in the preparation and optical purity of benzylic ester pyrethroid enantiomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bertok, B., et al.: J. Environ. Sci. Health, Part B., 31, 495 (1996); Chuman, H., et al.: Journal of Chemical Software, 4, 143 (1998); Thielert, W., et al.: PCT Int. Appl. (2015), WO 2015132140 A1 20150911;<br></p>Formule :C23H26O3Couleur et forme :Colourless To YellowMasse moléculaire :350.45Decloxizine Dihydrochloride
CAS :Produit contrôlé<p>Impurity Hydroxyzine EP Impurity B<br>Applications Decloxizine Dihydrochloride (Hydroxyzine EP Impurity B) is a Hydroxyzine (H996500) impurity.<br>References Lulling, J., et al.: Medicina Pharmacol. Exp., 16 48 (1967),<br></p>Formule :C21H28N2O2·2ClHCouleur et forme :NeatMasse moléculaire :413.38Oxyphenbutazone-d9
CAS :Produit contrôléFormule :C192H9H11N2O3Couleur et forme :BeigeMasse moléculaire :333.43Mirtazapine-d4
CAS :Produit contrôlé<p>Applications Mirtazapine-d4 is the labeled analogue of Mirtazapine (M365000), which is an α2-Adrenergic blocker, analogue of Mianserin, and antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990);<br></p>Formule :C17H15D4N3Couleur et forme :White To Light YellowMasse moléculaire :269.386-Hydroxy-2-mercaptobenzimidazole
CAS :Produit contrôléFormule :C7H6N2OSCouleur et forme :NeatMasse moléculaire :166.20Tolcapone
CAS :Produit contrôlé<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>Formule :C14H11NO5Couleur et forme :ColourlessMasse moléculaire :273.24Sitagliptin Monohydrochloride Monohydrate
CAS :<p>Applications Sitagliptin Monohydrochloride Monohydrate has therapeutic applications and is used in pharmaceutical compositions in the form of immediate release tablets.<br>References Arroyo Hidalgo, S., & Pladevall Roses, M.: PCT Int. Appl. (2015), WO 2015114152 A1<br></p>Formule :C16H15F6N5O·HCl·H2OCouleur et forme :NeatMasse moléculaire :407.31 + 36.46 + 18.023,4-Dihydro-7-hydroxyquinoline-2(1H)-one
CAS :Formule :C9H9NO2Couleur et forme :NeatMasse moléculaire :163.17Thioridazine Disulfoxide
CAS :Produit contrôléFormule :C21H26N2O2S2Couleur et forme :NeatMasse moléculaire :402.576,7-Dimethoxyquinazoline-4-one
CAS :<p>Applications Gefitinib intermediate.<br>References Kelly, L., et al.: Cancer Cell., 1, 421 (2002), Pandey, A., et al.: J. Med. Chem., 45, 3772 (2002), Ciardiello, F., et al.: Exp. Opin Emerg. Drugs, 8, 501 (2003), Caponigro, F., et al.: Curr. Opin Oncol., 16, 225 (2004),<br></p>Formule :C10H10N2O3Couleur et forme :NeatMasse moléculaire :206.20N-Methylnitroacetamide
CAS :Produit contrôlé<p>Impurity Ranitidine EP Impurity H<br>Applications N-Methylnitroacetamide (Ranitidine EP Impurity H) is a degradation product of Ranitidine (R120000).<br>References Sharma, N. et al.: Sci. Pharmac., 79, 309 (2011); Haywood, P.A. et al.: J. Chem. Soc., 5, 951 (1987);<br></p>Formule :C3H6N2O3Couleur et forme :NeatMasse moléculaire :118.09Zileuton
CAS :Produit contrôlé<p>Applications An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.<br>References Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991), Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992), McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)<br></p>Formule :C11H12N2O2SCouleur et forme :NeatMasse moléculaire :236.294'-[(1,7'-Dimethyl-2'-propyl[2,5'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic Acid
CAS :Produit contrôlé<p>Impurity Telmisartan EP Impurity B; Timolol USP Related Compound B<br>Applications 4’-Desmethyl-7’-methyl Telmisartan (Telmisartan EP Impurity B; Timolol USP Related Compound B) is an impurity of Telmisartan (T017000), an angiotensin II receptor antagonist.<br></p>Formule :C33H30N4O2Couleur et forme :Off-WhiteMasse moléculaire :514.62(E/Z)-Tamoxifen-d5
CAS :Produit contrôlé<p>Applications Mixture of labelled Tamoxifen and its (E)-isomer.<br></p>Formule :C26H24D5NOCouleur et forme :Off White SolidMasse moléculaire :376.55N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine Impurity)
CAS :Produit contrôlé<p>Impurity Cimetidine EP Impurity H<br>Applications N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine EP Impurity H) is an impurity of Cimetidine (C441650), an H2-receptor antagonist that is used for the treatment and prevention of stress-induced gastroduodenal lesions.<br>References Burland, W., et al.: Brit. J. Clin. Pharm., 2, 481 (1975); Kauffman, G. & Morton, I.: Gastroenterology, 75, 1099 (1978); Peura, D. & Johnson, L.: Ann. Int. Med., 103, 173 (1985)<br></p>Formule :C10H18N8S2Couleur et forme :Off-WhiteMasse moléculaire :314.432'-Hydroxy-3'-methoxyacetophenone
CAS :Produit contrôlé<p>Applications 2'-Hydroxy-3'-methoxyacetophenone, is an intermediate used for he synthesis of various chemical compounds. It can be used for the synthesis of 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.<br>References Nadine, d. M., et al.: J. Med. Chem., 34, 736 (1991);<br></p>Formule :C9H10O3Couleur et forme :NeatMasse moléculaire :166.18Omeprazole Sulfone N-Oxide
CAS :<p>Impurity Omeprazole EP Impurity I<br>Applications Omeprazole Sulfone N-Oxide (Omeprazole EP Impurity I) is a metabolite of Omeprazole. Impurity I.<br>References Stevens, C.M., et al.: J. Biol. Chem., 75, 182 (1950), Okamoto, S., et al.: Biochem. Biophys. Res. Commun., 101, 440 (1981)<br></p>Formule :C17H19N3O5SCouleur et forme :NeatMasse moléculaire :377.41trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol(Ambroxol Impurity C)
CAS :Produit contrôlé<p>Impurity Ambroxol EP Impurity C Hydrochloride<br>Stability Light Sensitive<br>Applications trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug and the metabolite of Bromhexine (B678600). Ambroxol EP Impurity C<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formule :C13H16Br2N2OCouleur et forme :NeatMasse moléculaire :376.09(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
CAS :Produit contrôlé<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate used to prepare trans-2-arylcyclopropylamines as potent and selective dipeptidyl peptidase IV inhibitors.<br>References Tsai, T., et al.: Bioorg. Med. Chem., 17, 2388 (2009)<br></p>Formule :C9H9F2N·HClCouleur et forme :Off White SolidMasse moléculaire :205.632Agomelatine Dimer Urea
CAS :<p>Impurity Agomelatine Impurity 4<br>Applications Agomelatine Dimer Urea is an impurity of Agomelatine (A430020). Agomelatine Impurity 4<br>References Depreux, P., et al.: J. Med. Chem., 37, 3231 (1994); Wregget, K., et al.: J. Biol. Chem., 270, 22488 (1995); Ying, S., et al.: Eur. J. Pharmacol., 296, 33 (1996);<br></p>Formule :C27H28N2O3Couleur et forme :NeatMasse moléculaire :428.52Bis(2-aminoethylthio)methane Dihydrochloride
CAS :Produit contrôlé<p>Applications Bis(2-aminoethylthio)methane is a potential inhibitor of γ-glutamylcysteine synthetase, the first enzyme in the glutathione biosynthesis pathway.<br>References Sweetman, B.J., et al.: J. Med. Chem., 12, 888 (1969); Seelig, G.F., et al.: J. Biol. Chem., 259, 3534 (1984);<br></p>Formule :C5H14N2S2·2(HCl)Couleur et forme :NeatMasse moléculaire :239.222',6'-Picolinoxylidide
CAS :Produit contrôléFormule :C14H14N2OCouleur et forme :NeatMasse moléculaire :226.27(5S,6R)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3-morpholinone [Aprepit
CAS :Produit contrôlé<p>Applications Aprepitant-M3 is an active metabolite of Aprepitant.<br>References Ballard, T., et al.: Eur. J. Pharmacol., 412, 255 (2001), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Severini, C., et al.: Pharmacol. Rev., 54, 285 (2002),<br></p>Formule :C20H16F7NO3Couleur et forme :NeatMasse moléculaire :451.33Robenidine-d8
CAS :Produit contrôlé<p>Applications Labelled Robenidine (R639000). Robenidine is used as a coccidiostat.<br>References Kantor, et al.: Science, 373, 168 (1970), Wong, et al.: Biochem. Biophys. Res. Commun., 46, 621 (1972)<br></p>Formule :C15H5D8Cl2N5Couleur et forme :YellowMasse moléculaire :342.25aR-Brivaracetam
CAS :Produit contrôlé<p>Applications αR-Brivaracetam acts as a reagent for the preparation of 2-Oxo-1-pyrrolidine derivatives and their anticonvulsants activity. Also, is an impurity of Brivaracetam (B677645), a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Differding, E., et al.: PCT Int. Appl. (2001), WO 2001062726 A2 20010830; Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formule :C11H20N2O2Couleur et forme :NeatMasse moléculaire :212.29Sitagliptin Triazecine Analog
CAS :Produit contrôlé<p>Impurity Sitagliptin Tablets EP Impurity FP-B<br>Applications Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.<br>References Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formule :C16H13F6N5O2Couleur et forme :NeatMasse moléculaire :421.30N-Demethyl Ivabradine Hydrochloride
CAS :Produit contrôléFormule :C26H34N2O5·ClHCouleur et forme :NeatMasse moléculaire :491.02D-Tryptophan Methyl Ester Hydrochloride
CAS :Produit contrôlé<p>Applications Intermediate for the synthesis of Tryptophan derivatives.<br>References Deveau, A., et al.: Bioorg. Med. Chem. Lett., 18, 3522 (2008),<br></p>Formule :C12H14N2O2·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :254.71N-Desmethyl Imatinib Dimesylate
Produit contrôlé<p>Stability Hygroscopic<br>Applications N-Desmethyl Imatinib Dimesylate is a by-product of the synthesis of N-Desmethyl Imatinib Mesylate (D292345), a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Formule :C28H29N7O•C3H8O2SCouleur et forme :NeatMasse moléculaire :479.58210816Finasteride Acid
CAS :Produit contrôléFormule :C19H27NO3Couleur et forme :WhiteMasse moléculaire :317.424’-Bromomethyl-2-cyanobiphenyl
CAS :Produit contrôlé<p>Impurity Irbesartan Bromo Nitrile Impurity<br>Applications Halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References KIm, Y.S., et al.: Bioorg. Med. Chem., 3, 2667 (1993),<br></p>Formule :C14H10BrNCouleur et forme :NeatMasse moléculaire :272.14L-Aminobutyric Acid
CAS :<p>Applications Receptor antagonist.<br>References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995),<br></p>Formule :C4H9NO2Couleur et forme :NeatMasse moléculaire :103.12Ketanserin Tartrate
CAS :Produit contrôlé<p>Applications Ketanserin Tartrate is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis for preventing a variety of diseases ranging from cancer to ischemic injury.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gohil, V. M., et al.: Nat. Biotechnol, 28, 249 (2010)<br></p>Formule :C22H22FN3O3·C4H6O6Couleur et forme :Off-WhiteMasse moléculaire :545.51Benzhydrol
CAS :<p>Impurity Diphenhydramine EP Impurity D<br>Applications Intermediate in the preparation of Modafinil (M482500).<br>References Kumar, C., et al.: Eur. J. Med. Chem., 44, 1223 (2009),<br></p>Formule :C13H12OCouleur et forme :WhiteMasse moléculaire :184.23Maropitant Citrate Salt
CAS :<p>Applications Maropitant is a neurokinin type 1 (NK-1) receptor antagonist. Recent studies show that Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs.<br>References Boscan, P. et al.: Am. J. Vet. Res., 72, 1576 (2011);<br></p>Formule :C32H40N2O·C6H8O7Couleur et forme :Off White SolidMasse moléculaire :660.81-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine
CAS :Produit contrôlé<p>Applications 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine is an intermediate used to prepare nonracemic γ-bicyclic heteroarylpiperazine- and heteroarylpiperidine-substituted prolinylthiazolidines as selective and orally active dipeptidylpeptidase 4 inhibitors for use as antidiabetic agents.<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012)<br></p>Formule :C14H18N4Couleur et forme :NeatMasse moléculaire :242.32Cinitapride Tartrate
CAS :<p>Applications Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.<br>References Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997); Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007); Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>Formule :C21H30N4O4·C4H6O6Couleur et forme :NeatMasse moléculaire :552.574-Amino-3,5-dichloropyridine
CAS :<p>Applications 4-Amino-3,5-dichloropyridine is a metabolite of the selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).<br>References Jeffrey, A.D. et al.: Drug Chem. Toxicol., 25, 93 (2002); Cassidy, K.C. et al.: J. Pharmac. Biomed. Anal., 22, 869 (2000);<br></p>Formule :C5H4Cl2N2Couleur et forme :NeatMasse moléculaire :163.0S-[5-Chloro-3-(trifluoromethyl)pyrid-2-yl]-S-methylsulfilimine 2,4,6-trimethylbenzenesulfonate
CAS :Formule :C16H18ClF3N2O3S2Degré de pureté :95.0%Masse moléculaire :442.9Nadifloxacin
CAS :<p>Applications Fluorinated quinolone antibacterial (topical).<br>References Kurokawa, I., et al.: J. Am. Acad. Dermatol., 25, 674 (1991),<br></p>Formule :C19H21FN2O4Couleur et forme :White To Off-WhiteMasse moléculaire :360.38Methyl 2-Methyl-6-(3-nitrophenyl)-4-oxo-2-cyclohexene-1-carboxylate
CAS :<p>Applications Methyl 2-Methyl-6-(3-nitrophenyl)-4-oxo-2-cyclohexene-1-carboxylate is a nicardipine impurity. Also, it is derived from Methyl Acetoacetate (O848425), which is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Vaghela, B. K., et al.: J. Liq. Chromatogr. Related Technol., 36, 2166-2181 (2013);<br></p>Formule :C15H15NO5·C16H17NO5Couleur et forme :NeatMasse moléculaire :592.595,5''-Dibromo-3,3''-dihexyl-2,2':5',2''-terthiophene
CAS :Degré de pureté :97%Masse moléculaire :574.4899902343752,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine-7,8-diamine
CAS :Produit contrôlé<p>Applications Varenicline intermediate.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005),<br></p>Formule :C13H14F3N3OCouleur et forme :NeatMasse moléculaire :285.26Lansoprazole Sulfone
CAS :<p>Impurity Lansoprazole USP Related Compound A<br>Applications A metabolite of Lansoprazole, as gastric pump inhibitor. Lansoprazole USP Related Compound A.<br>References De Morais, S., et al.: Mol. Pharmacol., 46, 594 (1994), Spencer, C., et al.: Drugs, 48, 404 (1994), Pearce, R., et al.: J. Pharmacol. Exp. Ther., 277, 805 (1996), Tassaneeyakul, W., et al.: Br. J. Clin. Pharmacol., 49, 139 (2000),<br></p>Formule :C16H14F3N3O3SCouleur et forme :NeatMasse moléculaire :385.36Diminazene-13C2,15N4 Dihydrochloride (major)
CAS :<p>Applications Labelled Diminazene (D479550). Antiprotozoal (Trypanosoma, Babesia).<br>References Braithwaite, A.W.<br></p>Formule :C1213C2H17Cl2N315N4Couleur et forme :Yellow To Dark YellowMasse moléculaire :360.2Dolutegravir Sodium
CAS :<p>Applications Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)<br></p>Formule :C20H18F2N3O5·NaCouleur et forme :NeatMasse moléculaire :441.36Levofloxacin-d3 Sodium Salt
CAS :Produit contrôlé<p>Applications Levofloxacin-d3 Sodium Salt, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>Formule :C18H16D3FN3NaO4Couleur et forme :NeatMasse moléculaire :386.374-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
CAS :<p>Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formule :C21H16Cl2N2O3Couleur et forme :NeatMasse moléculaire :415.27N-Mesyldronedarone
CAS :Produit contrôlé<p>Applications N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009); Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009); Mahender, M., et al.: Org. Process Res. Dev., 18, 157 (2014)<br></p>Formule :C32H46N2O7S2Couleur et forme :NeatMasse moléculaire :634.854-(Benzo[d]thiazol-2-ylthio)morpholine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :252.35000610351562(2-Chloropyridin-4-yl)(2,4-dimethylphenyl)methanone
CAS :Degré de pureté :95%Masse moléculaire :245.7100067138672Cimetidine Amide Dihydrochloride
CAS :Produit contrôlé<p>Impurity Cimetidine EP Impurity C<br>Applications Cimetidine Amide Dihydrochloride (Cimetidine EP Impurity C) is an impurity of Cimetidine.<br>References Durant, G.J., et al.: J. Med. Chem., 18, 830 (1975), Pounder, R.E., et al.: Br. Med. J., 2, 307 (1975),<br></p>Formule :C10H18N6OS·2ClHCouleur et forme :White To Off-WhiteMasse moléculaire :343.284-(4-Phenylbutoxy)benzoic Acid
CAS :Produit contrôlé<p>Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.<br></p>Formule :C17H18O3Couleur et forme :NeatMasse moléculaire :270.32Hydroxy Dehydro Nifedipine Lactone
CAS :Produit contrôléFormule :C16H12N2O6Couleur et forme :NeatMasse moléculaire :328.28Lisinopril Cyclohexyl Analogue
CAS :Produit contrôlé<p>Impurity Lisinopril EP Impurity F<br>Applications Lisinopril Cyclohexyl Analogue (Lisinopril EP Impurity F) is a Lisinopril (L468985) impurity.<br>References Paraskevas, G., et al.: J. Pharm. Biomed. Anal., 29, 865 (2002),<br></p>Formule :C21H37N3O5Couleur et forme :NeatMasse moléculaire :411.54Des(oxopentyl) Valsartan
CAS :Produit contrôlé<p>Impurity Valsartan Desvaleryl Impurity<br>Applications An impurity in the synthesis of Valsartan (V095750).<br>References Carini, D., et al.: J. Med. Chem., 34, 2525 (1991), Buhlmayer, P., et al.: Bioorg. Med. Chem. Lett., 4, 29 (1994),<br></p>Formule :C19H21N5O2Couleur et forme :WhiteMasse moléculaire :351.40Boc-L-Nitroarginine
CAS :Produit contrôlé<p>Applications Boc-L-Nitroarginine, can be used in peptide chemistry. It has been also shown to act as NO synthase inhibitor, and thus used in the study of The effects of methylene blue (MB) for treatment of sepsis induced by bowel perforation.<br>References Galili, Y. Euro. surg. Rese. vol. 29, P:390-395 (19997);<br></p>Formule :C11H21N5O6Couleur et forme :NeatMasse moléculaire :319.312-(Diphenylmethoxy)-N-methylethylamine
CAS :Produit contrôlé<p>Applications 2-(Diphenylmethoxy)-N-methylethylamine is used in the pereparation of H1 and H2 receptor antagonists containing Diphenhydramine (D486900) derivatives. Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine (D486900) is categorized as an antihistaminic; sedative, hypnotic.<br>References Wolf, C. et al.: Archiv. de Pharm., 329, 87 (1996); Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),<br></p>Formule :C16H19NOCouleur et forme :Light Yellow To YellowMasse moléculaire :241.33ABT 199 (Venetoclax)
CAS :Produit contrôlé<p>Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>Formule :C45H50ClN7O7SCouleur et forme :Light Yellow To YellowMasse moléculaire :868.44Apalutamide
CAS :Produit contrôlé<p>Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Formule :C21H15F4N5O2SCouleur et forme :White To Off-WhiteMasse moléculaire :477.4347(S) FTY720 Phosphate
CAS :<p>Applications FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. FTY720 Phosphate is the active metabolite of FTY720-phosphate.<br>References Chiba, K., et al.: J. Immunol., 160, 5037 (1998), Brinkmann, V., et al.: J. Biol. Chem., 277, 21453 (2002), Kiuchi, M., et al.: Bioorganic & Medicinal Chemistry, 13, 425 (2005<br></p>Formule :C19H34NO5PCouleur et forme :WhiteMasse moléculaire :387.45Ethyl 2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
CAS :Produit contrôlé<p>Applications Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (cas# 27143-07-3) is a useful research chemical.<br></p>Formule :C11H13N2O3ClCouleur et forme :NeatMasse moléculaire :256.68Valsartan Benzyl Ester
CAS :<p>Impurity Valsartan USP Related Compound C<br>Applications Valsartan (V095750) intermediate. Valsartan USP Related Compound C.<br>References Cramer., et al.: J. Med. Chem., 42, 3919 (1999),<br></p>Formule :C31H35N5O3Couleur et forme :NeatMasse moléculaire :525.644-(4-Nitrophenyl)-3-morpholinone
CAS :Produit contrôléFormule :C10H10N2O4Couleur et forme :NeatMasse moléculaire :222.20(4S)-Brivaracetam
CAS :Produit contrôléFormule :C11H20N2O2Couleur et forme :NeatMasse moléculaire :212.2893-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
CAS :Degré de pureté :95.0%Masse moléculaire :282.7300109863281Darunavir
CAS :<p>Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>Formule :C27H37N3O7SCouleur et forme :BeigeMasse moléculaire :547.662-Benzylacrylic Acid
CAS :Produit contrôlé<p>Stability Light Sensitive<br>Applications 2-Benzylacrylic Acid (cas# 5669-19-2) is a compound useful in organic synthesis.<br></p>Formule :C10H10O2Couleur et forme :NeatMasse moléculaire :162.192-Nitrobenzotrifluoride
CAS :Produit contrôlé<p>Applications 2-Nitrobenzotrifluoride can be used for self-repairing polyimide based on dynamic imine bond.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lei, X., et.al., Faming Zhuanli Shenqing, 15, (2019);<br></p>Formule :C7H4F3NO2Couleur et forme :NeatMasse moléculaire :191.107N-Nitroso-Vildagliptin
CAS :Produit contrôléFormule :C17H24N4O3Couleur et forme :NeatMasse moléculaire :332.4Ethyl 2-(2-(4-methoxyphenoxy)acetamido)-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate
CAS :Degré de pureté :98%Masse moléculaire :468.5199890136719Relcovaptan
CAS :<p>Stability Hygroscopic<br>Applications Relcovaptan is a selective vasopressin-1a receptor antagonist that prevents cellular swelling and provides treatment for post-traumatic brain edema.<br>References Marmarou, C.R., et. al.: Brain Res., 1581, 89 (2014)<br></p>Formule :C28H27Cl2N3O7SCouleur et forme :NeatMasse moléculaire :620.50
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