Dérivés de Quinazoline et de Quinoléine

<p>Chloromethyl olanzapinium chloride is an analytical reference material that can be used as a standard for HPLC-UV analysis. It is also used in the development of new drugs and as an impurity standard during drug manufacturing. Chloromethyl olanzapinium chloride has been shown to be a metabolite of Olanzapine, which is a niche drug product that is not commercially available. Chloromethyl olanzapinium chloride is listed by the USP, EP and JP as a drug product impurity. It can be synthesized from natural or synthetic sources.</p>

<p>Dasatinib is a cancer drug that is used to treat patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. It inhibits the activity of tyrosine kinases, in particular Bcr-Abl and Src. Dasatinib is a structural analog of imatinib, which has been shown to be effective against chronic myeloid leukemia by inhibiting the activity of Bcr-Abl. Dasatinib impurity is an unwanted substance found in dasatinib. It can be synthesized from formic acid, chloride and chlorine using a series of industrial processes. The salt form of dasatinib impurity is acidic and synthetic.</p>

<p>Desdifluoromethoxy hydroxy pantoprazole is a synthetic compound that is used as an impurity standard for the drug product Pantoprazole. It has a purity of ≥98% and is stable under ambient conditions. Desdifluoromethoxy hydroxy pantoprazole is not active on its own, but it is a metabolite of pantoprazole. It can be used to study the metabolism of pantoprazole.</p>

<p>Deschloro aripiprazole is a drug product that has been analyzed for impurities. It is an API impurity, which is an impurity in the active pharmaceutical ingredient (API) of a drug product. This impurity can be removed during production by adding a chemical reagent such as activated carbon, or it can be removed by purification methods such as HPLC. Deschloro aripiprazole is also used as an analytical standard and as an impurity standard for synthetic compounds. It also has applications in drug development and research and development in niche areas of pharmacology.</p>

<p>Quetiapine is a drug that belongs to the class of sulfoxides. It is usually administered orally, but can also be given intravenously or intramuscularly. Quetiapine has been studied for its clinical use in the treatment of schizophrenia and bipolar disorder. The plasma concentrations of quetiapine are determined by high-performance liquid chromatography (HPLC) with tandem mass spectrometry (LC-MS/MS) detection. Validation studies have shown that the HPLC-MS/MS method is accurate and precise, with good linearity over a range of concentrations. Analysis was performed on plasma samples from healthy volunteers who were administered either 2 mg or 10 mg doses of quetiapine by intravenous injection. Concentrations were calculated and compared to those found in patients with schizophrenia and bipolar disorder who had been given oral doses of 300 mg per day for four weeks, yielding a therapeutic plasma concentration range from 100 to 300 ng/mL.</p>

<p>Famotidine is a pharmaceutical agent that belongs to the class of H2-receptor antagonists. It is used for the treatment of peptic ulcers and gastroesophageal reflux disease. Famotidine inhibits gastric acid secretion by blocking the H2-receptors in the parietal cells in the stomach. There are two major impurities, 4-amino-N-[(4-[[[2-(aminosulphonyl)thiazol-4-yl]methyl]sulphanyl]ethyl]-3,5-bis[[2-[(aminoiminomethyl)amino]thiazol-4-yl]methyl]sulphanyl]ethyl]-1,2,4,6-thiatriazine 1,1 dioxide and 2-[(aminoiminomethyl)amino]-N-[(4-[[2-(aminosulphonyl)thiazol-4-yl</p>

<p>Solifenacin Impurity D is a synthetic impurity of solifenacin. Solifenacin is an anti-cholinergic drug used to treat overactive bladder and urinary incontinence. The purity of this product is 99%. It is soluble in methanol, ethanol, chloroform, and acetone. Solifenacin Impurity D can be used as a reference material for analytical purposes or as an impurity standard in the development of new drugs.</p>

<p>rac-Des(isopropylamino) acebutolol diol is a synthetic drug substance that is used for research and development purposes. It has a purity of 99% or greater, does not contain any impurities, and is manufactured using the latest technology. The rac-Des(isopropylamino) acebutolol diol is a pharmaceutical grade product with high purity and quality standards that have been verified by HPLC analysis. This compound is an analytical standard that can be used to calibrate mass spectrometry instruments. Rac-Des(isopropylamino) acebutolol diol is also metabolized into the natural metabolite noracebutanol by cytochrome P450 enzymes in humans.</p>

<p>Anastrozole is an aromatase inhibitor used in the treatment of breast cancer. It is a synthetic drug and impurity standard for HPLC analysis, pharmacopoeia monograph, and synthetic drug development. This product is a mixture of two stereoisomers - the active form, 4-hydroxyanastrozole (4HA), and the inactive form, 4-oxo-anastrozole (4OA). The purity of this product is &gt;99% with a melting point of 130°C.</p>

<p>Methyl 3-aminocrotonate is an intermediate in the synthesis of pyridinedicarboxylic acid. It is a white powder with a melting point of 160-165°C and a boiling point of 263°C. Methyl 3-aminocrotonate is soluble in water, alcohols, ethers, chloroform, and benzene. It has been detected by its UV absorption at 227 nm. The detection sensitivity for this compound was found to be 0.1 ppm. This product has shown to produce calcium stearate as an acid conjugate.<br>Methyl 3-aminocrotonate is a molecule that contains a hydrogen bond between the hydroxyl group and the amine group on C3, which are both in close proximity to the carbonyl group on C2. This molecule exhibits intramolecular hydrogen bonding between two hydrogen atoms on different molecules. <br>The IR spectrum for methyl 3-aminoc</p>

<p>Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (TMBDAC) is an impurity standard and a metabolite of the drug product. It is an analytical standard for HPLC. Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile is a high purity research and development chemical that can be custom synthesized to meet specific needs. This synthetic compound has shown potential as a niche metabolite in metabolism studies. CAS No. 120511-84-4.</p>

<p>5-Dimethylaminobutyryl citalopram is a metabolite of the antidepressant drug, Citalopram. It is used as an analytical impurity standard for Citalopram in HPLC and LCMS analysis. 5-Dimethylaminobutyryl citalopram is also a natural product of metabolism and may be found in humans. 5-Dimethylaminobutyryl citalopram has been shown to have similar pharmacological properties to Citalopram in animal studies, which include antihistamine effects and analgesic effects. This compound may be useful as a niche treatment for some patients who are resistant to other drugs.</p>

<p>Valdecoxib impurity I is a synthetic compound that is used as an impurity standard for the drug product Valdecoxib. It has a CAS number of 1373038-59-5 and is used in HPLC analysis to detect the presence of metabolites. Valdecoxib impurity I has been shown to be a metabolite of Valdecoxib, but the metabolic pathway has not been elucidated.</p>

<p>N-Hydroxy riluzole O-b-D-glucuronide is an analytical standard and drug development metabolite. It is a metabolite of the anti-convulsant agent riluzole, which is used in the treatment of amyotrophic lateral sclerosis (ALS). Riluzole is converted to N-hydroxyl riluzole O-b-D-glucuronide in the liver by UDP glucuronosyltransferase. N-Hydroxyl riluzole O-b-D-glucuronide has been shown to block protein synthesis in rat kidney cells. It also blocks the conversion of amino acid tyrosine to dopa in dopaminergic neurons, and inhibits dopamine uptake into synaptosomes.</p>

<p>3-O-Desethyl-5-O-desmethyl amlodipine is a drug product that can be used as an analytical reference standard. It is metabolized in vivo to form 5-O-desmethyl amlodipine, which is the active form of this drug. 3-O-Desethyl-5-O-desmethyl amlodipine is also an impurity in the drug product Amlodipine besylate and its CAS number is 1821498-25-2. The synthetic route for this compound starts with the reaction of 2,3,4,6 trichlorobenzeneethanol with sodium hydroxide followed by hydrogenation of the intermediate to yield 3-(2,6 dichlorophenyl) propanoic acid. This acid was then reacted with methylamine to yield 3-(2,6 dichlorophenyl)-N-[(methylamino) methyl]propionamide.</p>

<p>2-[[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (CAS No. 168167-42-8) is a synthetic compound that is used as an analytical reference standard for HPLC. It is also used in the study of drug metabolism, and it has been shown to induce natural oxidation in vitro. 2-[(4-Chloro-3-methylpyridinium)methylsulfinyl]-1Hbenzimidazole is an impurity found in pharmaceutical products that are synthesized from 1-(2,4,6trichlorophenyl)-3-[(4chloromethyl)phenyl]urea.</p>

<p>Granisetron is a drug that belongs to the group of serotonin receptor antagonists. It is used as an antiemetic, mainly in the prevention and treatment of nausea and vomiting caused by cancer chemotherapy and surgery. This drug has been shown to be effective in controlling nausea and vomiting, even when given after chemotherapy or surgical procedures. Granisetron hydrochloride was synthesized in 1988 by chemists at Hoffmann-La Roche. The synthesis was patented in 1990. Potential impurities are not listed on the USP or EP pharmacopeia, but these impurities have been detected during synthesis.</p>

<p>N2-Methyl alfuzosin hydrochloride (1:1) is a synthetic compound that is used as an impurity standard for the drug product Alfuzosin. It has been shown to be metabolized by the liver, and its metabolites are excreted through the bile. The N2-methyl group of this compound provides a marker for metabolism studies and it has been shown to inhibit bacterial growth in vitro.</p>

<p>Bisoprolol impurity G is a metabolite of bisoprolol. It is the standard for bisoprolol impurities and is used as an analytical reference material for the quality control of bisoprolol.</p>

<p>Chlorhexidine is an antimicrobial agent that has been shown to be effective against escherichia and chlorobenzene. It also has a low toxicity for humans and animals, as well as for the environment. Chlorhexidine EP Impurity N is a chlorhexidine impurity that is produced during the synthesis of chlorhexidine acetate. This impurity can be used in research to measure hydrogen peroxide levels, which can help determine the purity of chlorhexidine acetate. Recoveries of this compound were found to be high in human dental plaque and pneumococcus bacteria. Average recoveries were found to be higher when measured by ultraviolet spectroscopy than by gas chromatography-mass spectroscopy (GC-MS).</p>

<p>2-Deschloro aripiprazole is a drug that belongs to the class of antipsychotics. It is an atypical antipsychotic with a high affinity for human albumin and α1-acid glycoprotein, which are plasma proteins. 2-Deschloro aripiprazole has been shown to interact with human albumin and α1-acid glycoprotein in vitro, and it has been suggested that this interaction may be responsible for its pharmacological effects. 2-Deschloro aripiprazole has also been shown to bind to the dopamine D2 receptor, which is thought to be responsible for its therapeutic effects as an antipsychotic. The molecular interactions between 2-deschloro aripiprazole and human albumin have been studied using isothermal titration calorimetry (ITC) and molecular docking studies. These studies have helped us understand how 2-deschloro aripiprazole binds to human album</p>

<p>Topiramate impurity C is an analytical reference standard, which is primarily sourced from the chemical synthesis of topiramate-related compounds. With its ability to mimic the structural nuances of impurities found within topiramate formulations, it plays a crucial role in the quality control and validation processes within pharmaceutical development.Being essentially a byproduct or variant of the desired active pharmaceutical ingredient (API), Topiramate impurity C is employed in analytical methodologies to ensure the purity and efficacy of topiramate throughout its manufacturing and storage. Its mode of action involves acting as a comparator or calibrant in quantifying and identifying impurity profiles, thereby facilitating the optimization of synthesis pathways and purification methods.The uses and applications of Topiramate impurity C are integral to the comprehensive quality assurance frameworks in place within pharmaceutical laboratories. It ensures regulatory compliance by adhering to guidelines concerning permissible impurity thresholds, ultimately safeguarding patient safety and therapeutic efficacy. Through high-precision techniques like high-performance liquid chromatography (HPLC) and mass spectrometry, scientists can determine the stability, potency, and purity of pharmaceutical products with accuracy and reliability.</p>

<p>N2-Methyl alfuzosin-D7 is a drug product that belongs to the group of alfuzosin, which is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5) and is used for the treatment of benign prostatic hyperplasia. It has been designed to reduce the risk of adverse effects associated with other PDE5 inhibitors, such as erectile dysfunction and urinary retention. N2-Methyl alfuzosin-D7 has been shown to be effective in animal studies and in vitro experiments. However, its metabolism remains unknown.</p>

<p>Please enquire for more information about 5-Chloro-N-[3-[[(5-chloro-2-thienyl)carbonyl]amino]-2-hydroxypropyl]-N-[4-(3-oxo-4-morpholinyl)phenyl]-2-thiophenecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>9,10-Dioxo ketotifen is a drug product that belongs to the category of HPLC standards. It has been shown to be a metabolite of ketotifen and also an impurity in ketotifen. 9,10-Dioxo ketotifen has been shown to possess antihistamine activity and may have potential as a lead compound for the development of new drugs.</p>

<p>4'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxylic acid (4BMBCA) is a chemical compound that is used as an analytical method in drug discovery and development. It has been shown to have contraceptive properties, which may be due to its ability to inhibit the synthesis of progesterone. 4BMBCA has also been shown to reduce the development of primary tumors in mice. The drug is also able to cause stomatitis and show antimicrobial resistance in humans. Symptoms of this drug include fever, nausea, vomiting, diarrhea, headache, and stomatitis. 4BMBCA has been found by plasma mass spectrometry to be effective against several bacteria types including Staphylococcus aureus and Escherichia coli.</p>

<p>N-Formyl Saxagliptin is an analytical standard for HPLC. It is used as a drug development and API impurity in the pharmaceutical industry. It was synthesized by reacting formaldehyde with the amino acid L-glutamic acid, followed by purification to remove any other contaminants. The CAS number for this chemical is 57847-82-0.</p>

<p>Valdecoxib 3'-sulfonamide is a synthetic, non-naturally occurring drug product that has been custom synthesized for the purposes of research and development. It is not a natural API nor is it an impurity standard. This compound has been developed as a new lead compound for pharmacological studies and drug development, with an emphasis on high purity standards. The CAS number for this compound is 1373038-56-2.</p>

<p>4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a drug that has been developed for the treatment of cancer. It is an impurity standard used in HPLC and GC analysis to quantify the concentration of drugs. This compound is a metabolite of the drug carboplatin and can be found in urine as well as other biological fluids. Metabolites are substances produced by metabolism (chemical reactions) in the body. 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one can also be found naturally in plants such as ivy or wild parsnip.</p>

<p>Balsalazide Isopropyl ester is a synthetic compound that is used as an active pharmaceutical ingredient in the treatment of irritable bowel syndrome. Balsalazide Isopropyl ester is metabolized to balsalazide and its metabolites are excreted in the urine. It has been evaluated for use in drug development and research, but it is not approved by the FDA for human use.</p>

<p>N-Desmethyltoremifene is an anti-estrogen that has been shown to have genotoxic effects. It inhibits DNA synthesis and protein synthesis in human breast cancer cells. N-Desmethyltoremifene is a potent inducer of CYP3A4, which metabolizes many drugs. This drug also binds to α1-acid glycoprotein, which can lead to reduced plasma concentrations and pharmacokinetics. N-Desmethyltoremifene has been shown to inhibit the growth of renal cell carcinoma in animals, but not normal tissue, at high doses.</p>

<p>Lisinopril diketopipirazine is an analytical drug product. The CAS number for this product is 219677-82-4. This product requires a custom synthesis and impurity standard. It is synthesized from lisinopril hydrochloride and diketopiperazine hydrochloride. Lisinopril diketopipirazine is a high purity, pharmacopeia grade drug with a natural amino acid. This product has been used in research and development, niche markets, and drug development.</p>

<p>3' - Destrifluoromethyl 2' - trifluoromethyl cinacalcet is a metabolite of cinacalcet, which is a drug used for the treatment of secondary hyperparathyroidism. It is an impurity in the drug product and can be identified by HPLC.</p>

<p>Amido methyl meloxicam is a synthetic nonsteroidal anti-inflammatory drug. It is used to relieve inflammation and pain. Amido methyl meloxicam is chemically similar to the naturally occurring substance, meclofenamic acid, but it does not have the same side effects.<br>Amido methyl meloxicam is metabolized in the liver by CYP3A4/5 and then excreted by the kidneys.</p>

<p>N-(4-Amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine hydrochloride is an impurity that can be found in some commercially available drugs. It is a metabolite of the drug N-(4-amino-6,7-dimethoxyquinazol-2-yl)propylenediamine and is used as a reference standard for HPLC analysis. This compound has been shown to have antiplatelet activities.</p>

<p>(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.</p>

<p>2-Ethoxy-1-[2'-[1-(trityl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-4-carboxylic acid methyl ester is an impurity in the drug product, which is a synthetic drug for research and development. The impurity standard for 2-ethoxy-1-[2'-[1-(trityl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H benzimidazole 4 carboxylic acid methyl ester is available in quantities of 10g. The CAS number for the impurity is 150058-29-0. This compound has an API purity of 99.9%. Impurities are not expected to be present at greater than 1% by weight.</p>

<p>1,3-bis(1,1-Dimethylpropyl) benzene is a synthetic compound that is used in drug product formulation. It is also used as an analytical standard for the determination of 1,3-bis(1,1-dimethylethyl)benzene in drug products and as a natural impurity in API preparations. This compound is metabolized to 1,3-dibromobenzene and 1,2-dibromoethane during its metabolic process. The chemical properties of this compound are similar to those of other alkylbenzenes and it has been shown to have pharmacological effects such as analgesic and antiinflammatory activities.</p>

<p>5-O-Desethyl amlodipine is a metabolite of amlodipine. It has been used as an analytical reference standard for the determination of amlodipine and its metabolites in human plasma and urine. 5-O-Desethyl amlodipine has been reported to be excreted in human breast milk at a concentration that is about 20% of that found in maternal plasma. The drug product is manufactured by HPLC and is classified as a high purity pharmaceutical drug, which means it is free from extraneous substances such as other drugs, proteins, or bacteria.</p>

<p>Ketoconazole Impurity A is a synthetic impurity of Ketoconazole, which is used as an anti-fungal agent. Ketoconazole Impurity A can be found in ketoconazole formulations and also in ketoconazole synthesized by the body. Ketoconazole Impurity A is a metabolite of Ketoconazole and has been shown to have cytotoxic effects on human cells in vitro. Ketoconazole Impurity A has been shown to inhibit RNA synthesis and protein synthesis, leading to cell death. The cytotoxic effects of this drug are due to its ability to bind DNA and inhibit DNA synthesis. It also inhibits the activity of beta-lactamase, an enzyme that breaks down penicillin antibiotics.</p>

<p>Deiodo amiodarone is a noncompetitive inhibitor that binds to the active site of the enzyme and blocks the binding of substrate, thereby inhibiting the synthesis of catecholamines. Deiodo amiodarone has been shown to inhibit the oxidation of benzofuran derivatives in rat liver microsomes, human liver tissue samples, and chromatographic conditions. The inhibition constant for deiodo amiodarone was determined by liquid chromatography with a homogenizing technique.</p>

<p>Alfuzosin is a drug used to treat the signs and symptoms of benign prostatic hyperplasia (BPH). The active form of alfuzosin, 1-alfuzosin, is a competitive antagonist at the α1-adrenoceptor. Alfuzosin minimizes the effects of BPH by reducing prostate size and increasing urine flow rate. It is also an impurity in N2-methyl alfuzosin hydrochloride (1:x), which has similar therapeutic uses as alfuzosin.</p>

<p>Please enquire for more information about Benserazide EP Impurity B hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Des(oxopentyl) Valsartan Benzyl Ester is an analytical standard for the drug valsartan. It is a white to off-white, crystalline powder that is soluble in methanol and acetone. This compound can be used as an HPLC standard, or as an impurity standard in the development of valsartan drugs. Des(oxopentyl) Valsartan Benzyl Ester also has niche uses in natural product isolation and synthetic organic chemistry. It is a metabolite of des(oxopentyl)valsartan, which is a prodrug of valsartan.</p>

<p>Losartan is an angiotensin II receptor antagonist. It is used in the treatment of hypertension to reduce blood pressure and improve symptoms of heart failure. Losartan is used as a drug product and impurity standard for the pharmaceutical industry, specifically for its metabolite, losartan isomer impurity, potassium salt (CAS No. 860644-28-6). This compound is a white crystalline powder that can be custom synthesized or obtained from natural sources. High purity Losartan Isomer Impurity, Potassium Salt (CAS No. 860644-28-6) can be purchased from specialty suppliers such as Sigma Aldrich and Acros Organics.</p>

<p>Metabolite of montelukast</p>

<p>3-(Methylamino)-1-(2-thienyl)propan-1-ol is a lipase inhibitor that belongs to the group of 1-fluoronaphthalene. It is an efficient method for the demethylation of 1-fluoronaphthalene, which is used in the synthesis of many pharmaceuticals. The synthesis of this compound was achieved through a kinetic study and confirmed by x-ray crystallography. This compound has been shown to be an analytical method for the determination of impurities in other drugs. 3-(Methylamino)-1-(2-thienyl)propan-1-ol can also be used as a drug substance for other pharmaceuticals and has been shown to inhibit the transfer of chiral centers mediated by enzymes and substrates.</p>

<p>N,N'-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N,N'-dimethyl-1,3-propanediamine dihydrochloride is a synthetic compound that is metabolized to the natural product naphthol AS. It is an impurity in the drug product and can also be used as an analytical reference standard.</p>

<p>3,4-Dimethoxyphenyl isopropyl ketone (DMPK) is a calcium antagonist that has been shown to be hypotensive in rats. It is also used as a pharmacological agent to study muscle physiology and biotransformations. DMPK has been shown to have microbial uptake and chronotropic properties, which may explain its use in the treatment of bacterial infections. DMPK binds to sulfoxides and chiral compounds, blocking their activity by inhibiting the enzyme systems involved in oxidation reactions. The drug is an analog of benzyl alcohol, with which it shares similar pharmacological profile.</p>

<p>2-[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is a synthetic, impurity standard that is used in the synthesis of drug products. It has been shown to inhibit the metabolism of drugs and may be used as a marker for drug metabolism. This compound may also be used as a marker in analytical studies to assess the purity of a drug product. 2-[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole has not been evaluated for safety or efficacy.</p>

<p>1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[(4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methylsulfonyl]-1H-benzimidazole (MKC1807) is a synthetic drug product. MKC1807 is an analytical standard in the HPLC assay for the determination of Epiandrosterone sulfate and its metabolites. 1-[4-(3-Methoxypropoxy)-3,5,6,7,8 -pentamethylcyclohexyl]methyl 2-[(4-(3 -methoxypropoxy) 3,5,6,7,8 -pentamethylcyclohexyl)methylsulfonyl]-1H benzimidazole has been shown to be a natural metabolite of Epiandrosterone sulfate. This compound</p>

<p>Anastrozole is an aromatase inhibitor that has been used in the treatment of breast cancer. It binds competitively to the heme moiety of aromatase, blocking its access to substrate and thereby inhibiting estrogen production. Anastrozole dimer impurity is an analytical impurity found in drug products that is not a natural component of the API (active pharmaceutical ingredient). CAS No. 1216898-82-6 refers to this impurity standard as well as other synthetic analogues. This impurity is a custom synthesis with no pharmacopoeia standards for purity. The HPLC standard for this product is high purity (99%).</p>

<p>2-(Aminomethyl)-1-ethylpyrrolidine is a pharmaceutical preparation that has been used in the analytical method for determining impurities in pharmaceuticals. It has also been used as an intermediate for pharmaceutical dosage preparations and as a reagent for chromatographic analysis of various substances. 2-(Aminomethyl)-1-ethylpyrrolidine is produced by acylation of pyrrole with ethyl chloride, followed by hydrolysis with sodium carbonate and hydrochloric acid. The substance can be separated into its two components using chromatography, which is based on the difference in their polarity. 2-(Aminomethyl)-1-ethylpyrrolidine is a dopamine receptor antagonist that blocks uptake of dopamine into cells by inhibiting the dopamine transporter (DAT). This leads to increased levels of extracellular dopamine and subsequent activation of postsynaptic D2 receptors.</p>

<p>2-Methoxyethyl-3-aminocrotonate is an impurity of a drug product. It is an analytical standard that is used to quantify the metabolite in pharmaceutical preparations. 2-Methoxyethyl-3-aminocrotonate is a natural metabolite, which can be found in human urine. This compound has been shown to be a potent inhibitor of both bacterial and mammalian cell topoisomerase II and IV, but not mammalian cell topoisomerase I. It also inhibits protein synthesis by binding to the ribosomal 50S subunit. In addition, it has been shown to inhibit the growth of certain bacteria such as clostridium perfringens and Mycobacterium tuberculosis.</p>

<p>5,6-Dehydro-17beta-dutasteride is a synthetic drug product that is used as an analytical standard for the determination of metabolites and impurities in pharmaceuticals. It also has been used as a natural metabolite, which can be found in human urine. 5,6-Dehydro-17beta-dutasteride is a metabolite of dutasteride, which is an antiandrogen medication for the treatment of benign prostatic hyperplasia (BPH). It is also known to inhibit the metabolism of other drugs such as ketoconazole and metoprolol.</p>

<p>Impurity 65 is an impurity of Omeprazole, a drug used to treat gastroesophageal reflux disease and peptic ulcer. Impurity 65 is a metabolite of Omeprazole that can be found in the drug product at a concentration up to 0.5%. It has been shown to have anti-inflammatory effects and can be used as a research and development standard for HPLC analysis. Impurity 65 is also used as an impurity standard in the USP pharmacopoeia and other pharmacopoeias around the world.</p>

<p>3-(Dimethylamino)-1-(2-thienyl)propan-1-ol is an organic compound that is used as a chiral building block in the synthesis of drugs. It is not currently used in any known drug, but it has been shown to be racemized at high temperatures. 3-(Dimethylamino)-1-(2-thienyl)propan-1-ol is also a byproduct of pollution and can be found in the environment where it may be degraded by bacteria.</p>

<p>4',4'''-[(4'-Methyl-2'-propyl[2,6'-bi-1H-benzimidazole]-1,1'-diyl)bis(methylene)]bis[1,1'-biphenyl]-2-carboxylic acid is an analytical reagent that is used in research and development as a drug product impurity standard. This compound has been shown to be metabolized by cytochrome P450 1A1 and 2C8 to form 4-hydroxybenzoic acid and 4,4''-[(4'-methyl-2' propyl-[2,6']bi-1H-benzimidazol-1,1' diyl)bis(methylene)]bis[3-(4-hydroxyphenyl)-propionic acid], respectively. 4',4''-[(4'-Methyl-2' propyl-[2,6']bi-1</p>

<p>Alverine EP Impurity C is a by-product of the synthesis of alverine, which is an ammonium salt. The process involves the use of high yield, high purity triflic acid, and organic solvents. The reaction system is typically carried out in a solvent such as toluene or dichloromethane. The organic solvent is then removed by filtration and the desired product can be obtained by crystallization or recrystallization. Alverine EP Impurity C has been shown to have insecticidal properties when applied externally, due to its interaction with insect stereoisomers. It also has anticancer activity and may be used in cancer therapy treatments that involve decompressing tumours and increasing blood supply to the area. Alverine EP Impurity C also has a citric acid binding property that makes it insoluble in water.</p>

<p>Granisetron is a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. It is used in the prevention and treatment of nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, or surgery. Granisetron hydrochloride is a white to off-white powder with a molecular weight of 476.0. The chemical formula for granisetron hydrochloride is C22H24ClN2O2S. This drug has been shown to be efficient in the prevention and treatment of nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, or surgery. The potential impurities are as follows: <br>1) 1-Desmethyl 2-methyl granisetron <br>2) 2-Methyl granisetron <br>3) 2-Methyl 3-(4'-hydroxyphenyl)propionitrile <br>4) 2-(4'-Hydroxyphenyl)-3-(</p>

<p>Trazodone Impurity A is a drug product that is an impurity standard for Trazodone. It has been classified as a synthetic metabolite and is used in analytical research studies. Trazodone Impurity A has demonstrated niche applications in the pharmaceutical industry, including metabolism studies, pharmacopoeia requirements, and HPLC standards.</p>

<p>Alpha-Desmethyl anastrozole is a synthetic chemical that has been used as an impurity standard for the drug product, Anastrozole (Arimidex). This compound is metabolized in humans and is a metabolite of Arimidex. Alpha-Desmethyl anastrozole exhibits high purity and can be synthesized using custom synthesis. The CAS number for this compound is 1215780-15-6.</p>

<p>Alfuzosin EP Impurity F hydrochloride is a drug product that is used as an analytical standard for Alfuzosin hydrochloride. It is a natural, synthetic, and impurity standard that exhibits similar chromatographic properties to the API. The CAS number of this impurity is 19216-68-3. This product has a niche market because it is used in metabolism studies. It also exhibits high purity and pharmacopoeia grade quality.</p>

<p>2,3,4-Trimethoxybenzaldehyde is an organic compound that is used as a chemical intermediate in the synthesis of pharmaceuticals. It is also used as a reagent in the chemical industry and as a flavoring agent. 2,3,4-Trimethoxybenzaldehyde has been shown to be metabolized by human liver microsomes to yield metabolites that are not well characterized. The impurities found in this drug product are 2-methoxy-5-methylphenol and 2,6-dimethoxyphenol.</p>

<p>Desmethyl fluvoxamine is the active metabolite of fluvoxamine, which is a drug used to treat depression. It has been shown that desmethyl fluvoxamine binds to the human liver and can be detected in the blood. A liquid chromatography method was used to measure desmethyl fluvoxamine in wastewater samples. The uptake of desmethyl fluvoxamine into human liver cells was also studied using a polymerase chain reaction technique on cell cultures. Desmethyl fluvoxamine has been shown to induce antidepressant response in people who were administered caffeine. Clinical studies have been conducted on the use of desmethyl fluvoxamine as an antidepressant treatment, with some success.</p>

<p>3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime hydrochloride is an analytical reagent used for HPLC analysis of the impurities in pharmaceutical products. It is a white crystalline solid with a melting point of 235°C. 3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime hydrochloride is used as a reference standard and has been assigned CAS No. 112233-23-5 by the Chemical Abstracts Service (CAS). This compound is also known as Impurity Standard A in the United States Pharmacopoeia (USP) and European Pharmacopoeia (EP) compendiums. 3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime</p>

<p>Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-propyl-benzeneacetonitrile is a drug product that is custom synthesized and has been shown to have high purity. It is also used in analytical studies, metabolism studies, and natural drug development. This compound can also be found as an impurity standard for HPLC or as an API impurity.</p>

<p>4'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxamide is a custom synthesis drug product. It is used as an analytical standard and has been shown to be metabolized in vitro. The main metabolites are 4'-hydroxymethyl-[1,1'-biphenyl]-2-carboxamide and 4'-carboxy-[1,1'-biphenyl]-2-carboxamide. The drug product is also a natural product and can be found in the human body.</p>

<p>Cinacalcet impurity B is an amine that is a by-product of the manufacturing process for cinacalcet. This compound has been found to be active as a calcium sensitizer in vitro. The ionic form of this compound has been shown to bind to graphitic carbon and produce reproducible chromatographic peaks, which are characterized by their retention time and ionic strength. Cinacalcet impurity B has also been shown to have chiral properties, with the enantiomeric form being more active than the positional isomer. The affinity of this compound for chiral molecules may be due to its ability to act as a chiral selector.</p>

<p>Risperidone E-oxime impurity is a drug product that has been studied for its metabolism in humans, animals and plants. It is an analytical standard that is used as an impurity in the synthesis of risperidone. Risperidone E-oxime impurity is also a synthetic compound with CAS No. 691007-09-7. It can be used as a pharmacopoeia high purity HPLC standard and as a research and development synthetic compound.</p>

<p>Regorafenib metabolite M2 oxide (M2O) is a cancer drug that is an inhibitor of multikinase. It was developed as a prodrug for regorafenib, which is used to treat patients with metastatic colorectal cancer and has been shown to be effective against other cancers, such as lung and pancreatic cancer. M2O inhibits the efflux of drugs from cells by binding to the transporter protein P-glycoprotein. This prevents the accumulation of toxic concentrations of regorafenib in cells, which are responsible for its side effects, such as diarrhea and liver damage. The uptake of M2O by cells is also inhibited by light and acidic conditions. Oral administration of M2O leads to increased exposure to regorafenib in the body because it is not metabolized by CYP3A4 enzymes.</p>

<p>(RS)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-hydroxy-5-sulphamoylbenzamide is a white to off-white crystalline powder. It is soluble in methanol and ethanol, but insoluble in water. It has an assay of &gt;98% (HPLC), and a purity of &gt;99% (HPLC). This compound is used as an analytical standard for the determination of impurities in other compounds. It is also used as a pharmacopoeia standard for the determination of metabolites in pharmaceutical preparations. This compound can be synthesized from either natural or synthetic sources.</p>

<p>(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine is a compound that belongs to the class of cyclohexane ring. It has been shown to possess potent anti-infective activity against bacteria and fungi, but not against viruses. It is an inorganic compound that can be synthesized by the chlorination of (S)-(-)-2-aminoethanol. This method is efficient and does not require any organic solvents or catalysts. The binding of inhibitors to the enzyme can be studied by using this molecule as a model system. This molecule also has application as a coating for metal surfaces, which can inhibit corrosion.</p>

<p>Amiodarone is a drug that belongs to the group of annular compounds. It has been used in the treatment of cardiac arrhythmias, such as atrial fibrillation (AF) and ventricular tachycardia (VT). Amiodarone has been shown to have a high affinity for specific genes, including those involved in the regulation of the heart. This drug is also used in animals, such as dogs and rats. Amiodarone has been shown to have toxic effects on cardiac tissue and other organs, which may be due to its ability to inhibit the metabolism of thyroid hormones by deiodination. Amiodarone also inhibits synthesis of protein by binding to DNA, inhibiting transcription and translation.</p>

<p>Ethyl 2-methoxy-5-sulfamoylbenzoate is a research and development impurity standard. It is a white to off-white crystalline solid that is soluble in water. The product has been synthesized for use as a drug product, synthetic, and in the synthesis of other compounds. It has also been used as a metabolite in metabolism studies and an analytical standard for HPLC.</p>

<p>Alverine EP Impurity D is a synthetic impurity that is the result of the synthesis of Alverine EP. It is a metabolite that can be found in blood plasma and urine. This substance has been shown to have pharmacological activity, but its exact function is unknown. It is not present in natural sources and it does not have pharmacopoeia listing. Alverine EP Impurity D has been detected by HPLC analysis.END&gt;</p>

<p>Chlorhexidine digluconate EP Impurity L is a metabolite of chlorhexidine digluconate. It is an impurity found in the drug product, which is used for the treatment of skin and mucous membrane infections. The mechanism of action for chlorhexidine digluconate EP Impurity L is not known. However, it has been shown to be metabolized by CYP3A4 and CYP2C9 enzymes to form chlorhexidine acetate, a metabolite that inhibits bacterial growth, and hydrolyzed by esterases to form 2-hydroxychlorhexidine acetate. This metabolite has been found in the urine of rats following oral administration with chlorhexidine digluconate EP Impurity L.</p>

<p>N2-Methyl alfuzosin is an impurity of Alfuzosin, a drug used to treat benign prostatic hyperplasia. It can be used as an HPLC standard for the detection and quantification of Alfuzosin in pharmaceutical products. N2-Methyl alfuzosin is a metabolite of Alfuzosin that is formed by cytochrome P450 3A4. It has been shown to have anti-inflammatory effects, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Defluoropitavastatin calcium salt is a synthetic, high purity, pharmacopoeia drug product. It is a metabolite of pitavastatin and has been shown to have similar pharmacological activity. Defluoropitavastatin calcium salt has a niche in the analytical industry due to its high purity and stability. It has been used as an impurity standard for HPLC analysis. Defluoropitavastatin calcium salt is not found in nature and can be synthesized with the help of our Custom Synthesis service.</p>

<p>Rac-Benzyl phenylephrone hydrochloride is a synthetic compound that is not found in nature. It can be used as an analytical standard or a pharmacopoeia impurity standard. Rac-Benzyl phenylephrone hydrochloride has been shown to inhibit the activity of CYP3A4, an enzyme which metabolizes many drugs. As a result, it may be useful for drug development and research and could have applications in niche markets such as natural products.</p>

<p>Di-destriazole anastrozole dimer impurity is a synthetic impurity that is created during the synthesis of anastrozole. It has been studied as a possible metabolite of the drug, but its role in metabolism is not well understood. Di-destriazole anastrozole dimer impurity is soluble in water and methanol and has a melting point of between 1°C to 2°C. The purity of this compound is typically at least 99% with a specific gravity of 1.043 g/mL.</p>

<p>Please enquire for more information about Rivaroxaban impurity 79 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fluvoxketone is a drug that belongs to the class of selective non-steroidal anti-inflammatory drugs. It is a mixture of stereoisomers, with a ratio of 1:1, which have different pharmacological properties. Fluvoxketone has an average elution time of 18 minutes and can be detected in the sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) profile at around 10 minutes. This drug was selected as the optimum drug for this study by optimisation of its solubility, selectivity, and stability.</p>

<p>Please enquire for more information about N-Methyl omeprazole (Mixture of isomers with the methylated nitrogens of imidazole) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a chiral molecule with four stereocenters. It is synthesized by the reaction of sulfamic acid and cyclohexene in the presence of p-toluenesulfonic acid. The product formed is then dehydrogenated to produce (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline. This compound is soluble in organic solvents such as benzene and ethane and can be used as an acceptor for chiral stationary phases.</p>

<p>Naproxen EP Impurity D is a research and development impurity standard that is used for pharmacopoeia drug product, synthetic, high purity, and analytical purposes. Naproxen EP Impurity D is a metabolite of naproxen and has been shown to be an active form of the drug in animal studies. The CAS number for Naproxen EP Impurity D is 116883-62-6.</p>