Nucléosides et Nucléotides
Les nucléosides sont des composés formés par une base azotée liée à un sucre (ribose ou désoxyribose). Lorsqu’un groupe phosphate est ajouté au nucléoside, un nucléotide est formé. Ces composés sont essentiels en biologie cellulaire, car les nucléotides sont les blocs fondamentaux de l’ADN et de l’ARN, responsables du stockage et de la transmission de l’information génétique. Les nucléosides ont des applications dans le traitement des maladies virales, en tant qu’inhibiteurs de la réplication virale. Les nucléotides, en plus de leur rôle structurel dans les acides nucléiques, interviennent dans les processus énergétiques, comme la synthèse de l’ATP.
Chez CymitQuimica, nous proposons une large gamme de nucléosides et de nucléotides essentiels à la recherche en biologie moléculaire, virologie et pharmacologie.
3413 produits trouvés pour "Nucléosides et Nucléotides"
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Creatinine-d3
CAS :Produit contrôlé<p>Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.<br>References Folin, et al.: J. Biol. Chem., 17, 463 (1914),<br></p>Formule :C42H3H4N3OCouleur et forme :Off-WhiteMasse moléculaire :116.14Adenosine-3'-monophosphate
CAS :Produit contrôlé<p>Applications Adenosine-3'-monophosphate (cas# 84-21-9) is a useful research chemical.<br></p>Formule :C10H14N5O7PCouleur et forme :NeatMasse moléculaire :347.22125-(Hydroxymethyl)-2’-deoxycytidine
CAS :Produit contrôlé<p>Applications 4-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples<br>References Peng, X. et al.: J. Am. Chem. Soc., 130, 10299 (2008); Berkner, K. et al.: J. Biol. Chem., 252, 3185 (1977); Le, T. et al.: Anal. Biochem., 412, 203 (2011);<br></p>Formule :C10H15N3O5Couleur et forme :NeatMasse moléculaire :257.241’-epi-Entecavir
CAS :Produit contrôlé<p>Impurity Entecavir EP Impurity A<br>Applications An epimeric impurity of the antiviral drug Entecavir (E558900).<br></p>Formule :C12H15N5O3Couleur et forme :NeatMasse moléculaire :277.2796-Hydroxy-2,4,5-triaminopyrimidine, Sulfate
CAS :Produit contrôlé<p>Applications 6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.<br></p>Formule :C4H7N5O·H2O·H2O4SCouleur et forme :NeatMasse moléculaire :257.222’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine
CAS :Produit contrôléFormule :C23H19F2N3O6Couleur et forme :NeatMasse moléculaire :471.41D-Ribose
CAS :Produit contrôlé<p>Applications D-Ribose is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.<br>References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),<br></p>Formule :C5H10O5Couleur et forme :NeatMasse moléculaire :150.132-Phenylamino Adenosine
CAS :Produit contrôlé<p>Applications A selective A2-adenosine receptor agonist. Coronary vasodilator, antihypertensive and antipsychotic following systemic administration in vivo.<br>References Martin, et al.: Pharmacol. Biochem. Behav., 45, 951 (1993<br></p>Formule :C16H18N6O4Couleur et forme :NeatMasse moléculaire :358.35Adenosine 2’,3’-Cyclic Phosphate Triethylammonium Salt
CAS :<p>Applications A 2',3'-cyclic nucleotide phosphodiester.<br>References Voegtli, W., et al.: Biochemistry, 39, 15365 (2000), Bernstein, N., et al.: Mol. Cell, 17, 657 (2005), Blondal, T., et al.: J. Biol. Chem., 280, 5188 (2005), Shenoy, A., et al.: J. Mol. Biol., 365, 211 (2007),<br></p>Formule :C16H27N6O6PCouleur et forme :NeatMasse moléculaire :430.4Folic Acid-d2
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formule :C19H17D2N7O6Couleur et forme :NeatMasse moléculaire :443.418-Cyclopentyl-1,3-dipropylxanthine
CAS :Produit contrôlé<p>Applications DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist.<br>References Gessi, S., et al.: Mol. Pharmacol., 67, 2137 (2005), Minor, T.R., et al.: Behav. Neurosci., 122, 1236 (2008), Gracia, E., et al.: J. Neurochem., 107, 161 (2008), Gessi, S., et al.: Biochem. Pharmacol., 75, 562 (2008),<br></p>Formule :C16H24N4O2Couleur et forme :NeatMasse moléculaire :304.391-Chloro-2-[(4-ethoxyphenyl)methyl]benzene
CAS :Produit contrôléFormule :C15H15ClOCouleur et forme :NeatMasse moléculaire :246.732Adenosine Monophosphate (mixture of 2'(3')-phosphate isomers)-13C5 Sodium Salt
CAS :Produit contrôlé<p>Applications Labelled AMP mixture<br>References Jackson, E.K. et al.: Hypertension, 56, 151 (2010); Jackson, E.K. et al: J. Bio. Chem., 284, 33097 (2009);<br></p>Formule :C513C5H14N5O7P•x(Na)Couleur et forme :NeatMasse moléculaire :352.182299Lamivudine-15N2,13C
CAS :Produit contrôléFormule :CC7H1115N2NO3SCouleur et forme :White To BeigeMasse moléculaire :232.241'-Epi 2',2'-Difluoro-2'-deoxyuridine
CAS :<p>Applications The epimer of the degradation product of Gemcitabine (G305000), a new antitumor agent.<br>References Anliker, S.L., et al.: J. Pharmaceut. Sci., 83, 716 (1994),<br></p>Formule :C9H10F2N2O5Couleur et forme :Light Yellow SolidMasse moléculaire :264.18Nicotinic Acid Riboside
CAS :Produit contrôlé<p>Applications An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.<br>References Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);<br></p>Formule :C11H13NO6Couleur et forme :NeatMasse moléculaire :255.222',3'-Anhydroinosine
CAS :Produit contrôlé<p>Impurity Didanosine EP Impurity E<br>Applications 2',3'-Anhydroinosine (Didanosine EP Impurity E) is an impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950).<br>References Rao, D.V.N. et al.: J. Pharmac. Biomed.Anal., 45, 516 (2007);<br></p>Formule :C10H10N4O4Couleur et forme :NeatMasse moléculaire :250.215-Methoxyuracil
CAS :Produit contrôlé<p>Impurity Fluorouracil EP Impurity D<br>Applications 5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.<br>References Vorbrueggen, H. et al.: Chem. Ber., 114, 1279 (1981); Novacek, A. et al.: Coll. Czech. Chem. Comm., 32, 1045 (1967);<br></p>Formule :C5H6N2O3Couleur et forme :NeatMasse moléculaire :142.11Eritadenine
CAS :Produit contrôlé<p>Applications Hypocholesterolemic isolated from shiitake mushrooms, effecting phospholipid and linoleic acid metabolisms. Specifically, Eritadenine is a potent inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH), decreasing total cholesterol levels in plasma.<br>References Fukada, S., et al.: J. Nut., 136, 2797 (2006), Vilar, S., et al.: J. Med. Chem., 49, 1118 (2006), Yamada, T., et al.: Biochem. Pharmacol., 73, 981 (2007), Enman, J., et al.; J. Agric. Food Chem., 56, 2609 (2008),<br></p>Formule :C9H11N5O4Couleur et forme :Off White SolidMasse moléculaire :253.219-Oxofolic Acid
CAS :<p>Stability Hygroscopic<br>Applications 9-Oxofolic Acid is a derivative of Folic Acid (F680300) which is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA. Folic Acid also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formule :C19H17N7O7Couleur et forme :NeatMasse moléculaire :455.38Acyclovir Acetate
CAS :<p>Impurity Valaciclovir EP Impurity I/ Aciclovir USP Related Compound A<br>Applications Acyclovir Acetate (Valaciclovir EP Impurity I) is an Acyclovir (A192400) impurity, Aciclovir EP Impurity A<br>References Goskonda, V., et al.: J. Pharm. Sci., 88, 180 (1999); Chang, J., et al.: Pharm. Res., 17, 670 (2000),<br></p>Formule :C10H13N5O4Couleur et forme :NeatMasse moléculaire :267.24(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
CAS :Produit contrôléFormule :C15H12BrClO2Couleur et forme :NeatMasse moléculaire :339.6122-Amino-6-chloropurine
CAS :<p>Impurity Famciclovir USP Related Compound F<br>Applications Famciclovir USP Related Compound F<br></p>Formule :C5H4ClN5Couleur et forme :YellowMasse moléculaire :169.57(S)-N-[4-[[((S)-2-Amino-6,7,8,9-tetrahydro-8-methyl-4,9-dioxo-4H-pyrazino[1,2-a]-1,3,5-triazin-7-yl)
<p>Applications An impurity of Levomefolate (L375720), the natural form of folic acid.<br>References Verlinde, P.H.C.., et al.: J. Agr. Food. Chem., 57, 6803 (2009); Whiteley, J.M., et al.: Biochem. Biophy. Res. Comm., 101, 1259 (1981);<br></p>Formule :C20H23N7O7Couleur et forme :NeatMasse moléculaire :473.44Dapagliflozin-d5
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Dapagliflozin-D5 is a labelled analogue of Dapagliflozin (D185370), a selective sodium-glucose cotransporter-2 inhibitor that reduces renal glucose reabsorption and is used to treat patients with type 2 diabetes.<br>References List, J., et al.: Diabetes Care, 32, 650 (2009); Meng, W., et al.: J. Med. Chem., 51, 1145 (2008); Wilding, J., et al.: Diabetes Care, 32, 1656 (2009)<br></p>Formule :C21H20D5ClO6Couleur et forme :White To Off-WhiteMasse moléculaire :413.9Gemcitabine Monophosphate
CAS :<p>Applications Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.<br>References Balzarini, J., et al.: Biochem. Pharmacol., 37, 897 (1988), Abbruzzese, J., et al.: Investig. New Drugs, 7, 195 (1989), Balzarini, J., et al.: J. Biol. Chem., 264, 6127 (1989), Chu, C., et al.: Antimicrob. Agents Chemother., 39, 979 (1995)<br></p>Formule :C9H12F2N3O7PCouleur et forme :White To Off-WhiteMasse moléculaire :343.18Folic Acid-d4
CAS :Produit contrôlé<p>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formule :C192H4H15N7O6Couleur et forme :NeatMasse moléculaire :445.42Dihydroxy Melphatalan
CAS :Produit contrôlé<p>Applications Dihydroxy Melphatalan is an analogue of Melphalan (M216900), an antineoplastic.<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980);<br></p>Formule :C13H20N2O4Couleur et forme :NeatMasse moléculaire :268.315-(Methyl-d3)tetrahydrofolic Acid (Mixture of Diastereomers)
CAS :Produit contrôléFormule :C20H22D3N7O6Couleur et forme :NeatMasse moléculaire :462.47T-705 Ribofuranose
CAS :<p>Applications T-705 Ribofuranose is a reagent used for the preparation of pyrazine-ribofuranose derivatives as antiviral agents that are useful in the treatment of viral infections.<br>References Zhong, B., et al.: Faming Zhuanli Shenqing, 2014:924257 (2014)<br></p>Formule :C10H12FN3O6Couleur et forme :NeatMasse moléculaire :289.22Ganciclovir-d5
CAS :Produit contrôléFormule :C9H8D5N5O4Couleur et forme :WhiteMasse moléculaire :260.266-Mercaptopurine Disulfide
CAS :Produit contrôlé<p>Applications 6-Mercaptopurine Disulfide is an impurity of 6-Mercaptopurine (M225450, monohydrate) which is an immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br>References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004)<br></p>Formule :C10H6N8S2Couleur et forme :Yellow To Dark YellowMasse moléculaire :302.343'-[3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxy-thymidine
CAS :Produit contrôlé<p>Impurity Zidovudine USP Related Compound G<br>Stability Light Sensitive<br>Applications 3'-[3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxy-thymidine (Zidovudine USP Related Compound G) is used in the biological studies and in the preparation of N-3-substituted thymidine nucleosides as virucides as it has anti-HIV activity.<br>References Adams, D.R., et al.: J. Med. Chem., 40, 1550 (1997), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),<br></p>Formule :C20H25N7O8Couleur et forme :NeatMasse moléculaire :491.45N-Acetyl Glyphosate
CAS :<p>Stability Very Hygroscopic<br>Applications A metabolite of the pesticide Glyphosphate (G765000).<br>References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);<br></p>Formule :C5H10NO6PCouleur et forme :White To Off-WhiteMasse moléculaire :211.11Adenosine-2’,3’-cyclic Monophosphate Sodium Salt
CAS :Produit contrôléFormule :C10H11N5O6P·NaCouleur et forme :NeatMasse moléculaire :351.188Gemcitabine Triphosphate Ditriethylamine
CAS :Produit contrôlé<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Gemcitabine Triphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an antineoplastic agent.<br>References Kennedy., E.P., et al.: J. Biol. Chem., 222, 193 (1956),<br></p>Formule :C21H44F2N5O13P3Couleur et forme :NeatMasse moléculaire :705.52Canagliflozin 3-Glucuronide
Produit contrôlé<p>Applications Canagliflozin 3-glucuronide is a derivative of Canagliflozin (C175190). Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion.<br>References Devineni, D., et al.: Diab. Obes. Metab., 14, 539 (2012); Nicolle, L., et al.: Curr. Med. Res. Opin., 28, 1167 (2012)<br></p>Formule :C30H33FO11SCouleur et forme :NeatMasse moléculaire :620.64(-)-Inosine-1',2',3',4',5'-13C5
CAS :<p>Stability Hygroscopic<br>Applications Isotope labelled analogue of (-)-Inosine (I661000), compound that exhibits neuroprotective properties by improving axonal wiring and has also been used to treat stroke patients to restore neural function.<br>References Vandemeulebroucke, A., et al.: Biochem., 49, 8999 (2010), Nestor, G., et al.: J. Agric. Food Chem., 58, 10799 (2010),<br></p>Formule :C513C5H12N4O5Couleur et forme :White To Off-WhiteMasse moléculaire :273.19Adenosine 5'-Monophosphate-5',5''-d2 Disodium Salt
CAS :Produit contrôlé<p>Applications Isotope labelled analogue of Adenosine 5’-Monophosphate (A281790), a nucleotide that is used as a monomer in RNA.<br>References Watanabe, M., et al.: Arch. Dermatol., 127, 1689 (1991); Engelke, M., et al.: Br. J. Dermatol., 137, 219 (1997)<br></p>Formule :C10H10D2N5Na2O7PCouleur et forme :NeatMasse moléculaire :393.2Cytidine 2':3'-cyclic Monophosphate Monosodium Salt (>85%)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Cytidine 2':3'-cyclic Monophosphate Monosodium Salt is a key compound in the enzymic synthesis of short oligoribonucleotides. Reagent in the amine catalyzed solid-phase synthesis of oligonucleotides.<br>References Gusenkova, N. M., et al.: Zhurnal Obshchei Khimii, 46, 939 (1976); Tomasz, J., et al.: Nucleic Acid Chem., 2, 875 (1978)<br></p>Formule :C9H11N3NaO7PDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :327.16(+)-Isomenthol
CAS :<p>Applications (+)-Isomenthol is a reagent that has been used in the preparation of a phosphine activator.<br>References Rajendran., K.V., et. al.: Tetrahedron Lett., 54, 7009 (2013)<br></p>Formule :C10H20OCouleur et forme :White To Off-WhiteMasse moléculaire :156.27Acetoguanide
CAS :Produit contrôlé<p>Applications Acetoguanide is a degradation product of the sulfonylurea herbicide Iodosulfuron.<br>References Pramauro, E., et al.: Environ. Sci. Technol., 27, 1790 (1993); Rouchard, J., et al.: Toxicol. Environ. Chem., 85, 103 (2003); Brigante, M., et al.: J. Agric. Food Chem., 53, 5347 (2005);<br></p>Formule :C4H6N4OCouleur et forme :White To Light YellowMasse moléculaire :126.12N2,9-Diacetylguanine
CAS :Produit contrôlé<p>Impurity Acicclovir EP Impurity L<br>Applications N2,9-Diacetylguanine (Acicclovir EP Impurity L) is used to synthesize acyclic analogues of deoxyguanosine.<br>References Martin, J. C., et al.: J Med Chem. 26, 759 (1983)<br></p>Formule :C9H9N5O3Couleur et forme :NeatMasse moléculaire :235.209-[4-Acetoxy-3-(acetoxymethyl)butyl]-2-amino-6-chloropurine
CAS :Produit contrôlé<p>Impurity 6-Chloro Famciclovir Impurity<br>Applications 9-[4-Acetoxy-3-(acetoxymethyl)butyl]-2-amino-6-chloropurine is an impurity of Famciclovir (F101125), an antiviral agent and a prodrug of Penciclovir (P221500).<br>References Raman, N., et al.: J. Pharma. Biomed. Anal., 50, 797 (2009); Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Formule :C14H18ClN5O4Couleur et forme :NeatMasse moléculaire :355.78(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
CAS :Produit contrôlé<p>Applications A Lamivudine (L172500) intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993).<br></p>Formule :C18H27N3O4SCouleur et forme :NeatMasse moléculaire :381.49Lamivudine Acid
CAS :Produit contrôlé<p>Impurity Lamivudine EP Impurity A<br>Stability Hygroscopic<br>Applications Lamivudine Acid (Lamivudine EP Impurity A) is an impurity of Lamivudine (L172500). Impurity A per European Pharmacopoeia.<br>References Dwyer, O., et al.: Synlett, 11, 1163 (1995),<br></p>Formule :C8H9N3O4SCouleur et forme :White To Off-WhiteMasse moléculaire :243.24Abacavir
CAS :Produit contrôlé<p>Impurity Abacavir API<br>Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formule :C14H18N6OCouleur et forme :Off WhiteMasse moléculaire :286.338-Hydroxyacyclovir
CAS :Produit contrôlé<p>Applications Acyclovir (A192400) is the parent compound for 8-Hydroxyacyclovir. Acyclovir (ACV), an anti-virus drug, was widely detected in natural water at concns. . ranging from ng L-1 to μg L-1 due to inefficient biol. treatments in sewage treatment plant.<br>References Zhang, Q., et al.: Journal of Radioanalytical and Nuclear Chemistry, 320, 823 (2019);<br></p>Formule :C8H11N5O4Couleur et forme :NeatMasse moléculaire :241.2046-Hydroxytryptamine Creatinine Sulfate
CAS :Produit contrôlé<p>Applications A tryptamine derivative, a neurotransmitter agonist.<br>References Dalton, T., et al.: Br. J. Pharmacol., 65, 579 (1979), Kang, S., et al.: Mol. Pharmacol., 16, 1031 (1979), Wallis, D., et al.: Eur. J. Pharmacol., 70, 381 (1981),<br></p>Formule :C10H12N2O·C4H9N3O2·H2O4SCouleur et forme :White To Light BrownMasse moléculaire :405.43Emtricitabine Monophosphate Triethylammonium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Paff, M. et al.; Antimicrob. Agents Ch. 38, 1230 (1994)<br></p>Formule :C8H11FN3O6PS·(C6H15N)Couleur et forme :White To Off-WhiteMasse moléculaire :327.23 + x(101.19)6-Amino-9-methylpurine(9-Methyl Adenine)
CAS :Produit contrôlé<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>Formule :C6H7N5Couleur et forme :NeatMasse moléculaire :149.153,4,5,6-Tetrahydrouridine (>80%)
CAS :<p>Stability Light Sensitive<br>Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.<br>References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);<br></p>Formule :C9H16N2O6Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :248.23N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine
CAS :Produit contrôlé<p>Impurity Abacavir EP Impurity F<br>Applications N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine (Abacavir EP Impurity F) is an impurity of Abacavir (A104990), a guanosine analog that inhibits reverse transcriptase (NRTI) (1,2).<br>References (1) Hanumegowda, U., et al.: Chem. Res. Toxicol., 23, 749 (2010) (2) Prasse, C., et al.: Environ. Sci. Technol., 44, 1728 (2010)<br></p>Formule :C18H26N6OCouleur et forme :OrangeMasse moléculaire :342.4386Adenosine-3',5'-cyclic-13C5 Monophosphate
CAS :<p>Stability Hygroscopic<br>Applications Labelled Adenosine-3’,5’-cyclic Monophosphate (A280455). Adenosine-3’,5’-cyclic Monophosphate is an Adenosine (A280400) derivative useful as anticancer agent.<br>References Keast, R., et al.: Pharma. Res., 19, 1019 (2002),<br></p>Formule :C5C5H12N5O6PCouleur et forme :NeatMasse moléculaire :334.1692Nicotinamide Riboside Triflate, α/β mixture
CAS :Produit contrôlé<p>Stability Very Very Hygroscopic<br>Applications Nicotinamide (N407750) analog. Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which Nicotamide is converted into NAD (Nicotinamide Adenine Dinucleotide)<br>References Friedlos, F., et al.: J. Biochem. Pharmacol., 44, 25 (1992), Ong, S., et al.: Biochemistry, 11210 (1992), Zhang, X., et al.: J. Biol. Chem., 278, 13503 (2003),<br></p>Formule :C12H15F3N2O8SCouleur et forme :NeatMasse moléculaire :404.32Pterine-6-carboxylic Acid
CAS :Produit contrôlé<p>Applications Pterine-6-carboxylic Acid is a degradation product of Folic acid (F680300).<br>References Akhtar, M., et al.: J. Pharm. Biomed. Anal., 19, 269 (1999), Andrisano, V., et al.: J. Pharm. Biomed. Anal., 32, 983 (2003), Patro, B., et al.: Bioorg. Med. Chem. Lett., 15, 67 (2005),<br></p>Formule :C7H5N5O3Couleur et forme :NeatMasse moléculaire :207.15Folic Acid NHS Ester (γ : α =2 :1)
CAS :Formule :C23H22N8O8Couleur et forme :NeatMasse moléculaire :538.47Adenosine 5'-Diphosphate Sodium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Adenosine 5'-diphosphate monosodium salt (cas# 20398-34-9) is a useful research chemical.<br></p>Formule :C10H15N5O10P2·x(Na)Couleur et forme :White To Off-WhiteMasse moléculaire :427.20 + x(22.99)2’-Deoxy Cytidine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.<br>References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004); Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006); Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007);<br></p>Formule :C9H13N3O4Couleur et forme :NeatMasse moléculaire :227.22(1R,3R,4R)-Entecavir
CAS :Produit contrôlé<p>Applications (1R,3R,4R)-Entecavir is an isomeric impurity of Entecavir (E558900).<br></p>Formule :C12H15N5O3Couleur et forme :NeatMasse moléculaire :277.285-Methyl-2’-deoxy Cytidine-d3
CAS :Produit contrôlé<p>Applications A labelled Cytidine (C998300) analog and also an isostere of Thymidine (T412000).<br>References Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008),<br></p>Formule :C10H12D3N3O4Couleur et forme :White To Off-WhiteMasse moléculaire :244.265'-Deoxy-5'-(methylthio)adenosine
CAS :<p>Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).<br>References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),<br></p>Formule :C11H15N5O3SCouleur et forme :White To Off-WhiteMasse moléculaire :297.33Cytarabine
CAS :<p>Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.<br>References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);<br></p>Formule :C9H13N3O5Couleur et forme :NeatMasse moléculaire :243.22Cytarabine-13C3 5’-Monophosphate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A labelled derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Formule :C6C3H14N3O8PCouleur et forme :NeatMasse moléculaire :326.175-Fluoro Cytosine-13C,15N2
CAS :Produit contrôléFormule :CC3H4F15N2NOCouleur et forme :White To Light BrownMasse moléculaire :132.07Thiouric Acid Sodium Salt Dihydrate
CAS :Formule :C5H3N4O2S·Na·2H2OCouleur et forme :NeatMasse moléculaire :242.19Lamivudine (R)-Sulfoxide
CAS :Produit contrôlé<p>Impurity Lamivudine EP Impurity H<br>Stability Hygroscopic<br>Applications Lamivudine (R)-Sulfoxide (Lamivudine EP Impurity H) is a metabolite of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has been used for treatment of chronic hepatitis B.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977)<br></p>Formule :C8H11N3O4SCouleur et forme :NeatMasse moléculaire :245.26Ribavirin
CAS :Produit contrôlé<p>Applications Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Formule :C8H12N4O5Couleur et forme :WhiteMasse moléculaire :244.202-Amino-7-(chloromethyl)pteridin-4(1H)-one (>90%)
CAS :Produit contrôlé<p>Applications 2-Amino-7-(chloromethyl)pteridin-4(1H)-one is the impurity F of Folic acid (F680300) as per EP monograph.<br></p>Formule :C7H6ClN5ODegré de pureté :>90%Couleur et forme :Dark YellowMasse moléculaire :211.611-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester(Ribavirin Impurity H)
CAS :Produit contrôléFormule :C9H13N3O7Couleur et forme :NeatMasse moléculaire :275.22Folic Acid
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formule :C19H19N7O6Couleur et forme :NeatMasse moléculaire :441.40N-Nitroso Abacavir
CAS :Produit contrôléFormule :C14H17N7O2Couleur et forme :Light Yellow To YellowMasse moléculaire :315.339-Carboxymethoxymethylguanine
CAS :Produit contrôlé<p>Applications 9-Carboxymethoxymethylguanine is a metabolite of Acyclovir (A192400) which is an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses.<br>References Gunness, P., et al.: Transl. Res., 158, 290 (2011); Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979), Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988), Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992),<br></p>Formule :C8H9N5O4Couleur et forme :Light Orange Colour SolidMasse moléculaire :239.192-Hydroxytetrahydrofuran
CAS :Produit contrôlé<p>Applications 2-Hydroxytetrahydrofuran (cas# 5371-52-8) is a compound useful in organic synthesis.<br></p>Formule :C4H8O2Couleur et forme :NeatMasse moléculaire :88.11Cabotegravir
CAS :<p>Applications Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015);<br></p>Formule :C19H17F2N3O5Couleur et forme :Off-WhiteMasse moléculaire :405.35Doxifluridine
CAS :Produit contrôlé<p>Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B<br>Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.<br>References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)<br></p>Formule :C9H11FN2O5Couleur et forme :NeatMasse moléculaire :246.19β-Nicotinic Acid Mononucleotide
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.<br>References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010);<br></p>Formule :C11H14NO9PCouleur et forme :NeatMasse moléculaire :335.22-Hydroxy-2,3-tetrahydrofuranyl Entecavir (Mixture of Diastereomers)
Produit contrôlé<p>Applications 2-Hydroxy-2,3-tetrahydrofuranyl Entecavir is an impurity of Entecavir (E558900).<br></p>Formule :C12H15N5O4Couleur et forme :NeatMasse moléculaire :293.286-Methylpterin
CAS :Produit contrôlé<p>Applications 6-Methylpterin is a derivative of Folic Acid (F680300) which is a precursor of coenzymes involved in metabolism of various nucleotides and nucleic acids.<br>References Dantola, M.L. et al.: Photochem Photobiol Sci., 9, 1604 (2010);<br></p>Formule :C7H7N5OCouleur et forme :NeatMasse moléculaire :177.163'-Chloro-3'-Deoxythymidine
CAS :Produit contrôlé<p>Impurity Zidovudine EP Impurity B<br>Applications 3'-Chloro-3'-deoxythymidine (Zidovudine EP Impurity B) is an impurity of 3'-Azido-3'-deoxythymidine (A825000), a potent and selective inhibitor of HIV-1 replication and a potential antiviral agent.<br>References Navaneethan, G., et al.: J. Food. Drug Anal., 20, 446 (2012); Srivastav, N.C., et al.: Bioorg. Med. Chem., 18, 7542 (2010); Shakya, N., et al.: J. Med. Chem., 53, 4130 (2010); Fukushima, M., et al.: BIochem. Pharmacol., 59, 1227 (2000);<br></p>Formule :C10H13ClN2O4Couleur et forme :BeigeMasse moléculaire :260.672'-Deoxyadenosine Monohydrate-13C5
CAS :Produit contrôlé<p>Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>Formule :C513C5H13N5O3•H2OCouleur et forme :Off-WhiteMasse moléculaire :274.22Abacavir sulfate
CAS :Produit contrôlé<p>Impurity Abacavir - In House Impurity<br>Applications Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formule :C14H18N6O·H2O4SCouleur et forme :Off WhiteMasse moléculaire :670.746,7-Dimethylpterin
CAS :Produit contrôlé<p>Applications 6,7-Dimethylpterin, a derivative of Folic Acid (F680300) is used as a biomarker for a non-invasive cancer diagnosis. Also can function as chromophores in light sensitive proteins allowing for analysis of target cells.<br>References Kritskii, M.S. et al.: Dokl. Akad. Nauk., 380, 408 (2001); Gamagedara, S. et al.: Clin. Chim. Acta., 412, 128 (2011);<br></p>Formule :C8H9N5OCouleur et forme :NeatMasse moléculaire :191.19Cytidine 5'-Phosphoromorpholidate N,N'-Dicyclohexyl-4-morpholinecarboximidamide
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Citicoline (C508050), a naturally occurring nucleotide.<br></p>Formule :C13H20N4O8P·C17H32N3OCouleur et forme :NeatMasse moléculaire :685.752,6-Diaminopurine-2’-deoxyriboside
CAS :<p>Applications 2,6-Diaminopurine-2’-deoxyriboside is a nucleoside analogs synthesized to interfere with DNA metabolism. A derivative of 2,6-Diaminopurine (D416580), which can be used as analyte for biological and analytical studies of incorporation of unnatural nucleotides into mutant tRNA and proteins.<br>References Kaminski, P. A., et al.: J. Biol. Chem., 288, 6534-6541 (2013); Ptacin, J., et al.: PCT Int. Appl., WO 2016115168 A1 20160721 (2016);<br></p>Formule :C10H14N6O3Couleur et forme :NeatMasse moléculaire :266.26Azathioprine-d3
CAS :Produit contrôlé<p>Applications Azathioprine-d3, is the labeled analogue of Azathioprine (A803350), an immunosuppressive antimetabolite, also active as disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)<br></p>Formule :C9H4D3N7O2SCouleur et forme :NeatMasse moléculaire :280.28Canagliflozin hemihydrate
CAS :<p>Canagliflozin hemihydrate (TA 7284) treats type 2 diabetes by blocking SGLT2, leading to glucose excretion in urine.</p>Formule :C48H52F2O11S2Degré de pureté :99.42% - 99.96%Couleur et forme :SolidMasse moléculaire :907.05Gemcitabine Diphosphate Triethylamine Salt (>90%)
CAS :Produit contrôlé<p>Applications Gemcitabine Diphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an antineoplastic agent.<br>References Baker, C., et al.: J. Med. Chem., 34, 1879 (1991), Huang, P., et al.: Cancer Res., 51, 6110 (1991), Plunkett, W., et al.: Nucleosides Nucleotides, 16, 1261 (1997),<br></p>Formule :C27H58F2N6O10P2Degré de pureté :>90%Couleur et forme :White To Off-WhiteMasse moléculaire :726.735-Azacytidine
CAS :<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Formule :C8H12N4O5Couleur et forme :Off-WhiteMasse moléculaire :244.20Methyl 2-Deoxy-D-ribofuranoside
CAS :Produit contrôléFormule :C6H12O4Couleur et forme :NeatMasse moléculaire :148.16L-Alanine 2-Ethylbutyl Ester Hydrochloride
CAS :Produit contrôlé<p>Applications L-Alanine 2-Ethylbutyl Ester Hydrochloride is used in the synthesis of phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Formule :C9H19NO2·ClHCouleur et forme :NeatMasse moléculaire :209.7136Methyl p-Toluate
CAS :Produit contrôlé<p>Stability Unstable in Solution<br>Applications Methyl p-toluate is an impurity of 3-Toluoyl Decitabine (T536260), which is an intermediate of decitabine (A796950 for β-Decitabine). It is used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.<br>References Deng, T., et al.: Life Sci., 84, 311 (2009), Horne, H., et al.: Mol. Cancer Res., 7, 199 (2009), Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),<br></p>Formule :C9H10O2Couleur et forme :NeatMasse moléculaire :150.17N-Nitroso-N-(phosphonomethyl)glycine
CAS :<p>Applications N-Nitroso-N-(phosphonomethyl)glycine is used as herbicide.<br>References Khan, S.U., et al.: J. Agr. Food Chem., 27, 1398 (1979), Ambrus, A., et al.: Pure Appl. Chem., 75, 937 (2003),<br></p>Formule :C3H7N2O6PCouleur et forme :Off White SolidMasse moléculaire :198.07Adenine Hemisulfate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Adenine Hemisulfate can be one of the factors that influence in vitro growth and shoot multiplication of pomegranate. It can be used in biological study along with varied levels of sucrose, light intensity, and MS medium hydrogen ion concentration where those factors can all significantly influence multiplication and growth of Punica granatum shoots.<br>References Singh, P., & Patel, R., M.: Bioscan, 9, 1031-1035 (2014)<br></p>Formule :C5H5N5·SO4H2Couleur et forme :NeatMasse moléculaire :368.33Etravirine-d8
CAS :Produit contrôlé<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>Formule :C202H6H9BrN6OCouleur et forme :NeatMasse moléculaire :441.31N,O-Diacetyllamivudine
CAS :Produit contrôléFormule :C12H15N3O5SCouleur et forme :Off-WhiteMasse moléculaire :313.33L-Tetrahydrofolic Acid (>70% when packaged)
CAS :Produit contrôlé<p>Stability We have observed that this material decomposes steadily over time. Use immediate<br>Applications L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt.<br>References Prinz-Langenohl, R., et al.: Brit. J. Pharmacol., 158, 2014 (2009), Martin, H., et al.: Anal. Biochem., 402, 137 (2010), Dasarathy, J., et al.: Am. J. Clin. Nut., 91, 357 (2010), Karas-Kuzelicki, N., et al.: Clin. Biochem., 43, 37 (2010),<br></p>Formule :C19H23N7O6Couleur et forme :NeatMasse moléculaire :445.43Oxiracetam
CAS :Produit contrôlé<p>Applications Nootropic. Analog of Piracetam with psychostimulant activity.<br>References Son, J., et al.: J. Pharm. Biomed. Anal., 36, 657 (2004), Hlinak, Z., et al.: Behaviour. Brain Res., 161, 213 (2005),<br></p>Formule :C6H10N2O3Couleur et forme :NeatMasse moléculaire :158.16Melphalan Hydrochloride
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);<br></p>Formule :C13H18Cl2N2O2·ClHCouleur et forme :NeatMasse moléculaire :341.666-Thioinosine Phosphate (>85%)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of 6-Mercaptopurine.<br>References Parker, W., et al.: Cancer Res., 51, 2386 (1991) , Munagala, N., et al.: J. Biol. Chem., 275, 37072 (2000), Guddat, L., et al.: Protein Sci., 11, 1626 (2002), Pinkel, D., et al.: J. Clin. Oncol., 11, 1826 (1993), Tripathy, D., et al.: Oncologist, 12, 375 (2007),<br></p>Formule :C10H13N4O7PSDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :364.271-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
CAS :Produit contrôlé<p>Applications Open ring Dapagliflozin. Dapagliflozin (D185370) impurity.<br></p>Formule :C21H27ClO7Couleur et forme :NeatMasse moléculaire :426.888Ethoxy-5-fluoro-4(3H)-pyrimidinone
CAS :Produit contrôlé<p>Impurity Fluorouracil EP Impurity F<br>Applications Ethoxy-5-fluoro-4(3H)-pyrimidinone (Fluorouracil EP Impurity F) is a derivative of 5-fluorouracil (3C,15N2 labelled, F596002) which is a potent antineoplastic agent in clinical use.<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),<br></p>Formule :C6H7FN2O2Couleur et forme :NeatMasse moléculaire :158.133-Methyl Cytidine Methosulfate
CAS :Produit contrôlé<p>Applications Cytidine derivative.<br>References Ueda, T., et al.: Chem. Pharmaceut. Bull., 22, 2377 (1974),<br></p>Formule :C10H16N3O5·CH3O4SCouleur et forme :NeatMasse moléculaire :369.35Acyclovir Monophosphate
CAS :<p>Stability Hygroscopic<br>Applications A nucleoside analog phosphates for topical use in the treatment of herpes virus infections. A topical treatment that seems to bypass a key mechanism responsible for resistance to Acyclovir.<br>References Furman, P., et al.: J. Virol., 32, 72 (1979), Darby, G., et al.: J. Gen. Virol., 48, 451 (1980),Prisbe, E., et al.: J. Med. Chem., 29, 671 (1986), Ellis, M., et al.: Antimicrob. Agents Chemother., 33, 304 (1989),<br></p>Formule :C8H12N5O6PCouleur et forme :Off-WhiteMasse moléculaire :305.18Stavudine
CAS :Produit contrôlé<p>Impurity Zidovudine EP Impurity A<br>Applications Stavudine (Zidovudine EP Impurity A) is used as an antiviral. A reverse transcriptase inhibitor.<br>References Mansuri, M.M., et al.: Antimicrob. Ag. Chemother., 34, 637 (1990), Cretton, E.M., et al.: Antimicrob. Ag. Chemother., 37, 1816 (1993), Browne, M.J., et al.: J. Infec. Dis., 167, 21 (1993)<br></p>Formule :C10H12N2O4Couleur et forme :WhiteMasse moléculaire :224.21Melamine-13C3,15N3
CAS :Produit contrôlé<p>Applications Isotope labelled Melamine (M208703), which forms synthetic resins with formaldehyde. It remains largely non-metabolized in male Wistar rats with 90% of the administered dose excreted in the urine (1,2) and thus acts as a non-protein nitrogen food additive found in milk (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Mast, R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Smith, J. et al.: Toxicol Appl Pharmacol. 1994 Apr;125(2):296-308.3. Anirudhan, T. et al.: Food Chem. 2017 Jul 15;227:85-92.<br></p>Formule :C3H6N315N3Couleur et forme :NeatMasse moléculaire :132.082’,2’-Difluoro-2’-deoxyuridine-13C,15N2
CAS :Formule :C813CH10F215N2O5Couleur et forme :White To Off-WhiteMasse moléculaire :267.16Lamivudine Monophosphate Triethylammonium Salt
CAS :Produit contrôlé<p>Applications A metabolite of Lamivudine (L172500).<br>References Soudeyns, H., et al.: Antimicrob. Agents Chemother., 35, 1386 (1991), Denapoli, L., et al.: Nucleosides Nucleotides, 12, 21 (1993),<br></p>Formule :C8H12N3O6PSC6H15NDegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :410.138891’-Epi Gemcitabine Hydrochloride
CAS :<p>Impurity Gemcitabine EP Impurity B<br>Applications 1’-Epi Gemcitabine Hydrochloride (Gemcitabine EP Impurity B) is an α-Anomer of Gemcitabine.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Formule :C9H12ClF2N3O4Couleur et forme :Off White SolidMasse moléculaire :299.669-Carboxymethoxymethylguanine-13C2,15N
CAS :<p>Stability Hygroscopic<br>Applications 9-Carboxymethoxymethylguanine-13C2,15N is the labelled analog of 9-Carboxymethoxymethylguanine (C179990) which is a metabolite of Acyclovir (A192400-an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses).<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992); Gunness, P., et al.: Transl. Res., 158, 290 (2011);<br></p>Formule :C2C6H915NN4O4Couleur et forme :Light Beige SolidMasse moléculaire :242.167Floxuridine
CAS :Produit contrôlé<p>Applications Floxuridine is an antiviral; antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harris, M., et al.: Biophys. J., 4, 203 (1964),<br></p>Formule :C9H11FN2O5Couleur et forme :NeatMasse moléculaire :246.19Dapagliflozin Keto Impurity
CAS :<p>Applications Dapagliflozin Keto Impurity is an impurity of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S., et al.: Diabetes, Obesity and Metabolism 13, 47 (2011);<br></p>Formule :C21H23ClO7Couleur et forme :Off-WhiteMasse moléculaire :422.86Emtricitabine S-Oxide (Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992); Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996); Feng, J.Y., et al.: FASEB J., 13, 1511 (1999); Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000);<br></p>Formule :C8H10FN3O4SCouleur et forme :Off-WhiteMasse moléculaire :263.255-Azacytidine 2’,3’5’-O-triacetate
CAS :<p>Applications 5-Azacytidine 2’,3’5’-O-triacetate is a useful compound for the treatment and prevention of cancer and disorders related to abnormal cell proliferation, hematological disorders, and myelodysplastic syndromes (MDS). It can be also used to synthesize 2'3'5'triacetyl-5-azacytidine which is a prodrug for azacitidine. Azacitidine is a FDA-appproved DNA metnyltransferase (DNMT) inhibitor.<br>References Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)<br></p>Formule :C14H18N4O8Couleur et forme :White To Off-WhiteMasse moléculaire :370.315-Methyltetrahydrofolic Acid Calcium Salt Hydrate
CAS :Produit contrôléFormule :C20H23CaN7O6•xH2OCouleur et forme :White To BeigeMasse moléculaire :497.523'-Azido-3'-deoxythymidine 5’-Monophosphate Sodium Salt
CAS :Produit contrôlé<p>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br>References Brehm, J., et al.: Biochem., 47, 14020 (2008), von Kleist, M., et al.: Eur. J. Pharm. Sci., 36, 532 (2009),<br></p>Formule :C10H13N5O7P·NaCouleur et forme :NeatMasse moléculaire :369.20Clofarabine
CAS :<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>Formule :C10H11ClFN5O3Couleur et forme :White To Off-WhiteMasse moléculaire :303.68Lobucavir
CAS :Produit contrôlé<p>Applications A nucleoside analog used in the treatment of viral infections, including those caused by human immunodeficiency virus, cytomegalovirus, and herpes virus.<br>References Faulds, D., et al.: Drugs, 39, 597 (1990), Greene, J., et al.: Fundam. Appl. Toxicol., 32, 140 (1996), Poirier, M., et al.: Toxicol. Appl. Pharmacol., 199, 151 (2004),<br></p>Formule :C11H15N5O3Couleur et forme :NeatMasse moléculaire :265.27(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
CAS :Produit contrôléFormule :C11H12ClN5O·ClHCouleur et forme :NeatMasse moléculaire :302.162,3’-Anhydrothymidine
CAS :Produit contrôlé<p>Applications An intermediate in the preparation of thymidine derivatives<br>References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),<br></p>Formule :C10H12N2O4Couleur et forme :NeatMasse moléculaire :224.21Tegafur-13C,15N2
CAS :Produit contrôléFormule :CC7H9F15N2O3Couleur et forme :NeatMasse moléculaire :203.15Adenosine 5’-Diphosphate-13C5 Ammonium Salt Hydrate
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications Adenosine 5’-Diphosphate-13C5 Ammonium Salt Hydrate is the isotope labelled analog of Adenosine 5’-Diphosphate Ammonium Salt Hydrate (A281700); a nucleoside diphosphate that interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12 and P2X1), to induce platelet activation. ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine receptors.<br>References Gamba, G. et al.: Haematologia, 58, 1215 (1973); Dejana, E. et al.: Thromb. Haemost., 39, 135 (1978)<br></p>Formule :C513C5H15N5O10P2xNH3xH2OCouleur et forme :NeatMasse moléculaire :432.16O,O'-Dipropanal Ganciclovir
CAS :Produit contrôlé<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>Formule :C15H21N5O6Couleur et forme :NeatMasse moléculaire :367.36N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine
CAS :Produit contrôlé<p>Applications N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine is used for developing platelet P2T receptor antagonists, which have potential applications for antithrombotic therapy.<br>References Ingall, A. H., et al.: J. Med. Chem. 42, 213 (1999)<br></p>Formule :C16H22F3N5O4S2Couleur et forme :NeatMasse moléculaire :469.56-Deoxypenciclovir hydrochloride
CAS :<p>Applications Hydrochloride salt metabolite of a metabolite of Famciclovir, an antiviral.<br>References Harnden, M.R., et al.: J. Med. Chem., 32, 1738 (1989)<br></p>Formule :C10H15N5O2·ClHCouleur et forme :White SolidMasse moléculaire :273.72UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt (90%)
CAS :Produit contrôlé<p>Applications UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt is a lipid A precursor for Escherichia coli.<br>References Anderson, M. S. et al.: Biochem., 27, 1908 (1988);<br></p>Formule :C35H64N4O22P2Degré de pureté :90%Couleur et forme :NeatMasse moléculaire :954.84N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine
CAS :Produit contrôlé<p>Applications N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine is used for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Formule :C21H27N2O7PCouleur et forme :NeatMasse moléculaire :450.422Desacetyl Famciclovir
CAS :Formule :C12H17N5O3Couleur et forme :White To Off-WhiteMasse moléculaire :279.30Adenosine
CAS :<p>Applications Adenosine is a nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Formule :C10H13N5O4Couleur et forme :NeatMasse moléculaire :267.24Melphalan-d8 Dihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Formule :C13H12D8Cl4N2O2Couleur et forme :NeatMasse moléculaire :386.17Cytidine 5'-Monophosphate
CAS :<p>Applications A constituent of nucleic acids. It was isolated from yeast nucleic acid.<br>References Parrou, J., et al.: Anal. Biochem., 248, 186 (1997), Phipps, A., et al.: Xenobiotica, 28, 527 (1998), Mohler, R., et al.: Anal. Chem., 78, 2700 (2006),<br></p>Formule :C9H14N3O8PCouleur et forme :White CrystallineMasse moléculaire :323.20Cladribine 5’-Monophosphate Ammonium (>85%)
CAS :Produit contrôlé<p>Applications Cladribine 5’-Monophosphate Ammonium Salt can be used as an antiviral, antibacterial and antileukemic agent.<br>References Cook, P., et al.: U.S., US 4719295 A 19880112 (1988);<br></p>Formule :C10H16ClN6O6PDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :382.7Thymine
CAS :Produit contrôlé<p>Impurity Zidovudine EP Impurity C<br>Applications Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA.<br>References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008); Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009); Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009);<br></p>Formule :C5H6N2O2Couleur et forme :WhiteMasse moléculaire :126.11Zanamivir Amine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A synthetic precursor of Zanamivir.<br>References Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Bergmann, R., et al.: J. Med. Chem., 50, 2708 (2007), Lue, W., et al.: Eur. J. Med. Chem., 43, 569 (2008),<br></p>Formule :C11H18N2O7Couleur et forme :NeatMasse moléculaire :290.27Adenosine 5'-Diphosphate
CAS :Produit contrôlé<p>Applications Adenosine-5'-diphosphate (ADP) is a central component of energy storage, metabolism, and signal transduction in vivo. It serves as a precursor for ATP and, in this capacity, is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.<br>References Knowles, J.R., et al.: Annual Reviews of Biochemistry 49, 877-919 (1980); Klingenberg, M., et al.: Biochimica et Biophysica Acta, 1778(10), 1978-2021 (2008);<br></p>Formule :C10H15N5O10P2Couleur et forme :NeatMasse moléculaire :427.201,2-Ethylene Glycol (Ethylene Glycol)
CAS :Formule :C2H6O2Couleur et forme :NeatMasse moléculaire :62.07Gemcitabine Hydrochloride
CAS :<p>Applications An antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Formule :C9H11F2N3O4·ClHCouleur et forme :NeatMasse moléculaire :299.66Levomefolate Calcium
CAS :<p>Applications The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid.<br>References Prinz-Langhebohi, R.: et al., Br. J. Pharmac., 158, 2014 (2009); Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010);<br></p>Formule :C20H23N7O6·CaCouleur et forme :Off-WhiteMasse moléculaire :497.526-Methylmercaptopurine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.<br>References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),<br></p>Formule :C6H6N4SCouleur et forme :White To BeigeMasse moléculaire :166.20Cytarabine 5’-Monophosphate
CAS :Produit contrôlé<p>Stability Hygroscopic, Unstable in Solution<br>Applications A derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Formule :C9H14N3O8PCouleur et forme :NeatMasse moléculaire :323.204-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
CAS :Produit contrôlé<p>Applications 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene is used as a reagent in the synthesis of Dapagliflozin (D185370); a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.<br>References Meng, W., et al.: J. Med. Chem., 51, 1145 (2008);<br></p>Formule :C15H14BrClOCouleur et forme :White To Off-WhiteMasse moléculaire :325.63Pteroic Acid (>85%)
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity D N-Desmethyl Impurity<br>Applications Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.<br>References Vickers, P.J. et al.: Can. J. Biochem. Cell Biol., 63, 777 (1985): Tafolla, W.H. et al.: J. Pharmac. Sci., 70, 1273 (1981); Iwai, K. et al.: J. Butrit. Sci. Vitaminol., 23, 95 (1977);<br></p>Formule :C14H12N6O3Degré de pureté :>85%Couleur et forme :NeatMasse moléculaire :312.285-Amino-1-methyl-4-nitroimidazole
CAS :Produit contrôlé<p>Applications 5-Amino-1-methyl-4-nitroimidazole is a moiety of Azathioprine (A803350); an immunosuppressive antimetabolite that is also active as a disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979); Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979); Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987); Sandborn, W.J., et al.: Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998)<br></p>Formule :C4H6N4O2Couleur et forme :NeatMasse moléculaire :142.12Methyl 1,2,4-Triazole-3-carboxylate
CAS :Produit contrôléFormule :C4H5N3O2Couleur et forme :Off-WhiteMasse moléculaire :127.110-Formyl-5,6,7,8-tetrahydro Folic Acid Disodium (Technical Grade)
CAS :Produit contrôlé<p>Stability Hygroscopic, Light Sensitive, Temperature Sensitive<br>Applications 10-Formyl-5,6,7,8-tetrahydro Folic Acid Disodium Salt is the disodium salt of F701085, which is a Folic Acid (F680300) derivative. Folic Acid is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.10-Formyl-5,6,7,8-tetrahydro Folic Acid Disodium Salt is also used in the diagnosis and prevention and therapy of cerebral folate dificiency in relation to formation of folate receptor autoantibodies and treatment with reduced folate and antioxidants.<br>References Slieker, L.J., et al.: Mol. Pharmacol., 25, 294-302 (1984); Xu, L., et al.: Mol. Pharm., 7, 1311 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010); Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010); McKay, D., et al.: Nut. J., 9 (2010)Ramaekers, WO 2006119589, (2006)<br></p>Formule :C20H21N7Na2O7Couleur et forme :NeatMasse moléculaire :517.4Gemcitabine
CAS :<p>Applications Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer.<br>References Hamsici, S., et al.: Bioconjugate Chem., (2017); Peng, T., et al.: J. Cell. Biochem., (2017)<br></p>Formule :C9H11F2N3O4Couleur et forme :Off-WhiteMasse moléculaire :263.22-Deoxy-D-ribose
CAS :Produit contrôlé<p>Applications 2-Deoxy-D-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.<br>References Fico, A., et al.: Free Radical Biology & Medicine, 45, 211 (2008),<br></p>Formule :C5H10O4Couleur et forme :NeatMasse moléculaire :134.13Melphalan
CAS :Produit contrôlé<p>Applications Melphalan is an antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Formule :C13H18Cl2N2O2Couleur et forme :NeatMasse moléculaire :305.204-Hydroxytryptamine Creatinine Sulfate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A tryptamine derivative, a neurotransmitter agonist.<br>References Creveling, C. R., et al.: Mol. Pharmacol., 11, 211 (1975),<br></p>Formule :C10H12N2O·C4H10N4O·H2O4SCouleur et forme :NeatMasse moléculaire :404.446-O-Methylguanine
CAS :Produit contrôléFormule :C6H7N5OCouleur et forme :Off-WhiteMasse moléculaire :165.15(1S,2R,5S)-(+)-Menthol
CAS :Produit contrôlé<p>Applications D-Menthol is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>Formule :C10H20OCouleur et forme :NeatMasse moléculaire :156.275’-O-Acetyl Ribavirin
CAS :Produit contrôlé<p>Applications 5’-O-Acetyl Ribavirin is an impurity of Ribavirin (R414475). Ribavirin impurity F.<br>References Zakharieva., et al.: Bioorganic. Medicinal. Chem., 1994, 4, 2831 (1994), Reichard., et al.: The Lancet, 351, 83 (1998),<br></p>Formule :C10H14N4O6Couleur et forme :NeatMasse moléculaire :286.24Iso Cytosine
CAS :Produit contrôlé<p>Applications A useful intermediate for chemical modifications of base and sugar moieties in natural nucleosides.<br>References Sashaki, T., et al.: J. Org. Chem., 40(1), 106 (1975)<br></p>Formule :C4H5N3OCouleur et forme :NeatMasse moléculaire :111.103'-Azido-3'-deoxy-5'-O-tritylthymidine
CAS :Produit contrôléFormule :C29H27N5O4Couleur et forme :NeatMasse moléculaire :509.56Lamivudine Triphosphate Triethylamine Salt (90%)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of Lamivudine (L172500).<br>References Burgess, K., et al.: Chem. Rev., 100, 2047 (2000), Gallois-Montbrun, S., et al.: Biochem. Pharmacol., 68, 1749 (2004),<br></p>Formule :C8H14N3O12P3SC6H15NxDegré de pureté :90%Couleur et forme :NeatMasse moléculaire :469.2010119Guanine
CAS :<p>Impurity Aciclovir EP Impurity B<br>Applications Guanine is one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. Aciclovir EP Impurity B.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010);<br></p>Formule :C5H5N5OCouleur et forme :White To Off-WhiteMasse moléculaire :151.13Cytidine 5'-Diphosphocholine
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications Cytidine 5'-diphosphocholine (cas# 987-78-0) is a useful research chemical.<br></p>Formule :C14H26N4O11P2Couleur et forme :Off-WhiteMasse moléculaire :488.32Emtricitabine-13C,15N2
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Labelled Emtricitabine. A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>Formule :CC7H10F15N2NO3SCouleur et forme :White To Light YellowMasse moléculaire :250.23Melamine (1 mg/10 mL in 84:16% ACN:H2O)
CAS :Produit contrôléFormule :C3H6N6Couleur et forme :Single SolutionMasse moléculaire :126.122-Amino-6-(chloromethyl)-4(3H)-pteridinone (>90%)
CAS :Produit contrôlé<p>Applications 2-Amino-6-(chloromethyl)-4(3H)-pteridinone is a reagent/intermediate used in the preparation of Folic Acid (F680300) and its derivatives.<br>References Qi, Y., et al.: Faming Zhuanli Shenqing. CN 103755706 A 20140430. Apr 30, 2014;<br></p>Formule :C7H6ClN5ODegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :211.612-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethylester N-Methyl-L-Valine
CAS :<p>Impurity Valaciclovir EP Impurity C<br>Applications 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethylester N-Methyl-L-Valine (Valaciclovir EP Impurity C) is a useful building block in the synthesis of various pharmaceuticals. Is used in preparation of N-Alkyl Valaciclovir compounds and intermediates thereof.<br>References Pu, T., et al.: Faming Zhuanli Shenqing, (2013);<br></p>Formule :C14H22N6O4Couleur et forme :White To Off-WhiteMasse moléculaire :338.366-Benzylaminopurine 9-(β-D-glucoside)
CAS :<p>Applications 6-Benzylaminopurine 9-(β-D-glucoside) (cas# 4294-17-1) is a compound useful in organic synthesis.<br></p>Formule :C18H21N5O5Couleur et forme :NeatMasse moléculaire :387.39Iso Ribavirin (Ribavirin Impurity G)
CAS :Produit contrôléFormule :C8H12N4O5Couleur et forme :NeatMasse moléculaire :244.2Phosphoric Acid Dibenzyl Ester
CAS :<p>Stability Moisture Sensitive<br>Applications Eye irritant.<br>References Bagley, D. M. et al.; Toxicol. In Vitro 13, 505 (1999); Gilleron, L. et al.; Toxicol. In Vitro 11, 641 (1997)<br></p>Formule :C14H15O4PCouleur et forme :NeatMasse moléculaire :278.24Adenine
CAS :Produit contrôlé<p>Applications Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coalaninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer.<br>References Philips, et al.: J. Pharmacol. Exp. Ther., 20, 104 (1952), Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),<br></p>Formule :C5H5N5Couleur et forme :Light YellowMasse moléculaire :135.135-Fluorodihydropyrimidine-2,4-dione
CAS :Produit contrôlé<p>Applications A metabolite of 5-Fluorouracil. (F596000)<br>References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)<br></p>Formule :C4H5FN2O2Couleur et forme :NeatMasse moléculaire :132.093Levomefolic Acid
CAS :<p>Applications A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.<br>References Willems, F. et al.: Br. J. Pharmacol., 145, 823 (2004); Prinz-Langhebohi, R.: et al., Br. J. Pharmacol., 158, 2014 (2009); Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010)<br></p>Formule :C20H25N7O6Couleur et forme :NeatMasse moléculaire :459.46Melphalan-d8 Monohydrochloride
CAS :Produit contrôléFormule :C13H10D8Cl2N2O2·HClCouleur et forme :WhiteMasse moléculaire :349.71Cytarabine-13C3
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.<br>References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)<br></p>Formule :C613C3H13N3O5Couleur et forme :BeigeMasse moléculaire :246.19Thymidine
CAS :Produit contrôlé<p>Applications Constituent of deoxyribonucleic acid.<br>References Levene, L., et al.: J. Bil. Chem. 83, 793 (1929), Tollin, et al.: Nature 217, 1148 (1968), Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009), Hazra, S., et al.: Biochem., 48, 1256 (2009), Yang, I., et al.: J. Biol. Chem., 284, 191 (2009),<br></p>Formule :C10H14N2O5Couleur et forme :White To Off-WhiteMasse moléculaire :242.23Adenosine 5'-monophosphate monohydrate
CAS :Produit contrôléFormule :C10H14N5O7P·H2OCouleur et forme :NeatMasse moléculaire :365.2310-Formyl Folic Acid-d4
CAS :Produit contrôlé<p>Stability Air Sensitive<br>Applications A labelled Folic acid (F680300) derivative (or folate) found in daily dietary intake that is often used in cancer risk correlation studies.<br>References Keszei, A.P. et al.: Cancer Epidimiol. Biomarker Prev., 18, 1785 (2009); Koning, E.J. et al.: Cancer, 95, 1421 (2002);<br></p>Formule :C20H15D4N7O7Couleur et forme :NeatMasse moléculaire :473.43Zanamivir-13C,15N2
CAS :Produit contrôlé<p>Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.<br>References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),<br></p>Formule :CC11H2015N2N2O7Couleur et forme :NeatMasse moléculaire :335.294-Desethoxy-2-ethoxy Dapagliflozin, >90%
CAS :Produit contrôlé<p>Applications (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(2-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Formule :C21H25ClO6Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :408.87Abacavir 5’-β-D-Glucuronide Sodium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formule :C20H25N6NaO7Couleur et forme :NeatMasse moléculaire :484.44Fenretinide
CAS :Produit contrôlé<p>Stability Light Sensitive - Protect from Light Exposure<br>Applications Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.A synthetic analog of Vitamin A.<br>References Marth, C., et al.:J. Nat. Cancer Inst., 75, 871 (1985), Delia, D., et al.: Cancer Res., 53, 6036 (1993), Costa., A., et al.: Cancer Res., 54, Suppl., 2032s (1994), Decensi., A., et al.: Eur. J. Cancer Prev., 3, 377 (1994)<br></p>Formule :C26H33NO2Couleur et forme :NeatMasse moléculaire :391.551-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one
CAS :Produit contrôlé<p>Stability Moisture Sensitive<br>Applications 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one is an impurity of 5-Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Formule :C10H14N4O6Couleur et forme :White To Off-WhiteMasse moléculaire :286.24Capecitabine
CAS :Produit contrôlé<p>Applications Capecitabine is an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).<br>References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>Formule :C15H22FN3O6Couleur et forme :NeatMasse moléculaire :359.35N,O-Diacetate Isoacyclovir
CAS :Produit contrôlé<p>Impurity Aciclovir EP Impurity M<br>Applications An impurity of Acyclovir. Aciclovir EP Impurity M<br>References Laskin, O., et al.: Clin. Pharmacok., 8, 187 (1983), Grass, G., et al.: Pharm. Res., 5, 372 (1988), Mahony, W., et al.: J. Biol. Chem., 263, 9285 (1988), Merino, V., et al.: J. Pharm. Sci., 84, 777 (1995),<br></p>Formule :C12H15N5O5Couleur et forme :NeatMasse moléculaire :309.2785’-Ethylcarboxamido Adenosine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cusack and Hourani: Br. J. Pharmacol., 72, 433 (1981), Knapp, et al.: Pharmacol. Biochem. Behav., 68, 797 (2001)<br></p>Formule :C12H16N6O4Couleur et forme :NeatMasse moléculaire :308.29Cidofovir Diphosphate Trisodium Salt (>85%)
CAS :Produit contrôlé<p>Applications Cidofovir Diphosphate Trisodium Salt has antiviral activity, which is used against herpes viruses. Cidofovir Diphosphate is a metabolite in human cells.<br>References Hitchcock, M. J. M., et al.: Antivir. Chem. Chemoth., 7, 115-127 (1996); Cihlar, T., et al.: Collect. Czech. Chem. C., 57, 661-72 (1992)<br></p>Formule :C8H13N3Na3O12P3Degré de pureté :>85%Couleur et forme :NeatMasse moléculaire :505.092Favipiravir
CAS :Produit contrôlé<p>Applications Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever. It is a COVID19-related research product.<br>References Oestereich, L., et al.: Antiviral Res., 105, 17 (2014); Baranovich, T., et al.: J. Virol. 87, 3741 (2013); Chem. and Eng. News p.8, Dec. 1 (2014)<br></p>Formule :C5H4FN3O2Couleur et forme :NeatMasse moléculaire :157.10Decitabine impurity 12
<p>Decitabine Impurity 12 is an analytical standard that is used in the research and development of drug products. It is a high purity, HPLC-grade impurity that complies with USP/NF requirements. Decitabine Impurity 12 has been shown to be a metabolite of decitabine, which is an anti-cancer drug used in the treatment of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This impurity has also been shown to have pharmacopoeia value as an impurity standard for drug products.</p>Formule :C4H6N6O2Degré de pureté :Min. 95%Masse moléculaire :170.13 g/molMethyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside
CAS :<p>Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is a synthetic impurity standard for the drug product. It has been used in studies on metabolism and as an analytical reference material. Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is also available as a custom synthesis at high purity.</p>Formule :C22H24O6Degré de pureté :Min. 95%Couleur et forme :White powder.Masse moléculaire :384.42 g/molAdefovir Dipivoxyl Impurity I
CAS :<p>Adefovir Dipivoxyl Impurity I is a white crystalline powder with a melting point of 232–234 °C. It is soluble in water, and insoluble in organic solvents. Adefovir Dipivoxyl Impurity I is used as an impurity standard for Adefovir Dipivoxyl and has been shown to be metabolized by CYP3A4 and UGT1A9. This impurity also has the potential to inhibit DNA synthesis in cells.</p>Formule :C21H34N5O9PDegré de pureté :Min. 95%Masse moléculaire :531.5 g/molDapagliflozin Impurity 4
<p>Dapagliflozin Impurity 4 is a research and development impurity standard for the drug Dapagliflozin. Dapagliflozin Impurity 4 is a white crystalline solid with a molecular weight of 646.5 and an empirical formula of C20H22N2O2. It is soluble in water, methanol, ethanol, and acetonitrile. The compound has a melting point of 181°C with decomposition and a boiling point of 254°C at 760 mm Hg. It is not oxidizable under aerobic conditions and does not react with acid or alkali to form any ionizable species.</p>Degré de pureté :Min. 95%Remdesivir impurity 2
<p>Remdesivir impurity 2 is an analytical standard used in the development of drugs. It is a metabolite found in the drug Remdesivir. It is a natural product that can be synthesized or isolated from natural sources. Remdesivir impurity 2 is soluble in water and acetonitrile, and it has a melting point of 80-81 degrees Celsius. It has a molecular weight of 208.3 g/mol and CAS number 249712-00-1. This compound is not listed on the current edition of the USP Pharmacopoeia.</p>Formule :C19H19N5O4Degré de pureté :Min. 95%Masse moléculaire :381.39 g/mol2-Acetamido-9-[[2-(acetyloxy)ethoxy]methyl]-6,9-dihydro-1H-purin-6-one
CAS :<p>2-Acetamido-9-[2-(acetyloxy)ethoxy]methyl-6,9-dihydro-1H-purin-6-one (ademetionine) is a prodrug that is metabolized in the liver to form ademetionine. Ademetionine is a potent inhibitor of guanosine deaminase, which is an enzyme that breaks down guanosine into guanine and ammonia. Ademetionine has shown efficacy in cancer treatment and may also be used to treat tuberculosis. The metabolism of this drug takes place in the liver, where it undergoes oxidation by cytochrome P450 enzymes to form the active metabolite ademetionine. Metabolism of this drug can be inhibited by drugs such as trifluoromethanesulfonic acid (TFMS), which are used for the treatment of malaria. TFMS inhibits the formation of ademetionine but does not affect the formation</p>Formule :C12H15N5O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :309.28 g/molAcyclovir acetate
CAS :<p>Acyclovir is an antiviral agent that prevents the growth of herpes simplex virus. Acyclovir is a prodrug, which is converted to acycloguanosine 5'-triphosphate (ACV-TP) in vivo. ACV-TP inhibits viral DNA polymerase and thereby prevents viral genome replication, replication. The molecular structure of Acyclovir was determined by X-ray crystallography at 3.2 Å resolution. It has been shown that ACV-TP can be activated by chloride ions and it has been suggested that this activation may be the result of an interaction with a ligand.<br>ACV-TP binds to guanine residues in the DNA chain and prevents the formation of hydrogen bonds between guanine and adenine or cytosine residues in the same chain, preventing DNA replication.</p>Formule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :267.24 g/mol2'-Deoxyribavirin
CAS :<p>Intermediate in the synthesis of ribavirin</p>Formule :C8H12N4O4Degré de pureté :Min. 95%Masse moléculaire :228.21 g/molRemdesivir impurity 12
CAS :<p>Remdesivir impurity 12 is a drug product that is used in research and development. It is a synthetic impurity standard for HPLC analytical methods. Remdesivir impurity 12 is an impurity of the drug, remdesivir, which has antiviral activity against HIV-1. Metabolism studies have been conducted to investigate how this impurity affects the pharmacokinetics of remdesivir. The use of synthetic material ensures high purity and quality for this product.</p>Formule :C21H31N6O8PDegré de pureté :Min. 95%Masse moléculaire :526.48 g/mol2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
CAS :<p>2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a synthetic building block which can undergo reaction with nucleophilic carbon species to afford C-ribosides (via the corresponding hemiacetal). Treatment of 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone with stronger reducing agents, such as sodium borohydride, affords ring opened products with a stereo-defined poly-oxygenated carbon chain backbone.</p>Formule :C26H26O5Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :418.48 g/mol3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate
<p>3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate (CAS No. 53477) is a drug product that belongs to the class of drugs called nucleosides. 3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This product has been shown to have antiplasmodial activity and may be useful in the treatment of malaria.</p>Formule :C20H15Cl2NO6Degré de pureté :Min. 95%Masse moléculaire :436.24 g/molRemdesivir impurity 7
CAS :<p>Remdesivir is an antiviral drug. It is an RNA-dependent RNA polymerase inhibitor that has been shown to be effective against a broad range of RNA viruses, including influenza A and B, rhinovirus, respiratory syncytial virus, and parainfluenza virus. Remdesivir impurity 7 (impurity) is a byproduct of the synthesis process of remdesivir. It is a white crystalline solid with a strong chemical odor. This impurity can be synthesized in high purity as well as in custom specifications to meet the needs of pharmaceutical companies developing new drugs.</p>Formule :C15H24NO5PDegré de pureté :Min. 95%Masse moléculaire :329.33 g/mol1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic acid methyl ester
CAS :<p>Intermediate in the synthesis of ribavirin</p>Formule :C9H13N3O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :259.22 g/mol2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate sodium, 10 mM aqueous solution
CAS :<p>2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate sodium, 10 mM aqueous solution is an analytical standard that is used in metabolism studies and as an impurity in some pharmaceuticals. This chemical is also used to develop drugs, such as antiviral and anti-inflammatory agents. 2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate sodium, 10 mM aqueous solution has a CAS number of 1440537-37-0 and the molecular weight of 463.88 g/mol. This compound is soluble in water, ethanol, DMSO, acetone and acetonitrile at room temperature. The purity for this compound is > 99%.</p>Formule :C9H14F2N3O13P3•NaxDegré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :503.14 g/molDecitabine impurity 14
CAS :<p>Decitabine impurity 14 is an impurity of decitabine. It is a stable, natural product that has been synthesized for use as an analytical standard and pharmacopoeia reference material. Decitabine impurity 14 is a white crystalline powder with a melting point of about 152°C. It is soluble in water, ethanol and ether. The chemical name for this compound is 2-amino-4,6-dihydroxypyrimidine-5-carbonitrile hydrochloride.</p>Formule :C5H11NO3Degré de pureté :Min. 95%Masse moléculaire :133.15 g/mol
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