Nucléosides et Nucléotides
Les nucléosides sont des composés formés par une base azotée liée à un sucre (ribose ou désoxyribose). Lorsqu’un groupe phosphate est ajouté au nucléoside, un nucléotide est formé. Ces composés sont essentiels en biologie cellulaire, car les nucléotides sont les blocs fondamentaux de l’ADN et de l’ARN, responsables du stockage et de la transmission de l’information génétique. Les nucléosides ont des applications dans le traitement des maladies virales, en tant qu’inhibiteurs de la réplication virale. Les nucléotides, en plus de leur rôle structurel dans les acides nucléiques, interviennent dans les processus énergétiques, comme la synthèse de l’ATP.
Chez CymitQuimica, nous proposons une large gamme de nucléosides et de nucléotides essentiels à la recherche en biologie moléculaire, virologie et pharmacologie.
3421 produits trouvés pour "Nucléosides et Nucléotides"
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9-[4-Acetoxy-3-(acetoxymethyl)butyl]-2-amino-6-chloropurine
CAS :Produit contrôlé<p>Impurity 6-Chloro Famciclovir Impurity<br>Applications 9-[4-Acetoxy-3-(acetoxymethyl)butyl]-2-amino-6-chloropurine is an impurity of Famciclovir (F101125), an antiviral agent and a prodrug of Penciclovir (P221500).<br>References Raman, N., et al.: J. Pharma. Biomed. Anal., 50, 797 (2009); Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Formule :C14H18ClN5O4Couleur et forme :NeatMasse moléculaire :355.78(2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
CAS :Produit contrôlé<p>Applications A Lamivudine (L172500) intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993).<br></p>Formule :C18H27N3O4SCouleur et forme :NeatMasse moléculaire :381.49Folic Acid NHS Ester (γ : α =2 :1)
CAS :Formule :C23H22N8O8Couleur et forme :NeatMasse moléculaire :538.47Lamivudine Acid
CAS :Produit contrôlé<p>Impurity Lamivudine EP Impurity A<br>Stability Hygroscopic<br>Applications Lamivudine Acid (Lamivudine EP Impurity A) is an impurity of Lamivudine (L172500). Impurity A per European Pharmacopoeia.<br>References Dwyer, O., et al.: Synlett, 11, 1163 (1995),<br></p>Formule :C8H9N3O4SCouleur et forme :White To Off-WhiteMasse moléculaire :243.24Abacavir
CAS :Produit contrôlé<p>Impurity Abacavir API<br>Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formule :C14H18N6OCouleur et forme :Off WhiteMasse moléculaire :286.338-Hydroxyacyclovir
CAS :Produit contrôlé<p>Applications Acyclovir (A192400) is the parent compound for 8-Hydroxyacyclovir. Acyclovir (ACV), an anti-virus drug, was widely detected in natural water at concns. . ranging from ng L-1 to μg L-1 due to inefficient biol. treatments in sewage treatment plant.<br>References Zhang, Q., et al.: Journal of Radioanalytical and Nuclear Chemistry, 320, 823 (2019);<br></p>Formule :C8H11N5O4Couleur et forme :NeatMasse moléculaire :241.2046-Hydroxytryptamine Creatinine Sulfate
CAS :Produit contrôlé<p>Applications A tryptamine derivative, a neurotransmitter agonist.<br>References Dalton, T., et al.: Br. J. Pharmacol., 65, 579 (1979), Kang, S., et al.: Mol. Pharmacol., 16, 1031 (1979), Wallis, D., et al.: Eur. J. Pharmacol., 70, 381 (1981),<br></p>Formule :C10H12N2O·C4H9N3O2·H2O4SCouleur et forme :White To Light BrownMasse moléculaire :405.43Emtricitabine Monophosphate Triethylammonium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Paff, M. et al.; Antimicrob. Agents Ch. 38, 1230 (1994)<br></p>Formule :C8H11FN3O6PS·(C6H15N)Couleur et forme :White To Off-WhiteMasse moléculaire :327.23 + x(101.19)6-Amino-9-methylpurine(9-Methyl Adenine)
CAS :Produit contrôlé<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>Formule :C6H7N5Couleur et forme :NeatMasse moléculaire :149.153,4,5,6-Tetrahydrouridine (>80%)
CAS :<p>Stability Light Sensitive<br>Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.<br>References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);<br></p>Formule :C9H16N2O6Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :248.23N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine
CAS :Produit contrôlé<p>Impurity Abacavir EP Impurity F<br>Applications N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine (Abacavir EP Impurity F) is an impurity of Abacavir (A104990), a guanosine analog that inhibits reverse transcriptase (NRTI) (1,2).<br>References (1) Hanumegowda, U., et al.: Chem. Res. Toxicol., 23, 749 (2010) (2) Prasse, C., et al.: Environ. Sci. Technol., 44, 1728 (2010)<br></p>Formule :C18H26N6OCouleur et forme :OrangeMasse moléculaire :342.4386Adenosine-3',5'-cyclic-13C5 Monophosphate
CAS :<p>Stability Hygroscopic<br>Applications Labelled Adenosine-3’,5’-cyclic Monophosphate (A280455). Adenosine-3’,5’-cyclic Monophosphate is an Adenosine (A280400) derivative useful as anticancer agent.<br>References Keast, R., et al.: Pharma. Res., 19, 1019 (2002),<br></p>Formule :C5C5H12N5O6PCouleur et forme :NeatMasse moléculaire :334.1692Nicotinamide Riboside Triflate, α/β mixture
CAS :Produit contrôlé<p>Stability Very Very Hygroscopic<br>Applications Nicotinamide (N407750) analog. Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which Nicotamide is converted into NAD (Nicotinamide Adenine Dinucleotide)<br>References Friedlos, F., et al.: J. Biochem. Pharmacol., 44, 25 (1992), Ong, S., et al.: Biochemistry, 11210 (1992), Zhang, X., et al.: J. Biol. Chem., 278, 13503 (2003),<br></p>Formule :C12H15F3N2O8SCouleur et forme :NeatMasse moléculaire :404.32Pterine-6-carboxylic Acid
CAS :Produit contrôlé<p>Applications Pterine-6-carboxylic Acid is a degradation product of Folic acid (F680300).<br>References Akhtar, M., et al.: J. Pharm. Biomed. Anal., 19, 269 (1999), Andrisano, V., et al.: J. Pharm. Biomed. Anal., 32, 983 (2003), Patro, B., et al.: Bioorg. Med. Chem. Lett., 15, 67 (2005),<br></p>Formule :C7H5N5O3Couleur et forme :NeatMasse moléculaire :207.15Adenosine 5'-Diphosphate Sodium Salt
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Adenosine 5'-diphosphate monosodium salt (cas# 20398-34-9) is a useful research chemical.<br></p>Formule :C10H15N5O10P2·x(Na)Couleur et forme :White To Off-WhiteMasse moléculaire :427.20 + x(22.99)2’-Deoxy Cytidine
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.<br>References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004); Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006); Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007);<br></p>Formule :C9H13N3O4Couleur et forme :NeatMasse moléculaire :227.22(1R,3R,4R)-Entecavir
CAS :Produit contrôlé<p>Applications (1R,3R,4R)-Entecavir is an isomeric impurity of Entecavir (E558900).<br></p>Formule :C12H15N5O3Couleur et forme :NeatMasse moléculaire :277.285-Methyl-2’-deoxy Cytidine-d3
CAS :Produit contrôlé<p>Applications A labelled Cytidine (C998300) analog and also an isostere of Thymidine (T412000).<br>References Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008),<br></p>Formule :C10H12D3N3O4Couleur et forme :White To Off-WhiteMasse moléculaire :244.265'-Deoxy-5'-(methylthio)adenosine
CAS :<p>Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).<br>References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),<br></p>Formule :C11H15N5O3SCouleur et forme :White To Off-WhiteMasse moléculaire :297.33Cytarabine
CAS :<p>Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.<br>References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);<br></p>Formule :C9H13N3O5Couleur et forme :NeatMasse moléculaire :243.22Cytarabine-13C3 5’-Monophosphate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A labelled derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Formule :C6C3H14N3O8PCouleur et forme :NeatMasse moléculaire :326.175-Fluoro Cytosine-13C,15N2
CAS :Produit contrôléFormule :CC3H4F15N2NOCouleur et forme :White To Light BrownMasse moléculaire :132.07Thiouric Acid Sodium Salt Dihydrate
CAS :Formule :C5H3N4O2S·Na·2H2OCouleur et forme :NeatMasse moléculaire :242.19Lamivudine (R)-Sulfoxide
CAS :Produit contrôlé<p>Impurity Lamivudine EP Impurity H<br>Stability Hygroscopic<br>Applications Lamivudine (R)-Sulfoxide (Lamivudine EP Impurity H) is a metabolite of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has been used for treatment of chronic hepatitis B.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977)<br></p>Formule :C8H11N3O4SCouleur et forme :NeatMasse moléculaire :245.26Ribavirin
CAS :Produit contrôlé<p>Applications Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Formule :C8H12N4O5Couleur et forme :WhiteMasse moléculaire :244.202-Amino-7-(chloromethyl)pteridin-4(1H)-one (>90%)
CAS :Produit contrôlé<p>Applications 2-Amino-7-(chloromethyl)pteridin-4(1H)-one is the impurity F of Folic acid (F680300) as per EP monograph.<br></p>Formule :C7H6ClN5ODegré de pureté :>90%Couleur et forme :Dark YellowMasse moléculaire :211.611-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester(Ribavirin Impurity H)
CAS :Produit contrôléFormule :C9H13N3O7Couleur et forme :NeatMasse moléculaire :275.22Folic Acid
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formule :C19H19N7O6Couleur et forme :NeatMasse moléculaire :441.40N-Nitroso Abacavir
CAS :Produit contrôléFormule :C14H17N7O2Couleur et forme :Light Yellow To YellowMasse moléculaire :315.339-Carboxymethoxymethylguanine
CAS :Produit contrôlé<p>Applications 9-Carboxymethoxymethylguanine is a metabolite of Acyclovir (A192400) which is an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses.<br>References Gunness, P., et al.: Transl. Res., 158, 290 (2011); Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979), Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988), Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992),<br></p>Formule :C8H9N5O4Couleur et forme :Light Orange Colour SolidMasse moléculaire :239.192-Hydroxytetrahydrofuran
CAS :Produit contrôlé<p>Applications 2-Hydroxytetrahydrofuran (cas# 5371-52-8) is a compound useful in organic synthesis.<br></p>Formule :C4H8O2Couleur et forme :NeatMasse moléculaire :88.11Cabotegravir
CAS :<p>Applications Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015);<br></p>Formule :C19H17F2N3O5Couleur et forme :Off-WhiteMasse moléculaire :405.35Doxifluridine
CAS :Produit contrôlé<p>Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B<br>Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.<br>References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)<br></p>Formule :C9H11FN2O5Couleur et forme :NeatMasse moléculaire :246.19β-Nicotinic Acid Mononucleotide
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.<br>References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010);<br></p>Formule :C11H14NO9PCouleur et forme :NeatMasse moléculaire :335.22-Hydroxy-2,3-tetrahydrofuranyl Entecavir (Mixture of Diastereomers)
Produit contrôlé<p>Applications 2-Hydroxy-2,3-tetrahydrofuranyl Entecavir is an impurity of Entecavir (E558900).<br></p>Formule :C12H15N5O4Couleur et forme :NeatMasse moléculaire :293.286-Methylpterin
CAS :Produit contrôlé<p>Applications 6-Methylpterin is a derivative of Folic Acid (F680300) which is a precursor of coenzymes involved in metabolism of various nucleotides and nucleic acids.<br>References Dantola, M.L. et al.: Photochem Photobiol Sci., 9, 1604 (2010);<br></p>Formule :C7H7N5OCouleur et forme :NeatMasse moléculaire :177.163'-Chloro-3'-Deoxythymidine
CAS :Produit contrôlé<p>Impurity Zidovudine EP Impurity B<br>Applications 3'-Chloro-3'-deoxythymidine (Zidovudine EP Impurity B) is an impurity of 3'-Azido-3'-deoxythymidine (A825000), a potent and selective inhibitor of HIV-1 replication and a potential antiviral agent.<br>References Navaneethan, G., et al.: J. Food. Drug Anal., 20, 446 (2012); Srivastav, N.C., et al.: Bioorg. Med. Chem., 18, 7542 (2010); Shakya, N., et al.: J. Med. Chem., 53, 4130 (2010); Fukushima, M., et al.: BIochem. Pharmacol., 59, 1227 (2000);<br></p>Formule :C10H13ClN2O4Couleur et forme :BeigeMasse moléculaire :260.672'-Deoxyadenosine Monohydrate-13C5
CAS :Produit contrôlé<p>Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>Formule :C513C5H13N5O3•H2OCouleur et forme :Off-WhiteMasse moléculaire :274.22Abacavir sulfate
CAS :Produit contrôlé<p>Impurity Abacavir - In House Impurity<br>Applications Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formule :C14H18N6O·H2O4SCouleur et forme :Off WhiteMasse moléculaire :670.746,7-Dimethylpterin
CAS :Produit contrôlé<p>Applications 6,7-Dimethylpterin, a derivative of Folic Acid (F680300) is used as a biomarker for a non-invasive cancer diagnosis. Also can function as chromophores in light sensitive proteins allowing for analysis of target cells.<br>References Kritskii, M.S. et al.: Dokl. Akad. Nauk., 380, 408 (2001); Gamagedara, S. et al.: Clin. Chim. Acta., 412, 128 (2011);<br></p>Formule :C8H9N5OCouleur et forme :NeatMasse moléculaire :191.19Cytidine 5'-Phosphoromorpholidate N,N'-Dicyclohexyl-4-morpholinecarboximidamide
CAS :Produit contrôlé<p>Applications Intermediate in the preparation of Citicoline (C508050), a naturally occurring nucleotide.<br></p>Formule :C13H20N4O8P·C17H32N3OCouleur et forme :NeatMasse moléculaire :685.752,6-Diaminopurine-2’-deoxyriboside
CAS :<p>Applications 2,6-Diaminopurine-2’-deoxyriboside is a nucleoside analogs synthesized to interfere with DNA metabolism. A derivative of 2,6-Diaminopurine (D416580), which can be used as analyte for biological and analytical studies of incorporation of unnatural nucleotides into mutant tRNA and proteins.<br>References Kaminski, P. A., et al.: J. Biol. Chem., 288, 6534-6541 (2013); Ptacin, J., et al.: PCT Int. Appl., WO 2016115168 A1 20160721 (2016);<br></p>Formule :C10H14N6O3Couleur et forme :NeatMasse moléculaire :266.26Azathioprine-d3
CAS :Produit contrôlé<p>Applications Azathioprine-d3, is the labeled analogue of Azathioprine (A803350), an immunosuppressive antimetabolite, also active as disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)<br></p>Formule :C9H4D3N7O2SCouleur et forme :NeatMasse moléculaire :280.28L-Tetrahydrofolic Acid (>70% when packaged)
CAS :Produit contrôlé<p>Stability We have observed that this material decomposes steadily over time. Use immediate<br>Applications L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt.<br>References Prinz-Langenohl, R., et al.: Brit. J. Pharmacol., 158, 2014 (2009), Martin, H., et al.: Anal. Biochem., 402, 137 (2010), Dasarathy, J., et al.: Am. J. Clin. Nut., 91, 357 (2010), Karas-Kuzelicki, N., et al.: Clin. Biochem., 43, 37 (2010),<br></p>Formule :C19H23N7O6Couleur et forme :NeatMasse moléculaire :445.43Gemcitabine Diphosphate Triethylamine Salt (>90%)
CAS :Produit contrôlé<p>Applications Gemcitabine Diphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an antineoplastic agent.<br>References Baker, C., et al.: J. Med. Chem., 34, 1879 (1991), Huang, P., et al.: Cancer Res., 51, 6110 (1991), Plunkett, W., et al.: Nucleosides Nucleotides, 16, 1261 (1997),<br></p>Formule :C27H58F2N6O10P2Degré de pureté :>90%Couleur et forme :White To Off-WhiteMasse moléculaire :726.735-Azacytidine
CAS :<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Formule :C8H12N4O5Couleur et forme :Off-WhiteMasse moléculaire :244.20Methyl 2-Deoxy-D-ribofuranoside
CAS :Produit contrôléFormule :C6H12O4Couleur et forme :NeatMasse moléculaire :148.16L-Alanine 2-Ethylbutyl Ester Hydrochloride
CAS :Produit contrôlé<p>Applications L-Alanine 2-Ethylbutyl Ester Hydrochloride is used in the synthesis of phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Formule :C9H19NO2·ClHCouleur et forme :NeatMasse moléculaire :209.7136Methyl p-Toluate
CAS :Produit contrôlé<p>Stability Unstable in Solution<br>Applications Methyl p-toluate is an impurity of 3-Toluoyl Decitabine (T536260), which is an intermediate of decitabine (A796950 for β-Decitabine). It is used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.<br>References Deng, T., et al.: Life Sci., 84, 311 (2009), Horne, H., et al.: Mol. Cancer Res., 7, 199 (2009), Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),<br></p>Formule :C9H10O2Couleur et forme :NeatMasse moléculaire :150.17
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