Radicaux Libres et Agents Oxydants/Réducteurs
Les radicaux libres sont des molécules possédant des électrons non appariés qui peuvent endommager les structures cellulaires, affectant ainsi la stabilité des ingrédients pharmaceutiques actifs (API). Ces radicaux sont importants dans la formulation des API, car leur présence peut influencer la stabilité et l’efficacité du médicament. Les agents oxydants sont des substances qui facilitent la perte d’électrons, ce qui peut être utile dans la fabrication de certains API, mais qui peuvent également provoquer des réactions indésirables si elles ne sont pas correctement contrôlées. Les agents réducteurs, en revanche, peuvent stabiliser certains composés actifs en empêchant leur oxydation. Le contrôle des radicaux libres et la gestion des agents oxydants et réducteurs sont essentiels pour le développement d’API avec une durée de conservation prolongée et une activité thérapeutique efficace.
212 produits trouvés pour "Radicaux Libres et Agents Oxydants/Réducteurs"
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Visomitin
CAS :<p>Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).</p>Formule :C36H42BrO2PDegré de pureté :95.44% - 99.54%Couleur et forme :Highly Hydroscopic Solid)Masse moléculaire :617.61Acifluorfen
CAS :<p>Acifluorfen: PROTOX inhibitor herbicide causing photooxidative damage in plants; may induce liver tumors in rodents.</p>Formule :C14H7ClF3NO5Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :361.66Tempol
CAS :<p>Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.</p>Formule :C9H18NO2Degré de pureté :97% - 99.74%Couleur et forme :4-Hydroxy-Tempo Appears As Orange Flakes Solid FlakesMasse moléculaire :172.25N-Acetyl-D-cysteine
CAS :<p>N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group.</p>Formule :C5H9NO3SDegré de pureté :97.12% - 99.71%Couleur et forme :SolidMasse moléculaire :163.19S-(4-Hydroxybenzyl)glutathione
CAS :<p>L-γ-Glutamyl-S-[(4-hydroxyphenyl)methyl] from Gastrodia elata inhibits kainic acid binding to brain receptors.</p>Formule :C17H23N3O7SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :413.45ML-210
CAS :<p>ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor. ML-210 has antitumor activity and induces ferroptosis. Cost-effective and quality-assured.</p>Formule :C22H20Cl2N4O4Degré de pureté :97% - 99.03%Couleur et forme :SolidMasse moléculaire :475.32L-Theanine
CAS :<p>L-Theanine, a unique amino acid from Camellia sinensis tea, induces relaxation without drowsiness.</p>Formule :C7H14N2O3Degré de pureté :99.31% - 99.38%Couleur et forme :White Crystals From Ethanol + Water White Crystalline SolidMasse moléculaire :174.2TRi-1
CAS :<p>TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.</p>Formule :C12H9ClN2O5SDegré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :328.73Glutathione Sodium Salt
CAS :Formule :C10H16N3O6S·NaCouleur et forme :White To Off-White SolidMasse moléculaire :306.31 22.99L-Cysteine
CAS :<p>L-Cysteine: non-essential amino acid, aids protein synthesis, detox, collagen production, skin elasticity, and biochemical metabolism.</p>Formule :C3H7NO2SDegré de pureté :99.70% - 99.89%Couleur et forme :White Solid CrystallineMasse moléculaire :121.16JKE-1674
CAS :<p>JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210.Cost-effective and quality-assured.</p>Formule :C20H20Cl2N4O4Degré de pureté :98.02% - 98.4%Couleur et forme :SolidMasse moléculaire :451.3Diethylmaleate
CAS :<p>Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.</p>Formule :C8H12O4Degré de pureté :98%Couleur et forme :Colourless LiquidMasse moléculaire :172.18Nitecapone
CAS :<p>Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)</p>Formule :C12H11NO6Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :265.22L-Cysteine-glutathione Disulfide
CAS :Produit contrôlé<p>Applications L-Cysteine-glutathione Disulfide (cas# 13081-14-6) is a compound useful in organic synthesis.<br></p>Formule :C13H22N4O8S2Couleur et forme :White To Off-WhiteMasse moléculaire :426.47S-Nitroso-L-glutathione
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation.<br>References Thompson, C., et al.: Toxicol., App. Pharmacol., 233, 355 (2008), Bateman, R., et al.: J. Biol. Chem., 283, 35756 (2008), Foster, M., et al.: Biochem., 48, 792 (2009),<br></p>Formule :C10H16N4O7SDegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :336.32L-xylo-2-Hexulosonic Acid Methyl Ester
CAS :Produit contrôléFormule :C7H12O7Couleur et forme :NeatMasse moléculaire :208.166Ascorbyl Palmitate
CAS :<p>Applications Ascorbyl Palmitate is an ester formed from ascorbic acid (A786990) and palmitic acid (P144500) creating a fat soluble form of vitamin C. Ascorbyl Palmitate is also used as an antioxidant food additive.<br>References Adhikari, P., et al.: J. Am. Oil. Chemist. Soc., 89, 1961 (2012); Kong, J., et al.: J. Food. Sci., 77, S211 (2012);<br></p>Formule :C22H38O7Couleur et forme :Off-WhiteMasse moléculaire :414.532-Keto-L-gulonic Acid
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 2-Keto-L-gulonic Acid is used in biological studies for the formation of sorbitol metabolism by Acetobacter melanogenus.<br>References Okazaki, H., et al.: Agric. Biol. Chem., 33, 207 (1969)<br></p>Formule :C6H10O7Couleur et forme :NeatMasse moléculaire :194.14γ-Glu-Cys Trifluoroacetic Acid Salt (~90%)
CAS :Produit contrôlé<p>Stability Unstable in Solution<br>Applications γ-Glu-Cys is used in biological studies for the detection of thiols in yeast by HPLC coupled with LTQ-Orbitrap mass spectrometry after derivatization with p-(hydroxymercuri)benzoate.<br>References Rao, Y., et al.: J. Agri. Food Chem., 58, 3 (2010);<br></p>Formule :C8H14N2O5S•x(C2HF3O2)Degré de pureté :~90%Couleur et forme :NeatMasse moléculaire :250.2711402Ascorbic Acid Acetonide
CAS :Produit contrôlé<p>Applications Ascorbic Acid Acetonide (cas# 15042-01-0) is a compound useful in organic synthesis.<br>References Shibayama, H., et al.: Biosci., Biotechnol., Biochem., 72, 1015 (2008), Choi, H., et al.: Bioorg. Med. Chem. Lett., 19, 2079 (2009),<br></p>Formule :C9H12O6Couleur et forme :NeatMasse moléculaire :216.19Edaravone D5
CAS :Produit contrôlé<p>Applications Edaravone D5 is the labelled compound of Edaravone(E335000). synthesized and used for relative quant. anal. of oligosaccharides by mass spectrometry (MS). Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogene<br>References Zhang, Ping, et al.: Anal. Biochem., 418, 1(2011)<br></p>Formule :C10D5H5N2OCouleur et forme :Off-WhiteMasse moléculaire :179.23Glutathione
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. This compound has neuroprotective properties.<br>References Misko, T., et al.: J. Biol. chem., 273, 15646 (1998), Nakamura, K., et al.: J. Biol. Chem., 276, 34402 (2001) , Burdo, J., et al.: Brain Res. 1189, 12 (2008).<br></p>Formule :C10H17N3O6SCouleur et forme :Off-WhiteMasse moléculaire :307.32Glutathione (glycine-13C2,15N) Trifluoroacetate Salt
CAS :<p>Stability Hygroscopic<br>Applications Glutathione-glycine-13C2,15N Trifluoroacetate Salt is the labelled disodium salt derivative of Glutathione (G597951), a tripeptide thiol (composed of L-Cysteine [C995015], Glycine [G615990] and Glutamate) that is found in all cells, possesses an important role in metabolism and protects against reactive oxygen species in the body.<br>References Cooper, A. & Kristal, B.: Biol. Chem., 378, 793 (1997); Meister, A.: Science, 220, 472 (1983);<br></p>Formule :C813C2H17N215NO6S•C2HF3O2Couleur et forme :White To Off-WhiteMasse moléculaire :310.3011402Glutathione (glycine-13C2,15N) Sodium
CAS :<p>Applications Glutathione-glycine-13C2,15N Disodium Salt, is the labelled disodium salt derivative of Glutathione (G597951), a tripeptide thiol (composed of L-Cysteine [C995015], Glycine [G615990] and Glutamate) that is found in all cells, possesses an important role in metabolism and protects against reactive oxygen species in the body.<br>References Cooper, A. & Kristal, B.: Biol. Chem., 378, 793 (1997); Meister, A.: Science, 220, 472 (1983);<br></p>Formule :C813C2H17N215NO6S•xNaCouleur et forme :White To BeigeMasse moléculaire :310.302299Glutathione Disulfide
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A biomarker for fatty liver disease.<br>References Tsou, P.-S., et al.: J. Pharmacol. Exp. Ther., 329, 649 (2009), Yu, Y-C., et al.: J. Neurosci. Res., 87, 1884 (2009),<br></p>Formule :C20H32N6O12S2Couleur et forme :White To Off-WhiteMasse moléculaire :612.63Edaravone Trimer
CAS :Produit contrôléFormule :C29H24N6O3Couleur et forme :NeatMasse moléculaire :504.54Bispyrazolone
CAS :<p>Applications Bispyrazolone is an impurity of Edaravone (E335000).<br></p>Formule :C20H18N4O2Couleur et forme :NeatMasse moléculaire :346.38Ascorbyl Tetraisopalmitate
CAS :Produit contrôléFormule :C70H128O10Couleur et forme :NeatMasse moléculaire :1129.76L-threo-Hex-2-enaric acid 1,4-Lactone
CAS :Formule :C6H6O7Couleur et forme :Off-WhiteMasse moléculaire :190.11Oxalic Acid
CAS :<p>Applications An impurity of oxaliplatin which is a coordination complex that is used in cancer chemotherapy.A reducing agent and its conjugate base, known as oxalate (C2O42−), is a useful chelating agent for metal cations.<br>References Wheate, N., et al.: Dalton Trans., 39, 8113 (2010),<br></p>Formule :C2H2O4Couleur et forme :White To Off-WhiteMasse moléculaire :90.03D(-)-Isoascorbic Acid (Erythorbic Acid)
CAS :<p>Stability Moisture Sensitive<br>Applications Erythorbic Acid is used as a food additive as an antimicrobial and antioxidative agent.<br>References Sakagami, H. et al.: Anticanc. Res., 17, 221 (1997); Brahma, B. et al. J. Neurochem., 74, 1263 (2000);<br></p>Formule :C6H8O6Couleur et forme :WhiteMasse moléculaire :176.12L-threo-Hex-2-enaric acid 1,4-Lactone 6-Methyl Ester
CAS :Formule :C7H8O7Couleur et forme :NeatMasse moléculaire :204.13(1-Oxyl-2,2,5,5-tetramethyl-δ-3-pyrroline-3-methyl) Methanethiosulfonate
CAS :<p>Stability Light Sensitive<br>Applications A highly reactive thiol-specific spin-label. A specific conformational probe of thiol site structure by virtue of its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study.<br>References Huang, H., et al.: Biochem., 47, 12380 (2008), Antoniou, C., et al.: Anal. Biochem., 376, 160 (2008), Padmavathi, P., et al.: J. Mol. Biol., 378, 204 (2008),<br></p>Formule :C10H18NO3S2Couleur et forme :NeatMasse moléculaire :264.38S-(2-Hydroxyethyl)glutathione
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications A glutathione derivative as inhibitor of glutathione S-transferase.<br>References Dirr, H., et al.: Eur. J. Biochem., 196, 693 (1991), Oakley, A., et al.: J. Mol. Biol., 274, 84 (1997), Alcaro, S., et al.: Bioorg. Med. Chem., 13, 3371 (2005),<br></p>Formule :C12H21N3O7SCouleur et forme :NeatMasse moléculaire :351.38Potassium Dichromate
CAS :Produit contrôlé<p>Applications Potassium Dichromate is toxic if ingested, however has been used in tracing methods. Also, is used in treating patients suffering from COPD and related tracheal secretions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Frass, M. et al.: Chest., 127, 936 (2005); Mascorro, J. et al.: Stain. Technol., 50, 391 (1975);<br></p>Formule :Cr2O7·2KCouleur et forme :NeatMasse moléculaire :294.18L-Gulono-1,4-lactone
CAS :Produit contrôlé<p>Applications L-Gulono-1,4-lactone is a precursor in the biosynthesis of ascorbic acid, one of the many forms of Vitamin C.<br>References Wolucka, B. et al.: J. Biol. Chem., 278, 47483 (2003); Heller, R. et al.: J. Biol Chem., 274, 8254 (1999);<br></p>Formule :C6H10O6Couleur et forme :White To Off-WhiteMasse moléculaire :178.142-Phospho-L-ascorbic Acid Trisodium Salt
CAS :Produit contrôlé<p>Applications 2-Phospho-L-ascorbic Acid Trisodium Salt is a long-lasting vitamin C derivative used in studies of gene repression. Maximizes the benefical properties of vitamins C for personal care and a main active ingredient in medicated cosmetics for whitening. Also, it is substrate in the chromoamperometric method to detect tungsten in water.<br>References Fuchihata, M.: Frag. J., 43, 64-68 (2015); Alvarado-Gamez, A. L., et al.: Sens., 15, 2232-2243 (2015);<br></p>Formule :C6H6Na3O9PCouleur et forme :NeatMasse moléculaire :322.05L-Dehydro Ascorbic Acid (>90%)
CAS :Produit contrôlé<p>Applications The reversibly oxidized form of ascorbic acid.<br>References Moubasher, et al.: J. Biol. Chem., 176, 633 (1948), Sy, K., et al.: J. Food Prot., 68, 1176 (2005), Llorach, R., et al.: Food Chem., 2008, 108, 1028 (2008),<br></p>Formule :C6H6O6Couleur et forme :NeatMasse moléculaire :174.11
