Acides aminés (AA)

<p>Applications This compound is used as a reagent in the synthesis of acyl peptides that act as immunostimulants.<br>References Takeno, H. et al.: Chem. Pharm. Bull., 32, 2932 (1984);<br></p>

<p>Applications N-Methyliminodiacetic Acid (cas# 4408-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(N-Methylamino-N-aminoethyl)-1-phenylethene can be synthesized from Phenylacetaldehyde (T535860) and can be used to block chemicals.<br>References Javanmard, S., et al.: J. Med. Chem., 42, 4836-4843 (1999);<br></p>

<p>Applications D-Alanine-3,3,3-d3-N-t-BOC (CAS# 177614-70-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Dipropyl-2-(2-methyl-3-nitrophenyl)ethylamine is an intermediate used to prepare 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone and related compounds as a prejunctional dopamine receptor agonist.<br>References Gallagher, G., et al.: J. Med. Chem., 28, 1533 (1985); DeMarinis, R., et al.: J. Med. Chem., 29, 939 (1986)<br></p>

<p>Applications 2-(4-Bromophenyl)-1-methyl-5-nitro-1H-benzo[d]imidazole has been used in the study of 5-nitrofuran derivatives as an inhibitor of nucleic acid and protein synthesis in Ehrlich ascites tumor cells.<br>References Fuska, J., et. al.: Neoplasma, 20, 171 (1973)<br></p>

<p>Applications L-Methionine-13C5 is the isotope labelled analog of L-Methionine, which is an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.<br>References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),<br></p>

<p>Applications N-Suberylglycine-2,2-d2 (CAS# 1219799-02-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Methyl-bis-(2-aminophenoxymethylene)-N,N,N’,N’-tetraacetate Methyl Ester (cas# 96315-10-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methyl-α-[1-(methylamino)ethyl]-benzenemethanol Hydrochloride is a reagent used for analytical study in determination of drugs of abuse and their metabolites in wastewater using solid phase extraction coupled to liquid chromatography using high resolution mass spectrometry<br>References Prosen, H., et al.: J. Seperation Sci., 40, 3621 (2017)<br></p>

<p>Applications 3-Fluoro-2-methoxy-benzenesulfonyl-d3 Chloride is the isotope labelled analog of 3-Fluoro-2-methoxy-benzenesulfonyl Chloride (F593265), which is a derivative of 2-Fluoroanisole (F587670); a useful synthetic intermediate with antifungal activity.<br>References Pinto, M. F. S., et al.: J. Mol. Struc.: Theochem., 539, 303-310 (2001)<br></p>

<p>Applications 4-Fluoro-α-methylstyrene is used in the synthesis of Paroxetine (P205750), which is a selective serotonin reuptake inhibitor. Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Methyl-7-nitroisatoic Anhydride is a reagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in &lt;70 seconds.<br></p>

<p>Applications Fmoc-3-(2-naphthyl)-D-alanine is an intermediate used in the preparation of phosphoserine-containing tetrapeptides with hydrophobic N-terminal acyl groups as inhibitors of the BRCA1 protein.<br>References Yuan, Z., et al.: Med. Chem. Lett., 2, 767 (2011); Liu, T., et al.: ACS. Comb. Sci., 13, 537 (2011);<br></p>

<p>Applications 1-Methylimidazole-d3 (ring-d3) (CAS# 4166-68-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N2-Cbz-D-glutamine is an N-Cbz-protected form of D-Glutamine (G597295). D-Glutamine is an unnatural isomer of L-Glutamine (G597000) that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells.<br>References Almassy, R., et al.: Nature, 323, 304 (1986); Frank, H., et al.: J. Chromatog. B: Biomed. Sci. Appl., 224, 177 (1981); Jayme, D.: Cytotechnology, 5, 15 (1991); Kagan, H. &amp; Meister, A.: Biochemistry, 5, 725 (1966); Levintow, L. &amp; Meister, A.: J. Am. Chem. Soc., 75, 3039 (1953); Raj, D., et al.: Am. J. Phys. Endo. Metab., 280, E214 (2001); Varadi, M., et al.: Biosens. Bioelect., 14, 335 (1999)<br></p>

<p>Applications 1-(1H-Benzimidazol-2-yl)-3-methyl-1H-pyrazol-5-ol (cas# 516455-57-5) is a useful research chemical.<br></p>

<p>Applications N-Methylurea is used as a reagent in the synthesis of bis(aryl)(hydroxyalkyl)(methyl)glycoluril derivatives and is a potential byproduct of caffeine.<br>References Antonova, M.M., et al.: Chem. Heterocycl. Comp., 50, 503 (2014); Zarrelli, A., et al.: Sci. Total Environ., 470, 453 (2014)<br></p>

<p>Applications Used in the preparation of methylnitroquipazines as serotonin transporter inhibitors.<br></p>

<p>Applications gamma-D-Glutamylaminomethylsulfonic Acid is an AMPA/kainate receptor inhibitor used in reduction of renal hypoxia-​reoxygenation injury.<br>References Szoleczky, P., et al.: Arch. Biochem. Biophys., 517, 53 (2012);<br></p>

<p>Applications N-Methylisoamylamine is a reagent used in the synthesis of hepatitis C polymerase inhibitors.<br>References Cheng, C. et al: Bioorg.<br></p>

<p>Applications 5-Chloro-2-fluoro-3-methylphenylboronic acid<br></p>

<p>Applications Fmoc-O-sulfo-L-tyrosine sodium salt is a building block for solid-phase synthesis of sulfotyrosine peptides.<br>References Kitagawa, K., et al.: Pept. Chem. Proc. Jpn. Symp., 2nd, 42 (1993)<br></p>

<p>Applications 1H-1,2,3-Triazole-5-methanamine Dihydrochloride is used in the preparation of optimized 5-membered heterocycle-linked pterins for inhibition of ricin toxin A. Also used in the synthesis of orally bioavailiable human neurokinin-1 (hNK1) antagonists.<br>References Lin, P. et al.: Bioorg. Med. Chem. Lett., 17, 5191 (2007); Pruet, J. et al.: ACS Med. Chem. Lett., 3, 588 (2012);<br></p>

<p>Applications 4-(1,1-Dimethylethyl)-2-(1-methylpropyl)-6-[2-(2-nitrophenyl)diazenyl]phenol is an intermediate in the synthesis of 2-(2H-Benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (B206645), which is often used to increase product stability and to prevent discolouration in various consumer and industrial goods such as plastics. Benzotriazole UV stabilizers, such as 2-(2H-Benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)pheno, are pollutants for the aquatic environment and have been implicated as a potential stable and toxic ligands for the aryl hydrocarbon receptor in human.<br>References Liu, R., et al.: Talanta 120, 158 (2014); Nagayoshi, H., et al.: Environ Sci Technol. 49, 578 (2015).<br></p>

<p>Applications 2-Methoxypropanoic acid<br></p>

<p>Applications N1-tert-Butoxycarbonyl 1-(3-Methoxyphenyl)hydrazine (cas# 380383-81-3) is a compound useful in organic synthesis.<br></p>

<p>Applications D-4-Hydroxyphenyl-d4-alanine-2,3,3-d3 (CAS# 1426174-46-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetrahydro-3-methylpyran-2-one (cas# 10603-03-9) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Amino-5-methylthiophene-3-carboxylate is used as a starting reagent in the synthesis of Thieno[2,3-b]Pyridinones and 4-Hydroxy-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine derivatives, compounds that act as cytoprotectants and inhibitors of the N-Methyl-D-aspartate (NMDA) receptor.<br>References Buchstaller, H., et al.: J. Med. Chem., 49, 864 (2006); Hwang, K., et al.: Arch. Pharm. Res., 24, 270 (2001)<br></p>

<p>Applications Bis(3-methylpentyl) Phthalate-d4, is the labeled analogue of Bis(3-methylpentyl) Phthalate (B486010), used as a plasticizer to impart softness and flexibility to PVC products.<br>References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications 5-Hydroxy-L-lysine is a non-proteinogenic amino acid that can be used in the formation of crosslinks in engineered neocartilage and gelatin.<br>References Makris, Eleftherios A., et al.: FASEB J., 27(6), 2421-2430, 10.1096/fj.12-224030 (2013);Murphy, Meghan K., et al.: J. of the Royal Soc., Interface, 12(103), 20141075/1-20141075/9  (2015);Bozzini, Sabrina, et al.: J. of App. Biomat. &amp; Biomech., 7(3), 194-199 (2009)<br></p>

<p>Applications (1S)-2-(4-Chlorophenyl)-1-methylethylamine Hydrochloride (cas# 405-46-9) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-1-chloro-4-methyl-benzene is a useful synthetic intermediate. It can be used to synthesize N-heterocycle-fused phenanthridines via palladium-catalyzed tandem N-H/C-H arylation of aryl-N-heteroarenes with dihaloarenes. It can also be used to synthesize substituted fluorenes.<br>References Yan, L., et al.: Org. Biomol. Chem., 11, 7966 (2013); Dong, C., et al.: 64, 2537 (2008)<br></p>

<p>Applications 2-Methyl-5-oxo-1-cyclopentenyl Propionate (cas# 87-55-8) is a useful research chemical.<br></p>

<p>Applications Protected amino acid.<br></p>

<p>Applications 4-Amino-2-methoxyphenol Hydrochloride (cas# 4956-52-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(5-Methylfuran-2-yl)propan-1-one (cas# 10599-69-6) is a useful research chemical.<br></p>

<p>Applications N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester is a amino acid glycine (G615990) derivative, used widely in various synthetic preparations of pharmaceutical goods and antioxidants. N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester can be used in the preparation of Pregabalin (P704800), a GABA analogue used as an anticonvulsant.<br>References Ko, E.H., et al.: J. Am. Chem. Soc., 133, 462 (2011); Heller, S.T., et al.: Org. Lett., 12, 4572 (2010); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>

<p>Applications rac-6-Methyl-4-phenyl-2-chromanol-d6 is labelled rac-6-Methyl-4-phenyl-2-chromanol (M327070) which is an impurity of Tolterodine (T535800), an antimuscarinic agent used to treat patients with overactive bladder.<br>References Kaplan, S., et al.: JAmA, 296, 2319 (2006); Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997); Van Kerrebroeck, P., et al.: Urology, 57, 414 (2001)<br></p>

<p>Applications H-PHE-GLY-OH (cas# 721-90-4) is a useful research chemical.<br></p>

<p>Applications 4-BROMO-L-PHENYLALANINE (cas# 24250-84-8) is a useful research chemical.<br></p>

<p>Applications 4-Methoxyquinoline is used as a reactant in the synthesis of hybrid quinoline-4-yloxadiazoles/oxathiadiazoles as potent antifungal agents.<br>References Khan, Firoz A., et al.: Inter. J. of Pharmacy and Pharma. Sci., 7(4), 223-229 (2015)<br></p>

<p>Applications N1-(2-Aminophenyl)-N2,N2-dimethylglycinamide (cas# 35266-48-9) is a useful research chemical.<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.<br>References Thuring, J., et al.: Biochem., 41, 2002 (2002), Hausch, F., et al.: Chem. Biol., 10, 225 (2003), Palucki, B., et al.: Bioorg. Med. Chem. Lett.,15, 1993 (2005),<br></p>

<p>Applications 1-Methylimidazole-d6 (CAS# 285978-27-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications H-MET-ASP-OH (cas# 14595-65-4) is a useful research chemical.<br></p>