Peptides

<p>Please enquire for more information about H-CEKNKQDTITTKKYI-OH Acetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vascular endothelial growth factor receptor 2 (VEGF-VEGFR2) binding peptide. 95%, TFA salt.</p>

<p>Vascular endothelial growth factor receptor 2 (VEGF-VEGFR2) binding peptide. 95%, TFA salt.</p>

Pyr-Val-OH is a molecule that is catalysed by the enzyme histone deacetylase. Pyr-Val-OH has been shown to inhibit cancer cell proliferation and growth. Pyr-Val-OH also has been shown to reduce bacterial vaginosis in mice with bacterial vaginosis, as well as nephrology dialysis patients. Pyr-Val-OH is a diagnostic marker for cancer, bacterial vaginosis and nephrology dialysis patients. It can be used to diagnose these conditions by profiling specific metabolic profiles. This molecule may also be used in the diagnosis of bladder cancer, as it reacts with amp-activated protein, which is elevated in bladder cancer patients.

Please enquire for more information about H-PKEK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-KVK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-KVK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-KVK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-PKEK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-PKEK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about H-QDVH-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Please enquire for more information about H-PKEK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about H-QDVH-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Please enquire for more information about H-KVK-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about H-QDVH-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>Particle size 30 µm monosized; capacity: 0.2-0.3 meq/g.</p>

<p>TentaGel resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a "chameleon type" polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. The micro spherical shape and the monosized character of this resin allow applications in automated sorters, for creating huge libraries, high speed synthesis etc. particle size: 10 µm monosized capacity: 0.2 - 0.3 mmol/g.</p>

<p>α enolase (ENO1) is an isozyme of enolase, the other two being ENO2 (ENO-&amp;γ-) and ENO3 (ENO-β). Each isoform is a protein subunit that can hetero- or homodimerise to form αα, αβ, α&amp;γ-, ββ, and &amp;γ-&amp;γ- dimers. As an enolase, ENO1 is a glycolytic enzyme the catalyses the conversion of 2-phosphoglycerate to phosphoenolpyruvate. This isozyme is ubiquitously expressed in adult human tissues, including liver, brain, kidney, and spleen. Within cells, ENO1 predominantly localizes to the cytoplasm, though an alternatively translated form is localized to the nucleus. Its nuclear form, also known as MBP1, functions solely as a tumor suppressor by binding and inhibiting the c-myc protooncogene promoter, and lacks the glycolytic enzyme activity of the cytoplasmic form. ENO1 also plays a role in other functions, including a cell surface receptor for plasminogen on pathogens, such as streptococci, and activated immune cells, leading to systemic infection or tissue invasion- an oxidative stress protein in endothelial cells- a lens crystalline- a heat shock protein- and a binding partner of cytoskeletal and chromatin structures to aid in transcription.ENO1 overexpression has been associated with multiple tumours, as well as with autoimmune, gastrointestinal and haematological diseases.</p>

<p>Suc-Ile-Ile-Trp-MCA is a peptide that is used as a research tool to study protein interactions and receptor function. This peptide can be used to inhibit ion channels and act as an activator of certain proteins. Suc-Ile-Ile-Trp-MCA binds to the N terminus of the alpha subunit of the G protein, which has been shown to activate the enzyme adenylate cyclase. It also binds to other receptors, such as the beta 2 adrenergic receptor in erythrocytes that leads to increased levels of cAMP. The selectivity for these binding sites is not yet known.</p>

<p>Boc-Hyp(Bzl)-OH is a synthetic peptide that is used as a pharmacological research tool. It is an inhibitor of the ion channel Kv1.2, which is a voltage-gated potassium channel found in the central nervous system and peripheral tissues. Boc-Hyp(Bzl)-OH binds to the extracellular loop 2 of Kv1.2, blocking the flow of potassium ions through the channel and inhibiting its function. This peptide has been shown to inhibit cell proliferation and induce cell death in various cancer cells, such as breast carcinoma cells and lymphoma cells.</p>

Leu-Asp-AMC is a research tool that can be used in high-throughput screening to identify ligands, receptors, ion channels and other proteins. This product is a Ligand that binds to receptor sites on cells and changes their properties. Leu-Asp-AMC has been shown to inhibit the activity of ion channels, which are membrane proteins that control the flow of ions across cell membranes. It also inhibits antibody production by B cells and has been shown to be an inhibitor for peptide synthesis and protein interactions.

TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. TentaGel; HL (High Load) with Handles mean particle size 75 µm: capacity 03-04 meq/g

<p>Z-Leu-Leu-Leu-MCA is a peptide that is used as a research tool. It can be used to activate an antibody, or other cell surface receptor, by binding to the extracellular domain of the receptor. Z-Leu-Leu-Leu-MCA can also inhibit certain ion channels and ligand/receptor interactions. This peptide is highly pure and has CAS No. 152015-61-7.</p>

<p>Glt-Ala-Ala-Phe-AMC is a research tool which can be used as an activator or ligand to bind to receptors on cells. It is also used in cell biology, especially for antibody production. Glt-Ala-Ala-Phe-AMC has been shown to inhibit ion channels and is used as a pharmacological tool for studying the interactions of peptides and proteins. It has CAS No. 144398-31-2 and is purified with HPLC.</p>

<p>A synthetic spider toxin, sourced from the Funnel Web Spider, Agelenopsis aperta. This toxin can be applied as a P-type Ca2+ channel selective blocker and has disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34. This product is available as a 0.1mg vial.</p>

<p>TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.<br>Application: (90 µm)<br>Substitution Functional Group: -NH-CO-CH2-CH2-COOH</p>

<p>The septum is a thin, flexible membrane that separates the two chambers of a syringe. It is made from Teflon-coated silicone rubber and is typically used in research applications to separate two solutions or two cells. The Septum is also used as an activator in ligand receptor binding experiments, as well as a receptor in antibody-antigen interactions. The Septum can be used to isolate ion channels and study protein interactions. Peptides are commonly used to inhibit the function of ion channels, which may be useful for pharmacological purposes. The Septum can also be used in Cell Biology experiments to perform high purity protein interactions or cell culture.br&gt;<br>The Septum is available in 30 mL and 400 mL sizes.br&gt;<br>br&gt;br&gt;</p>

<p>Angiotensin I (Human) is a peptide that functions as a hormone. It is the major regulator of blood pressure and plays an important role in the regulation of fluid balance, electrolyte balance, and heart rate. Angiotensin I (Human) is a receptor ligand that binds to cell surface receptors which are coupled to G proteins. It has been used extensively as a research tool for studying protein interactions and ion channels.</p>

<p>LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37, this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also regulates many aspects of the innate immune system and overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis, making LL-37 the most studied form of the human cathelicidin peptides.More recently studies have shown that LL-37 binds to SARS-CoV-2 S protein and inhibits binding to its receptor hACE2, which may inhibit viral entry into the cell. LL-37 is upregulated by vitamin D, therefore this may be one mode of action for the positive outcomes seem with vitamin D treatment for Covid-19.This peptide contains 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Suc-Ala-Pro-Ala-AMC is a synthetic peptide that is used as a research tool in pharmacology, cell biology, and other life science fields. This peptide is an activator of ion channels, which are proteins that allow the flow of ions across cell membranes. Suc-Ala-Pro-Ala-AMC binds to ligand receptors on the surface of cells and activates them by opening the channel. The high purity of this product makes it suitable for use in research applications where specific binding is required.</p>

<p>substitution 1.0-1.6 meq/g; swelling (1g swells in 3ml DMF for 24hr).</p>

<p>Ac-Asp-Asn-Leu-Asp-MCA is a peptide that is used as an inhibitor of protein interactions. It has been shown to activate the beta2 adrenergic receptor and inhibit the alpha1A and alpha1B receptors. Ac-Asp-Asn-Leu-Asp-MCA can be used in research as a tool to study receptor binding, ion channels, and other proteins. It is also used in antibody production for life science research.</p>

<p>Pro-Pro-Gly is a peptide with a molecular mass of 10,000 daltons. It is an inhibitor of the enzyme collagenase, which is involved in the breakdown of type IV collagen. Collagenase is also involved in the breakdown of necrotic tissues. Pro-Pro-Gly has been shown to inhibit collagenase from various sources, such as human skin and rat liver. This activity may be due to its ability to bind to the enzyme's active site, thereby inhibiting its function.</p>

<p>100-200mesh, 1% DVB.  Typical substitution 0.45meq/g</p>

MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂ is a peptide that was designed to bind to ion channels. It is an activator of the nicotinic acetylcholine receptor. The peptide has also been shown to inhibit protein interactions and be a ligand for the serotonin receptor. MOCAc binds to the extracellular domain of the nicotinic acetylcholine receptor, which leads to a conformational change in the receptor's structure. This changes the shape of the channel, which allows potassium ions to flow out of the cell and sodium ions to flow in. MOCAc does not have any effects on other receptors or ion channels. MOCAc has been used as a research tool to study protein interactions and as an antibody for immunostaining and Western blotting as well as for cell biology studies.

<p>Leu-MCA is a peptide that is an activator of ion channels. It is used as a research tool for the study of protein interactions, receptor and ligand binding, and pharmacology. Leu-MCA can be used to study the activation of ion channels by G-protein coupled receptors. In this way, Leu-MCA can be used to investigate the structure and function of these proteins in cells. The high purity of Leu-MCA offers researchers a means to control the concentration of this compound in experiments.</p>

<p>Fmoc-Cha-OH is an activated, histidine building block that is used to synthesize biomolecules such as proteins and peptides. It has been shown to modulate the activity of acidic phospholipases in inflammatory diseases, specifically colorectal carcinoma. This building block can be used for solid-phase synthesis, and has a high chemical stability and low potency. Fmoc-Cha-OH can be reversibly hydrolyzed to release free histidine, with a half life of around two hours. It binds to mitochondria, which are organelles found in cells that generate energy from food molecules. Fmoc-Cha-OH is an analog of the amino acid histidine, making it structurally similar but not identical.</p>

<p>Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4 lysine rich tail plays a role in the higher order chromatin folding.Acetyl-Histone H4 (1-23)-GG-[Lys(5-FAM)] has a C-terminal GGK linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag. Additionally, the peptide has an uncharged C-terminal amide and is protected from N-terminal modifications by a covalently bonded acetyl group.</p>

<p>This product is a septum for use in peptide synthesis. It is a Teflon-coated silicone rubber septum that includes a screw cap and is available in three sizes (5, 10, and 15 mL). The septum has an opening that can be used to introduce reagents into the flask.</p>

<p>The peptide Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-MCA is a synthetic, nonapeptide analog of the vasoactive intestinal peptide (VIP). It inhibits the activity of protein interactions, activator, and ligand. Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-MCA is used as a research tool for studying the structure and function of ion channels and receptors. This product is available in high purity and can be used in biological research.</p>

<p>Unsubstituted Resins for Solid Phase Synthesis; 0.3-0.6 meq/g</p>

<p>Hepcidin is a peptide hormone that plays a key role in the regulation of iron metabolism in the body. It is produced by the liver and is secreted into the bloodstream, where it interacts with cells in the intestine and other tissues to control the absorption and distribution of iron.<br>Hepcidin acts as a negative regulator of iron uptake and release by binding to and inhibiting the activity of ferroportin, a protein that facilitates the export of iron from cells into the bloodstream. When hepcidin levels are high, ferroportin activity is reduced, leading to decreased iron absorption from the diet and reduced iron release from cells. When hepcidin-24 levels are low, ferroportin activity is increased, leading to increased iron absorption and release.<br>Imbalances in hepcidin levels can lead to a variety of disorders, including iron-deficiency anemia, hemochromatosis (an iron overload disorder), and anemia of chronic disease. <br>In addition to its role in iron metabolism, hepcidin has been shown to have antimicrobial properties, as it can inhibit the growth of certain bacteria and fungi. It may also be involved in the regulation of immune function and inflammation.<br>One-Letter Formula: DTNFPICIFCCKCCNNSQCGICCKT</p>

<p>Antimicrobial peptide with disulfide bonds between Cys1- Cys29, Cys3- Cys18, and Cys8- Cys28 and available as a 0.1mg vial. Alpha-defensin-2 is a small, cationic peptide that is part of the alpha-defensin family of antimicrobial peptides in humans. It is primarily produced by neutrophils, which are a type of white blood cell that plays a critical role in the immune response to bacterial infections.<br>Alpha-defensin-2 is known to have broad-spectrum antimicrobial activity against a wide range of bacterial pathogens, including both Gram-positive and Gram-negative bacteria. Like other alpha-defensins, alpha-defensin-2 achieves its antimicrobial activity by disrupting the cell membranes of the pathogens, leading to cell lysis and death.<br>In addition to its antimicrobial activity, alpha-defensin-2 has been found to have other functions in the body, including modulating the immune response and promoting tissue repair. It has also been implicated in the pathogenesis of certain inflammatory and autoimmune diseases, including Crohn's disease and psoriasis.<br>Alpha-defensin-2 is typically found in various bodily fluids, including blood, semen, and synovial fluid, which is the fluid that lubricates and nourishes joints. In synovial fluid, elevated levels of alpha-defensin-2 can be indicative of a bacterial infection in the joint, which can help to guide treatment decisions.</p>

CART (Rat, 55-102) is an antibody that binds to the CART receptor. It can be used in research and as a cell biology tool for protein interactions, such as studying the biological effects of peptides. CART (Rat, 55-102) is a high-purity product that has been extensively characterized.

Amyloid beta-protein (Aβ) is a peptide that is found in the human brain. It is one of the major components of amyloid plaque, which are deposits of a protein fragment in the brain that form as a result of aging and Alzheimer’s disease. It is produced by cleavage of the amyloid precursor protein (APP). Aβ has been shown to be toxic to cells, causing them to die. This toxicity may be due to its ability to inhibit ATP production and increase oxidative stress. Aβ can also induce apoptosis by binding to receptors on cell surfaces and activating intracellular signaling pathways. These events lead to activation of caspases, which are proteolytic enzymes that contribute to programmed cell death.

<p>Suc-Ala-Ala-Ala-pNA is a protease inhibitor that is used in the treatment of metabolic disorders. It has been shown to have neurotrophic effects, which may be due to its ability to inhibit the activity of proteases, such as cathepsin B and proteinase 3. Suc-Ala-Ala-Ala-pNA has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the activity of proinflammatory cytokines such as interleukin 1β, tumor necrosis factor α, and prostaglandin E2. Suc-Ala-Ala-Ala-pNA has long term efficacy in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.</p>

<p>Ghrelin is a 28 amino acid peptide hormone that has various effects on the body, including stimulating appetite, nutrient sensing and meal initiation. It has also been found to regulate insulin resistance, diabetes and obesity and asserts its functional affects through acting as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Its wider functions such as glucose homeostasis, energy homeostasis, cardio-protective effects, its role in bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases. This product is available in the trifluoroacetate salt form and as a 0.1mg vial.</p>

<p>Ac-Leu-Glu-His-Asp-MCA is a synthetic peptide that is used as a research tool. The peptide has been shown to bind to the alpha subunit of the nicotinic acetylcholine receptor, which is responsible for binding acetylcholine and transmitting nerve impulses. Ac-Leu-Glu-His-Asp-MCA activates the receptor by mimicking the effects of acetylcholine. Acetylcholine binding to the alpha subunit causes an influx of sodium ions into the cell, which leads to depolarization and an action potential. This synthetic peptide also binds to other types of receptors, including those for serotonin, dopamine, and adrenaline. Acetylcholine binding to these receptors leads to neurotransmitter release.</p>

p-Methyl-Benzhydrylamine Resin • HCl is a solid phase building block for peptide synthesis. It is an unsubstituted resin with a high capacity for the condensation of amino acids and other reagents. The resin is designed to be used in conjunction with the other building blocks to synthesize peptides. p-Methyl-Benzhydrylamine Resin • HCl can be used as a substitute for other unsubstituted resins, such as benzhydrylamine resin or methylbenzhydrylamine resin.

<p>Actinonin is a natural product with antimicrobial activity. It inhibits the growth of bacteria by binding to their ribosomes and inhibiting protein synthesis. Actinonin has been shown to inhibit the growth of gram-positive species such as Streptococcus pyogenes, group A beta-hemolytic streptococci, and Enterococcus faecalis. Actinonin also inhibits a number of enzymes including target enzymes for antimicrobial agents such as penicillin and erythromycin. Actinonin has been shown to be a potential biomarker for bowel disease in humans by its ability to bind to mitochondria in cells from patients with inflammatory bowel disease. This compound binds to basic proteins, which are found in high concentrations in the cell nucleus of organisms including humans.</p>

<p>Matrix Metalloproteinase-9 (Human) (recombinant) is a recombinant protein that is an inhibitor of matrix metalloproteinases. This protein binds to the active site of MMP-9, preventing it from degrading collagen in the extracellular matrix. It is used for research purposes and as a pharmacological tool.</p>

<p>Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.</p>

<p>Boc-Arg-Val-Arg-Arg-AMC is a new type of peptidomimetic ligand that can be used as an inhibitor for ion channels. It has been shown to inhibit the activity of a number of ion channel types, including sodium and calcium channels. Boc-Arg-Val-Arg-Arg-AMC also binds to the receptor site of acetylcholine in muscle cells. This is an important pharmacological tool for research on ion channels, receptors, and peptide interactions.</p>

Ubenimex (Bestatin) is an enzyme inhibitor that belongs to the class of dpp-iv inhibitors. It is used as an antifungal agent and has been shown to be effective against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton mentagrophytes, and Microsporum canis. Ubenimex (Bestatin) inhibits the synthesis of protein by binding to the 30S ribosomal subunit and blocking the peptidyl transferase activity of the 50S ribosomal subunit. This drug also has a cytostatic effect on cancer cells in vitro.

Copeptin is a human protein that is found in the blood and urine. It functions as a competitive inhibitor of lysine-specific proteases, such as cathepsin D, elastase, and trypsin. Copeptin binds to the active site of these enzymes and prevents them from cleaving their substrates. Copeptin is also an antigen used in immunohistochemistry with an antibody against it for use in detection of various cancers. The biotinylated form of copeptin can be used for binding to avidin or streptavidin coated plates or antibodies (e.g., peroxidase-conjugated antibody) for use in enzyme-linked immunosorbent assays (ELISA). Copeptin binds to primary antibodies raised against it by the immune system, which are then detected using fluorescent secondary antibodies or peroxidase-conjugated antibodies.

<p>lipophilic peptide</p>

<p>Fmoc-3, Iodo-L-Tyr-OH is a building block used in the synthesis of peptides. This compound is a protected form of L-tyrosine that can be labeled with iodide and reacted with an amino acid or other organic molecule to produce a peptide. Fmoc-3, Iodo-L-Tyr-OH can also be used for radiolabeling, labeling, and death studies. The neurotransmitter dopamine has been detected in Fmoc-3, Iodo-L-Tyr-OH by electrophysiology. This compound is also used as an excitotoxic tool to study neuronal cell death.</p>

<p>MeO-Suc-Arg-Pro-Tyr-MCA is a peptide substrate for chymotrypsin. It is used as an inhibitor of the enzyme and has been shown to inhibit the activity of chymotrypsin with an IC50 of 0.2 mM.</p>

Hydroxymethyl Polystyrene Resin is a solid phase synthesis resin that is used in building blocks for peptide synthesis. It has a particle size of 100-200 mesh and 1% DVB. Hydroxymethyl Polystyrene Resin has many applications, including the synthesis of peptides, oligonucleotides, and other biological molecules.

<p>LCBiot-(Ahx)AEEEYFFLFA-amide is a synthetic peptide that can be used as a research tool for investigating protein interactions. It can be used to identify the receptor and ligand of a given protein and, in some cases, can be used to inhibit the activity of the protein. LCBiot-(Ahx)AEEEYFFLFA-amide has been shown to bind to ion channels and Ligand-gated ion channels (LGICs). This peptide is also able to activate high-purity receptors and Peptides. LCBiot-(Ahx)AEEEYFFLFA-amide is an excellent inhibitor of LGICs such as acetylcholine receptors (AChRs), nicotinic acetylcholine receptors (nAChRs), serotonin receptors (5HT3), and dopamine receptors (D2).</p>

<p>7-Alkynyl-Fucose Tetraacetate is a synthetic peptide that can be used as an activator or inhibitor of ion channels, receptor and ligand interactions. 7-Alkynyl-Fucose Tetraacetate binds to the extracellular loops of potassium channels, which are the regions of voltage-gated ion channels responsible for opening and closing the channel. This peptide can be used to study the regulation of potassium channels.</p>

<p>The Boc-Ser(Bzl)-OH is a synthetic peptide that is used in the process of peptide synthesis. It is a chiral molecule, meaning it has two different forms, or isomers. The Boc-Ser(Bzl)-OH is an enantiomer of the Boc-Ser(Bzl)-OMe. This product can be used to study the spatial location of bioactive molecules and as a tool for peptide synthesis. It can also be used as a reagent in analytical methods for studying primary amino acid sequences and functional groups.</p>

<p>β-Defensin-3 is a human peptide that belongs to the class of defensins. β-Defensin-3 is a potent activator of ion channels, and has been shown to be an inhibitor of ligand binding. β-Defensin-3 is also known to have antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus. This protein interacts with receptors, such as TNF receptor 1, and can be used as a research tool for studying protein interactions. β-Defensin 3 has been shown to inhibit the growth of tumor cells in vitro by interacting with the intracellular proteins, phosphatidylserine (PS) and annexin A2, which are involved in apoptosis.</p>

<p>Boc-Trp(Hoc)-OH is a peptide that binds to the C-terminus of the protein N-ethylmaleimide sensitive factor (NSF) and inhibits NSF. Boc-Trp(Hoc)-OH has been shown to inhibit ion channels, protein interactions, and receptor activity. It is an inhibitor of the phospholipase A2 enzyme and can be used as a pharmacological tool for research in cell biology and pharmacology.</p>

Boc-Ala-Gly-Pro-Arg-AMC is a research tool that belongs to the ligand category. It is a cell biology reagent that can be used as an activator or inhibitor of various ion channels, including potassium and sodium channels. Boc-Ala-Gly-Pro-Arg-AMC has been shown to inhibit the binding of antibodies to their antigen and has been used in pharmacology studies involving peptides. This product is also used for research in cell biology, antibody production, protein interactions, and pharmacology.

<p>MOCAc-Ala-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(Dnp)-NH₂ is a peptide that is a potent inhibitor of the potassium channel Kv1.3. It binds to the N terminus of the channel and blocks it, preventing voltage gating. MOCAc-Ala-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(Dnp)-NH₂ is used in research as a tool to study ion channels and as an antibody for immunofluorescence studies.</p>

This reagent contains a biotin moiety linked to an azide moiety through a spacer arm containing a cleavable DADPS linker. Captured biomolecules can be efficiently released under mild conditions (10% formic acid, 0.5 h) and the small molecular fragment (143 Da) left on the labeled protein following cleavage.

<p>Anti-false positive reagent for rapid test</p>

Tyrosylleucine: a dipeptide of tyrosine and leucine; may affect physiology or cell signaling.

<p>CLV3 peptide is a synthetic peptide that contains the CLV3 amino acid sequence. It is an activator of ion channels, which are vital for a number of physiological processes in cells. The CLV3 peptide is used as a research tool to study protein interactions and pharmacology. The CAS number for this product is 48871-06-9.</p>

Lysipressin amide, acetate is an analog of vasopressin, a powerful vasopressin used to regulate blood pressure. Endogenous vasopressin in most mammalian species.

<p>Agouti-related protein (Agrp) is a peptide that is secreted by the Agouti gene. It is an inhibitor of the alpha-melanocyte-stimulating hormone receptor, which regulates the production of melanin in the skin. Agrp has been shown to be a potent activator of G protein coupled receptors and ion channels, as well as a ligand for certain receptors. The high purity and quality of this product make it ideal for use in research.</p>

<p>H-Glu(His-OH)-OH is a protein, which can be found in the plasma samples of patients with fatty acid metabolism disorders. It is one of the most selective markers for identifying these disorders and has been extensively used for profiling and genomic analyses. H-Glu(His-OH)-OH is also present in rat cerebral cortex and it has been shown to be statistically significantly elevated in cerebral cortex samples from patients with Alzheimer's disease. This protein has been observed to have an acidic property and can be used as a biomimetic marker. Regression analysis has shown that H-Glu(His-OH)-OH levels are correlated with the severity of neuronal damage. This protein may serve as a biomarker for different diseases, including Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis (ALS).</p>

Lunasin, a bioactive peptide derived from soybean, exhibits antioxidant, anti-inflammatory, anticancer, and anti-aging properties.

<p>Applications Azido-PEG8-NHS ester series of products contain an azide function on one end of a single molecular weight dPEG® spacer and a reactive group on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target.<br></p>

<p>Applications Fmoc-l-propargylglycine has been used to study the bioorthogonal chemical tagging of protein cholesterylation in living cells.<br>References William P. H., et al., ChemComm., 47, 4081-4083 (2011)<br></p>

<p>Applications Fmoc-d-asn(trt)-oh, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Applications D-Biotin 4-Ntrophenyl Ester, can be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies.<br>References Chia-Ho Chu et. al; Scientific reports, 7(1), undefined (2017-7-14);<br></p>

<p>Applications Nα-Fmoc-Nε-biotinyl-L-lysine is used in the synthesis of site-specific biotinylated probes.<br>References Macielag, M., et al.: Int. J. Pep. Protein Res., 44, 582 (1994)<br></p>

<p>Applications Fmoc-Aph(Hor)-OH (CAS# 1253282-31-3) is an intermediate of degarelix, a pharmeceutical hormone used in the treatment of prostate cancer. Fmoc-Aph(Hor)-OH has been used as a building block in peptide elongation reactions.<br>References Guryanov, I.; et al.: WO 2017103275 (2017); Takahashi, D.; et al.: Angew. Chem. Int. Ed., 56, 7803 (2017).<br></p>

<p>Stability Light Sensitive<br>Applications A PEG derivative, which contains a free amine that can be conjugated to biological molecules directly by an amide linkage (or via the corresponding isothiocyanate) and an azide that can be reduced to an amine for conjugation to other molecules. PEG derivatives are water soluble. Bifunctional water soluble compounds with flexible dimensions allow for conjugation of small molecules to proteins or molecular probes. 1-amino-11-azido-3,6,9-trioxaundecane can be reacted with small organic molecules for the synthesis of heterobifunctional compounds. It has been used to synthesize a mannose-fluorescein conjugate for the study of cell-surface mannose-specific lectins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aslan, K., et al.: J. Fluoresc., 14, 391 (2004), Gole, A., et al.: Langmuir, 20, 7117 (2004), Cavalcante, A., et al.: Biochem. Eng. J., 29, 258 (2006),<br></p>

<p>Applications Phenylalanine derivative used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.<br>References Tomisaka, K. et al.: Chem. Comm., 1, 133 (2001); Magours, R., et al.: Biochim. Biophys. Acta, Mol. Cell Res., 858, 158 (1985)<br></p>

<p>Applications Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5.<br></p>

<p>Applications N-tert-Boc-D-alanine is an N-Boc-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.<br>References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. &amp; Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)<br></p>

<p>Applications N-Acetyl-L-tyrosine Amide is an analogue of L-tyrosine which stimulate the transport of L-Tyr, mainly by the ASC system.<br>References Jara, J.R., et al.: Melanoma Res., 1(1), 15 (1991),<br></p>

<p>Applications A Wittig reagent.<br>References Laine, D., et al.: J. Med. Chem., 52, 5241 (2009), Nakao, A., et al.: Bioorg. Med. Chem. Lett., 19, 4607 (2009), Arakawa, Y., et al.: Chem. Pharm. Bull., 57, 167 (2009),<br></p>

<p>Applications L-valyl-L-histidyl-L-leucyl-L-threonyl-L-prolyl-L-glutamic Acid, is used as an analyte for the determination of ionization efficiency of glycated and non-glycated peptides from N-terminal of Hb β-chain by electrospray ionization mass spectrometry.<br>References Nakanishi, T., et al., J. Chromatogr. B. Biomed. Sci. Appl., 746, 83 (2000)<br></p>

<p>Applications Mal-amido-peg6-NHS can be used as a crosslinking agent and modifier of DNA.<br>References Vogel, Katrin, et al.: Small, 9(2), 255-262 (2013);Talvitie, Elina, et al.: Carbohydrate Polymers, 89(3), 948-954 (2012)<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 40,000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenner, G.W., Seely, J., J. Am. Chem. Soc., 94, 3259 (1972), Castro, B., et al.: Tetrahedron Lett., 1219 (1975)<br></p>

<p>Applications N-Boc-ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon., et al.: J. Pharmacol., 58, 53 (1936), Boissier, J., et al.: Eur. J. Pharmacol., 22, 141 (1973), Nillne, E., et al.: J. Biol. Chem., 277, 48587 (2002),<br></p>

<p>Applications N-Acetyl-L-arginine Methyl Ester is used in the synthetic route to biologically important L-arginine peptides.<br>References Levison, P.R., et al.: Synthetic Communic., 13, 167 (1983),<br></p>

<p>Applications 1-Amino-3,6,9-trioxaundecanyl-11-ol (cas# 86770-74-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Saralasin are angiotensin II receptor agonists.<br>References Guimond, M., et al.: J. Med. Chem. Lett., 5, 1129 (2014)<br></p>