Peptides

<p>Applications FMOC-ALA-GLY-OH (cas# 116747-54-7) is a useful research chemical.<br></p>

<p>Applications N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate is used as an efficient coupling agent in phosphonamidation reactions; used as coupling reagent in the synthesis of solid phase peptide<br>References Fredriksen, K., et al.: Eur. J. Org. Chem., 3, 474 (2016); Achyuthan, K., et al.: J. Pept. Sci., 21, 751 (2015);<br></p>

<p>Applications Boc-Lys(Z)-OH, is used in the synthesis of Isodesmosine Chloride (I815050), which is a component of elastin.<br>References Partridge, S., et al.: Nature, 209, 399 (1966),<br></p>

<p>Applications 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azahexadecan-16-oic Acid has been used as a reactant for the preparation of vaccines.<br>References Kaiser, A., et. al.: Angew. Chem. Int. Edit., 48, 7551 (2009); Dziadek, S., et. al.: Angew. Chem. Int. Edit., 44, 7630 (2005); Cai, H., et. al.: Eur. J. Org. Chem., 2011, 3685 (2011); Nuhn, L., et. al.: Angew. Chem. Int. Edit. 52, 10652 (2013)<br></p>

<p>Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.<br>References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);<br></p>

<p>Applications Fmoc-L-Tyr(tBu)-OH is tyrosine derivative used in soiid phase peptide synthesis.<br>References Atherton, E., et al.: J. Chem. Soc. Chem. Comm., 20, 970 (1980);<br></p>

<p>Applications Fmoc-Aph(Hor)-OH (CAS# 1253282-31-3) is an intermediate of degarelix, a pharmeceutical hormone used in the treatment of prostate cancer. Fmoc-Aph(Hor)-OH has been used as a building block in peptide elongation reactions.<br>References Guryanov, I.; et al.: WO 2017103275 (2017); Takahashi, D.; et al.: Angew. Chem. Int. Ed., 56, 7803 (2017).<br></p>

<p>Applications N-Acetyl-L-tyrosine Amide is an analogue of L-tyrosine which stimulate the transport of L-Tyr, mainly by the ASC system.<br>References Jara, J.R., et al.: Melanoma Res., 1(1), 15 (1991),<br></p>

<p>Applications Fmoc-l-propargylglycine has been used to study the bioorthogonal chemical tagging of protein cholesterylation in living cells.<br>References William P. H., et al., ChemComm., 47, 4081-4083 (2011)<br></p>

<p>Applications Phenylalanine derivative used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.<br>References Tomisaka, K. et al.: Chem. Comm., 1, 133 (2001); Magours, R., et al.: Biochim. Biophys. Acta, Mol. Cell Res., 858, 158 (1985)<br></p>

<p>Applications 23-Azido-3,6,9,12,15,18,21-Heptaoxatricosan-1-ol is used in the synthesis of heterobifunctionalized oligo(ethylene glycol) linkers for use in drug delivery.<br>References Goswami, L. et al.: Org. Biomol. Chem., 11, 1116 (2013);<br></p>

<p>Applications Boc-​β-​Ala-​OH is a reagent used in the synthesis of quinazolines as platelet aggregation inhibitors and ligands of integrin.<br>References Krysko, A. et al.: Bioorg. Med. Chem. Lett., 26, 1839 (2016);<br></p>

<p>Applications L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.<br>References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);<br></p>

<p>Stability Unstable in alkaline solution<br>Applications Met-enkephalin is an endogenous opioid peptide that increases expression levels of δ, μ and κ-opioid receptors, inhibits growth, apoptosis and proliferation in human melanoma A375 cells. Antitumor effect via regulating dendritic cells. Regulation of the immune system, therapy effects of antitumor, autoimmune diseases, AIDS, and other immune-related diseases.<br>References Wang, D., et al.: Mol. Med. Rep., 14, 5521 (2016); Feng, P., et al.: Weishengwuxue Zazhi, 35, 100 (2015); Meng, Y., et al.: Int. Immunopharmacol., 44, 61 (2017)<br></p>

<p>Applications 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol (cas# 106984-09-2) is a compound useful in organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications A PEG derivative, which contains a free amine that can be conjugated to biological molecules directly by an amide linkage (or via the corresponding isothiocyanate) and an azide that can be reduced to an amine for conjugation to other molecules. PEG derivatives are water soluble. Bifunctional water soluble compounds with flexible dimensions allow for conjugation of small molecules to proteins or molecular probes. 1-amino-11-azido-3,6,9-trioxaundecane can be reacted with small organic molecules for the synthesis of heterobifunctional compounds. It has been used to synthesize a mannose-fluorescein conjugate for the study of cell-surface mannose-specific lectins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aslan, K., et al.: J. Fluoresc., 14, 391 (2004), Gole, A., et al.: Langmuir, 20, 7117 (2004), Cavalcante, A., et al.: Biochem. Eng. J., 29, 258 (2006),<br></p>

<p>Applications N-tert-Boc-D-alanine is an N-Boc-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.<br>References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. &amp; Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)<br></p>

<p>Applications A Wittig reagent.<br>References Laine, D., et al.: J. Med. Chem., 52, 5241 (2009), Nakao, A., et al.: Bioorg. Med. Chem. Lett., 19, 4607 (2009), Arakawa, Y., et al.: Chem. Pharm. Bull., 57, 167 (2009),<br></p>

<p>Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.<br>References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);<br></p>

<p>Applications Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5.<br></p>

<p>Applications (Fmoc-amino)-PEG6-carboxylic acid (CAS# 882847-34-9) is a useful building block used in the preparation of cyclic megamolecules, and in L- and D-oligopeptides with circularly polarized luminescence.<br>References Modica, J. A.; et al.: J. Am. Chem. Soc., 140, 6391 (2018); Nishikawa, T.; et al.: Org. Biomol. Chem., 13, 11426 (2015).<br></p>

<p>Applications D-Biotin 4-Ntrophenyl Ester, can be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies.<br>References Chia-Ho Chu et. al; Scientific reports, 7(1), undefined (2017-7-14);<br></p>

<p>Applications N-Boc-ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon., et al.: J. Pharmacol., 58, 53 (1936), Boissier, J., et al.: Eur. J. Pharmacol., 22, 141 (1973), Nillne, E., et al.: J. Biol. Chem., 277, 48587 (2002),<br></p>

<p>Applications N-CBZ-Glycyl-L-proline 7-Amido-4-methylcoumarin is a fluorogenic substrate used for post-proline cleaving enzyme prolyl endopeptidase.<br>References J. Momand, S. Clarke Biochemistry 26, 7798, (1987)<br></p>

<p>Applications Nα-Fmoc-Nε-biotinyl-L-lysine is used in the synthesis of site-specific biotinylated probes.<br>References Macielag, M., et al.: Int. J. Pep. Protein Res., 44, 582 (1994)<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 40,000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications N-Formyl-Met-Leu-Phe is an inducer of superoxide release and agonist for FPR1.<br></p>

<p>Applications Bis(NHS)PEG5 (CAS# 756526-03-1) is a useful research chemical compound.<br></p>

<p>Applications L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine is a connexin mimetic peptide that inhibits pannexin-1 gap junctions.<br>References Wang, J., et al.: Am J Physiol 293, C1112 (2007); Pinheiro, A. R., et al.: Cell Commun Signal. 18, 11 (2013)<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 30,000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications L-valyl-L-histidyl-L-leucyl-L-threonyl-L-prolyl-L-glutamic Acid, is used as an analyte for the determination of ionization efficiency of glycated and non-glycated peptides from N-terminal of Hb β-chain by electrospray ionization mass spectrometry.<br>References Nakanishi, T., et al., J. Chromatogr. B. Biomed. Sci. Appl., 746, 83 (2000)<br></p>

<p>Applications N-Acetyl-L-arginine Methyl Ester is used in the synthetic route to biologically important L-arginine peptides.<br>References Levison, P.R., et al.: Synthetic Communic., 13, 167 (1983),<br></p>

<p>Applications AZIDO-PEG7-AMINE (cas# 1333154-77-0) is a useful research chemical.<br></p>

<p>Applications Boc-L-Valine is used in amino acid conjugates as proteasome inhibitors.<br>References Wan, S. et al.: Int. J. Mol. Med., 26, 447 (2010);<br></p>

<p>Applications M-PEG4-THIOL (cas# 52190-55-3) is a useful research chemical.<br></p>

<p>Applications 1-Amino-3,6,9-trioxaundecanyl-11-ol (cas# 86770-74-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Fmoc-L-isoleucine is a N-Fmoc-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.<br>References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);<br></p>

<p>Applications 2-NBDG is a fluorescent glucose uptake indicator, used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry.<br>References Zou, Chenhui., et al.: J Biochem Biophys Methods., 64, 207 (2005); Yamada, Katsuya., et al.: J. Biol. Chem., 275, 22278 (2000)<br></p>

<p>Applications Nα-Boc-D-tryptophan is an N-Boc-protected form of D-Tryptophan (T947205). D-Tryptophan is an unnatural isomer of L-Tryptophan (T947210) and is classified as an essential amino acid. D-Tryptophan has been synthesized as part of some potent Oxytocin (Acetate: O878500) antagonists that treat preterm labour.<br>References Chan, Y. &amp; Huang, K.: Am. J. Physiol., 224, 140 (1973); Evans, B., et al.: Proc. Nat. Acad. Sci., 83, 4918 (1986); Romero, R., et al.: Am. J. Obstet. Gynecol., 182, 1173 (2000)<br></p>

<p>Applications Derivative of N6-​[(1,​1-​Dimethylethoxy)​carbonyl]​-​N2-​[(9H-​fluoren-​9-​ylmethoxy)​carbonyl]​-D-​lysine is a hetero-bifunctional traceless linker for temporarily attaching highly solubilizing peptide sequences onto insoluble peptides.<br>References Jacobsen, M., et al.: J. Am. Chem. Soc., 138, 11775-11782 (2016)<br></p>

<p>Applications A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenner, G.W., Seely, J., J. Am. Chem. Soc., 94, 3259 (1972), Castro, B., et al.: Tetrahedron Lett., 1219 (1975)<br></p>

<p>Applications Mal-amido-peg6-NHS can be used as a crosslinking agent and modifier of DNA.<br>References Vogel, Katrin, et al.: Small, 9(2), 255-262 (2013);Talvitie, Elina, et al.: Carbohydrate Polymers, 89(3), 948-954 (2012)<br></p>

<p>Applications Elastatinal is an elastase inhibitor.<br></p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of GSTA3 antibody, catalog no. 70R-2939</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PARD6B antibody, catalog no. 70R-2394</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of KIAA1189 antibody, catalog no. 70R-4446</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of FJX1 antibody, catalog no. 70R-6368</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of XRCC5 antibody, catalog no. 70R-1235</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of AADACL4 antibody, catalog no. 70R-6766</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SIN3B antibody, catalog no. 20R-1129</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PHACTR1 antibody, catalog no. 70R-4246</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZMPSTE24 antibody, catalog no. 70R-7342</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of FBXL10 antibody, catalog no. 70R-8391</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SLCO1C1 antibody, catalog no. 70R-6553</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF548 antibody, catalog no. 70R-8143</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TRIB3 antibody, catalog no. 70R-3572</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CYP2U1 antibody, catalog no. 70R-10392</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of GFRA4 antibody, catalog no. 70R-10340</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of RWDD1 antibody, catalog no. 70R-9705</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of NEURL2 antibody, catalog no. 70R-5854</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SERBP1 antibody, catalog no. 70R-4696</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of IRAK2 antibody, catalog no. 70R-10272</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CCDC138 antibody, catalog no. 70R-3552</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of NDUFC2 antibody, catalog no. 70R-6518</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PIWIL4 antibody, catalog no. 70R-2275</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ANKS3 antibody, catalog no. 70R-3461</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of POLR2B antibody, catalog no. 70R-7925</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SEPP1 antibody, catalog no. 70R-2714</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZNHIT1 antibody, catalog no. 70R-8926</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZDHHC14 antibody, catalog no. 70R-7047</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of INSIG1 antibody, catalog no. 70R-6612</p>