Peptides

<p>[Pmp1, Tyr(Me)2]-Arg8-vasopressin is a peptide that has been shown to activate the V2 receptor and inhibit vasopressin-induced water retention. It has also been shown to inhibit the binding of vasopressin to its receptor. The peptide is an excellent research tool for studying the interaction between the V2 receptor and vasopressin. The peptide is supplied at high purity in lyophilized form and can be reconstituted with water or buffer before use.</p>

<p>Amyloid beta-protein (Aβ) is a peptide that is derived from amyloid precursor protein (APP). Aβ is the main component of amyloid plaques which are found in the brains of people with Alzheimer's disease. It has been shown to be a ligand for LRP1 and LRP2, two receptors involved in the clearance of APP. Amyloid beta-protein (Aβ) is an activator of ion channels in cell membranes and can affect the activity of several types of ion channels, including high-voltage activated potassium channels and low-voltage activated calcium channels.</p>

<p>Chemotactic peptides are peptides that possess chemotactic properties, which means they attract cells. One well-known chemotactic peptide is For-Met-Leu-Phe (FMLP) and is a chemoattractant for phagocytic leukocytes and neutrophils. During the acute inflammatory response chemotactic factors activate neutrophils which have seven transmembrane G-protein coupled receptors. FMLP bind to these G-protein coupled receptors on the surface of neutrophils and activate NF- κB, MAPK and PI3K pathways. In particular FMLP is known to induce Interleukin-8 (IL-8) which is responsible for both tissue damage and the pathogenesis of inflammatory processes resulting from neutrophils. Chemotactic peptide have been used to study the function of polymorphonuclear leukocytes and other white blood cells in inflammation. Chemotactic peptides are often used as fluorescent probes to measure intracellular metabolic responses to chemoattractant stimulation.</p>

<p>Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.<br>This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.5mg vial.</p>

<p>Ac-Trp-Glu-His-Asp-AMC is a peptide that can be used as a research tool in cell biology and pharmacology. Ac-Trp-Glu-His-Asp-AMC has been shown to inhibit ion channels, which are proteins that control the flow of ions across the cell membrane. It binds to specific receptor sites on the outside of cells, which causes conformational changes in the ion channel that prevent it from opening. Ac-Trp-Glu-His-Asp AMC has been shown to increase the intracellular concentration of calcium ions, which is necessary for muscle contraction and other cellular processes.</p>

<p>m-dPEG®24-Azide (Azido-m-dPEG®24) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-Azide (Azido-m-dPEG®24) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Bz-Gly-His-Leu is a peptide that has the amino acid sequence of Hippuryl-Histidyl-Leucine. The peptide binds to Angiotensin I Converting Enzyme I Substrates and prevents the enzyme from converting Angiotensin I to Angiotensin II, thereby lowering blood pressure. Bz-Gly-His-Leu has been shown to be effective in reducing blood pressure in patients with congestive heart failure as well as those with normal cardiac function.

Thyrotropin releasing hormone (TRH) is a peptide that is produced in the hypothalamus. It has various functions, including being an activator of thyroid stimulating hormone (TSH) and releasing growth hormone from the anterior pituitary gland. TRH also has anti-inflammatory effects and is used as a research tool in cell biology. TRH binds to receptors on cells and can activate ion channels, which causes an influx of calcium ions into cells. This leads to the activation of protein kinases, which are important in cell signaling pathways. TRH also interacts with other proteins, such as receptor tyrosine kinases and G-protein coupled receptors.

<p>TentaGel® R PHB Resin (90 um) can be used for the preparation of peptide acids; particle size 90 µm; capacity: 018-023 meq/g and is specially designed for difficult and long sequences.<br>TentaGel, is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.</p>

Chlorotoxin is a neurotoxic peptide that belongs to the class of macrocyclic lactones. It was originally isolated from the venom of the deathstalker scorpion, Leiurus quinquestriatus, which is found in North Africa. Chlorotoxin has potent immunosuppressive and cytotoxic effects that are mediated by its ability to bind to ion channels in cell membranes through disulfide bonds. This peptide induces apoptosis and inhibits tumor growth in mice by targeting cancer cells and inducing cell death. The chlorotoxin molecule is conjugated with a variety of molecules to increase its stability and bioavailability for delivery into cells.

<p>Please enquire for more information about Protein Kinase C (530-558) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 660 kDa.  For solubility use phosphate buffer, pH&gt;7.0 containing 0.15M NaCl.</p>

<p>S-Acetyl-dPEG®12-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, S-Acetyl-dPEG®12-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>BNP Human is a peptide with a molecular weight of 5.5 kDa. It is the human form of brain natriuretic peptide (BNP) and is used for research purposes in cell biology, immunology, pharmacology, and life science. BNP Human is an activator of ion channels and inhibits protein interactions. BNP Human has been shown to have effects on receptors and ligands. It has CAS number: 60714-06-2.</p>

<p>SPDP-dPEG®36-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®36-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>The Peptide YY (Rat, Mouse) EIA Kit is a research tool that can be used to detect peptides in rat and mouse samples. It is an immunoassay kit that detects the presence of peptide YY in rat and mouse samples. The assay has a high sensitivity and specificity for the detection of peptide YY. The kit contains all the necessary components for performing the test, including antibodies, buffers, standards and controls. The kit also contains a detailed protocol for performing the assay.</p>

<p>Chromogranin A (CgA) is a peptide hormone found in the human body that is released from the cells of the pancreas and stomach. The CgA-EIA Kit is a solid phase enzyme immunoassay that can be used to measure CgA levels in human serum or plasma. Antibodies against CgA are coated onto a microtiter plate, and samples are added to the wells. After incubation, any CgA in the sample binds to the antibodies on the plate. The bound CgA is then detected using specific antibodies conjugated with horseradish peroxidase. The color reaction is measured at 450 nm with a reference wavelength of 630 nm.</p>

<p>TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>These resins are designed for single bead synthesis and single bead analysis (mean particle size 280-320 µm: capacity 02-03 meq/g) and substitutional functional group: -CH2-CH2-SH.</p>

<p>Please enquire for more information about [Ser25]-PKC (19 - 31), biotinylated including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about SARS-CoV-2 Spike protein (674-689) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Particle size: 130 µmcapacity: 0.2 - 0.3 mmol/g</p>

<p>HSP-70 Cofactor (HSP24) E.coli (recombinant) is a recombinant protein that can be used as a research tool to investigate protein interactions, receptor binding, and peptide activation. HSP-70 Cofactor (HSP24) E.coli (recombinant) binds to the N terminus of Hsp70, which is involved in the chaperone cycle and facilitates the folding of newly synthesized proteins. It also activates peptides by binding to them and stabilizing their tertiary structure. The protein also plays a role in ion channel activity and ligand binding, thereby affecting cellular processes such as receptor signaling, neurotransmitter release, or memory formation. This product has a CAS number of 628255-27-4.END&gt;&gt;</p>

<p>Portion of Influenza NP</p>

<p>TFF1 is a protein that belongs to the TNF family of cytokines. It is a homodimer with two identical chains that are linked by disulfide bonds at specific positions. TFF1 has been shown to be secreted by monocytes, macrophages, and lymphocytes in response to LPS stimulation. TFF1 binds to the cell membrane of target cells and induces proinflammatory responses such as cytokine production and the activation of NF-κB. These effects are mediated through its ability to activate the transcription factor nuclear factor-κB (NF-κB) which regulates gene expression in immune cells.<br>DISULFIDE BONDS: The covalent linkage between two polypeptide chains or between two amino acid residues <br>CHROMATOGRAPHY: A process for separating mixtures based on molecular weight, size, shape, or other physical properties <br>RECOMBINANT: Produced by recombining genetic material from different</p>

<p>Please enquire for more information about Atrial Natriuretic Peptide (126-150) (rat) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anti P2X4 (370-388) (Rat) Serum is a research tool that can be used to measure the activation of P2X4 receptors. It is suitable for use in antibody-based applications, such as Western blotting and immunohistochemistry. Anti P2X4 (370-388) (Rat) Serum is a high purity product that has been extensively characterized by NMR spectroscopy, mass spectrometry, and amino acid analysis. The purified peptide is supplied at a concentration of 1 mg/mL in phosphate buffered saline with 0.02% sodium azide as preservative and 50% glycerol as cryoprotectant. The product is sold under reference number CAS No. 74941-79-6 and has the molecular weight of 3199.87 Da. Anti P2X4 (370-388) (Rat) Serum can be used to study protein interactions, receptor ligand pharmacology, ion</p>

<p>CGRP, humanAntiserum is a peptide that is the major peptide in the calcitonin gene-related peptide family. CGRP inhibits the activation of certain ion channels, which are proteins in cell membranes that allow ions to cross the membrane. It is also known to be an activator of certain G protein-coupled receptors, as well as a ligand for some receptor types. CGRP has been shown to play a role in vascular smooth muscle contraction and pain regulation.</p>

Please enquire for more information about [Gln18]-Platelet Factor 4 (15-22) (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Please enquire for more information about Lymphocyte Activating Pentapeptide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Maltose Binding Protein E.coli Recombinant is a maltose binding protein derived from E. coli that can be used as a research tool in pharmacology and cell biology. Maltose Binding Protein E.coli Recombinant is an antibody that binds to the maltose receptor on the surface of cells, which are found on the outer membrane of most bacteria. Maltose Binding Protein E.coli Recombinant is a high-purity recombinant protein with a molecular weight of about 31 kDa, and has been shown to be an activator and inhibitor of ion channels, depending on its concentration. This protein also interacts with various proteins in the cytoplasm and binds to peptides that have been identified as ligands for this receptor.</p>

<p>Please enquire for more information about Calcitonin, rat including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>MAL-dPEG®4-Glu(TFP Ester)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.</p>

Charybdotoxin is a peptide toxin that is found in scorpion venom. It acts as a potent inhibitor of the adenylyl cyclase, which is an enzyme that catalyzes the formation of cAMP from ATP. Charybdotoxin binds to the cavity of the enzyme and blocks access to ATP, preventing the accumulation of cAMP. This inhibition leads to a decrease in calcium ions in cells, and thus causes relaxation of smooth muscle tissue. Charybdotoxin has been shown to cause relaxation of bowel disease in mice by inhibiting contraction of intestinal muscle tissue. Charybdotoxin also has been shown to have therapeutic effects on pluripotent cells such as miapaca-2 cells by increasing their ability to form new blood vessels.

<p>m-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-Amido-dPEG®24-DSPE is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>GLP-2 (Rat)-EIA Kit is a kit for the qualitative detection of GLP-2 in rat plasma. GLP-2 is a peptide hormone that regulates glucose levels and insulin secretion from the pancreas. This kit can be used to measure the presence of GLP-2 in plasma samples. It is designed for use in conjunction with an ELISA reader.</p>

<p>CH3O-PEG-NH2 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CH3O-PEG-NH2 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino-dPEG®12-Tris (-dPEG®24-t-butyl Ester)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®12-Tris (-dPEG®24-t-butyl Ester)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>For preparation of peptide acids; particle size 90 µm; capacity: 0.2-0.3 meq/g<br>TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.</p>

<p>Amino-dPEG®12-Tris (m-dPEG®24)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®12-Tris (m-dPEG®24)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>IL10 is a cytokine that is produced by T cells and macrophages. IL 10 inhibits the production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNFα. IL10 also regulates the production of IFNγ and IL4 by Th1 and Th2 cells respectively. It has been shown to activate ion channels in neurons, which may be related to its role in neuroprotection. The mouse monoclonal antibody against human IL-10 recognizes rat, mouse, human, dog, monkey and bovine protein but not chicken or sheep protein.</p>

<p>Please enquire for more information about Caspase 3 Substrate 1m (Apopain), fluorogenic including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anti PTHrP (1-34)-NH₂ is a peptide that belongs to the group of research tools. It is an activator of ion channels and has been shown to inhibit protein interactions. The CAS number is 6078-00-3, and the molecular weight is 7.5 kDa. Anti PTHrP (1-34)-NH₂ can be used as a pharmacological tool for studying the function of receptors and ligands, including those associated with cell biology and immunology.</p>

<p>Please enquire for more information about Simian Virus 40 Large Tumor Antigen Amino-Terminal Peptide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anti Met-Enkephalin-Arg6-Gly7-Leu8 Serum is a research tool for the study of ion channels, ligands and receptors. Anti Met-Enkephalin-Arg6-Gly7-Leu8 Serum blocks the binding of peptides to receptors and can be used to determine the specificity of receptor binding. Anti Met-Enkephalin-Arg6-Gly7-Leu8 Serum is also a useful reagent in cell biology, as it can be used to block peptide interactions with proteins such as ion channels or membrane receptors. The antibody has been shown to inhibit the activity of the enzyme tyrosine phosphatase, which regulates cellular growth and differentiation.</p>

Please enquire for more information about Pneumadin (rat) including the price, delivery time and more detailed product information at the technical inquiry form on this page

m-dPEG®8-DSPE is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®8-DSPE is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>H-Asp-Glu-OH is a molecule that may be a potential biomarker for prostate cancer cells. It was found to affect the brain functions, including the growth of brain cells and neurotransmitter release. H-Asp-Glu-OH has been shown to inhibit the growth of tumor cells in mice, but it is not as potent as other molecules in this class. This compound has also been shown to enhance hematopoietic cell proliferation and suppress the production of Th2 cytokines. Magnetic resonance spectroscopy studies have indicated that H-Asp-Glu-OH binds with low potency to GABA receptors in brain tissue, which may be associated with its ability to regulate neuronal excitability and inhibit epileptic seizures.</p>

<p>Anti TNF-Alpha (Rat) Serum Host Goat is a research tool that is used to inhibit the production of tumor necrosis factor-α (TNF-α). It is an antibody that binds to TNF-α and prevents it from binding to its receptor. Anti TNF-Alpha (Rat) Serum Host Goat has been shown to inhibit the production of TNF-α in vitro, but not in vivo. This serum can be used as a control for other antibodies that are inhibiting the production of TNF-α.</p>

Human GIP (Active) ELISA (1ea) is a human GIP ELISA kit that detects the presence of active human GIP in a sample. This kit is designed to detect human GIP in serum, plasma, and urine. The assay has been validated for the quantitative measurement of active human GIP in samples from healthy subjects and patients with type 2 diabetes mellitus.

<p>IGF-Like Family Receptor 1 is a recombinant protein that belongs to the receptor family. It is also known as insulin-like growth factor I (IGF-I) receptor, and it has been shown to have ion channel activity. IGF-Like Family Receptor 1 can be used in research and development of pharmacological agents. This recombinant protein will not react with any antibodies or peptides, and it has high purity.</p>

An apolipoprotein E C-term heavy tryptic peptide standard for use in protein identification and quantitation studies. As part of a fat-binding protein family, apolipoprotein E plays a role in the metabolism of fats in the body through interacting with the low density lipoprotein receptor, which is involved in the catabolism of triglyceride rich lipoproteins. Apolipoprotein E is also a major component in cholesterol metabolism and is a carrier of cholesterol in the brain. Additionally when forming a complex with C1q, apolipoprotein E is an inhibitor of the classical complement pathway. The N and C terminal regions of apolipoprotein are connected by a hinge region and the C-terminal region is a hydrophobic surface made up of three alpha helices and a low density lipoprotein receptor binding site.

<p>Putative orf1ab Polyprotein (3233-3247) [SARS Coronavirus] is a high purity, recombinant protein that can be used as a research tool in cell biology, receptor pharmacology and biochemistry. It can also be used as an antibody to detect the presence of SARS coronavirus in cells. Putative orf1ab Polyprotein (3233-3247) [SARS Coronavirus] is an inhibitor of ion channels and ligand for receptor.</p>

<p>Suc-Ala-Glu-AMC is a synthetic molecule that is used as a research tool to study protein interactions, ion channels, and other cell biology. Suc-Ala-Glu-AMC binds to specific receptors and activates them. This compound can also be used to isolate ligand/receptor complexes. Suc-Ala-Glu-AMC is a high purity compound with an analytical purity of 98%. It has been shown in pharmacological studies to inhibit the activity of peptides such as vasopressin and oxytocin at the receptor level.</p>

<p>Anti ACTH (1-23) (Rat) Serum is a recombinant peptide that is an activator of the hypothalamus. It has been shown to have a high affinity for the receptor, and it can be used as a research tool in cell biology and pharmacology. Anti ACTH (1-23) (Rat) Serum is used in the study of ion channels, ligands, and antibodies. This peptide has been used to inhibit the release of ACTH from the pituitary gland and can be used to study the effects of anti-ACTH on other hormones. Anti ACTH (1-23) (Rat) Serum is purified from E. coli cells with a CAS number of 58612-37-8.</p>

<p>Peptide T is a macrophage-activating peptide that has been shown to be effective in treating AIDS-related immunodeficiency. It interacts with the specific target on human macrophages, causing them to proliferate and secrete cytokines. This peptide is effective in humans and has not been found to cause any adverse side effects. It also increases the number of blood lymphocytes in immunocompetent individuals, indicating its safety as a treatment for AIDS-related immunodeficiency.</p>

<p>Native Melan-A (26-35) decapeptide derives from the melanocyte lineage-specific protein Melan-A/MART-1, which is expressed in almost 75-100% of primary and metastatic melanomas.<br>The region 26-35 of Melan-A protein acts as an antigenic peptide that is recognized by CD8+ tumor-reactive cytolytic T lymphocytes (CTLs) for designing antigen-specific cancer vaccines1. It has been shown that CD8+ Melan-A-specific CTLs isolated from melanoma patients efficiently lyse the Melan-A-expressing HLA-A*0201+ melanoma cell line. However, CTLs preferentially recognize the Melan-A (26-35) peptide as compared with the Melan-A (27-35) peptide. Moreover, the Melan-A (26-35) A27L analog (ELAGIGILTV) has a higher binding affinity to HLA-A*0201 than the native Melan-A (26-35) peptide (EAAGIGILTV), and consequently displays more potent antigenicity and immunogenicity.<br>It has been reported that the concentration of Melan-A (26-35) A27L analog required to obtain 50% of maximal antigenic activity (EC50) is 0.01nM, whereas that of the native Melan-A (26-35) peptide is 0.25nM1. Therefore, the relative activity of Melan-A (26-35) A27L analog is 25 fold higher than that of the native Melan-A (26-35) peptide.<br>Furthermore, functional competition assay has shown that the concentration of Melan-A (26-35) A27L analog required to achieve 50% inhibition (IC50) of tumor lysis is 2nM, which is 10 fold lower than that of the native Melan-A (26-35) peptide. Regarding peptide stability in human serum, the half-lifes (t1/2) of the native Melan-A (26-35) peptide and the A27L analog are quite similar (45 and 40min, respectively) as measured by HPLC-ESI-MS, but much higher than that of the Melan-A (27-35) nonapeptide (5min).</p>

<p>Monobiotin is a ligand-gated ion channel that prevents calcium ions from entering the cell. It is also a protein interaction inhibitor and can be used to study receptor-ligand interactions. Monobiotin binds to the extracellular domain of the ligand-gated ion channel INSL6, preventing it from opening and preventing calcium ions from entering the cell. This inhibition leads to decreased production of nitric oxide (NO) in activated macrophages and reduced vascular permeability in endothelial cells. Monobiotin is also an antibody activator, which can be used to activate immune cells by binding to a specific antibody on the surface of immune cells. The monobiotin-antibody complex then activates the immune response by triggering further activation of other immune cells such as cytotoxic T lymphocytes or natural killer cells.</p>

<p>MAL-dPEG®2-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®2-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>As a member of the Histatin family, Histatin 5 is a 24 amino acid, antimicrobial peptide rich in histidine. The Histatin family’s large histidine presence allow Histatins to associate with metal ions through the histidine side chains.Histatin 5 is found naturally in human saliva, and is a proteolytic fragment of Histatin 3. It exhibits antifungal properties and is thus useful in inhibiting the growth of yeast and C. albicans.<br>Histatin 5 contains a functional domain located at amino acids 11 to 24 and this is where the antimicrobial activity of Histatin 5 takes place. It also has a random secondary structure with α-helices which are believed to allow it to enter the cytoplasm of the pathogenic cell. Once it has gained entry into the cells of pathogens, it is known to induce an ATP influx and the production of reactive oxygen species.However it is important to note that while Histatin 5 displays potent antifungal activity, this is reduced when in saliva due to the exposure to interfering metals, proteins and salts.</p>

<p>Enkephalins are endogenous opioid peptides that inhibit pain and have a variety of other physiological effects. They bind to specific receptors on the surface of neurons, which are called opioid receptors. Enkephalin is a peptide consisting of two amino acids, D-Ala2,D-Leu5. Enkephalins can be produced by linking two amino acids together with an amide bond or by modifying one of the amino acids in the sequence. This drug has been shown to induce mitochondrial membrane depolarization in hippocampal cells and autophagy in neuronal cells. It also has antinociceptive properties and is able to penetrate the blood-brain barrier due to its absorption enhancer property. The drug is also able to induce locomotor activity in mice and cause neuronal death in vivo models.</p>

<p>Pentraxin-3 is a peptide that is an inhibitor of the activator protein. It is used in pharmacology and cell biology research to identify ligands, receptors, and ion channels. Pentraxin-3 has shown to be a useful research tool for learning about the activation of various types of ion channels, including nicotinic acetylcholine receptors, glutamate receptors, and voltage-gated potassium channels. It can also be used as an antibody to identify cells that have been activated by specific ligands or signaling pathways.</p>

<p>t-boc-NH-dPEG®24-Tris (-TFP Ester)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-boc-NH-dPEG®24-Tris (-TFP Ester)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Parathyroid hormone (PTH) is a peptide hormone that regulates the calcium and phosphate levels in the blood. It is produced by the parathyroid glands, located near the thyroid gland in the neck. PTH increases blood calcium levels by increasing bone breakdown, stimulating bone formation, and increasing reabsorption of calcium. This protein also stimulates phosphaturia to increase serum phosphate levels.</p>

<p>Lysyl-bradykinin (Kallidin) is a peptide that is a member of the kallikrein family. It has been shown to be an effective inhibitor of the enzyme lysyl oxidase, which is involved in the cross-linking of collagen and elastin. The inhibition of this enzyme leads to the breakdown of collagen and elastin, which are important components for maintaining healthy skin. Lysyl-bradykinin has been immobilized with covalent immobilization techniques and has been shown to be an effective inhibitor of lysyl oxidase in an enzymatic reaction.<br>BRADYKININ: Bradykinins are peptides that are generated from kininogens by kallikreins, including prekallikreins and kallikreins. They act as vasodilators by stimulating smooth muscle cells in the walls of blood vessels to release nitric oxide. Bradykinins also increase</p>

Nma-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(Dnp)-D-Arg-D-Arg is a synthetic peptide that belongs to the group of activators. It is used as a research tool in studies on ion channels and protein interactions. The CAS number for this product is 106071, and it has a molecular weight of 567.1 Da and a purity of >99%.

<p>Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) is a research tool that can be used to study the effects of neuromedin U on the activation of receptors. This peptide is a ligand for the receptor and has been shown to inhibit ion channels. Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) may also be used as an antibody or in protein interactions studies. This product is made from high purity materials and can be used in pharmacology and life science experiments.</p>

<p>NHS-m-dPEG® is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG® is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Phebestin is a peptide that activates the immune system. It is an activator of antibodies and an inhibitor of ion channels. Phebestin has been shown to inhibit protein interactions and receptor binding, as well as ligand-receptor binding. It is used in research tools for studying cell biology, pharmacology, and protein interactions. Phebestin has a CAS number of 187402-73-9 and is available in high purity.</p>

<p>H-Ala-Pro-OH is a molecule that has the ability to bind to the active site of enzymes. It inhibits the activity of esterases and proteases by binding to their active sites and blocking access to substrates. This drug also inhibits the uptake of drugs in cells by competitively inhibiting membrane transport proteins, such as P-glycoprotein. H-Ala-Pro-OH binds to gamma-aminobutyric acid receptors and shows a kinetic effect on this neurotransmitter’s activity. The conformational properties of H-Ala-Pro-OH are not fully understood, but it is thought that its low energy allows it to bind to intracellular proteins more easily than other molecules.</p>

<p>Dermcidin-1L is a protein that belongs to the family of ion channels. It is a ligand for the receptor DCC. Dermcidin-1L has been shown to activate the receptor and induce chemotaxis in human neutrophils, which is mediated via activation of phospholipase C and elevation of intracellular calcium levels. This peptide also binds to the receptor LRP6 and inhibits Wnt signaling by competitively binding with LRP6-ligand complexes. Dermcidin-1L has been shown to inhibit proliferation of various cell lines, including pancreatic cancer cells, breast cancer cells, and leukemia cells.</p>

<p>Bromoacetamido-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Vn96 scramble peptide is a negative control peptide that is used in pharmacological and cell biology research. It is an inhibitor of protein interactions and can also be used as a research tool for identifying the ligand or receptor of a protein. Vn96 scramble peptide has been shown to inhibit ion channels, including potassium channels, which are involved in nerve transmission.</p>

Serum Amyloid A Heavy Tryptic Peptide Standard can be use in protein identification and quantitation studies and level of serum amyloid A are present at a blood concentration of below 3 mg/L in healthy individual. However elevated levels of this protein are found in inflammatory rheumatic diseases, hence making serum amyloid A an excellent biomarker for these types of diseases.

Anti LH-RH (Human, Rat) Serum is a serum that inhibits the binding of LHRH to its receptor. This serum has been shown to be an effective inhibitor of LH-RH binding in both human and rat systems. Anti LH-RH (Human, Rat) Serum is also a research tool used to study the effects of peptides on cells, as well as the interactions between proteins. The high purity and low endotoxin levels make this serum suitable for use in life science and cell biology experiments.

Angiotensin II is a peptide that acts as an agonist of the angiotensin receptors. It is a hormone that regulates blood pressure and fluid balance. The antagonist can block the effects of the peptide, which may be useful in treating cardiovascular diseases such as hypertension and congestive heart failure.

<p>IL-5 is a mouse monoclonal antibody that is used as a research tool. This antibody binds to the IL-5 receptor and is an activator of the receptor. IL-5 has been shown to activate ion channels and inhibit protein interactions, among other things. IL-5 has been shown to inhibit the binding of Ligand to Receptor, which may be due to its ability to bind to both Ligand and Receptor simultaneously.</p>

Nucleoside Diphosphate Kinase E.coli (recombinant) is a research peptide that belongs to the group of protein kinases. It is used in scientific studies and experiments to investigate various cellular processes and signaling pathways. This recombinant protein kinase has been shown to play a crucial role in the phosphorylation of nucleoside diphosphates, which are important molecules involved in energy metabolism and cell signaling. By catalyzing the transfer of phosphate groups, Nucleoside Diphosphate Kinase E.coli regulates the balance of nucleotide triphosphates, which are essential for DNA replication, RNA synthesis, and protein synthesis. Its unique properties make it an invaluable tool for researchers studying cellular mechanisms and developing new therapeutic strategies.

This is a TenetalGel B resin product which represents a line of bifunctional resins that are useful for orthogonal synthesis. TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.  Particle size: 90 µm; Boc capacity: 0.2 - 0.3 mmol/g; free NH2 capacity: 4 - 8 µmol/g

<p>NHS-dPEG®4-( m-dPEG®12)3-Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-dPEG®4-( m-dPEG®12)3-Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Snakin-1 is a peptide that interacts with the nicotinic acetylcholine receptor (nAChR). It is a high purity, potent and selective inhibitor of nAChRs.

<p>FRETS-25Gly is a synthetic peptide that is used as a research tool in the study of ion channels and their ligands. This peptide is an activator of the feline erythrocyte receptor for thrombopoietin (FRETS). FRETS-25Gly has been shown to inhibit the binding of fluorescein isothiocyanate-labeled ligands to human cell membranes.</p>

<p>This antibody is a rabbit polyclonal antibody against human amyloid beta protein. It has been shown to bind to the major type of amyloid beta peptide and is recommended for use in Western blotting, immunoprecipitation and immuno-fluorescence as well as other applications. This antibody will not cross-react with other proteins in human tissue samples.</p>

An Alpha-2-antiplasmin light tryptic peptide standard for protein identification and quantitation studies. Alpha-2-antiplasmin is a serine protease inhibitor of plasmin, an enzyme involved in fibrinolysis.

<p>Leptin is a hormone that regulates energy metabolism by modulating appetite and body weight. Leptin is produced by fat cells and signals to the hypothalamus of the brain about how much fat tissue there is. It also helps regulate other metabolic processes, such as insulin resistance and glucose tolerance. Leptin has been shown to have an anorectic effect in rodents, which may be due to its ability to reduce food intake or increase energy expenditure. In humans, leptin levels are higher in obese individuals than in those with normal weight, which indicates that this hormone may play a role in obesity.</p>

Please enquire for more information about Val-His-[D7]Leu-Thr-Pro-Glu including the price, delivery time and more detailed product information at the technical inquiry form on this page

Lipoprotein-associated phospholipase A2 (LP-PLA2) heavy tryptic peptide standard for protein identification and quantitation studies. LP-PLA2 is a phospholipase A2 enzyme known as platelet-activating factor acetylhydrolase and it is largely associated with low density lipoprotein in the blood.

<p>Glutathione synthetase is an enzyme that catalyzes the synthesis of glutathione from gamma-glutamylcysteine and glycine. It is a homodimeric protein composed of two identical subunits with a molecular weight of about 30 kDa. Each subunit contains one active site for the catalysis. The recombinant human glutathione synthetase has been shown to be stable in different pH buffers and can be used as a research tool or an inhibitor in cell biology experiments.</p>

<p>Amyloid β (42-1) is a protein that is used as a research tool. Amyloid β (42-1) is an activator of the Ligand Receptor interaction, and also binds to cell surface receptors. It has been shown to inhibit ion channels in cells, which may be related to Alzheimer's disease.</p>

<p>Z-Phe-Tyr-Leu is a synthetic peptide that has been shown to have prognostic value in patients with pancreatic cancer. It is a substrate for the protease carboxypeptidase and can be cleaved by trypsin to form Z-Phe-Tyr and Leu. Z-Phe-Tyr has been shown to reduce cell proliferation by inhibiting transcriptional regulation of genes, including those involved in epithelial mesenchymal transition. The studies suggest that Z-Phe-Tyr may be useful as an anti-cancer agent, as it inhibits tumor growth by reducing cell proliferation.</p>

<p>Please enquire for more information about DBCO-TFP Ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>IL 17A/F Human is a recombinant protein that activates the IL-17 receptor, which is a member of the IL-1 family. It can be used as a research tool in pharmacology and cell biology to study protein interactions. IL 17A/F Human is also an inhibitor of IL-17 and can be used for the treatment of autoimmune diseases.</p>

<p>Anti Galanin (1-15) (Rat) Serum is a peptide that is expressed in the rat brain and has an inhibitory effect on the release of galanin from neurons. The peptide interacts with high affinity to receptors for galanin, which are present in many tissues, including the central nervous system. Anti Galanin (1-15) (Rat) Serum is used as a research tool for the study of ion channels and ligands. This product can be used as an inhibitor for various activities such as receptor binding, enzyme inhibition, and cell signaling.</p>

The recombinant Borrelia Burgdorferi Outer Surface Protein A (rBOSPA) is a peptide that can be used as a research tool for studying the activation of ion channels and protein interactions. The rBOSPA is an inhibitor of the hKv1.3 channel and has been shown to bind to the GABA receptor. This recombinant protein is purified from E. coli, which makes it suitable for use in experimentation, as it does not contain any potential contaminants or other proteins. The CAS number for this product is

<p>A soluble transferrin receptor (sTfR) light tryptic peptide standard for protein identification and quantitation studies. sTfR is a cleaved extracellular segments of the transferrin receptor 1 and it can be used to measure the status of iron in the blood and thus help in studies into anemia, where iron is deficient.</p>

<p>Antiproliferative factor Sialoglycopeptide is a research tool that has been shown to activate the immune system. It has been used as a vaccine carrier and in immunotherapy. Antiproliferative factor Sialoglycopeptide binds to the C-type lectin receptor on erythrocytes, triggering an antibody response. This protein also interacts with ion channels, such as Ca2+ channels, and inhibits protein synthesis by inhibiting the tyrosine kinase activity of protein kinase A (PKA). Antiproliferative factor Sialoglycopeptide is a peptide that is active against many types of cancer cells and has been shown to inhibit tumor growth in mice. The CAS number for Antiproliferative Factor Sialoglycopeptide is 12074-48-2.</p>

<p>BD 3 Human is a recombinant cytokine that has been shown to have a spectrum of activity against gram-positive and gram-negative bacteria, as well as yeast. BD 3 Human is produced by recombinant DNA technology and encodes the amino acid sequence of human interleukin-1 beta (IL-1β). It is a member of the IL-1 family, which includes IL-1α, IL-1β, IL-18, and IL-33. The molecular mass of BD 3 Human is 18 kDa. Cytokines are proteins that regulate cellular activities in response to stimuli from other cells or from the extracellular environment. Recombinant cytokines are produced by microorganisms or cells into which recombinant DNA has been introduced. They are used for research purposes, but not for diagnostic purposes or other therapeutic applications. Reconstitute with sterile water for injection before use. Reconstituted solutions may be stored at 2°C to 8°C</p>

NO Synthase I (Human, Rat)-EIA Kit (1ea) is a kit that includes antibodies, peptide antisera, and other reagents for the detection of nitric oxide synthase. The kit detects nitric oxide synthase by measuring the nitrite concentration in the sample. Nitric oxide synthases catalyze the conversion of L-arginine to citrulline and nitrite. The assay is used to measure NO production in cell culture or tissue samples.

<p>Amino-dPEG®4-(m-dPEG®12)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-(m-dPEG®12)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

RS09/Toll Like Receptor (TLR) 4 agonist – APPHALS

<p>CEP1, C-Terminally Encoded Peptide 1 is involved in the regulation of plant growth and abiotic stress through cellular communication.</p>