Peptides

<p>6-FAM-AEEAC-SHK TFA, a peptide neurotoxin derived from Stichodactyla helianthus and conjugated with a fluorescent marker, selectively blocks voltage-gated potassium channels (kv1.1 and kv1.2). By prolonging action potentials, it interferes with neural signal conduction, making it valuable in neuroscience research.</p>

<p>Herceptide (HER2-targeting peptide), a peptide that targets HER2, can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of theranostic agents.</p>

<p>The HiBiT tag, a complementary peptide (VSGWRLFKKIS), exhibits high affinity for LgBiT. It is fused with the Gβ subunit of the receptor. The interaction between LgBiT and HiBiT facilitates the stabilization of ETR and G proteins. Additionally, HiBiT can be attached to target proteins (GFP) to quantify their transport to the cytosol.</p>

<p>CMVpp65 (415-429) is a CEF control peptide derived from cytomegalovirus (CMV).</p>

<p>Nucleoprotein (118-126),a fragment of Nucleoprotein, is a 9-aa peptide .</p>

<p>EC-1456 is a folate-microtubule targeting agent that exhibits significant antiproliferative activity against folate receptor (FR) positive tumors, including models resistant to anticancer drugs. EC-1456 is utilized in cancer research.</p>

<p>pYEEI, a tetrapeptide containing phosphotyrosine, binds to the SrcSH2 domain with a dissociation constant (Kd) of 100 nM and an inhibitory concentration (IC50) of 6.5 μM. This compound plays a crucial role in cancer research.</p>

<p>RO7196472 is a potent macrocyclic peptide antibiotic that selectively inhibits the activity of Acinetobacter strains. It targets the lipopolysaccharide (LPS) binding site on the inner membrane's LptB2FG complex, inhibiting lipopolysaccharide transport and thereby suppressing the activity of Acinetobacter strains.</p>

<p>Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.</p>

<p>Body Protection Compound 157 (BPC 157) is a pentadecapeptide derived from BPC, identified in gastric juice, exhibiting diverse biological activities. At 2 µg/ml, BPC 157 enhances primary rat tendon fibroblast cell migration and F-actin formation. Furthermore, doses of 0.01 and 10 µg/kg, intraperitoneally (i.p.), mitigate paw swelling, bone erosion, and mononuclear cell infiltration in the joints of rats with rheumatoid arthritis induced by complete Freund's adjuvant (CFA). It also diminishes gastric ulcer size in rats caused by indomethacin, aspirin, or diclofenac at these doses. Additionally, BPC 157 reduces catalepsy duration and tremor severity in a mouse model of Parkinson's disease triggered by MPTP.</p>

<p>Val-Lys(Boc)-PAB, an ADC linker, facilitates the synthesis of camptothecin peptide conjugates as antitumor agents and serves as a non-linear self-immolative linker to lessen the hydrophobicity of antibody-drug conjugates in cancer therapy.</p>

<p>TKD (450-463), a 14-peptide (TKDNNLLGRFELSG), exhibits the ability to stimulate NK cells' cytolytic and proliferative activities at concentrations comparable to the full-length Hsp70 protein.</p>

<p>α-Conotoxin GI acetate is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR).</p>

<p>AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants.</p>

<p>Human TNF alpha (46-65) peptide.</p>

<p>VGB3 is a peptide antagonist of vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2, exhibiting anti-angiogenic and anti-tumor properties. It binds to VEGFR1 and VEGFR2, thereby inhibiting VEGF-driven endothelial cell proliferation, migration, and tube formation, as well as suppressing tumor growth and metastasis in a mouse 4T1 breast cancer model.</p>

<p>µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.</p>