Peptides

Cyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)], is a peptide that mimics the amino acid sequence of the RGD motif found in fibronectin, which has been shown to be involved in cell attachment and proliferation. Cyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)] binds to integrin receptors and inhibits tumor growth. It also shows potential as a targeting agent for anticancer drugs. Cyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)] is a cyclic peptide that can be derivatized with reactive groups such as azides, alcohols, esters, haloalkanes, and isocyanates.

Ubiquitin carboxyl-terminal esterase L5 is a peptide that belongs to the ubiquitin carboxyl-terminal hydrolase family. It is expressed in humans as an approximately 20 kDa protein. Ubiquitin carboxyl-terminal esterase L5 is an activator of the ion channel TRPM4 and also inhibits the protein interactions of SH2 domain proteins. This enzyme has been used as a research tool for studying ion channels, cell biology, and pharmacology.

Cyclo(Arg-Ala-Asp-D-Tyr-Cys) is a peptide that has been shown to activate ion channels, which may lead to an increase in the permeability of the membrane. Cyclo(Arg-Ala-Asp-D-Tyr-Cys) has also been shown to inhibit ligand binding to receptors and antibody production. Cyclo(Arg-Ala-Asp-D-Tyr-Cys) is not intended for use as a research tool or in cell biology.

<p>H-Thr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis. It is used to immobilize amino acids, thiols, and other building blocks in order to synthesize peptides. This resin can be used for a variety of applications, including the synthesis of small organic molecules, oligonucleotides, and polysaccharides. H-Thr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB has been shown to react with amines and thiols.</p>

CLEAR-Base Resin (HCl) is a high-purity resin that has been used in the study of protein interactions, such as receptor and ligand binding. CLEAR-Base Resin (HCl) is also an inhibitor that can be used to block ion channels.

Glucagon, human recombinant is a protein that is used to treat low blood sugar levels in people with diabetes. It is a hormone that triggers the release of glucose from the liver and other stored sources of energy. Glucagon, human recombinant can be reconstituted with sterile water for injection and then freeze-dried. This product is calibrated to contain 1 mg of glucagon per milliliter (1 mg/mL) with an n-terminal amino acid sequence that has been determined by Edman degradation to be methionine, valine, threonine, alanine, glutamic acid, proline, lysine and serine. Glucagon, human recombinant is prepared in a chromatographic purification process that utilizes dna replication and biochemical assays for quality control.br> Glucagon, human recombinant is used to treat low blood sugar levels in people with diabetes. It should not be used to treat type 1

Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh) is a research tool that is used in the study of protein interactions. It has been shown to be an effective inhibitor for ion channels and cell biology. This resin can also be used to identify ligands and receptors, as well as their binding affinities. Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh) is a high purity product that can be used in pharmacology and peptide synthesis.

Cyclo[Arg-Ala-Asp-D-Phe-Lys(PEG-PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

H-Arg(Pbf)-2-ClTrt-Resin (200-400 mesh) 1% DVB is an alcohol resin that is used as a building block in peptide synthesis. It can be used with other alcohol resins, amines and thiols to synthesize peptides. The resin is also compatible with a variety of functional groups including carboxylic acids, amino acids and thiols. H-Arg(Pbf)-2-ClTrt-Resin (200-400 mesh) 1% DVB has been shown to be effective in the synthesis of peptides containing Arg, Lys, Trp and Tyr. This resin is soluble in organic solvents such as dichloromethane and ether.

Myelin PLP (57-70) is a peptide that is immunogenic and biochemically active. It has been shown to have immunogenic properties and can be used as an adjuvant for vaccines. Myelin PLP (57-70) is a peptide fragment of myelin basic protein that has been shown to be immunogenic in animal models. It induces an antibody response against myelin basic protein, which can be used for the treatment of multiple sclerosis. 6-Fluoro-3-indoxyl-beta-D-galactopyranoside Tilmicosin 3-Desacetylcefotaxime potassium Gatifloxacin Myelin PLP (57-70)

A labeled synthetic Sea Anemone toxin; a useful tool for detection of the presence of T-Lymphocytes with high expression of Kv13 channels in normal and diseased tissue. This product is available in the salt form: trifluoroacetate and has the following disulfide bonds: Cys3 and Cys35; Cys12 and Cys28; Cys17 and Cys32.

<p>H-ß-Ala-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin that can be used in peptide synthesis. It contains amines, alcohols, and thiols. H-ß-Ala-2-ClTrt-Resin (100-200 mesh) 1% DVB is insoluble in water and soluble in organic solvents. This resin has a wide range of applications, such as building blocks for synthetic chemistry and peptide synthesis. H-ß-Ala-2-ClTrt Resin (100 to 200 mesh) 1% DVB is resistant to hydrolysis by acids, bases, and oxidizing agents.</p>

Beta-2 Microglobulin Human is a research tool that can be used to study the activation of receptors, ion channels, and protein interactions. It is a ligand that binds to cell surface receptors. It is also an inhibitor that blocks the formation of antibodies by binding to human immunoglobulin G (IgG) and prevents it from binding to antigens. Beta-2 Microglobulin Human is a high purity protein with a CAS number of 1768-01-7.

In this special TentaGel resin, the PEG spacer is attached to the polystyrene/DVB matrix by a cleavable linkage. Therefore, the PEGylated compound can easily be cleaved and separated from the insoluble support. This can be achieved with either 10 mL/g of TFA/thioanisole (95:5) for 12 hours at room temperature, or with 10 mL/g of TFA/trimethylsilyl bromide/thioanisole (94:1:5) for 1 hour at room temperature. TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. Even less soluble peptides may be completely solubilized with this linker. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. (90 µm) 0.2-0.25 meq/g Product Application: Using this resin, cleavage yields the POE-peptide conjugates.

This product is an antiserum targeting amino acids 37-43 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms. This product may also be used to detect amyloid beta protein in cell cultures, tissues, or fluids by immunohistochemistry or ELISA. It is suitable for use in life sciences, cell biology, and pharmacology studies.

SUAM-14746 is a peptide that inhibits the interactions between proteins. It has been shown to be an activator of the receptor for nerve growth factor, and it may also inhibit the activity of ion channels. SUAM-14746 is a research tool for studying protein interactions and antibody binding. It is a high purity product with CAS number 126898-09-7.

IGF1 N15 Human is a desiccated, freeze-dried protein that is stable isotope and suitable for use in metabolic studies. IGF1 N15 Human has the same amino acid sequence as human insulin-like growth factor 1 (IGF1). IGF1 N15 Human can be used to study cell proliferation, sulfation, and sulfate conjugation. This protein is also used in Cytokines research as an alternative to recombinant human IGF1. Reconstitute with water or buffer prior to use.

<p>VP2 (70-86) is a peptide that is associated with the viral protein VP2. It has been shown to be immunogenic and may be used in the treatment of experimental autoimmune encephalomyelitis (EAE). VP2 (70-86) is a Biologically Active Peptide and can be used for research purposes.</p>

Unsubstituted Resins for Solid Phase Synthesis

Fmoc-Gln(Trt)-Rink-Amide MBHA Resin is a peptide resin that can be used as an activation and coupling agent for the synthesis of peptides. It is also used in the production of antibodies, and has been shown to inhibit ion channels. Fmoc-Gln(Trt)-Rink-Amide MBHA Resin is a high purity material with a CAS number, which can be used in research tools, cell biology, and pharmacology.

<p>Antimicrobial peptide consisting of disulfide bonds between Cys2-Cys30, Cys4-Cys19, and Cys9-Cys29. Alpha-defensin-4 is a small, cationic peptide that is part of the alpha-defensin family of antimicrobial peptides in humans. It is primarily produced by neutrophils, which are a type of white blood cell that plays a critical role in the immune response to bacterial infections.<br>Alpha-defensin-4 is known to have broad-spectrum antimicrobial activity against a wide range of bacterial pathogens, including both Gram-positive and Gram-negative bacteria. Like other alpha-defensins, alpha-defensin-4 achieves its antimicrobial activity by disrupting the cell membranes of the pathogens, leading to cell lysis and death.<br>In addition to its antimicrobial activity, alpha-defensin-4 has been found to have other functions in the body, including modulating the immune response and promoting tissue repair. It has also been implicated in the pathogenesis of certain inflammatory and autoimmune diseases, including rheumatoid arthritis and psoriasis.<br>Alpha-defensin-4 is typically found in various bodily fluids, including blood, urine, and semen, and its levels can be used as a diagnostic marker for certain conditions. For example, elevated levels of alpha-defensin-4 in joint fluid can be indicative of a bacterial infection in the joint, which can help to guide treatment decisions.</p>

Desmin, human, recombinant is a protein that is commonly used in research studies. It is produced using E.coli as the host organism. Desmin plays a crucial role in maintaining the structural integrity of muscle cells. It forms a network of intermediate filaments that provide support and stability to muscle fibers. This recombinant form of desmin is often used in experiments to study its function and interactions with other proteins. Researchers can use this protein to gain insights into various cellular processes and mechanisms related to muscle development, contraction, and disease. Its high purity and quality make it an ideal choice for scientific investigations requiring reliable and consistent results.

<p>supplied as the TFA salt</p>

ProTx-II is a synthetic peptide that activates the TRPV1 receptor, a member of the capsaicin receptor family. ProTx-II has been shown to inhibit NGF-induced neurite outgrowth, and can be used as a research tool in studying the structure and function of TRPV1 receptors. ProTx-II is also an inhibitor of protein interactions with the TNF receptor, and has been shown to selectively inhibit NFκB activation by inhibiting IKK kinase activity.

<p>Catalogue peptide; min. 95% purity; TFA salt</p>

Cyclo(Arg-Gly-Asp-D-Tyr-Lys) is a new synthetic peptide with anticancer activity. It has been shown to inhibit the growth of bladder cancer cells in vitro and in vivo, with no evidence of toxicity to normal bladder cells. Cyclo(Arg-Gly-Asp-D-Tyr-Lys) is a light sensitive molecule that can be delivered by an injection or as a pill. The peptide has been shown to have synergistic anticancer effects when combined with epirubicin, a chemotherapeutic drug used for the treatment of solid tumours, such as glioma and other cancers. Cyclo(Arg-Gly-Asp-D-Tyr-Lys) is also taken up by cells and causes DNA damage at the cellular level, leading to apoptosis.

Fmoc-Trp(Boc)-Wang resin is a solid phase peptide synthesis resin that can be used to synthesize peptides. It contains an amino acid sequence of Trp-Boc-Wang, which has been shown to inhibit the activity of ion channels. Fmoc-Trp(Boc)-Wang resin is also a useful tool for studying protein interactions and receptor binding. This resin is manufactured by Applied Biosystems, Inc., and is available in 100-200 mesh size. The product comes with a 1% DVB content and purity of >97%.

<p>Influenza B native 5-peptide mixture of:<br>H-SHFANLK-OHH-SYFANLK-OHH-GVLLPQK-OHH-NLNSLSELEVK-OHH-GILLPQK-OHAAA: Concentration - Duplicate<br>100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots</p>

<p>H-STQAAIDQINGK^-OHH-STQAAIDQISGK^-OHH-SDAPIGK^-OHH-DEALNNR^-OHH-EFSEVEGR^-OHH-TITNDR^-OHR^ = Arginine (U-13C6,15N4)K^ = Lysine (U-13C6,15N2)Peptide purity: &gt;98%AAA: Concentration – Duplicate100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots</p>

<p>Catalogue peptide; min. 95% purity; TFA salt</p>

<p>H-VNSVIEK-OHH-EQLSSVSSFER-OHH-TLDYHDSNVK-OHH-ITFEATGNLVAPR-OHPeptide purity: &gt;98%AAA: Concentration - Duplicate<br>kit contains 100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots</p>

Please enquire for more information about Ag85B (41-61) including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>H-D-Tyr-Val-NH2 is a regulatory group that acts as the prosthetic group for a number of peptidyl and peptide hormones. H-D-Tyr-Val-NH2 is also involved in catalytic mechanism, as it is the amino acid responsible for the formation of peptide bonds in proteins. H-D-Tyr-Val-NH2 is found in high concentrations in the cerebriform tissue and has been shown to be important for the biosynthesis of amides, which are prohormones. H-D-Tyr-Val NH2 also participates in a number of cellular reactions, including those that have a kinetic rate.</p>

<p>H-Ile-Asn-OH is a chloroplastic amide that is used as a substrate in polymerase chain reactions. It can be used to study the structure of proteins and enzymes by the use of monoclonal antibodies. H-Ile-Asn-OH has been sequenced and assayed, and found to have high binding affinity for carboxylate groups. This chemical has been shown to have multidomain structures as well as an isotype that is specific for triticum aestivum. H-Ile-Asn-OH may also be involved in plant physiology due to its role in photosynthesis.</p>

<p>Please enquire for more information about rec GM-CSF (murine) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>ACTH(1-39) trifluoroacetate is a synthetic form of ACTH that is used for the diagnosis of autoimmune diseases and bowel disease. It is also used to assess the function of the adrenal gland in cases of suspected Cushing's syndrome. The blood sampling procedure involves withdrawing a small amount of blood from the patient and adding ACTH(1-39) trifluoroacetate to it, which causes an increase in cortisol concentration. ACTH(1-39) trifluoroacetate binds to corticotropin receptors on cells in the body, causing them to release basic proteins that are responsible for inflammation. This drug may be a potential biomarker for metabolic disorders such as obesity. It has been shown to have anti-inflammatory properties and can be used as a nonsteroidal anti-inflammatory drug (NSAID).</p>

<p>For-Met-Leu-AMC is a chemical compound that belongs to the group of speciality chemicals. It is a high quality, versatile building block that can be used as a reagent in organic synthesis and a reaction component in the synthesis of pharmaceuticals and other fine chemicals. For-Met-Leu-AMC is also a useful intermediate for the synthesis of complex compounds with potential for use as research chemicals or scaffolds for drug discovery.</p>

<p>Gly-Gly-Gly-Gly-Arg-Gly-Asp-Ser-Pro is a peptide used as an activator in research. It can be used to study protein interactions and the effects of ligands on ion channels and receptors. Gly residues are able to form hydrogen bonds, which is why they are often used as spacers in proteins. This peptide has a high purity and CAS number.</p>

<p>H-Pro-Arg-AMC dihydrochloride is a high quality reagent that is used as an intermediate in the synthesis of peptides and other chemistries. H-Pro-Arg-AMC dihydrochloride can also be used as a building block for the synthesis of complex compounds. It has been found to be useful in various reactions involving amines, amino acids, and alcohols. H-Pro-Arg-AMC dihydrochloride is a versatile building block that can be used in reactions with other chemicals to produce speciality chemicals or research chemicals.</p>

<p>H-D-Phe-Homopro-Arg-pNA·diacetate is a versatile building block that can be used as a reaction component or a reagent. It is a useful scaffold for the preparation of biologically active compounds due to its high quality and versatility. It has been shown to be useful in the synthesis of complex compounds, such as peptides, antibiotics, and anti-cancer agents. This chemical is also an intermediate in the production of drugs. H-D-Phe-Homopro-Arg-pNA·diacetate is not listed on the U.S. Environmental Protection Agency TSCA Chemical Substance Inventory and has no known potential health effects at this time.</p>

Tachyplesin is a type of cationic β-hairpin antimicrobial peptide (AMP) discovered from horseshoe crab hemocytes. This product has disulfide bonds between Cys3-Cys16, Cys7-Cys12 and is available as a trifluoroacetate salt. One letter code: H-KWCFRVCYRGICYRKCR-NH2

Fmoc-Phe-Ser(Psi(Me,Me)Pro)-OH is a diastereomer of Fmoc-Phe-Ser. It is used as a substrate for peptide synthesis and can be used to synthesize oxytocin receptor antagonists. It has been shown to have high affinity for the oxytocin receptor and inhibits the binding of oxytocin to the receptor by competing with it for the same site on the receptor. This inhibition leads to decreased levels of oxytocin that are responsible for uterine contractions during labour and milk ejection from the breast during breastfeeding. Fmoc-Phe-Ser(Psi(Me,Me)Pro)-OH also has been shown to be useful in filtration techniques such as chlorides, propargylamines, and divalent cyclopentenones.

<p>Ac-Gly-Lys-OMe acetate salt is a reactive chemical compound that is used in the synthesis of peptides. This salt is synthesized by reacting glycine with lysine and formaldehyde. Ac-Gly-Lys-OMe acetate salt has been shown to have hemolytic activity and can be used as a synthetic substrate for kinetic studies. It has also been found to activate complement, which may be due to its disulfide bond formation. Ac-Gly-Lys-OMe acetate salt has been shown to inhibit fibrinogen and nitrosylation, which may result in thrombotic disorders.</p>

<p>H-Gln(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for the synthesis of peptides. It is a building block that can be used to synthesize peptides. H-Gln(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is an alcohols, amines, and thiols resin that can be used to synthesize peptides. H-Gln(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB has been shown to react with thiols, alcohols and amines, which are building blocks for peptide synthesis.</p>

Please enquire for more information about rec IL-4 (murine) including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>H-Pro-Val-OH is an amide that is used to treat renal disorders by inhibiting leukocyte elastase. It has been shown to be a potent inhibitor of serine proteases, including chymotrypsin and trypsin. H-Pro-Val-OH binds to the active site on serine proteases and blocks the release of peptides from the enzyme. The binding constant for H-Pro-Val-OH with chymotrypsin was found to be in the range of 3 x 10 M, which is significantly higher than that for other amides. In addition, H-Pro-Val-OH inhibits cytolysis by lysosomal enzymes and protects against liver injury caused by chronic liver disease. This drug also shows low molecular weight and high water solubility, making it effective in treating acute hepatitis.</p>

Please enquire for more information about LL-37 amide trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

H-Lys-Asp-OH is a molecule that binds to the receptor binding molecule for the colony stimulating factor. It has been shown to be effective in protecting against experimental models of hepatic steatosis and monoclonal antibody induced liver injury. The therapeutic potential of H-Lys-Asp-OH is being investigated as a treatment for human hepatic steatosis, which is a condition characterized by high levels of fat in the liver. This drug also has pharmacokinetic properties that are important in its use as an experimental model for studying the effects of antibiotics on bacterial DNA synthesis, and as a diagnostic tool for detecting antibiotic resistant bacteria.

H-Trp-Lys-Tyr-Met-Val-Met-NH2 is a natural compound that belongs to the group of pharmacological agents. It has been shown to have a therapeutic effect on congestive heart failure, bowel disease and autoimmune diseases. This compound has also been shown to stimulate locomotor activity in mice by increasing dopamine levels in the brain. H-Trp-Lys-Tyr-Met-Val-Met NH2 has been found to inhibit the growth of HL60 cells in culture, which are a type of white blood cell that is involved in immune response. H-Trp-Lys Tyr Met Val Met NH2 also binds to receptors for formyl and sesquiterpenoid lactones, which are chemical compounds that are used as pharmacological agents for cancer therapy and treatment of inflammatory bowel disease.

<p>Please enquire for more information about Thymosin β10 trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>