Modulateurs d'enzymes
Les modulateurs d'enzymes sont des composés qui peuvent augmenter ou inhiber l'activité des enzymes, régulant ainsi la vitesse des réactions biochimiques. Ces modulateurs jouent un rôle essentiel dans le contrôle des voies métaboliques, de la signalisation cellulaire et de divers processus physiologiques. Les modulateurs d'enzymes sont largement utilisés dans la recherche et le développement de médicaments pour étudier les fonctions enzymatiques et développer des agents thérapeutiques. Chez CymitQuimica, nous proposons une gamme complète de modulateurs d'enzymes de haute qualité pour soutenir vos recherches sur la régulation enzymatique et la découverte de médicaments.
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
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MK 1775
CAS :Wee1 inhibitor with an IC50 of 5.2 nMFormule :C27H32N8O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :500.6 g/molPeiminine
CAS :Inhibitor of TGF-α, CTGF, ERK1/2, NF-κB and FasL; anti-inflammatoryFormule :C27H43NO3Degré de pureté :Min. 98 Area-%Masse moléculaire :429.64 g/molSGC AAK1 1
CAS :Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_Formule :C21H25N5O3SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :427.52 g/molSNS 314 mesylate
CAS :Inhibitor of Aurora kinases A, B and CFormule :C18H15ClN6OS2•CH4O3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :527.04 g/molHistone deacetylase inhibitor VIII
CAS :Potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 2.4 nM. Its anti-inflammatory activity was examined in a mouse model for acute colitis. The compound protected from intestinal inflammation by prevention of infiltration of CD19+ B-cells into the lamina propria of colonic epithelium and attenuated neutrophil activation. Its broad anti-inflammatory response involved decrease in 24 inflammatory chemokines and cytokines. Also, it is a potent inhibitor of cell proliferation in pancreatic cancer cell lines.
Formule :C22H30N4O6Degré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :446.21653Hydroxychloroquine sulfate - Bio-X ™
CAS :Hydroxychloroquine is a drug that is used to treat multiple types of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus and discoid lupus. It is a prodrug, which is activated in the liver to hydroxychloroquine. It inhibits the production of inflammatory cytokines and nitric oxide by binding to the toll-like receptor 4 (TLR4) and inhibiting signaling pathways downstream of TLR4 activation. Additionally, Hydroxychloroquine is used to prevent and treat malaria caused by parasitic protozoan from the Plasmodium genus. Furthermore, recent studies revealed that hydroxychloroquine has beneficial effects on COVID-19 patients, as the current evidence shows that hydroxychloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the spike glycoprotein.Formule :C18H28ClN3O5SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :433.95 g/molEN 6
CAS :Autophagy activator that acts through targeting the ATP6V1A subunit of vATPaseFormule :C19H14F2N4O2Degré de pureté :Min. 95%Couleur et forme :White To Yellow To Beige SolidMasse moléculaire :368.34 g/molNilotinib HCl monohydrate - Bio-X ™
CAS :Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formule :C28H22F3N7O•HCl•H2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :583.99 g/molCobicistat
CAS :Cobicistat is an inhibitor of human cytochrome P450 3A enzymes (CYP) with no antiviral activity. Cobicistat is used in the treatment of HIV-1 infection, as an alternative to ritonavir, to increase the half-life of antiviral medications (von Hentig, 2016). Cobicistat acts as a booster by selectively inhibiting the hepatic degradation of the drugs, for example, in the pharmacological regime against HIV-1, which often includes protease inhibitors, such as, darunavir, atazanavir, and lopinavir, or the integrase inhibitor elvitegravir (Deeks, 2014).Formule :C40H53N7O5S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :776.03 g/molO151
CAS :Selective and potent inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.6 μM. OGG1 is a key enzyme in DNA repair mechanism called base excision repair (BER). The compound inhibits the hydrolysis of glycosidic bond required for the excision of 8-oxoguanine from double stranded DNA, which leads to accumulation of mutations. It has been proposed as monotherapy for certain types of cancers as well as adjuvant for cancer therapy with DNA damaging agents. It has potential to sensitize tumours for chemotherapy and inhibit development of drug resistance mechanisms.Formule :C13H15BrN2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :295.18 g/molZileuton- Bio-X ™
CAS :Zileuton is an inhibitor of the 5-lipoxygenase enzyme, thus preventing the leukotrienes LTE4, LDT4, LTB4 and LTC4 from being formed. This in turn reduces inflammation, bronchoconstriction and mucus secretion in the airways. As a result, Zileuton can be used in the treatment and management of asthma and allergic rhinitis. Studies have shown that Zileuton has the potential to reverse dementia-related brain damage.Formule :C11H12N2O2SDegré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :236.29 g/mol4-Deoxyuridine
CAS :A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, hydrophilic compound forms covalent complexes between DNMT and zebularine-substrate DNA. It causes DNA lesions that block replication and cause replication fork collapse, leading to the formation of DNA double-strand breaks. It was also shown that zebularine-induced DNA methylation decrease in the IL-1β promoter region and disrupts molecular mechanisms of neuroinflammation. Moreover, this molecule down-regulates the DNA-methylation profile in the pluripotency genes’ promoters, which leads to improved development of somatic cell nuclear transfer (SCNT) embryos.Formule :C9H12N2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :228.21 g/molPelitinib
CAS :EGFR tyrosine kinase inhibitor; pro-apoptotic; antiproliferative in cancer cellsFormule :C24H23ClFN5O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :467.92 g/molApremilast - Bio-X ™
CAS :Apremilast is the commercial name of a phosphodiesterase-4 (PDE4) inhibitor developed to treat chronic inflammatory disorders. Similarly to thalidomide, the apremilast molecule carries a phthalimide ring, but it lacks however the glutarimide ring needed to bind to cereblon, specifically targeted by thalidomide. As a drug, apremilast is indicated for the treatment of psoriasis and psoriatic arthritis.Formule :C22H24N2O7SDegré de pureté :Min. 99 Area-%Couleur et forme :White/Off-White SolidMasse moléculaire :460.5 g/molKenpaullone
CAS :Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.
Formule :C16H11BrN2ODegré de pureté :Min. 95%Couleur et forme :Yellow To Dark Yellow SolidMasse moléculaire :326.00548U 0126 monoethanolate
CAS :Inhibitor of MEK1 and MEK2 kinasesFormule :C18H16N6S2•C2H6ODegré de pureté :Min. 95%Couleur et forme :White To Beige SolidMasse moléculaire :426.56 g/molNolatrexed dihydrochloride
CAS :Thymidylate synthase inhibitorFormule :C14H14Cl2N4OSDegré de pureté :Min. 95%Couleur et forme :White To Light (Or Pale) Yellow SolidMasse moléculaire :357.26 g/molGSK 2606414
CAS :Inhibitor of EIF2AK3/PERK kinasesFormule :C24H20F3N5ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :451.44 g/molMeloxicam - Bio-X ™
CAS :Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) which is used to treat various types of pain and inflammation caused by arthritis. It is also a COX-2 inhibitor which reduces gastrointestinal effects of this drug. Inhibiting these enzymes, allow for a decrease in inflammatory symptoms.Formule :C14H13N3O4S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :351.4 g/molPimecrolimus
CAS :Immune suppressant; prevents pro-inflammatory cytokine releaseFormule :C43H68ClNO11Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :810.45 g/molMK 886 sodium salt
CAS :Inhibitor of 5-lipoxygenase activating protein_x000D_
Formule :C27H33ClNNaO2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :494.06 g/molGefitinib - Bio-X ™
CAS :Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.Formule :C22H24ClFN4O3Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :446.9 g/molLenalidomide - Bio-X ™
CAS :Produit contrôléLenalidomide is a thalidomide derivative that is used to treat multiple myeloma and anemia. This drug exerts immunomodulatory effects by altering cytokine production. Lenalidomide also directly inhibits the cullin ring E3 ubiquitin ligase complex.Formule :C13H13N3O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :259.26 g/molA 939572 - Bio-X ™
CAS :A 939572 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It exhibits anticancer activity as it inhibits cell growth and promotes cell death in human non-small cell lung carcinoma cells.Formule :C20H22ClN3O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :387.86 g/molAtorvastatin sodium salt - Bio-X ™
CAS :Atorvastatin is an HMG-CoA reductase inhibitor which is used to lower lipid levels and to reduce the risk of cardiovascular disease. This drug belongs to the class of medicines called statins. It lowers abnormal levels of cholesterol and lipids to reduce the risk of cardiovascular disease by inhibiting the enzyme HMG-CoA.Formule :C33H35FN2O5•NaDegré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :581.63 g/molDMAT
CAS :Inhibitor of protein kinase CK2
Formule :C9H7Br4N3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :476.79 g/molDeracoxib
CAS :Inhibitor of COX-2 and PDE4 enzymes; NSAID of coxib classFormule :C17H14F3N3O3SDegré de pureté :Min. 95%Couleur et forme :White To Off-White To Brown SolidMasse moléculaire :397.37 g/mol6-Thioguanine - Bio-X ™
CAS :6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.Formule :C5H5N5SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :167.19 g/molSC 560
CAS :Inhibitor of COX1 cyclooxygenaseFormule :C17H12ClF3N2ODegré de pureté :Min. 95%Masse moléculaire :352.74 g/molPolmacoxib
CAS :Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID), which is derived through synthetic chemical processes. It functions as a selective cyclooxygenase-2 (COX-2) inhibitor. By selectively inhibiting the COX-2 enzyme, polmacoxib reduces the conversion of arachidonic acid to prostaglandins that mediate inflammation and pain, while sparing the COX-1 enzyme that protects gastric mucosa and maintains platelet function.
Formule :C18H16FNO4SDegré de pureté :Min. 95%Couleur et forme :Light (Or Pale) Yellow To Yellow SolidMasse moléculaire :361.07841Erdafitinib
CAS :Fibroblast growth factor receptor inhibitorFormule :C25H30N6O2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :446.54 g/mol(+/-)-Thalidomide - Bio-X ™
CAS :Produit contrôléThalidomide is a piperidinyl isoindole drug that is used to treat various cancers such as myeloma and erythema nodosum leprosum. This drug is immunosuppressive and has anti-angiogenic activity. Thalidomide’s mechanism of action is not fully understood however it is thought to block the activity of tumor necrosis factor-alpha (TNF-α).Formule :C13H10N2O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :258.23 g/molVH 298
CAS :A selective VHL inhibitor that stabilizes the hydroxylated form of HIF-α, resulting in upregulation of downstream target genes and proteins. Provides a tool for studying hypoxic signaling pathway.Formule :C27H33N5O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :523.65 g/molBRD 6989
CAS :A small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells. Modulatory action on inflammatory responses has therapeutic potential.Formule :C16H16N4Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :264.33 g/molIndomethacin - Bio-X ™
CAS :Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C19H16ClNO4Degré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :357.79 g/molA 769662
CAS :Allosteric activator of AMP-activated protein kinase (AMPK) acting on the AMPK-β subunit with therapeutic potential in metabolic disorders such as diabetes, obesity, etc. A769662 also blocks the differentiation of mouse embryonic stem cells (mESCs) and maintains the mESCs in naïve state even in the absence of leukemia inhibitory factor (2i/L).Formule :C20H12N2O3SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :360.39 g/molToceranib phosphate - Bio-X ™
CAS :Produit contrôléToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Formule :C22H25FN4O2·H3O4PDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :494.45 g/molDutasteride - Bio-X ™
CAS :Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign prostatic hyperplasia (BPH) and male pattern baldness. Dutasteride reduces prostate volume and improves symptoms of BPH by inhibiting the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone.Formule :C27H30F6N2O2Degré de pureté :(%) Min. 99%Couleur et forme :PowderMasse moléculaire :528.53 g/molDiclofenac sodium salt - Bio-X ™
CAS :Diclofenac is a non-steroidal anti-inflammatory drug that is used to treat the signs and symptoms of arthritis and osteoarthritis. This drug inhibits COX-1 and COX-2 enzymes. As a result, it reduces pain and inflammation in joints. Diclofenac is usually used as a first line therapy for acute and chronic pain.Formule :C14H11NO2Cl2•NaDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :319.14 g/molRosuvastatin lactone
CAS :HMG-CoA reductase inhibitorFormule :C22H26FN3O5SDegré de pureté :Min. 98%Couleur et forme :PowderMasse moléculaire :463.52 g/molAZD 9291
CAS :A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.Formule :C28H33N7O2Degré de pureté :Min. 97%Couleur et forme :SolidMasse moléculaire :499.61 g/molRamipril - Bio-X ™
CAS :Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of high blood pressure, congestive heart failure and other cardiovascular diseases. Ramipril inhibits the conversion of angiotensin I to angiotensin II by blocking ACE, which lowers blood pressure and reduces fluid retention.This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C23H32N2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :416.51 g/molPAC 1
CAS :PAC 1 is a small-molecule apoptosis inducer, derived from synthetic sources, with a unique mode of action targeting the apoptotic pathways in cancer cells. PAC 1 functions by selectively activating procaspase-3, an inactive precursor of the caspase enzymes, which play a crucial role in the execution phase of cell apoptosis. By facilitating the conversion of procaspase-3 to its active form, PAC 1 enhances the apoptotic response in cancer cells, promoting cell death and offering potential therapeutic advantages.Formule :C23H28N4O2Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :392.49 g/molR-Rolipram
CAS :Inhibitor of PDE4 enzyme; anti-inflammatory
Formule :C16H21NO3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :275.34 g/molNGI1
CAS :A cell permeable inhibitor of oligosaccharyltransferase that interferes with the transfer of mature glycan precursors to recipient proteins. Causes reduced proliferation, G1 arrest and senescence in EGFR- and FGFR-dependent non-small-cell lung carcinoma (NSCLC) cells.Formule :C17H22N4O3S2Degré de pureté :Min. 99 Area-%Masse moléculaire :394.51 g/molVolitinib
CAS :Inhibitor of c-Met kinaseFormule :C17H15N9Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :345.36 g/molPamidronic acid disodium hydrate - Bio-X ™
CAS :Pamidronic acid is a bisphosphate used in the treatment of Paget’s disease, osteolytic bone lesions and in the treatment of hypercalcemia of malignancy. This drug inhibits farnesyl diphosphate and induces apoptosis of hematopoietic tumor cells.Formule :C3H9NNa2O7P2·4H2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :351.11 g/molAZD 9291 mesylate
CAS :Inhibitor of EGFR transmembrane receptorFormule :C28H33N7O2·CH4O3SDegré de pureté :Min. 98 Area-%Couleur et forme :White To Yellow To Brown SolidAmlexanox - Bio-X ™
CAS :Amlexanox is an antiallergic and anti-inflammatory drug that has been shown to be effective in treating rhinitis and allergic asthma in clinical studies. It prevents the slow-reacting substance of anaphylaxis (SRS-A) from being released chemically as a mediator and may have antagonistic effects on interleukin-3.Formule :C16H14N2O4Degré de pureté :(%) Min. 99%Couleur et forme :PowderMasse moléculaire :298.29 g/mol
