Modulateurs d'enzymes
Les modulateurs d'enzymes sont des composés qui peuvent augmenter ou inhiber l'activité des enzymes, régulant ainsi la vitesse des réactions biochimiques. Ces modulateurs jouent un rôle essentiel dans le contrôle des voies métaboliques, de la signalisation cellulaire et de divers processus physiologiques. Les modulateurs d'enzymes sont largement utilisés dans la recherche et le développement de médicaments pour étudier les fonctions enzymatiques et développer des agents thérapeutiques. Chez CymitQuimica, nous proposons une gamme complète de modulateurs d'enzymes de haute qualité pour soutenir vos recherches sur la régulation enzymatique et la découverte de médicaments.
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
643 produits trouvés pour "Modulateurs d'enzymes".
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(R)-Lansoprazole
CAS :Gastric proton pump inhibitorFormule :C16H14F3N3O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :369.36 g/molL 690330
CAS :Inositol monophosphatase (IMPase) inhibitorFormule :C8H12O8P2Degré de pureté :Min. 95%Masse moléculaire :298.12 g/molOdevixibat
CAS :Odevixibat is a pharmacological agent that functions as an ileal bile acid transport inhibitor, which is synthesized through complex organic chemistry methods to create a specific molecular structure targeting bile acid transport mechanisms. It works by inhibiting the apical sodium-dependent bile acid transporter (ASBT) in the terminal ileum. This action reduces the reabsorption of bile acids from the small intestine back into the liver, thereby reducing overall bile acid levels in the body.Formule :C37H48N4O8S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :740.93 g/molRosuvastatin
CAS :Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis.Formule :C22H28FN3O6SDegré de pureté :Min. 95%Masse moléculaire :481.54 g/molCyclosporin G
CAS :Cyclosporin G is an immunosuppressive agent, which is derived from fungal sources with a specific mode of action that involves inhibiting calcineurin. The source of Cyclosporin G is primarily from the fermentation of the fungus *Tolypocladium inflatum*. Its mode of action involves binding to the cytosolic protein cyclophilin in T-lymphocytes, which subsequently inhibits the phosphatase activity of calcineurin. This inhibition prevents the dephosphorylation and nuclear translocation of the nuclear factor of activated T-cells (NFAT), thereby reducing the transcription of interleukin-2 and other cytokines critical for T-cell activation.Formule :C63H113N11O12Degré de pureté :Min. 95%Masse moléculaire :1,216.64 g/molAR-AO 14418
CAS :Inhibitor of GSK3β kinaseFormule :C12H12N4O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :308.31 g/molGKA 50
CAS :Glucokinase activatorFormule :C26H28N2O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :464.51 g/molBIBF 1202
CAS :BIBF 1202 is a potent inhibitor of phospholipase A2, prostaglandin synthase and cyclooxygenase-2. It inhibits the production of arachidonic acid from membrane phospholipids and is used in cancer research. BIBF 1202 has been shown to have anti-tumour activity in a number of animal models, including human liver cancer cells. This molecule has also been shown to inhibit the activation of nuclear factor kappa B (NF-κB), which is involved in carcinogenesis.
Formule :C30H31N5O4Degré de pureté :Min. 95%Masse moléculaire :525.6 g/molTizoxanide
CAS :Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitorFormule :C10H7N3O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :265.25 g/molTDZD 8
CAS :TDZD 8 is a selective, non-ATP competitive inhibitor of the glycogen synthase kinase GSK3β. TDZD 8 inhibits GSK3β with IC50 of 2 μM and was reported to not significantly affect Cdk-1/cyclin B, casein kinase CK-II, protein kinase A and C (PKA, PKC) activities. TDZD 8 was also identified as an inhibitor of the main protease in coronaviruses. In an in vitro study, TDZD 8 was characterised as an aggregate-based inhibitor as the presence of Triton-X decreased the inhibitory potency to Mpro protease of the SARS-CoV-2 virus (IC50 without Triton-X: 2.15 μM).Formule :C10H10N2O2SDegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :222.26 g/molWM 1119
CAS :Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values in low nanomolar range. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and was shown to arrest lymphoma progression in mice models. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.
Formule :C18H13F2N3O3SDegré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :389.38 g/mol(+/-)-Blebbistatin
CAS :Inactive enantiomer of the inhibitor of myosin II-ATPaseFormule :C18H16N2O2Degré de pureté :Min. 95%Masse moléculaire :292.33 g/molNeostigmine methyl sulfate
CAS :Inhibitor of acetylcholinesteraseFormule :C13H22N2O6SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :334.39 g/molCAY10727
CAS :CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.Formule :C21H22Cl2N4O2Degré de pureté :Min. 95%Masse moléculaire :433.3 g/molN-(5-Aminopentyl) methotrexate amide-LC-biotin
N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.Formule :C41H59N13O7SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :878.06 g/molPD 0325901
CAS :A potent non ATP-competitive inhibitor of MAP/ERK kinase (MEK). Has anti-tumor activity in melanoma and papillary thyroid cancer cells with B-Raf mutations. Enhances generation and survival of induced pluripotent stem cells (iPSCs).Formule :C16H14F3IN2O4Degré de pureté :Min. 95%Masse moléculaire :482.19 g/molSemagacestat
CAS :γ-secretase inhibitor; inhibits notch signaling
Formule :C19H27O4N3Degré de pureté :Min. 95%Masse moléculaire :361.44 g/molCYT 387
CAS :Inhibits JAK1 and JAK2 kinasesFormule :C23H22N6O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :414.46 g/molGDC 0941
CAS :Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).
Formule :C23H27N7O3S2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :513.64 g/molPimasertib
CAS :A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formule :C15H15FIN3O3Degré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :431.2 g/mol
