Ruxolitinib Phosphate

CAS: 1092939-17-7

Rif. TR-R702005

Informazioni sul prodotto

• Nome: Ruxolitinib Phosphate
• Sinonimi: 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1), INC 424 phosphate, INCB 018424 phosphate, Jakafi, (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile, 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1), Incb-018424, Jakavi, R-Incb018424, R-Ruxolitinib, Ruxolitinib (INCB 018424), Ruxolitinib phosphate, Ruxolitinib phosphate salt
• CAS: 1092939-17-7

Descrizione

Applications The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 404.36
• Formula: C₁₇H₁₈N₆•HPO₄
• Colore/Forma: Off White Solid
• InChI: InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1
• SMILES: N#CC[C@H](C1CCCC1)n1cc(-c2nc[nH]c3nccc2-3)cn1.O=P(O)(O)O