CAS 124-94-7

Triamcinolone

Descrizione:

Triamcinolone è un corticosteroide sintetico con proprietà anti-infiammatorie e immunosoppressive, comunemente usato nel trattamento di varie condizioni come allergie, asma e disturbi autoimmuni. È caratterizzato dalla sua capacità di inibire il rilascio di mediatori infiammatori e modulare le risposte immunitarie. La struttura chimica di Triamcinolone include uno scheletro steroideo, che contribuisce alla sua attività biologica e farmacocinetica. Viene tipicamente somministrato per vie topiche, orali o iniettabili, a seconda della condizione da trattare. Triamcinolone è noto per la sua potenza relativamente alta rispetto ad altri corticosteroidi e può essere formulato in varie forme, tra cui creme, unguenti e sospensioni iniettabili. Il suo uso può essere associato a effetti collaterali, in particolare con l'uso a lungo termine, come soppressione surrenale, aumento di peso e aumento del rischio di infezioni. Come per qualsiasi farmaco, è essenziale utilizzare Triamcinolone sotto supervisione medica per gestire efficacemente i potenziali rischi e benefici.

Formula: C₂₁H₂₇FO₆

InChI: InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1

InChI key: InChIKey=GFNANZIMVAIWHM-OBYCQNJPSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](O)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Sinonimi:

• (11Beta,16Alpha)-9-Fluoro-11,16,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
• (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
• (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (8Xi,11Beta,14Xi,16Alpha)-9-Fluoro-11,16,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
• 11β,16α,17α,21-Tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
• 11β,16α,17α,21-Tetrahydroxy-9α-fluoro-Δ1,4-pregnadiene-3,20-dione
• 11β,16α,17α,21-Tetrahydroxy-9α-fluoro-Δ^1,4-pregnadiene-3,20-dione
• 9-Alpha-Fluoro-11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
• 9-Alpha-Fluoro-16-Alpha-Hydroxyprednisolone
• 9-Fluoro-11,16,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
• 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
• 9α-Fluoro-16α-hydroxyprednisolone
• Acetonide
• Adcortyl
• Aristocort
• Cinolone
• Cl 19823
• Delphicort
• Fluoxiprednisolone
• Fluoxyprednisolone
• Kenacort
• Kenacort AG
• Ledercort
• Mycolog
• Nsc 13397
• Omicilon
• Polcortolon
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-
• Rodinolone
• Triamcinlon
• Triamcinolon
• Triamcinolone Base
• Triancinolona
• Tricortale

Triamcinolone

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 394.44

Ref: 3B-T2303

TRIAMCINOLONE CRS

CAS: 124-94-7

TRIAMCINOLONE CRS

Colore e forma: Added Modified

Ref: 41-T1899990

Triamcinolone

CAS: 124-94-7

Triamcinolone

Formula: C₂₁H₂₇FO₆

Purezza: 99.5%

Colore e forma: White. To. Light Yellow

Peso molecolare: 394.17917

Ref: 47-338

Triamcinolone

CAS: 124-94-7

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₁H₂₇FO₆

Colore e forma: White Off-White Powder

Peso molecolare: 394.17917

Ref: 45-1676000

Triamcinolone

CAS: 124-94-7

Triamcinolone

Formula: C₂₁H₂₇FO₆

Purezza: 99.5%

Peso molecolare: 394.43

Ref: 54-BUP18210

Triamcinolone

CAS: 124-94-7

Triamcinolone

Formula: C₂₁H₂₇FO₆

Purezza: 98%

Peso molecolare: 394.43

Ref: 54-PC109250

Triamcinolone

CAS: 124-94-7

Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Formula: C₂₁H₂₇FO₆

Purezza: 98.66% - 99.60%

Colore e forma: White Solid

Peso molecolare: 394.4339

Ref: TM-T0798

Triamcinolone (Triamcinolone Acetonide EP Impurity A)

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Peso molecolare: 394.44

Ref: 4Z-T-5314

Triamcinolone

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Purezza: 97.5 - 102.5 %

Colore e forma: White to off-white crystalline powder

Peso molecolare: 394.43

Ref: 7W-GP2518

Triamcinolone-d7 (Triamcinolone Acetonide EP Impurity A-d7)

CAS: 124-94-7

Formula: C₂₁H₂₀FO₆D₇

Peso molecolare: 401.49

Ref: 4Z-T-5325

Triamcinolone

Prodotto controllato

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Colore e forma: Neat

Peso molecolare: 394.43

Ref: 86-MM0198.01

Triamcinolone (Standard)

CAS: 124-94-7

Triamcinolone (Standard) is the standard substance of Triamcinolone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.

Formula: C₂₁H₂₇FO₆

Colore e forma: Solid

Peso molecolare: 394.4339

Ref: TM-TMSM-2288

11β,16α,17α,21-Tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 394.4339

Ref: IN-DA0080N5

Triamcinolone

Prodotto controllato

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Colore e forma: Neat

Peso molecolare: 394.43

Ref: 04-C17634900

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Prodotto controllato

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Colore e forma: Mixture

Ref: 04-A50000094ME

Triamcinolone

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Colore e forma: Neat

Peso molecolare: 394.43

Ref: TR-T767160

Triamcinolone RS

CAS: 124-94-7

Colore e forma: White Or Almost White Solid Crystalline Powder

Ref: 2K-109400002

Triamcinolone Acetonide EP Impurity A

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Peso molecolare: 394.44

Ref: ST-EA-CP-T78001

Triamcinolone

CAS: 124-94-7

Formula: C₂₁H₂₇FO₆

Peso molecolare: 394.44

Ref: ST-EA-CP-T98000

Triamcinolone

Prodotto controllato

CAS: 124-94-7

Triamcinolone is a synthetic corticosteroid that reduces inflammation, suppresses the immune system, and relieves pain. It inhibits the production of cytokines and other inflammatory mediators by binding to specific receptors located in the cells of the immune system. Triamcinolone acetonide is an ester prodrug that is converted to triamcinolone in vivo. This drug has a long-term efficacy because it can be released slowly over time after intravitreal injection. The pharmacokinetic properties of triamcinolone are determined by its lipophilicity and water solubility. Triamcinolone acetonide has been shown to reduce inflammation in chronic arthritis, as well as reducing symptoms of eye disorders such as uveitis or glaucoma. This drug also prevents tumor growth by inhibiting protein synthesis and gene expression at the level of transcription, which leads to decreased cell proliferation or apoptosis.

Formula: C₂₁H₂₇FO₆

Purezza: Min. 97 Area-%

Colore e forma: White Powder

Peso molecolare: 394.43 g/mol

Ref: 3D-FT28383