CAS 14484-47-0

Deflazacort

Descrizione:

Deflazacort è un corticosteroide sintetico con proprietà anti-infiammatorie e immunosoppressive, utilizzato principalmente nel trattamento di varie condizioni infiammatorie e autoimmuni. È caratterizzato dalla sua capacità di modulare la risposta immunitaria e ridurre l'infiammazione, rendendolo efficace nella gestione di malattie come l'artrite reumatoide, il lupus e alcuni disturbi della pelle. Deflazacort è noto per i suoi effetti collaterali relativamente inferiori rispetto ad altri corticosteroidi, in particolare in termini di aumento di peso e soppressione surrenalica. Il composto viene tipicamente somministrato per via orale ed è metabolizzato nel fegato nella sua forma attiva. Il suo meccanismo d'azione implica il legame ai recettori dei glucocorticoidi, portando alla regolazione dell'espressione genica e alla successiva modulazione dei mediatori infiammatori. Deflazacort è anche noto per il suo profilo farmacocinetico favorevole, che consente una somministrazione una volta al giorno in molti casi. Come con tutti i corticosteroidi, l'uso a lungo termine richiede un attento monitoraggio a causa dei potenziali effetti collaterali, tra cui osteoporosi, ipertensione e maggiore suscettibilità alle infezioni.

Formula: C₂₅H₃₁NO₆

InChI: InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1

InChI key: InChIKey=FBHSPRKOSMHSIF-GRMWVWQJSA-N

SMILES: C(COC(C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)=N2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]

Sinonimi:

• (11β,16β)-11-hydroxy-2-methyl-5β-H-progna-1,4-dieno[17,16-d]Oxazolo-3,20-dione
• (11β,16β)-21-(Acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
• (4Ar,4Bs,5S,6As,9Ar,10As,10Bs)-6B-Acetyl-5-Hydroxy-4A,6A,8-Trimethyl-4A,4B,5,6,6A,6B,9A,10,10A,10B,11,12-Dodecahydro-9-Oxa-7-Aza-Pentaleno[2,1-A]Phenanthren-2-One
• (4aR,4bS,5S,6aS,9aR,10aS,10bS)-6b-acetyl-5-hydroxy-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one
• 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
• 2-(5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl)-2-oxoethyl acetate
• 2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl]-2-oxoethyl acetate
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d]oxazole, 5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione deriv.
• 5′H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2′-methyl-, (11β,16β)-
• 5′β<span class="text-smallcaps">H</span>-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11β,21-dihydroxy-2′-methyl-, 21-acetate
• Azacort
• Azacortinol
• Calcort
• Deflan
• Deflazacort Intermediate
• Dezacor
• Dezacort
• Dl 458It
• Emflaza
• Flantadin
• L 5458
• Lantadin
• Mdl 458
• Oxazacort
• Pregna-1,4-Diene-11B-Ol-17A,16A-D-2-Methyl-Oxazoline-3,20-Dione
• Deflazacort
• DEFLAZACORT
• Deflazacort intermediate(D5)

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Purezza: >98.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 441.52

Ref: 3B-D4523

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Colore e forma: White To Off-White Solid

Peso molecolare: 441.52

Ref: 4Z-D-311

Deflazacort

CAS: 14484-47-0

Deflazacort (MDL 458) is a glucocorticoid served as an immunosuppressant and anti-inflammatory. It can be used to treat autoimmune diseases due to inhibiting the immune system. It can also be acted in the therapy of some types of Ys. Deflazacort can help to prevent and to treat the rejection of transplanted organs.

Formula: C₂₅H₃₁NO₆

Purezza: 99.55%

Peso molecolare: 441.5167

Ref: TM-T0485

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Purezza: ≥ 98.0%

Colore e forma: White to almost white powder

Peso molecolare: 441.52

Ref: 7W-GP7998

Deflazacort

Prodotto controllato

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Colore e forma: Neat

Peso molecolare: 441.52

Ref: 04-C12111000

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Colore e forma: Neat

Peso molecolare: 441.52

Ref: 86-MM1224.00

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Prodotto controllato

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Colore e forma: Mixture

Ref: 04-A50000094ME

Deflazacort-d3 (Major)

Prodotto controllato

CAS: 14484-47-0

Formula: C₂₅H₂₈D₃NO₆

Colore e forma: Neat

Peso molecolare: 444.54

Ref: TR-D228977

Deflazacort

Prodotto controllato

CAS: 14484-47-0

Applications A systemic corticosteroid. A derivative of prednisolone. Used for rheumatoid arthritis and lupus.
References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),

Formula: C₂₅H₃₁NO₆

Colore e forma: Neat

Peso molecolare: 441.52

Ref: TR-D228975

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Peso molecolare: 441.52

Ref: ST-EA-CP-D14000

Deflazacort-d3

Prodotto controllato

CAS: 14484-47-0

Applications Deflazacort-d3, is the labeled analogue of Deflazacort (D228975), a systemic corticosteroid, and a derivative of prednisolone. Used for rheumatoid arthritis and lupus.
References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),

Formula: C₂₅H₂₈D₃NO₆

Colore e forma: Neat

Peso molecolare: 444.54

Ref: TR-D228978

Deflazacort

Prodotto controllato

CAS: 14484-47-0

Deflazacort is a corticosteroid used to treat chronic inflammatory diseases of the bowel and skin. It has been shown to inhibit the growth of human tumor xenografts in mice, although it is not active against bacteria or fungi. Deflazacort has also been shown to have an antimicrobial effect on human cells in culture. The mechanism of action is not known, but may be due to its ability to stimulate production of an antimicrobial protein called defensin. Deflazacort has also been shown to be effective in treating rheumatoid arthritis, lupus erythematosus, and other autoimmune diseases. Deflazacort has a side-effect profile that includes hypertension, hyperglycemia, hypokalemia, and gastrointestinal ulceration.

Formula: C₂₅H₃₁NO₆

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 441.52 g/mol

Ref: 3D-FD20886

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Peso molecolare: 441.5

Ref: BE-GBW(E)091169

Deflazacort in Acetonitrile

CAS: 14484-47-0

Acetonitrile

Formula: C₂₅H₃₁NO₆

Peso molecolare: 441.5

Ref: BE-BePure-21678YA-1000

Deflazacort in Acetonitrile

CAS: 14484-47-0

Acetonitrile

Formula: C₂₅H₃₁NO₆

Peso molecolare: 441.5

Ref: BE-BePure-21678XA-100

Deflazacort

CAS: 14484-47-0

Formula: C₂₅H₃₁NO₆

Peso molecolare: 441.5

Ref: BE-BePure-21678

21-Deacetoxy-21-dimethoxy Deflazacort

Prodotto controllato

CAS: 14484-47-0

Formula: C₂₅H₃₃NO₆

Colore e forma: Neat

Peso molecolare: 443.533

Ref: TR-D238660