CAS 25122-46-7

Propionato di clobetasolo

Descrizione:

Propionato di clobetasolo è un corticosteroide sintetico con potenti proprietà anti-infiammatorie e immunosoppressive, utilizzato principalmente in dermatologia per il trattamento di varie condizioni della pelle, tra cui psoriasi ed eczema. È classificato come un corticosteroide di classe I, indicando la sua alta potenza. La struttura chimica presenta uno scheletro steroideo a 21 carboni con un estere di propionato nella posizione 17, che ne migliora la penetrazione nella pelle e l'efficacia. Propionato di clobetasolo è tipicamente formulato come creme topiche, unguenti o soluzioni, consentendo un trattamento localizzato con minima assorbimento sistemico. Il suo meccanismo d'azione implica l'inibizione dei mediatori infiammatori e la modulazione delle risposte immunitarie, portando a una riduzione del rossore, del gonfiore e del prurito. Sebbene sia efficace, l'uso prolungato può portare a effetti collaterali come assottigliamento della pelle, strie e potenziali effetti sistemici se assorbito in quantità significative. Pertanto, è raccomandato per un uso a breve termine sotto supervisione medica. La sostanza è elencata sotto il numero CAS 25122-46-7, che la identifica in modo univoco nei database chimici.

Formula: C₂₅H₃₂ClFO₅

InChI: InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

InChI key: InChIKey=CBGUOGMQLZIXBE-XGQKBEPLSA-N

SMILES: O(C(CC)=O)[C@@]1(C(CCl)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]

Sinonimi:

• (11Beta,16Beta)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
• (11β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
• (8Xi,11Beta,14Xi,16Beta)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
• 17-Propionate De 21-Chloro-9-Fluoro-11Β,17-Dihydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione
• 17-Propionato De 21-Cloro-9-Fluoro-11Β,17-Dihidroxi-16Β-Metilpregna-1,4-Dieno-3,20-Diona
• 21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
• 21-Chloro-21-deoxybetamethasone 17-propionate
• 21-Chloro-9-Fluoro-11Β,17-Dihydroxy-16Β-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate
• CCl 4725
• Cgp 9555
• Clobederm
• Clobesol
• Clobetasol 17-propionate
• Clobetasole Propionate
• Clobetazol Propiorate
• Clobex
• Dermoval
• Dermovate
• Dermoxin
• Dermoxinale
• Gr 2/925
• Karison
• Olux-E
• Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate
• Skin Cap
• Temovate

Clobetasol 17-Propionate

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 466.97

Ref: 3B-C2612

Clobetasol propionate

CAS: 25122-46-7

Clobetasol propionate

Formula: C₂₅H₃₂ClFO₅

Purezza: 99.5%

Colore e forma: Off White Solid

Peso molecolare: 466.19223

Ref: 47-521

CLOBETASOL PROPIONATE FOR PEAK IDENTIFICATION CRS

CAS: 25122-46-7

CLOBETASOL PROPIONATE FOR PEAK IDENTIFICATION CRS

Colore e forma: Added Modified

Ref: 41-Y0002164

CLOBETASOL PROPIONATE CRS

CAS: 25122-46-7

CLOBETASOL PROPIONATE CRS

Colore e forma: Added Modified

Ref: 41-Y0000559

Clobetasol Propionate

CAS: 25122-46-7

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₅H₃₂ClFO₅

Colore e forma: White Cream Powder

Peso molecolare: 466.19223

Ref: 45-1138405

Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 466.9700

Ref: IN-DA002QJS

Clobetasol propionate

CAS: 25122-46-7

Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated

Formula: C₂₅H₃₂ClFO₅

Purezza: 99.41%

Colore e forma: White Crystalline Powder

Peso molecolare: 466.97

Ref: TM-T1561

Clobetasol propionate, Ph. Eur. grade

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Purezza: ≤ 0.1%

Colore e forma: White or almost white crystalline powder

Peso molecolare: 466.97

Ref: 7W-GP1910

Clobetasol propionate, USP grade

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Purezza: ≤ 1.0%

Colore e forma: White to almost white crystalline powder

Peso molecolare: 466.97

Ref: 7W-GP0268

Clobetasol Propionate

CAS: 25122-46-7

Clobetasol Propionate

Purezza: 99%

Peso molecolare: 466.97g/mol

Ref: 54-PC108784

Clobetasol propionate

CAS: 25122-46-7

Clobetasol propionate

Purezza: ≥98%

Peso molecolare: 466.97g/mol

Ref: 54-BUP16910

Clobetasol propionate

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White to off-white powder

Peso molecolare: 466.97

Ref: 7W-GP2221

Clobetasol Propionate

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Colore e forma: White To Off-White Solid

Peso molecolare: 466.98

Ref: 4Z-C-101001

Clobetasol Propionate

Prodotto controllato

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Colore e forma: Neat

Peso molecolare: 466.97

Ref: 86-MM0769.00

GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol

Prodotto controllato

CAS: 105102-22-5, 1177-87-3, 124-94-7, 13609-67-1, 14484-47-0, 1524-88-5, 2135-17-3, 2152-44-5, 25122-46-7, 25122-57-0, 3093-35-4, 33564-31-7, 356-12-7, 378-44-9, 3801-06-7, 3870-07-3, 426-13-1, 4419-39-0, 50-02-2, 50-03-3, 50-04-4, 50-23-7, 50-24-8, 51022-69-6, 51333-22-3, 514-36-3, 53-06-5, 5534-09-8, 5593-20-4, 57524-89-7, 66734-13-2, 67-78-7, 73771-04-7, 76-25-5, 80474-14-2, 83-43-2, 987-24-6

Colore e forma: Mixture

Ref: 04-A50000094ME

Clobetasol propionate

Prodotto controllato

CAS: 25122-46-7

Formula: C₂₅H₃₂ClFO₅

Colore e forma: Neat

Peso molecolare: 466.97

Ref: 04-C11678000

Clobetasol Propionate RS

CAS: 25122-46-7

Colore e forma: White To Pale Yellow-White Solid Powder

Ref: 2K-1050000021

Clobetasol 17-Propionate

Prodotto controllato

CAS: 25122-46-7

Applications Topical corticosteroid. Glucocorticoid; anti-inflammatory.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Formula: C₂₅H₃₂ClFO₅

Colore e forma: White To Off-White

Peso molecolare: 466.97

Ref: TR-C583500

Clobetasol 17-Propionate-d5

Prodotto controllato

CAS: 25122-46-7

Applications Clobetasol 17-Propionate-d5 is labelled Clobetasol 17-Propionate (C583500) which is a topical corticosteroid. Clobetasol 17-Propionate (C583500) is anti-inflammatory.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Formula: C₂₅H₂₇D₅ClFO₅

Colore e forma: Neat

Peso molecolare: 472.0

Ref: TR-C583502

Clobetasol 17-propionate

Prodotto controllato

CAS: 25122-46-7

Clobetasol 17-propionate is a synthetic, long-acting corticosteroid that has been used in the treatment of a variety of autoimmune and inflammatory conditions. It is an ester prodrug of clobetasol, which is converted to its active form, clobetasol propionate (CPA), in vivo. Clobetasol 17-propionate has been shown to have anti-inflammatory effects and inhibit the progression of skin cancer. Antimicrobial agents are also known to cause changes in the skin's barrier function by increasing transepidermal water loss and decreasing stratum corneum hydration. Chronic oral administration of clobetasol 17-propionate may result in accumulation of the drug in the liver, kidneys, and heart. !-- END QUOTE -->

Formula: C₂₅H₃₂ClFO₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 466.97 g/mol

Ref: 3D-FC20489