CAS 265121-04-8: Fosaprepitant dimeglumina

Descrizione: Fosaprepitant dimeglumina è un composto sintetico utilizzato principalmente come antiemetico nella prevenzione della nausea e del vomito associati alla chemioterapia. È un pro-farmaco di aprepitant, che agisce come un antagonista selettivo del recettore della neurochinina-1 (NK1), inibendo così l'azione della sostanza P, un neuropeptide coinvolto nel riflesso del vomito. La sostanza è caratterizzata dalla sua alta solubilità in acqua grazie alla presenza del gruppo dimeglumina, che ne migliora la biodisponibilità. Fosaprepitant viene tipicamente somministrato per via endovenosa ed è noto per la sua efficacia in combinazione con altri agenti antiemetici. La sua farmacocinetica include una rapida conversione in aprepitant nel corpo, con una emivita relativamente lunga, che consente effetti antiemetici sostenuti. Gli effetti collaterali comuni possono includere affaticamento, vertigini e disturbi gastrointestinali. Come agente terapeutico, Fosaprepitant dimeglumina gioca un ruolo cruciale nel migliorare la qualità della vita dei pazienti sottoposti a trattamento per il cancro gestendo efficacemente nausea e vomito indotti dalla chemioterapia.

Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

InChI: InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1

InChI key: InChIKey=UGJUJYSRBQWCEK-GGXTVIBHSA-N

SMILES: O=C1NC(=NN1P(=O)(O)O)CN2CCOC(OC(C=3C=C(C=C(C3)C(F)(F)F)C(F)(F)F)C)C2C4=CC=C(F)C=C4.OCC(O)C(O)C(O)C(O)CNC

Sinonimi:

• 1-Deoxy-1-(Methylamino)-D-Glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]Phosphonate
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
• D-Glucitol, 1-deoxy-1-(methylamino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1) (salt)
• Fosaprepitant di(N-methylglucamine)
• Fosaprepitant dimeglumine [USAN]
• Ivemend
• Mk-0517
• Phosphonic acid, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
• Phosphonic acid, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-, compd. with 1-deoxy-1-(methylamino)-<span class="text-smallcaps">D</span>-glucitol (1:2)
• Unii-D35Fm8T64X
• Fosaprepitant dimeglumine
• Fosapitant Dimeglumine
• D-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)

Fosaprepitant dimeglumine

CAS: 265121-04-8

• Formula: C₃₇H₅₆F₇N₆O₁₆P
• Purezza: 99%
• Colore e forma: Solid
• Peso molecolare: 1004.8337

Fosaprepitant Dimeglumine

CAS: 265121-04-8

• Formula: C₂₃H₂₂F₇N₄O₆PC₇H₁₇NO₅
• Colore e forma: White To Off-White Solid
• Peso molecolare: 614.41 2*195.22

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

• Formula: C₂₃H₁₈D₄F₇N₄O₆PC₇H₁₇NO₅
• Colore e forma: White To Off-White Solid
• Peso molecolare: 618.44 2*195.22

Fosaprepitant Dimeglumine

CAS: 265121-04-8

• Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅
• Purezza: >95.0%(HPLC)(qNMR)
• Colore e forma: White to Light yellow powder to crystal
• Peso molecolare: 1,004.84

Fosaprepitant Impurity 10

CAS: 265121-04-8

• Formula: C₂₃H₂₂F₇N₄O₇P
• Colore e forma: White To Off-White Solid
• Peso molecolare: 630.42

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine (MK-0517) is a soluble prodrug of aprepitant, which prevents nausea by blocking NK1 …

• Formula: C₃₇H₅₆F₇N₆O₁₆P
• Purezza: 97.39% - 98.75%
• Colore e forma: Solid
• Peso molecolare: 1004.83

Bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol); (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid

CAS: 265121-04-8

• Purezza: 98.05%
• Peso molecolare: 1004.844

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Applications Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a …

• Formula: C₂₃H₂₂F₇N₄O₆PC₇H₁₇NO₅
• Colore e forma: Off White
• Peso molecolare: 1004.83

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

Applications Fosaprepitant-d4 Dimeglumine is a labeled analogue of Fosaprepitant Dimeglumine (F727305), a selective neurokinin-1 (NK-1) …

• Formula: C₃₇H₅₂D₄F₇N₆O₁₆P
• Colore e forma: Neat
• Peso molecolare: 1008.86

1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]m ethyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate

CAS: 265121-04-8

Fosaprepitant is a drug that belongs to the class of drugs used for chemotherapy. It …

• Formula: C₂₃H₂₂F₇N₄O₆P•(C₇H₁₇NO₅)₂
• Purezza: Min. 95%
• Colore e forma: White To Off-White Solid
• Peso molecolare: 1,004.83 g/mol

Fosaprepitant-13C,15N3 Dimeglumine

CAS: 265121-04-8

• Formula: C₃₆CH₅₆F₇N₃N₃O₁₆P
• Colore e forma: Neat
• Peso molecolare: 1008.82