Angiogenesi
Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.
Sottocategorie di "Angiogenesi"
- BTK(158 prodotti)
- Bcr-Abl(113 prodotti)
- EGFR(598 prodotti)
- FAK(72 prodotti)
- FLT(90 prodotti)
- Recettore del fattore di crescita dei fibroblasti (FGFR)(182 prodotti)
- JAK(246 prodotti)
- PDGFR(126 prodotti)
- RAAS(90 prodotti)
- Src(81 prodotti)
- Syk(37 prodotti)
- Trombina(53 prodotti)
- VDA(2 prodotti)
- VEGFR(250 prodotti)
Mostrare 6 più sottocategorie
Trovati 2040 prodotti di "Angiogenesi"
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Dasatinib hydrochloride
CAS:<p>Dasatinib hydrochloride is an oral Src/Bcr-Abl inhibitor with potent antitumor effects, Ki values of 16 pM (Src) and 30 pM (Bcr-Abl).</p>Formula:C22H27Cl2N7O2SPurezza:99.88% - 99.98%Colore e forma:SolidPeso molecolare:524.47PKI-166
CAS:PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Formula:C20H18N4OPurezza:99.2%Colore e forma:SolidPeso molecolare:330.38Pimicotinib
CAS:Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Formula:C22H24N6O3Purezza:99.8%Colore e forma:SolidPeso molecolare:420.46Sunvozertinib
CAS:Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formula:C29H35ClFN7O3Purezza:98.11% - 99.63%Colore e forma:SolidPeso molecolare:584.08SKLB 1028
CAS:SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formula:C24H29N9Purezza:99.99% - >99.99%Colore e forma:SolidPeso molecolare:443.55Tyrphostin A25
CAS:Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formula:C10H6N2O3Purezza:98.98%Colore e forma:Yellow Green Powder /Off-White SolidPeso molecolare:202.17WDR5-0102
CAS:<p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>Formula:C18H19ClN4O3Purezza:98.03%Colore e forma:SolidPeso molecolare:374.82SRX3207
CAS:SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.Formula:C29H29N7O3SPurezza:99.85%Colore e forma:SolidPeso molecolare:555.65EGFR-IN-9
CAS:EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formula:C29H24N4O3Purezza:99.8%Colore e forma:SolidPeso molecolare:476.53Rezivertinib
CAS:Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formula:C27H30N6O3Purezza:99.26% - 99.98%Colore e forma:SolidPeso molecolare:486.57MY10
CAS:MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption andFormula:C15H10F6OS2Purezza:98.64%Colore e forma:SolidPeso molecolare:384.36Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formula:C32H45N9O3SPurezza:98.12% - 99.54%Colore e forma:SolidPeso molecolare:635.82CGP77675
CAS:CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormula:C26H29N5O2Purezza:99.66%Colore e forma:SolidPeso molecolare:443.54SI-2 hydrochloride
CAS:<p>SI-2 hydrochloride, an SRC-3 inhibitor, induces breast cancer cell death (IC50: 3-20 nM) with good oral bioavailability.</p>Formula:C15H16ClN5Purezza:98.6%Colore e forma:SolidPeso molecolare:301.77Epitinib succinate
CAS:Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formula:C28H32N6O6Purezza:98.02% - 99.79%Colore e forma:SolidPeso molecolare:548.59Falnidamol
CAS:Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formula:C18H19ClFN7Purezza:98.816%Colore e forma:SolidPeso molecolare:387.84BRD7389
CAS:BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.Formula:C24H18N2O2Purezza:99.51%Colore e forma:SolidPeso molecolare:366.41(Z)-FeCP-oxindole
CAS:(Z)-FeCP-oxindole is a selective inhibitor of VEGFR2 with an IC50 of 200 nM for human. (Z)-FeCP-oxindole shows anticancer activity.Formula:C19H15FeNOPurezza:99.63% - 99.84%Colore e forma:SolidPeso molecolare:329.17(E)-FeCP-oxindole
CAS:(E)-FeCP-oxindole 是一种 VEGFR2 抑制剂，IC50 为 214 nM。Formula:C19H15FeNOPurezza:99.85%Colore e forma:SolidPeso molecolare:329.17EGFR-IN-99
CAS:EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formula:C25H22FN7O3Purezza:97.75%Colore e forma:SolidPeso molecolare:487.49JNJ-49095397
CAS:<p>JNJ-49095397 (RV568) is a p38 MAPK-α and p38 MAPK-γ kinase inhibitor for the study of respiratory syncytial virus infection.</p>Formula:C34H36N6O4Purezza:98.33% - 99.04%Colore e forma:SolidPeso molecolare:592.69Larotinib
CAS:Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formula:C24H26ClFN4O4Purezza:99.73%Colore e forma:SolidPeso molecolare:488.94TP0427736 hydrochloride
CAS:TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.Formula:C14H11ClN4S2Purezza:98.99%Colore e forma:SolidPeso molecolare:334.85HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formula:C12H6ClN5O5Purezza:98.11%Colore e forma:SolidPeso molecolare:335.66EGFR-IN-71
CAS:<p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>Formula:C16H9ClIN3Colore e forma:SolidPeso molecolare:405.62BMS-599626 Hydrochloride
CAS:BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.Formula:C27H28ClFN8O3Purezza:99.98%Colore e forma:SolidPeso molecolare:567.01BPIQ-I
CAS:BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.Formula:C16H12BrN5Colore e forma:SolidPeso molecolare:354.2FM-479
CAS:<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Formula:C25H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:442.523SNIPER(TACC3)-11
CAS:SNIPER(TACC3)-11 is a powerful FGFR3-TACC3 protein degrader, reducing its amount and hindering FGFR3-TACC3+ cancer cell growth.Formula:C51H66N10O7S2Colore e forma:SolidPeso molecolare:995.26Famitinib malate
CAS:Famitinib malate (SHR1020) is a potent oral kinase inhibitor targeting c-kit, VEGFR-2, and PDGFRβ, with IC50s 2.3, 4.7, 6.6 nM, useful for cancer research.Formula:C27H33FN4O7Colore e forma:SolidPeso molecolare:544.57Roslin 2 bromide
CAS:Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Formula:C13H19BrN4Purezza:99.34%Colore e forma:SolidPeso molecolare:311.22PF-303
CAS:PF-303, a reversible covalent BTK inhibitor, shows potential for cancer and autoimmune therapy.Formula:C22H21ClN6O2Colore e forma:SolidPeso molecolare:436.89JNJ-17029259
CAS:JNJ-17029259 is an orally selective, potent inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2).Formula:C26H30N6OPurezza:98%Colore e forma:SolidPeso molecolare:442.56Simotinib
CAS:Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.Formula:C25H26ClFN4O4Purezza:99.7%Colore e forma:SolidPeso molecolare:500.95SD 1008
CAS:SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.Formula:C18H19NO5Purezza:98%Colore e forma:SolidPeso molecolare:329.35ALK/EGFR-IN-2
CAS:ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.Formula:C27H34ClN7O3SColore e forma:SolidPeso molecolare:572.12BTK-IN-11
CAS:<p>BTK-IN-11: potent BTK inhibitor; may research autoimmune, inflammatory diseases, cancer. (Patent WO2022063101A1, Z2)</p>Formula:C26H22ClN5O3Colore e forma:SolidPeso molecolare:487.94VEGFR-2-IN-37
CAS:VEGFR-2-IN-37 (compound 12), a VEGFR-2 inhibitor, exhibits an inhibition rate of approximately 56.9 μM at a concentration of 200 μM.Formula:C18H16N2O2SPurezza:98%Colore e forma:SolidPeso molecolare:324.4Itacnosertib (hydrocholide)
CAS:Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].Formula:C26H29ClN8OColore e forma:SolidPeso molecolare:505.01UNC4203
CAS:UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.Formula:C30H44N6OColore e forma:SolidPeso molecolare:504.71BTK inhibitor 13
CAS:BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).Formula:C29H26FN5O3Purezza:98%Colore e forma:SolidPeso molecolare:511.55BGB-102
CAS:<p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>Formula:C22H25BrN4O2Purezza:99.02%Colore e forma:SolidPeso molecolare:457.36FGFR-IN-4
CAS:FGFR-IN-4 is a potent inhibitor of FGFR. FGFR-IN-4 has potential for cancer disease studies.Formula:C24H21N7O2Colore e forma:SolidPeso molecolare:439.47EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFormula:C54H54Cl2FN7O7S2Purezza:98%Colore e forma:SolidPeso molecolare:1067.08HPK1-IN-2 dihydrochloride
CAS:HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].Formula:C19H22Cl2N6OSColore e forma:SolidPeso molecolare:453.39MTP
CAS:MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation.Formula:C29H23F3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:516.51Rocbrutinib
CAS:Rocbrutinib is a Bruton's tyrosine kinase (BTK) inhibitor that exhibits antineoplastic properties [1].Formula:C42H51N9O5Colore e forma:SolidPeso molecolare:761.91FC 11
CAS:FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.Formula:C41H42F3N13O9SColore e forma:SolidPeso molecolare:949.91HER2-IN-5
CAS:<p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>Formula:C27H33N7O3Colore e forma:SolidPeso molecolare:503.6Nazartinib S-enantiomer
CAS:Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.Formula:C26H31ClN6O2Purezza:98%Colore e forma:SolidPeso molecolare:495.02TAK-659
CAS:TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Formula:C17H21FN6OPurezza:98%Colore e forma:SolidPeso molecolare:344.39N-desmethyl Regorafenib N-oxide
CAS:N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.Formula:C20H13ClF4N4O4Colore e forma:SolidPeso molecolare:484.79PonatiLink-1-24
CAS:Ponatinib, also known as PonatiLink-1-24, is a selective inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formula:C101H144ClF5N12O29Colore e forma:SolidPeso molecolare:2120.73SIM010603
CAS:SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Formula:C22H25FN4O2Colore e forma:SolidPeso molecolare:396.46HDAC-IN-63
CAS:<p>HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.</p>Formula:C25H26Cl2N6O3Colore e forma:SolidPeso molecolare:529.42NMS-P953
CAS:NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formula:C16H11ClF3N5OColore e forma:SolidPeso molecolare:381.74Cremastranone
CAS:Cremastranone: natural homoisoflavanone that hinders human retinal cell proliferation, migration, and tube creation.Formula:C18H18O7Colore e forma:SolidPeso molecolare:346.33Infigratinib-Boc
CAS:Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].Formula:C29H35Cl2N7O5Colore e forma:SolidPeso molecolare:632.54Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormula:C25H17F3N4O3Purezza:97.99% - 98%Colore e forma:SolidPeso molecolare:478.42JGK-068S
CAS:<p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>Formula:C22H23BrFN5O2Purezza:98%Colore e forma:SolidPeso molecolare:488.35EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Formula:C34H39ClFN7O2Purezza:98%Colore e forma:SolidPeso molecolare:632.17SG3-179
CAS:SG3-179 is a BET inhibitor.Formula:C28H35ClFN7O3SColore e forma:SolidPeso molecolare:604.14ALK/EGFR-IN-3
CAS:ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-Formula:C27H34ClN7O3SColore e forma:SolidPeso molecolare:572.12OTS447
CAS:OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .Formula:C27H32ClN3O2Purezza:98.78%Colore e forma:SolidPeso molecolare:466.02TCJL37
CAS:TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formula:C17H11ClF2N4O2Colore e forma:SolidPeso molecolare:376.74BCR-ABL-IN-4
CAS:BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).Formula:C27H24ClF2N5O4Colore e forma:SolidPeso molecolare:555.96EGFR-IN-36
CAS:EGFR-IN-36 inhibits EGFR, HER2, & mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).Formula:C26H25ClN6O2Colore e forma:SolidPeso molecolare:488.97GW-6604
CAS:GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.Formula:C19H14N4Purezza:99.6%Colore e forma:SolidPeso molecolare:298.34TIE-2/VEGFR-2 kinase-IN-5
CAS:TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.Formula:C21H13F6N5O2Purezza:99.79%Colore e forma:SolidPeso molecolare:481.35KB SRC 4
CAS:KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.CAS 번호13460-73-83-4Formula:C32H23ClN8Purezza:98.83% - 99.34%Colore e forma:SolidPeso molecolare:555.03BPR1J-340
CAS:BPR1J-340, a novel potent FLT3 inhibitor, shows anticancer promise, with IC50 ~25 nM and GC50 ~5 nM, causing apoptosis in AML cells.Formula:C29H34N8O3Colore e forma:SolidPeso molecolare:542.63EGFR-IN-85
CAS:EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFormula:C26H30N8O2Purezza:98%Colore e forma:SolidPeso molecolare:486.57DW10075
CAS:DW10075, a novel potent and highly selective inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.Formula:C29H23N5O3Colore e forma:SolidPeso molecolare:489.52Tyk2-IN-9
CAS:Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.Formula:C20H17N9Purezza:98%Colore e forma:SolidPeso molecolare:383.41Cinsebrutinib
CAS:Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.Formula:C22H26FN3O2Purezza:98%Colore e forma:SolidPeso molecolare:383.46BMX-IN-1
CAS:BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosineFormula:C29H24N4O4SPurezza:98.38%Colore e forma:SolidPeso molecolare:524.59HDAC/JAK/BRD4-IN-1
CAS:HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4.Formula:C24H28N6O3Purezza:98%Colore e forma:SolidPeso molecolare:448.52YS-363
CAS:<p>YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (</p>Formula:C30H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:494.58JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormula:C22H24N6O3Purezza:98%Colore e forma:SolidPeso molecolare:420.4610Z-Hymenialdisine
CAS:Pan kinase inhibitorFormula:C11H10BrN5O2Purezza:98%Colore e forma:Light Yellow SolidPeso molecolare:324.13Henatinib
CAS:Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Formula:C25H29FN4O4Colore e forma:SolidPeso molecolare:468.52BT424
CAS:BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].Formula:C22H15BCl2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:421.08Risvodetinib
CAS:Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.Formula:C33H34N8O2Colore e forma:SolidPeso molecolare:574.68EGFR kinase inhibitor 1
CAS:Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.Formula:C30H31N7O2Colore e forma:SolidPeso molecolare:521.61FGFR-IN-2
CAS:FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).Formula:C25H30N6O2Colore e forma:SolidPeso molecolare:446.54Sulfatinib
CAS:<p>Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to</p>Formula:C24H28N6O3SPurezza:99.21% - >99.99%Colore e forma:SolidPeso molecolare:480.58EGFR-IN-30
CAS:EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.Formula:C28H33BrN7O2PColore e forma:SolidPeso molecolare:610.49FGFR-IN-8
CAS:FGFR-IN-8, potent oral FGFR inhibitor for wild-type/mutant types, induces apoptosis with anti-cancer properties.Formula:C27H31Cl2N9O2Colore e forma:SolidPeso molecolare:584.5FLT3/ITD-IN-4
CAS:FLT3/ITD-IN-4 inhibits FLT3-ITD mutations in acute myeloid leukemia (IC50: 2.3 nM).Formula:C25H22N4O5Colore e forma:SolidPeso molecolare:458.47CHMFL-FLT3-122
CAS:<p>CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia.</p>Formula:C26H29N7O2Purezza:99.63%Colore e forma:SolidPeso molecolare:471.55MS 154
CAS:MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.Formula:C46H54ClFN8O8Colore e forma:SolidPeso molecolare:901.42GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formula:C24H26N2O2Colore e forma:SolidPeso molecolare:374.48BTK-IN-19
CAS:BTK-IN-19 is a reversible BTK inhibitor with an IC 50 of <0.001 μM .Formula:C21H22Cl2N6OColore e forma:SolidPeso molecolare:445.35MET kinase-IN-3
CAS:MET kinase-IN-3 is a potent, orally active MET inhibitor (IC50: 9.8 nM) that exhibits good broad-spectrum anti-proliferative effects on cancer cells.Formula:C25H16ClF2N5O2Colore e forma:SolidPeso molecolare:491.88FLT3/ITD-IN-5
CAS:FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Formula:C23H25N7O2Colore e forma:SolidPeso molecolare:431.49HDAC-IN-50
CAS:HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.Formula:C31H41N7O4Colore e forma:SolidPeso molecolare:575.7EVT801
CAS:EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.Formula:C19H21N5O3Purezza:97.4%Colore e forma:SolidPeso molecolare:367.4PF-06250112
CAS:PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.Formula:C22H20F2N6O2Purezza:98%Colore e forma:SolidPeso molecolare:438.43(Rac)-PF-06250112
CAS:(Rac)-PF-0625011 is a racemic mix, orally active, selective BTK inhibitor, also targeting BMX and TEC kinases.Formula:C22H20F2N6O2Purezza:98%Colore e forma:SolidPeso molecolare:438.43DZD1516
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