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Angiogenesi

Angiogenesi

Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.

Sottocategorie di "Angiogenesi"

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Trovati 2061 prodotti di "Angiogenesi"

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  • Protein kinase inhibitor 10
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    Protein kinase inhibitor 10

    CAS:
    Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.
    Formula:C14H9FN6S2
    Colore e forma:Solid
    Peso molecolare:344.39

    Ref: TM-T205111

  • I194496
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    I194496

    CAS:
    <p>I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.</p>
    Formula:C28H23F2N5O5S
    Colore e forma:Solid
    Peso molecolare:579.58

    Ref: TM-T201096

  • Logo CymitQuimica
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    Ki11502

    CAS:
    Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM). It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.
    Formula:C26H23N3O4S
    Peso molecolare:473.54

    Ref: TM-T208725

  • EG31
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    EG31

    CAS:
    EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.
    Formula:C30H13Br2N3O6
    Colore e forma:Solid
    Peso molecolare:671.25

    Ref: TM-T207269

  • Dual Cathepsin L/JAK-IN-1
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    Dual Cathepsin L/JAK-IN-1

    CAS:
    DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).
    Formula:C19H18ClN5
    Colore e forma:Solid
    Peso molecolare:351.833

    Ref: TM-T205041

  • SJ-C1044
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    SJ-C1044

    CAS:
    <p>SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.</p>
    Formula:C25H14F7N7O
    Colore e forma:Solid
    Peso molecolare:561.41

    Ref: TM-T200357

  • Logo CymitQuimica
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    FAK-IN-6

    FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.
    Formula:C25H31ClN5O6PS
    Colore e forma:Solid
    Peso molecolare:596.04

    Ref: TM-T64207

  • LSD1/EGFR-IN-1
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formula:C21H20ClN3O4
    Colore e forma:Solid
    Peso molecolare:413.854

    Ref: TM-T204471

  • ALKBH5-IN-3
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    ALKBH5-IN-3

    CAS:
    ALKBH5-IN-3 (Compound 20m) is a selective ALKBH5 inhibitor (IC50=21 nM), effectively stabilizes ALKBH5 in HepG2 cells and elevates m6A levels in intact cells.
    Formula:C11H7F3N2O3
    Purezza:98.32%
    Colore e forma:Solid
    Peso molecolare:272.18

    Ref: TM-T201322

  • JP-153
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    JP-153

    CAS:
    JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
    Formula:C21H19NO5
    Colore e forma:Solid
    Peso molecolare:365.379

    Ref: TM-T206442

  • Logo CymitQuimica
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    HER2-IN-12

    HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.
    Formula:C17H18BrN5O2S
    Colore e forma:Solid
    Peso molecolare:436.33

    Ref: TM-T62487

  • ALK-IN-31
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    ALK-IN-31

    CAS:
    ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC).
    Formula:C30H33N5O2S
    Colore e forma:Solid
    Peso molecolare:527.68

    Ref: TM-T207183

  • Protein kinase inhibitor 11
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    Protein kinase inhibitor 11

    CAS:
    Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.
    Formula:C21H18FN5O2S
    Colore e forma:Solid
    Peso molecolare:423.463

    Ref: TM-T205016

  • Squalamine
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    Squalamine

    CAS:
    Squalamine is an aminosterol compound, with potent broad spectrum antiviral activity.
    Formula:C34H65N3O5S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:627.96

    Ref: TM-T12995

  • VEGFR-IN-3
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    VEGFR-IN-3

    CAS:
    VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.
    Formula:C27H28N2O6
    Colore e forma:Solid
    Peso molecolare:476.52

    Ref: TM-T63112

  • Logo CymitQuimica
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    EGFR/HER2/DHFR-IN-1

    Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.
    Formula:C14H11BrN4O2S
    Colore e forma:Solid
    Peso molecolare:379.23

    Ref: TM-T61596

  • W23-1006
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    W23-1006

    CAS:
    W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).
    Formula:C17H12BrN3O5
    Colore e forma:Solid
    Peso molecolare:418.198

    Ref: TM-T205034

  • Logo CymitQuimica
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    JAK2/FLT3-IN-1 TFA

    JAK2/FLT3-IN-1 (TFA), an oral JAK2/FLT3 inhibitor, shows anticancer properties; IC50: JAK2 (0.7 nM), FLT3 (4 nM), JAK1 (26 nM), JAK3 (39 nM).
    Formula:C27H35F4N7O3
    Colore e forma:Solid
    Peso molecolare:581.61

    Ref: TM-T64104

  • RGB-286638
    Targetmol
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    RGB-286638

    CAS:
    RGB-286638 inhibits multiple CDKs and GSK-3β, TAK1, Jak2, MEK1 with IC50s as low as 1-54 nM.
    Formula:C29H37Cl2N7O4
    Colore e forma:Solid
    Peso molecolare:618.55

    Ref: TM-T73196

  • Logo CymitQuimica
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    BTK-IN-6

    BTK-IN-6, a potent BTK inhibitor, may treat immune, cardiac, cancer, viral, inflammatory, metabolic, and neurological disorders.
    Formula:C23H22FN5O3
    Colore e forma:Solid
    Peso molecolare:435.45

    Ref: TM-T62472