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Angiogenesi

Angiogenesi

Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.

Sottocategorie di "Angiogenesi"

Mostrare 6 più sottocategorie

Trovati 2040 prodotti di "Angiogenesi"

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  • Logo CymitQuimica
    Targetmol
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    HAT-SIL-TG-1&AT

    HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.
    Formula:C60H69N17O11S
    Colore e forma:Solid
    Peso molecolare:1236.36

    Ref: TM-T74800

  • FGFR1 inhibitor-2
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    FGFR1 inhibitor-2

    CAS:
    FGFR1 inhibitor-2, potent at 4.55 μM IC50 in MDA-MB-231, targets triple-negative breast cancer.
    Formula:C25H22F5N3O3
    Colore e forma:Solid
    Peso molecolare:507.461

    Ref: TM-T39992

  • Lyso-Monosialoganglioside GM3
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    Lyso-Monosialoganglioside GM3

    CAS:
    Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.
    Formula:C41H74N2O20
    Colore e forma:Solid
    Peso molecolare:915.028

    Ref: TM-T206584

  • AKN-028
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    AKN-028

    CAS:
    <p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>
    Formula:C17H14N6
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:302.33

    Ref: TM-T38562

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    MET/PDGFRA-IN-1

    MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.
    Formula:C26H23N7O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:449.51

    Ref: TM-T78843

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    HSK205

    HSK205 is a dual FLT3 and haspin inhibitor, exhibiting potent antitumor activity [1], with an IC50 of 0.187 nM for FLT3.
    Colore e forma:Odour Solid

    Ref: TM-T82169

  • BIIB091
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    BIIB091

    CAS:
    BIIB091 is a highly selective, reversible BTK inhibitor for treating autoimmune diseases.
    Formula:C28H34N10O2
    Colore e forma:Solid
    Peso molecolare:542.648

    Ref: TM-T39761

  • PROTAC BTK Degrader-6
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    PROTAC BTK Degrader-6

    CAS:
    <p>PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression</p>
    Formula:C45H47N11O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:837.92

    Ref: TM-T78782

  • Logo CymitQuimica
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    Gefitinib N-oxide hydrochloride

    Gefitinib N-oxide hydrochloride is an N-oxide of EGFR inhibitor Gefitinib with IC50 of 2-37 nM.
    Formula:C22H24ClFN4O41·5HCl
    Colore e forma:Solid
    Peso molecolare:517.59

    Ref: TM-T73627

  • SNIPER(ABL)-049
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    SNIPER(ABL)-049

    SNIPER(ABL)-049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels,
    Formula:C52H66N10O8
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:959.14

    Ref: TM-T18693

  • AD57
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    AD57

    CAS:
    <p>AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.</p>
    Formula:C22H20F3N7O
    Purezza:99.05%
    Colore e forma:Soild
    Peso molecolare:455.44

    Ref: TM-T22552L

  • Ibrutinib-biotin
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    Ibrutinib-biotin

    CAS:
    <p>Ibrutinib-biotin probe links Ibrutinib to biotin, with IC50 0.755-1.02 nM for BTK (patent WO2014059368A1).</p>
    Formula:C56H80N12O9S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1097.39

    Ref: TM-T18049

  • SJF 1528
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    SJF 1528

    CAS:
    Potent EGFR & HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).
    Formula:C55H57ClFN7O8S
    Colore e forma:Solid
    Peso molecolare:1030.61

    Ref: TM-T36245

  • ALK protein ligand-1
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    ALK protein ligand-1

    CAS:
    ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.
    Formula:C24H29ClN6O3S
    Colore e forma:Solid
    Peso molecolare:517.043

    Ref: TM-T204887

  • Logo CymitQuimica
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    EGFR-TK-IN-5

    EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.
    Formula:C26H20ClFN4OS
    Colore e forma:Solid
    Peso molecolare:490.98

    Ref: TM-T205705

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    BTK ligand-14

    BTKligand-14 is a PROTAC-targeting ligand for BTK, suitable for the synthesis of FDU73.
    Colore e forma:Odour Solid

    Ref: TM-T206576

  • Logo CymitQuimica
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    VnP-16

    VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates
    Formula:C82H112N20O17
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1649.89

    Ref: TM-T80529

  • PROTAC EGFR degrader 6
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    PROTAC EGFR degrader 6

    CAS:
    <p>PROTAC EGFR degrader 6 effectively degrades EGFR Del19 in HCC827 cells (DC50=45.2 nM) and induces apoptosis and G1 arrest.</p>
    Formula:C49H57FN12O5
    Colore e forma:Solid
    Peso molecolare:913.05

    Ref: TM-T74525

  • Logo CymitQuimica
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    MP-RM-1

    MP-RM-1 is a selective murine monoclonal antibody inhibitor that targets the human epidermal growth factor receptor 3 (ErbB-3). It blocks ErbB-3 activation induced by neuregulin 1 (NRG-1β), facilitates ErbB-3 internalization and degradation, and inhibits downstream signaling pathways like PI3K-Akt. MP-RM-1 shows potential for research on ErbB-3-overexpressing solid tumors such as breast cancer, melanoma, and prostate cancer.
    Colore e forma:Odour Liquid

    Ref: TM-T9901A-1055

  • Logo CymitQuimica
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    FGFRs-IN-1

    <p>FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.</p>
    Formula:C28H26Cl2N4O3
    Colore e forma:Solid
    Peso molecolare:537.44

    Ref: TM-T205323