Angiogenesi
Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.
Sottocategorie di "Angiogenesi"
- BTK(163 prodotti)
- Bcr-Abl(117 prodotti)
- EGFR(591 prodotti)
- FAK(72 prodotti)
- FLT(91 prodotti)
- Recettore del fattore di crescita dei fibroblasti (FGFR)(183 prodotti)
- JAK(246 prodotti)
- PDGFR(128 prodotti)
- RAAS(90 prodotti)
- Src(82 prodotti)
- Syk(37 prodotti)
- Trombina(53 prodotti)
- VDA(2 prodotti)
- VEGFR(246 prodotti)
Mostrare 6 più sottocategorie
Trovati 2175 prodotti di "Angiogenesi"
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Depatuxizumab
CAS:Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.Purezza:95%Colore e forma:LiquidApatinib-d8
CAS:Apatinib-d8 is a deuterated compound of Apatinib. Apatinib has a CAS number of 811803-05-1. Apatinib is an orally bioavailable and specific VEGFR2 inhibitor (IC50: 1 nM). In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.Formula:C24H15D8N5OPeso molecolare:405.52Dasatinib-d8
CAS:Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.Formula:C22H26ClN7O2SPurezza:98%Colore e forma:SolidPeso molecolare:496.06Ibrutinib-d5
CAS:Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.Formula:C25H24N6O2Purezza:98%Colore e forma:SolidPeso molecolare:445.53EGFR-IN-109
CAS:EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].Formula:C12H16N4OSColore e forma:SolidPeso molecolare:264.35IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Colore e forma:SolidPeso molecolare:387.39ZM39923
CAS:ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).Formula:C23H25NOPurezza:98%Colore e forma:SolidPeso molecolare:331.45(3S,4S)-Tofacitinib
CAS:(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Formula:C16H20N6OPurezza:98%Colore e forma:SolidPeso molecolare:312.37MAPK-IN-2
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cellFormula:C20H11Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:380.23EGFR-IN-117
CAS:EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.Formula:C25H30BrN7O2SColore e forma:SolidPeso molecolare:572.52Dovitinib Dilactic Acid
CAS:Dovitinib dilactic acid: multitarget RTK inhibitor for FLT3/c-Kit (IC50=1-2 nM), FGFR1/3, VEGFR1-4 (IC50=8-13 nM), less effective on InsR, EGFR. Phase 4.Formula:C21H21FN6O·2C3H6O3Purezza:98%Colore e forma:SolidPeso molecolare:572.59AD1058
CAS:AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.Formula:C19H20N6O3SPurezza:98.24%Colore e forma:SolidPeso molecolare:412.47Ref: TM-T200105
1mg78,00€5mg169,00€10mg264,00€25mg567,00€50mg873,00€100mg1.169,00€200mg1.568,00€1mL*10mM (DMSO)178,00€HVH-2930
CAS:HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.Formula:C29H36N4O3Colore e forma:SolidPeso molecolare:488.62Erlotinib mesylate
CAS:Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.Formula:C23H27N3O7SPurezza:98%Colore e forma:SolidPeso molecolare:489.54ZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formula:C22H19ClFN3O2Purezza:99.43%Colore e forma:SolidPeso molecolare:411.86Ref: TM-T1991
1mg35,00€5mg70,00€10mg101,00€25mg236,00€50mg389,00€100mg582,00€200mg823,00€1mL*10mM (DMSO)72,00€GZD856 formic
CAS:GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.Formula:C30H29F3N6O3Colore e forma:SolidPeso molecolare:578.58ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formula:C23H27N7OColore e forma:SolidPeso molecolare:417.51Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formula:C22H21N3O4Purezza:99.76% - 99.94%Colore e forma:SolidPeso molecolare:391.42Tyrphostin AG 1478
CAS:Prodotto controllato<p>Applications Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.<br></p>Formula:C16H14ClN3O2Colore e forma:NeatPeso molecolare:315.75Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS:Prodotto controllato<p>Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.<br>References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)<br></p>Formula:C24H20ClN5O2Colore e forma:NeatPeso molecolare:445.9
