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Angiogenesi

Angiogenesi

Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.

Sottocategorie di "Angiogenesi"

Mostrare 6 più sottocategorie

Trovati 2121 prodotti di "Angiogenesi"

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  • (Z)-RG-13022
    Targetmol
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    (Z)-RG-13022

    CAS:
    (Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].
    Formula:C16H14N2O2
    Colore e forma:Solid
    Peso molecolare:266.29

    Ref: TM-T84525

  • BTK-IN-18
    Targetmol
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    BTK-IN-18

    CAS:
    BTK-IN-18 is a potent, reversible inhibitor of Bruton's tyrosine kinase (BTK) with an inhibitory concentration (IC50) of 0.002 µM.
    Formula:C20H22Cl2N6O
    Colore e forma:Solid
    Peso molecolare:433.33

    Ref: TM-T73318

  • CT-721
    Targetmol
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    CT-721

    CAS:
    CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.
    Formula:C30H29ClN6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:525.04

    Ref: TM-T10897

  • Logo CymitQuimica
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    EGFR/CSC-IN-1

    CAS:
    EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential
    Formula:C54H54Cl2FN7O7S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1067.08

    Ref: TM-T73995

  • EVT801
    Targetmol
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    EVT801

    CAS:
    EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.
    Formula:C19H21N5O3
    Purezza:97.4%
    Colore e forma:Solid
    Peso molecolare:367.4

    Ref: TM-T73516

  • 15-deoxy-Δ12,14-Prostaglandin D2
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    15-deoxy-Δ12,14-Prostaglandin D2

    CAS:
    15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 µg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.
    Formula:C20H30O4
    Colore e forma:Solid
    Peso molecolare:334.456

    Ref: TM-T84623

  • TIE-2/VEGFR-2 kinase-IN-5
    Targetmol
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    TIE-2/VEGFR-2 kinase-IN-5

    CAS:
    TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.
    Formula:C21H13F6N5O2
    Purezza:99.79%
    Colore e forma:Solid
    Peso molecolare:481.35

    Ref: TM-T79860

  • VEGFR2-IN-3
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    VEGFR2-IN-3

    CAS:
    VEGFR2-IN-3 (compound 385) is a potent inhibitor of VEGFR2 [1].
    Formula:C26H28ClN5O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:509.98

    Ref: TM-T79009

  • Itacnosertib (hydrocholide)
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    Itacnosertib (hydrocholide)

    CAS:
    Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].
    Formula:C26H29ClN8O
    Colore e forma:Solid
    Peso molecolare:505.01

    Ref: TM-T84696

  • EGFR-IN-32
    Targetmol
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    EGFR-IN-32

    CAS:
    EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)
    Formula:C31H34N6O3
    Colore e forma:Solid
    Peso molecolare:538.64

    Ref: TM-T63798

  • Lepzacitinib
    Targetmol
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    Lepzacitinib

    CAS:
    Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.
    Formula:C18H21N5O3
    Purezza:99.85%
    Colore e forma:Solid
    Peso molecolare:355.39

    Ref: TM-T78207

  • BTK-IN-11
    Targetmol
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    BTK-IN-11

    CAS:
    BTK-IN-11: potent BTK inhibitor; may research autoimmune, inflammatory diseases, cancer. (Patent WO2022063101A1, Z2)
    Formula:C26H22ClN5O3
    Colore e forma:Solid
    Peso molecolare:487.94

    Ref: TM-T63254

  • Sulfatinib
    Targetmol
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    Sulfatinib

    CAS:
    <p>Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to</p>
    Formula:C24H28N6O3S
    Purezza:99.21% - >99.99%
    Colore e forma:Solid
    Peso molecolare:480.58

    Ref: TM-T4075

  • GSK2646264
    Targetmol
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    GSK2646264

    CAS:
    <p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>
    Formula:C24H26N2O2
    Colore e forma:Solid
    Peso molecolare:374.48

    Ref: TM-T61527

  • DosatiLink-2
    Targetmol
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    DosatiLink-2

    CAS:
    DosatiLink-2 is an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].
    Formula:C65H85Cl2F2N13O15S
    Colore e forma:Solid
    Peso molecolare:1429.42

    Ref: TM-T82530

  • Logo CymitQuimica
    Targetmol
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    EGFR/HER2-IN-13

    CAS:
    EGFR/HER2-IN-13 (Compd 38) serves as an inhibitor targeting mutant EGFR/HER2s that show resistance to existing drugs. It is primarily utilized in cancer research.
    Formula:C27H36N8O3
    Peso molecolare:520.63

    Ref: TM-T88051

  • N-desmethyl Regorafenib N-oxide
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    N-desmethyl Regorafenib N-oxide

    CAS:
    N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.
    Formula:C20H13ClF4N4O4
    Colore e forma:Solid
    Peso molecolare:484.79

    Ref: TM-T84977

  • GW-6604
    Targetmol
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    GW-6604

    CAS:
    GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
    Formula:C19H14N4
    Purezza:99.6%
    Colore e forma:Solid
    Peso molecolare:298.34

    Ref: TM-T9947

  • Atiprimod (free base)
    Targetmol
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    Atiprimod (free base)

    CAS:
    Atiprimod: an oral azaspirane inhibiting STAT3, blocking IL-6/VEGF pathways, and promoting apoptosis by downregulating Bcl-2 and Mcl-1.
    Formula:C22H44N2
    Colore e forma:Solid
    Peso molecolare:336.6

    Ref: TM-T71176

  • BT424
    Targetmol
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    BT424

    CAS:
    BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].
    Formula:C22H15BCl2N2O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:421.08

    Ref: TM-T79516