Angiogenesi
Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.
Sottocategorie di "Angiogenesi"
- BTK(157 prodotti)
- Bcr-Abl(113 prodotti)
- EGFR(596 prodotti)
- FAK(72 prodotti)
- FLT(88 prodotti)
- Recettore del fattore di crescita dei fibroblasti (FGFR)(180 prodotti)
- JAK(246 prodotti)
- PDGFR(126 prodotti)
- RAAS(90 prodotti)
- Src(81 prodotti)
- Syk(37 prodotti)
- Trombina(52 prodotti)
- VDA(2 prodotti)
- VEGFR(250 prodotti)
Mostrare 6 più sottocategorie
Trovati 2002 prodotti di "Angiogenesi"
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VEGFR-2-IN-19
CAS:VEGFR-2-IN-19 (15b) effectively inhibits VEGFR2, induces apoptosis, and increases oxidative stress, showing potential as an anticancer drug.Formula:C21H19N3O2Colore e forma:SolidPeso molecolare:345.39JG26
CAS:JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively,Formula:C19H22Br2N4O6SPurezza:98.79% - 99.08%Colore e forma:SolidPeso molecolare:594.27YLT192
CAS:<p>YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.</p>Formula:C21H19N3O4Purezza:98%Colore e forma:SolidPeso molecolare:377.39EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formula:C36H44BrN10O2PColore e forma:SolidPeso molecolare:759.68JBJ-04-125-02
CAS:JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formula:C29H26FN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:543.61DS21360717
CAS:DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Formula:C21H23N7OPurezza:98%Colore e forma:SolidPeso molecolare:389.45Tyk2-IN-5
CAS:Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Formula:C21H19FN8O2Purezza:98%Colore e forma:SolidPeso molecolare:434.43JAK3/BTK-IN-6
CAS:JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.Formula:C21H17BF3N5O3Colore e forma:SolidPeso molecolare:455.2NSC 33994
CAS:NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Formula:C28H42N2O2Purezza:98%Colore e forma:SolidPeso molecolare:438.65TG53
CAS:TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.Formula:C21H22ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:411.88Thi-DPPY
CAS:Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.Formula:C28H28ClN5O4SColore e forma:SolidPeso molecolare:566.07M1002
CAS:<p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>Formula:C15H8F6N2O2SPurezza:99.95%Colore e forma:SolidPeso molecolare:394.29UNC-CA359
CAS:UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formula:C18H14ClN3O2Colore e forma:SolidPeso molecolare:339.78CAY10717
CAS:CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formula:C29H25F3N6O3Colore e forma:SolidPeso molecolare:562.54EGFR-IN-52
CAS:EGFR-IN-52, a potent EGFR inhibitor, has IC50s: 0.358 μM (wild-type), 86.02 μM (L858R-TK), 432.67 μM (T790M-TK); induces cancer cell apoptosis.Formula:C19H18N4O3SColore e forma:SolidPeso molecolare:382.44EGFR/HER2/CDK9-IN-3
CAS:<p>EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.</p>Formula:C24H21N3O4S2Colore e forma:SolidPeso molecolare:479.57VEGFR-2-IN-22
CAS:VEGFR-2-IN-22 blocks VEGFR-2/beta-tubulin, IC50=19.82 nM, induces apoptosis.Formula:C26H24ClFN4O6Colore e forma:SolidPeso molecolare:542.94HSP90-IN-13
CAS:HSP90-IN-13 (5k): potent HSP90 inhibitor, IC50 25.07 nM, targets EGFR/VEGFR-2/Topo-2, blocks MCF-7 G2/M cycle, induces apoptosis.Formula:C26H21N5O3SColore e forma:SolidPeso molecolare:483.54CPL304110
CAS:CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.Formula:C25H30N6O2Colore e forma:SolidPeso molecolare:446.54EGFR-IN-57
CAS:EGFR-IN-57: potent EGFR-TK blocker, IC50 0.054 μM, oral. Halts VEGFR-2, CK2α, topo IIβ, tubulin. Causes G2/M, pre-G1 arrest, cancer cell death.Formula:C22H15N3O2SColore e forma:SolidPeso molecolare:385.44Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formula:C25H22ClFN6O2SPurezza:98.45%Colore e forma:SolidPeso molecolare:525E-4177
CAS:E-4177 is an angiotensin II type 1 receptor (AT1R) antagonist and can be used to study cardiovascular diseases.Formula:C24H21N3O2Purezza:98.67% - 99.57%Colore e forma:SolidPeso molecolare:383.44ProMMP-9 inhibitor-3c
CAS:<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Formula:C18H20FN3O2SColore e forma:SolidPeso molecolare:361.43EGFR-IN-39
CAS:EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Formula:C24H25ClN6O3Colore e forma:SolidPeso molecolare:480.95MG-262
CAS:<p>MG-262 is a reversible proteasome inhibitor with multiple biological activities [1] [2] [3].</p>Formula:C25H42BN3O6Colore e forma:SolidPeso molecolare:491.43BI-1622
CAS:BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.Formula:C26H24N10O2Colore e forma:SolidPeso molecolare:508.53PHM16
CAS:PHM16 is an ATP competitive FAK and FGFR2 inhibitor.Formula:C20H22N6O4Purezza:98%Colore e forma:SolidPeso molecolare:410.43Peficitinib hydrobromide
CAS:Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.Formula:C18H23BrN4O2Colore e forma:SolidPeso molecolare:407.312EGFR-IN-53
CAS:EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formula:C14H13N3O2SColore e forma:SolidPeso molecolare:287.34Ficonalkib
CAS:Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Formula:C29H39N7O3SColore e forma:SolidPeso molecolare:565.73EGFR/CDK2-IN-1
CAS:EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFormula:C19H12BrClO2Colore e forma:SolidPeso molecolare:387.65BTK-IN-23
CAS:BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.Formula:C27H28N6O2Colore e forma:SolidPeso molecolare:468.55SMU-B
CAS:<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Formula:C26H25Cl2FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:515.41BI1002494
CAS:BI1002494 is an effective and selective Syk inhibitor.Formula:C23H25N3O5Purezza:98%Colore e forma:SolidPeso molecolare:423.46JAK3-IN-12
CAS:<p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>Formula:C19H19N5O4SColore e forma:SolidPeso molecolare:413.45Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Formula:C27H52BrN8O3PPurezza:98%Colore e forma:SolidPeso molecolare:647.644FGFR-IN-3
CAS:FGFR-IN-3: potent, oral FGFR modulator, BBB-penetrating, neuroprotective, potential in neurodegeneration study.Formula:C18H27F2N5O2Colore e forma:SolidPeso molecolare:383.44Ebselen oxide
CAS:Ebselen oxide (EB-2) is a HER2 inhibitor with antibacterial and antifungal activity and has shown cytoprotective effects against HN2 in vitro.Formula:C13H9NO2SePurezza:98%Colore e forma:SolidPeso molecolare:290.18EGFR/HER2-IN-9
CAS:EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFormula:C25H25ClFN5O4Colore e forma:SolidPeso molecolare:513.95TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Formula:C23H17N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:427.48CHMFL-ABL-053
CAS:CHMFL-ABL-053: potent, selective BCR-ABL/SRC/p38 inhibitor (IC50: 70/90/62 nM). Orally available, potential CML drug.Formula:C28H26F3N7O2Colore e forma:SolidPeso molecolare:549.55Derazantinib Racemate
CAS:Derazantinib Racemate is an oral ATP competitive kinase inhibitor targeting FGFR1/2/3 (IC50s: 4.5/1.8/4.5 nM).Formula:C29H29FN4OPurezza:98%Colore e forma:SolidPeso molecolare:468.57EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Formula:C10H6N6S2Colore e forma:SolidPeso molecolare:274.32RO9021
CAS:RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).Formula:C18H25N7OPurezza:99.90%Colore e forma:SolidPeso molecolare:355.44Lorpucitinib
CAS:Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.Formula:C22H28N6O2Purezza:99.72%Colore e forma:SolidPeso molecolare:408.5EMI48
CAS:EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Formula:C21H20N2O3Colore e forma:SolidPeso molecolare:348.4PDGFRα/FLT3-ITD-IN-3
CAS:PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to beFormula:C26H39N9Colore e forma:SolidPeso molecolare:477.65EGFR-IN-40
CAS:EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM).Formula:C23H20N6O3Colore e forma:SolidPeso molecolare:428.44CS12192
CAS:CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Formula:C25H23ClFN7O2Colore e forma:SolidPeso molecolare:507.95Lck Inhibitor III
CAS:Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM.Formula:C25H30N6O4Colore e forma:SolidPeso molecolare:478.54EGFR-IN-56
CAS:EGFR-IN-56 (13a) inhibits EGFR, EGFRT790M (IC50: 541.7nM), EGFRT790M/L858R (IC50: 132.1nM), blocks G2/M phase, and triggers apoptosis.Formula:C23H22N4O3SColore e forma:SolidPeso molecolare:434.51KL-1156
CAS:KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.Formula:C17H17NO4Purezza:98%Colore e forma:SolidPeso molecolare:299.32(E/Z)-AG490
CAS:(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Formula:C17H14N2O3Colore e forma:SolidPeso molecolare:294.3EGFR/C797S-IN-1
CAS:EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Formula:C28H30N4O3Colore e forma:SolidPeso molecolare:470.56TM-233
CAS:TM-233 is an inhibitor of both JAK/STAT and proteasome activities that acts by inducing cell death in myeloma cells.Formula:C25H20O4Purezza:98%Colore e forma:SolidPeso molecolare:384.42pan-HER-IN-2
CAS:pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that acts on EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50Formula:C19H15BrClN5OColore e forma:SolidPeso molecolare:444.71K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Formula:C15H13F2N7O2S2Purezza:99.12%Colore e forma:SolidPeso molecolare:425.44BLK-IN-2
CAS:<p>BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。</p>Formula:C39H41N9O3Colore e forma:SolidPeso molecolare:683.8BCR-ABL-IN-2
CAS:BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).Formula:C24H25Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:502.39FLT3-IN-11
CAS:FLT3-IN-11, an oral FLT3 kinase inhibitor: potent, selective, IC50 - wild-type 7.22 nM, FLT3-D835Y 4.95 nM, anti-AML IC50 3.2 nM for MV4-11.Formula:C20H25F3N6OColore e forma:SolidPeso molecolare:422.45Antiproliferative agent-30
CAS:Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM againstFormula:C24H26N4O4Colore e forma:SolidPeso molecolare:434.49TC-S 7003
CAS:TC-S 7003 (Lck Inhibitor) is a Lck inhibitor with anti-inflammatory activity that inhibits T-cell proliferation and can be used to study arthritis.Formula:C31H30N8OPurezza:99.74%Colore e forma:SolidPeso molecolare:530.62MAX-40279 hemifumarate
CAS:<p>MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.</p>Formula:C48H50F2N12O6S2Colore e forma:SolidPeso molecolare:993.12TG 100801 Hydrochloride
CAS:TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.Formula:C33H31Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:616.54BTK-IN-22
CAS:BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.Formula:C26H26N6O2Colore e forma:SolidPeso molecolare:454.52ZK-261991
CAS:<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Formula:C24H25N7O2Purezza:98%Colore e forma:SolidPeso molecolare:443.5EGFR-IN-63
CAS:EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Formula:C20H12BrN5SColore e forma:SolidPeso molecolare:434.31PHA-680626
CAS:PHA-680626 is a PLK inhibitor, effective on resistant leukemia cells, with IC50: Plk1 (0.53 μM), Plk2 (0.07 μM), Plk3 (1.61 μM).Formula:C23H26N6O2SColore e forma:SolidPeso molecolare:450.56GDC-4379
CAS:GDC-4379 is a JAK1 inhibitor that can be used to study asthma.Formula:C21H18ClF2N7O3Colore e forma:SolidPeso molecolare:489.86Atopaxar Hydrobromide
CAS:Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Formula:C29H39BrFN3O5Purezza:98%Colore e forma:SolidPeso molecolare:608.54Luxeptinib
CAS:<p>Luxeptinib (CG-806) is an oral, non-covalent pan-FLT3/BTK inhibitor for acute myeloid leukemia.</p>Formula:C25H17F4N5O2Colore e forma:SolidPeso molecolare:495.43BCR-ABL-IN-5
CAS:BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.Formula:C25H21Cl2N5O2Colore e forma:SolidPeso molecolare:494.37FLT3/ITD-IN-2
CAS:<p>FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.</p>Formula:C23H26F3N7O2Colore e forma:SolidPeso molecolare:489.49EGFR-IN-64
CAS:EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Formula:C20H21N3O3Colore e forma:SolidPeso molecolare:351.4FLT3/CDK4-IN-1
CAS:FLT3/CDK4-IN-1: Oral FLT3 (7 nM IC50) & CDK4 (11 nM IC50) inhibitor with strong in vivo anti-cancer properties.Formula:C25H28F2N8Colore e forma:SolidPeso molecolare:478.54α7 nAchR-JAK2-STAT3 agonist 1
CAS:α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM).Formula:C25H30O6Colore e forma:SolidPeso molecolare:426.5CAY10583
CAS:CAY10583 is a selective BLT2 agonist that increases TGF-β1 and bFGF, promotes keratinocyte migration, accelerates wound healing in diabetic mice.Formula:C25H25NO3Purezza:98%Colore e forma:SolidPeso molecolare:387.47VEGFR-2-IN-6
CAS:VEGFR-2-IN-6 (WO 02/059110, example 64) is a potent inhibitor of VEGFR2, a crucial receptor involved in the regulation of angiogenesis [1].Formula:C20H21N7O2SPurezza:99.01%Colore e forma:SolidPeso molecolare:423.49AFG206
CAS:AFG206 is the novel first-generation type II" FLT3 inhibitor."Formula:C20H19N3O2Colore e forma:SolidPeso molecolare:333.38ON 146040
CAS:ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.Formula:C24H23N7O3SPurezza:97.39%Colore e forma:SolidPeso molecolare:489.55AGL 2043
CAS:AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.Formula:C15H12N4SColore e forma:SolidPeso molecolare:280.35Lck-IN-1
CAS:Lck-IN-1 is a potent inhibitor of lymphocyte protein tyrosine kinase (Lck) [1].Formula:C14H15N5Colore e forma:SolidPeso molecolare:253.3PD 173955-Analog1
CAS:PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.Formula:C21H14Cl2N4O3Colore e forma:SolidPeso molecolare:441.27VEGFR-2-IN-23
CAS:VEGFR-2-IN-23 (11b) is a potent VEGFR-2 inhibitor with an IC50 of 0.34 nM, exhibits antitumor effects, and causes G1 cell cycle arrest.Formula:C22H15N5O2Colore e forma:SolidPeso molecolare:381.39Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurezza:99.14%Colore e forma:SolidPeso molecolare:236.23AFG210
CAS:AFG210 is a novel first-generation “type II” FLT3 inhibitor.Formula:C19H14F3N3O2Colore e forma:SolidPeso molecolare:373.33Spebrutinib besylate
CAS:Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).Formula:C28H28FN5O6SPurezza:98%Colore e forma:SolidPeso molecolare:581.62LDC0496
CAS:LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formula:C32H35N5O3Colore e forma:SolidPeso molecolare:537.65EGFR/HER2/TS-IN-1
CAS:EGFR/HER2/TS-IN-1 inhibits EGFR (0.203 μM), HER2 (0.088 μM), TS (0.168 μM), and induces apoptosis in MCF7 cells.Formula:C24H15N5O4S2Colore e forma:SolidPeso molecolare:501.54EGFR/BRAFV600E-IN-1
CAS:EGFR/BRAFV600E-IN-1 inhibits EGFR (0.08 μM) & BRAFV600E (0.15 μM), affects A-549, MCF-7, Panc-1 & HT-29 (IC50: 0.79-1.3 μM).Formula:C24H24ClN3O3Colore e forma:SolidPeso molecolare:437.92MAX-40279
CAS:MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.Formula:C22H23FN6OSColore e forma:SolidPeso molecolare:438.52RG 14467
CAS:RG 14467 is an antagonist of epidermal growth factor-urogastrone.Formula:C14H14N2O3Colore e forma:SolidPeso molecolare:258.27EGFR/HER2/CDK9-IN-1
CAS:EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.Formula:C23H21N3O3S2Colore e forma:SolidPeso molecolare:451.56(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formula:C27H27N5O3Purezza:98%Colore e forma:SolidPeso molecolare:469.54AhR modulator-1
CAS:AhR modulator-1: orally active, selective, inhibits metastasis and prostatic VEGF, anti-estrogenic in rat uterus.Formula:C13H7Cl3OPurezza:98%Colore e forma:SolidPeso molecolare:285.55BCR-ABL1-IN-1
CAS:BCR-ABL1-IN-1: potent, orally active ABL kinase inhibitor with high specificity, promising for CNS research.Formula:C18H12F3N3O2Colore e forma:SolidPeso molecolare:359.3Sch 13835
CAS:Sch 13835 is an inhibitor of platelet derived growth factor.Formula:C15H10ClNO4SPurezza:98%Colore e forma:SolidPeso molecolare:335.76PDGFRα kinase inhibitor 1
CAS:PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.Formula:C34H34N8O2Purezza:99.78%Colore e forma:SolidPeso molecolare:586.69EL-102
CAS:EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can be used to study prostate cancer.Formula:C19H16N2O3S2Purezza:99.34%Colore e forma:SolidPeso molecolare:384.47PF-00956980
CAS:PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Formula:C18H26N6OColore e forma:SolidPeso molecolare:342.44TK4b
CAS:TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).Formula:C21H22N2O2Colore e forma:SolidPeso molecolare:334.41BIBX 1382 Dihydrochloride
CAS:BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Formula:C18H21Cl3FN7Colore e forma:SolidPeso molecolare:460.76HS-438
CAS:HS-438 inhibits imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.Formula:C17H17N3O3SColore e forma:SolidPeso molecolare:343.4PDZ1i
CAS:PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Formula:C28H26N8O4Colore e forma:SolidPeso molecolare:538.56VEGFR-2-IN-21
CAS:VEGFR-2-IN-21 is a potent inhibitor of VEGFR-2 (IC50: 0.10 μM) and exhibits anticancer effects.Formula:C28H24ClN7O3SColore e forma:SolidPeso molecolare:574.05FAK-IN-5
CAS:FAK-IN-5 is a FAK signaling inhibitor that induces apoptosis and autophagy.Formula:C29H29ClF3N3O4Colore e forma:SolidPeso molecolare:576.01Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formula:C29H35FN8O3Purezza:98%Colore e forma:SolidPeso molecolare:562.64Con B-1
CAS:ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .Formula:C38H52ClN7O6SColore e forma:SolidPeso molecolare:770.38MAX-40279 hydrochloride
CAS:MAX-40279 HCl: potent FLT3/FGFR inhibitor; potential in AML research.Formula:C22H24ClFN6OSColore e forma:SolidPeso molecolare:474.98VEGFR-2/BRAF-IN-2
<p>VEGFR-2/BRAF-IN-2 inhibits VEGFR-2, BRAF V600E, BRAF WT (IC50: 0.111/0.089/0.071 µM); induces G1 arrest and apoptosis.</p>Formula:C26H21ClF3N5O3S2Colore e forma:SolidPeso molecolare:608.05BSc5371
CAS:BSc5371: Irreversible FLT3 inhibitor; Kds 0.83-5.8 nM for various FLT3 mutants including wild type.Formula:C24H31N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:485.6EGFR/HER2/TS-IN-2
CAS:EGFR/HER2/TS-IN-2: Strong EGFR, HER2 & TS inhibitor; EGFR IC50=0.173μM, HER2 IC50=0.125μM, TS IC50=1.12μM; kills MDA-MB-231 cells (IC50=1.69μM).Formula:C26H21N7OS2Colore e forma:SolidPeso molecolare:511.62PP2 Analog
CAS:PP2 Analog is an analog of PP2. It also acts as a protein trafficking modulator.Formula:C16H17ClN4Purezza:98%Colore e forma:SolidPeso molecolare:300.79Cyt-PTPε Inhibitor-1
CAS:Cyt-PTPε Inhibitor-1 (A Inhibitor-1) is an inhibitor of cytosolic protein tyrosine phosphatase ε.Formula:C19H20N4O2SPurezza:99.55% - 99.82%Colore e forma:SolidPeso molecolare:368.45Adhesamine
CAS:Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.Formula:C24H32Cl4N8O2S2Colore e forma:SolidPeso molecolare:670.51Povorcitinib
CAS:Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Formula:C23H22F5N7OColore e forma:SolidPeso molecolare:507.469T338C Src-IN-2
CAS:T338C Src-IN-2: Potent c-Src T338C kinase inhibitor; IC50: 317 nM, T338C/V323A: 57 nM, T338C/V323S: 19 nM.Formula:C17H18FN5OPurezza:98%Colore e forma:SolidPeso molecolare:327.36Nuvenzepine
CAS:Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.Formula:C19H20N4O2Purezza:98%Colore e forma:SolidPeso molecolare:336.39FM19G11
CAS:<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Formula:C23H17N3O8Purezza:99.70%Colore e forma:SolidPeso molecolare:463.4JS25
CAS:JS25, a selective BTK inhibitor, inactivates it with a 5.8 nM IC50, halts cancer cell growth, induces death, and aids against lymphoma.Formula:C29H24N4O4SColore e forma:SolidPeso molecolare:524.59pan-HER-IN-1
CAS:<p>Compound C5: Irreversible, oral pan-HER inhibitor with low IC50s for EGFR/HERs; induces apoptosis and has antitumor effects.</p>Formula:C19H14BrN5OColore e forma:SolidPeso molecolare:408.25EGFR-IN-68
CAS:EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Formula:C24H22N2OColore e forma:SolidPeso molecolare:354.44JAK3-IN-1
CAS:JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formula:C26H30ClN7O2Colore e forma:SolidPeso molecolare:508.02FAK inhibitor 2
CAS:FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .Formula:C29H33F3N8O2S2Colore e forma:SolidPeso molecolare:646.75Cenisertib benzoate
CAS:Cenisertib benzoate is an orally bioavailable, synthetic, small-molecule multi-Aurora kinase inhibitor with potential antineoplastic activity.Formula:C31H36FN7O3Colore e forma:SolidPeso molecolare:573.66AAE871
CAS:<p>AAE871 is a type I FLT3 inhibitor.</p>Formula:C24H34N8O2SColore e forma:SolidPeso molecolare:498.64PD173952
CAS:PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.Formula:C24H21Cl2N5O2Purezza:99.5%Colore e forma:SolidPeso molecolare:482.36PDGFRα/FLT3-ITD-IN-2
CAS:PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM).Formula:C28H41N9OColore e forma:SolidPeso molecolare:519.68DMH4
CAS:DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM.Formula:C24H24N4O2Purezza:99.58%Colore e forma:SolidPeso molecolare:400.47FAK inhibitor 5
CAS:FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.Formula:C20H21N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:367.46(2R,5S)-Ritlecitinib
CAS:(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].Formula:C15H19N5OColore e forma:SolidPeso molecolare:285.34S116836
CAS:S116836 is a tyrosine kinase inhibitor.Formula:C27H21F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:502.49TX-1918
CAS:TX-1918, a tyrphostin, blocks eEF-2K to hinder HepG2, HCT116 cell growth.Formula:C14H12O3Colore e forma:SolidPeso molecolare:228.24RG 14921
CAS:RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Formula:C11H9NO3Colore e forma:SolidPeso molecolare:203.19VEGFR-2-IN-30
VEGFR-2-IN-30: VEGFR-2 inhibitor, IC50 66 nM; blocks PDGFR, EGFR & FGFR1; halts cancer cell cycle, induces apoptosis.Formula:C28H23ClN6O4S2Colore e forma:SolidPeso molecolare:607.1FGFR3-IN-5
CAS:<p>FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.</p>Formula:C24H24FN7O3Colore e forma:SolidPeso molecolare:477.49BTK-IN-24
CAS:BTK-IN-24 is a Bruton's tyrosine kinase (BTK) inhibitor with potential anticancer activity, and it can be used in the study of myeloproliferative disorders.Formula:C26H19F4N5O2Purezza:99.61%Colore e forma:SolidPeso molecolare:509.46Multi-kinase-IN-3
CAS:Multi-kinase-IN-3 (compound 2) is a potent inhibitor of angiokinase and inhibits VEGFR-2 (IC50: 58.3 nM) and PDGFRβ (IC50: 55 nM).Formula:C33H33N5O3Colore e forma:SolidPeso molecolare:547.65Debio 0617B
CAS:Debio 0617B inhibits kinases for AML stem cell treatment, targeting JAK, ABL, SRC, and STAT3-related tumours.Formula:C28H23ClF3N7O2Colore e forma:SolidPeso molecolare:581.98VEGFR-2-IN-28
CAS:VEGFR-2-IN-28 is a potent inhibitor of VEGFR-2 (IC50: 0.83 μM). VEGFR-2-IN-28 induces apoptosis and exhibits antitumor effects.Formula:C26H17N7O7Colore e forma:SolidPeso molecolare:539.46YF-452
CAS:YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling.Formula:C24H26BrN3OPurezza:98%Colore e forma:SolidPeso molecolare:452.39QL-X-138
CAS:<p>QL-X-138: Dual BTK/MNK inhibitor; covalent to BTK, IC50=9.4 nM; non-covalent to MNK1/2, IC50=107.4/26 nM; dengue virus 2 IC50=3.5 μM; for B-cell malignancies.</p>Formula:C25H19N5O2Purezza:98.82% - 99.50%Colore e forma:SolidPeso molecolare:421.45CGP60474
CAS:CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Formula:C18H18ClN5OPurezza:98.81%Colore e forma:SolidPeso molecolare:355.82FGFR2-IN-1
CAS:FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used to study FGFR2-associated cancers.Formula:C22H19N3O2Purezza:98.71%Colore e forma:SolidPeso molecolare:357.41BLK degrader 1
CAS:<p>BLK degrader 1 is a BLK degrader with anticancer activity for cancer research.</p>Formula:C32H25F3N6O2Purezza:99.22% - 99.24%Colore e forma:SolidPeso molecolare:582.58TUL01101
CAS:TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.Formula:C22H25F2N5O2Colore e forma:SolidPeso molecolare:429.46OXSI-2
CAS:OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.Formula:C18H15N3O3SPurezza:98%Colore e forma:Dark Orange SolidPeso molecolare:353.39JAK-IN-20
CAS:JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.Formula:C28H30FN7O2Colore e forma:SolidPeso molecolare:515.58c-Met-IN-11
CAS:c-Met-IN-11 is a potent inhibitor of c-MET (IC50: 41.4 nM) and VEGFR-2 (IC50: 71.1 nM).Formula:C30H20F2N4O3Colore e forma:SolidPeso molecolare:522.5TOP1210
CAS:TOP1210, a narrow spectrum kinase inhibitor, potently inhibits P38α, Src, and Syk kinase activities.Formula:C45H48N8O6Colore e forma:SolidPeso molecolare:796.91FLT3-IN-17
CAS:FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.Formula:C23H24N6O2S2Colore e forma:SolidPeso molecolare:480.61KRC-108
CAS:KRC-108 is a potent kinase inhibitor targeting Ron, Flt3, TrkA, and c-Met with strong anti-proliferative effects on various cancer cells.Formula:C20H20N6OColore e forma:SolidPeso molecolare:360.41EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formula:C19H15N3O2SPurezza:99.94%Colore e forma:SolidPeso molecolare:349.41HP1328
CAS:HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.Formula:C23H23N3O3Colore e forma:SolidPeso molecolare:389.45DMPQ dihydrochloride
CAS:PDGFRβ inhibitorFormula:C16H16Cl2N2O2Purezza:99.51%Colore e forma:SolidPeso molecolare:339.22MMPP
CAS:MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.Formula:C17H18O3Purezza:99.31% - 99.83%Colore e forma:SolidPeso molecolare:270.32HKI-357 dimaleate
CAS:HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formula:C39H37ClFN5O11Colore e forma:SolidPeso molecolare:806.2Aminoquinuride
CAS:Surfen, or Aminoquinuride, reduces inflammation but blocks remyelination in MS mouse models and regulates murine T cell activation.Formula:C21H20N6OColore e forma:SolidPeso molecolare:372.42TK4g
CAS:<p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.</p>Formula:C19H19N3O4SColore e forma:SolidPeso molecolare:385.44Peficitinib hydrochloride
CAS:Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).Formula:C18H23ClN4O2Colore e forma:SolidPeso molecolare:362.86XST-14
CAS:XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.Formula:C16H21NO4Purezza:99.84% - 99.84%Colore e forma:SolidPeso molecolare:291.34ZK-304709 HCl
CAS:ZK-304709 is an oral multitarget tumor growth inhibitor with activity against cell-cycle progression and angiogenesis.Formula:C22H29ClN6O2Colore e forma:SolidPeso molecolare:444.96UniPR1331
CAS:UniPR1331 is a novel selective antagonist of the Eph-ephrin system.Formula:C35H48N2O4Colore e forma:SolidPeso molecolare:560.77BPIQ-II (hydrochloride)
CAS:BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Formula:C15H11BrClN5Colore e forma:SolidPeso molecolare:376.64EGFR-IN-67
CAS:EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formula:C18H17N3SColore e forma:SolidPeso molecolare:307.41PDGFRα/FLT3-ITD-IN-1
CAS:PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively.Formula:C27H39N9OColore e forma:SolidPeso molecolare:505.66ACP-5862
CAS:ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.Formula:C26H23N7O3Colore e forma:SolidPeso molecolare:481.51TYRA-200
CAS:TYRA-200 is an effective oral inhibitor of FGFR1/2/3. In both wild-type FGFR2 and FGFR2 mutant models, TYRA-200 can produce tumor regression effects in a dose-dependent manner. TYRA-200 can be used in the research of advanced or metastatic intrahepatic cholangiocarcinoma and other solid tumors driven by FGFR2.Formula:C23H24FN7O2Peso molecolare:449.48Squarunkin A hydrochloride
CAS:Squarunkin A HCl inhibits UNC119-cargo binding, specifically blocks Src kinase activation, IC50=10 nm.Formula:C25H33ClF3N5O4Colore e forma:SoildPeso molecolare:560.02JAK-2/3-IN-2
CAS:JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).Formula:C19H19ClN2OSColore e forma:SolidPeso molecolare:358.89NVP-AAD777
CAS:NVP-AAD777 is a specific VEGFR-2 inhibitor.Formula:C22H14F6N4Purezza:98%Colore e forma:SolidPeso molecolare:448.36JNJ-64264681
CAS:JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Formula:C27H30N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:518.63THS-044
CAS:THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFormula:C11H12F3N3O3Purezza:99.89%Colore e forma:SolidPeso molecolare:291.23JNJ-47117096 hydrochloride
CAS:JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.Formula:C21H23ClN4O2Colore e forma:SolidPeso molecolare:398.89NSC114126
CAS:<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formula:C22H20O4Colore e forma:SolidPeso molecolare:348.39AC430
CAS:AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.Formula:C19H16FN5OColore e forma:SolidPeso molecolare:349.36JNJ28871063 hydrochloride
CAS:ErbB receptor family inhibitorFormula:C24H28Cl2N6O3Purezza:98%Colore e forma:SolidPeso molecolare:519.42BTK inhibitor 10
CAS:BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.Formula:C25H23N5O3Purezza:98%Colore e forma:SolidPeso molecolare:441.48AC710 Mesylate
CAS:AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).Formula:C32H46N6O7SPurezza:98%Colore e forma:SolidPeso molecolare:658.81Atopaxar
CAS:<p>Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Formula:C29H38FN3O5Purezza:97.07% - 98.07%Colore e forma:SolidPeso molecolare:527.63J-1048
CAS:J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Formula:C23H17FN6S2Colore e forma:SolidPeso molecolare:460.55RTC-5
CAS:RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formula:C24H22ClF3N2O3SPurezza:98.14%Colore e forma:SolidPeso molecolare:510.96RK-20448
CAS:RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259Formula:C29H34N6OColore e forma:SolidPeso molecolare:482.62GDC-0834 S-enantiomer
CAS:GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK).Formula:C33H36N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:596.74ZD4190 HCl
CAS:ZD-4190, a potent VEGFR inhibitor, prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.Formula:C19H17BrClFN6O2Purezza:98%Colore e forma:SolidPeso molecolare:495.73Tyrphostin 51
CAS:Tyrphostin 51 is an effective inhibitor of EGFR kinase.Formula:C13H8N4O3Purezza:98%Colore e forma:SolidPeso molecolare:268.23ALK-IN-21
CAS:ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Formula:C35H45ClN6O6S4Colore e forma:SolidPeso molecolare:809.48HZ-A-005
CAS:HZ-A-005 is a selective, potent, covalent inhibitor of Bruton's tyrosine kinase (BTK). HZ-A-005 significantly inhibits tumour growth in a xenograft mouse model.Formula:C25H23ClN6O2Colore e forma:SolidPeso molecolare:474.94JAK-IN-18
CAS:<p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>Formula:C27H28F2N6O3Colore e forma:SolidPeso molecolare:522.55ALK5-IN-29
CAS:<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formula:C19H18BrClN6OPurezza:97.03%Colore e forma:SolidPeso molecolare:461.74AXL-IN-13
CAS:AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.Formula:C34H41FN6O5Purezza:99.95%Colore e forma:SolidPeso molecolare:632.72Flonoltinib
CAS:<p>Flonoltinib (JAK2/FLT3-IN-1) is an orally active and efficient JAK2/FLT3 inhibitor with anti-cancer properties.</p>Formula:C25H34FN7OPurezza:99.52%Colore e forma:SolidPeso molecolare:467.58c-ABL-IN-2
CAS:C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.Formula:C21H20N4OColore e forma:SolidPeso molecolare:344.41SDZ281-977
CAS:SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formula:C18H20O5Purezza:99.64%Colore e forma:SolidPeso molecolare:316.35MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formula:C47H56ClFN8O8Colore e forma:SolidPeso molecolare:915.45EGFR-IN-50
CAS:EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Formula:C24H26BrN3O4S2Colore e forma:SolidPeso molecolare:564.51JAK3-IN-9
CAS:JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.Formula:C17H23N5O4SColore e forma:SolidPeso molecolare:393.46JAK-IN-14
CAS:<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Formula:C19H15FN4OPurezza:98.27%Colore e forma:SolidPeso molecolare:334.35
