Angiogenesi
Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.
Sottocategorie di "Angiogenesi"
- BTK(167 prodotti)
- Bcr-Abl(119 prodotti)
- EGFR(590 prodotti)
- FAK(71 prodotti)
- FLT(87 prodotti)
- Recettore del fattore di crescita dei fibroblasti (FGFR)(183 prodotti)
- JAK(236 prodotti)
- PDGFR(130 prodotti)
- RAAS(91 prodotti)
- Src(82 prodotti)
- Syk(37 prodotti)
- Trombina(59 prodotti)
- VDA(2 prodotti)
- VEGFR(252 prodotti)
Mostrare 6 più sottocategorie
Trovati 2327 prodotti per "Angiogenesi". Vengono mostrati i primi 500.
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SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formula:C36H36N10O5Colore e forma:SolidPeso molecolare:688.74hCA/VEGFR-2-IN-4
hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic anhydrases hCA IX/Formula:C22H23FN6O5SPurezza:98%Colore e forma:SolidPeso molecolare:502.52bFGF (119-126)
CAS:bFGF (119-126) is a biologically active peptide corresponding to the residues of human, bovine (119-126), mouse, rat (118-125), and Heparin-Binding GrowthFormula:C44H76N14O12Colore e forma:SolidPeso molecolare:993.16VEGFR-2-IN-36
VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstratedFormula:C24H23N7O5Purezza:98%Colore e forma:SolidPeso molecolare:489.48PF15 TFA
PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM.Formula:C46H50F3N13O8Purezza:98%Colore e forma:SolidPeso molecolare:969.97JBJ-09-063 TFA
JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.Formula:C33H30F4N4O5SColore e forma:SolidPeso molecolare:670.67ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 for hALK5. Administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. This compound holds potential for research in developing inhalable ALK5 inhibitors.Formula:C20H20ClFN6OPeso molecolare:414.86VEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.Formula:C72H123N9O6Colore e forma:SolidPeso molecolare:1210.8SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormula:C43H45N13O9SPurezza:98%Colore e forma:SolidPeso molecolare:919.96Antitumor agent-123
Antitumor agent-123 (Compound 4d) effectively inhibits various kinase targets with anticancer properties, including JAK2, JAK3, HDAC1, and HDAC6, with IC50 values of 34.6 μM for JAK2 and 2.6 μM for JAK3. In solid tumor models, Antitumor agent-123 demonstrates moderate activity.Formula:C19H14ClFN6O2Colore e forma:SolidPeso molecolare:412.08508Bevasiranib
CAS:Bevasiranib is a siRNA targeting VEGF production, key in choroidal neo-vascularization and wet AMD.Colore e forma:SolidPLM-101
PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET.Formula:C22H22FN5O2Colore e forma:SolidPeso molecolare:407.44Anticancer agent 133
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.Formula:C24H19Cl3N5ORhPurezza:98%Colore e forma:SolidPeso molecolare:602.71PROTAC FAK degrader 1
CAS:PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).Formula:C47H56F3N9O8S2Purezza:98%Colore e forma:SolidPeso molecolare:996.13hCA/VEGFR-2-IN-1
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (Formula:C21H17FN6O3SPurezza:98%Colore e forma:SolidPeso molecolare:452.46JH-XI-10-02
CAS:JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formula:C53H69N5O9Purezza:98%Colore e forma:SolidPeso molecolare:920.161Abl Cytosolic Substrate
CAS:Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ).Formula:C64H101N15O16Purezza:98%Colore e forma:SolidPeso molecolare:1336.58NRX-0492
CAS:NRX-0492: orally active BTK degrader, induces ubiquitylation/proteasomal breakdown, potent with DC50 ≤0.2 nM, DC90 ≤0.5 nM, disrupts BCR signaling.Formula:C43H51N11O6Colore e forma:SolidPeso molecolare:817.94HER2-IN-13
CAS:HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with anFormula:C26H23ClF2N8O3Colore e forma:SolidPeso molecolare:568.96SNIPER(ABL)-020
SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.Formula:C44H59ClN10O8SPurezza:98%Colore e forma:SolidPeso molecolare:923.52
