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Angiogenesi

Angiogenesi

Gli inibitori dell'angiogenesi sono composti che interferiscono con la formazione di nuovi vasi sanguigni, un processo cruciale nella crescita e metastasi del cancro. Inibendo l'angiogenesi, questi composti possono limitare l'apporto di sangue ai tumori, rallentandone o arrestando la crescita. Gli inibitori dell'angiogenesi sono fondamentali nella ricerca sul cancro e nello sviluppo terapeutico, offrendo approfondimenti sui meccanismi di progressione tumorale e potenziali trattamenti per il cancro e altre malattie legate all'angiogenesi. Presso CymitQuimica, offriamo un'ampia gamma di inibitori dell'angiogenesi di alta qualità per supportare le tue ricerche in oncologia e biologia vascolare.

Sottocategorie di "Angiogenesi"

Mostrare 6 più sottocategorie

Trovati 2002 prodotti di "Angiogenesi"

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  • Logo CymitQuimica
    Targetmol
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    AKN-028 acetate

    AKN-028 acetate: an oral TK inhibitor for AML research, targets FLT3 with IC50 of 6 nM, inhibits autophosphorylation, and induces apoptosis.
    Formula:C19H18N6O2
    Colore e forma:Solid
    Peso molecolare:362.39

    Ref: TM-T61358

  • JP-153
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    JP-153

    CAS:
    JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
    Formula:C21H19NO5
    Colore e forma:Solid
    Peso molecolare:365.379

    Ref: TM-T206442

  • AZD0424
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    AZD0424

    CAS:
    AZD0424: oral Src/Abl kinase inhibitor; potential anticancer; induces apoptosis, cell cycle arrest in lymphoma.
    Formula:C25H29ClN6O5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:528.99

    Ref: TM-T14370

  • AFP464 free base
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    AFP464 free base

    CAS:
    AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
    Formula:C22H23F3N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:448.44

    Ref: TM-T10258

  • NSC381467
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    NSC381467

    CAS:
    NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.
    Formula:C20H16O7
    Colore e forma:Solid
    Peso molecolare:368.34

    Ref: TM-T61441

  • (Rac)-PT2399
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    (Rac)-PT2399

    CAS:
    (Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
    Formula:C17H10F5NO4S
    Colore e forma:Solid
    Peso molecolare:419.32

    Ref: TM-T12675

  • Protein kinase inhibitor 11
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    Protein kinase inhibitor 11

    CAS:
    Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.
    Formula:C21H18FN5O2S
    Colore e forma:Solid
    Peso molecolare:423.463

    Ref: TM-T205016

  • Logo CymitQuimica
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    EGFR/HER2/DHFR-IN-1

    Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.
    Formula:C14H11BrN4O2S
    Colore e forma:Solid
    Peso molecolare:379.23

    Ref: TM-T61596

  • W23-1006
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    W23-1006

    CAS:
    W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).
    Formula:C17H12BrN3O5
    Colore e forma:Solid
    Peso molecolare:418.198

    Ref: TM-T205034

  • Logo CymitQuimica
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    VEGFR-2-IN-14

    VEGFR-2-IN-14 (Compound 5) is a potent inhibitor of VEGFR-2, which inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.
    Formula:C24H23N3O3S
    Colore e forma:Solid
    Peso molecolare:433.52

    Ref: TM-T62439

  • BTK-IN-10
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    BTK-IN-10

    CAS:
    BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50<5 nM) or mutant BTK (C481S) (IC50<5 nM).
    Formula:C25H24F2N4O2
    Colore e forma:Solid
    Peso molecolare:450.48

    Ref: TM-T62716

  • EGFR-IN-3
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    EGFR-IN-3

    EGFR-IN-3 is an EGFR inhibitor with antitumor activity.EGFR-IN-3 inhibits EGFRwt-TK, induces apoptosis (cell death), and can block cells in the G2/M phase.
    Formula:C24H18F4N6O2S
    Purezza:98.1%
    Colore e forma:Solid
    Peso molecolare:530.5

    Ref: TM-T63732

  • Logo CymitQuimica
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    ALK-IN-23

    ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.
    Formula:C26H29ClN8O3S
    Colore e forma:Solid
    Peso molecolare:569.08

    Ref: TM-T64027

  • Clifutinib
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    Clifutinib

    CAS:
    <p>Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.</p>
    Formula:C29H34N4O4
    Colore e forma:Solid
    Peso molecolare:502.605

    Ref: TM-T206767

  • MM-589 TFA
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    MM-589 TFA

    CAS:
    MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
    Formula:C30H45F3N8O7
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:686.72

    Ref: TM-T12091L

  • Logo CymitQuimica
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    FGFR1 inhibitor-6

    FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.
    Formula:C27H19N5O4S2
    Colore e forma:Solid
    Peso molecolare:541.6

    Ref: TM-T63816

  • EGFR-IN-161
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    EGFR-IN-161

    CAS:
    <p>EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.</p>
    Formula:C33H36Cl2N8O2
    Colore e forma:Solid
    Peso molecolare:647.597

    Ref: TM-T206760

  • PF-06463922 acetate
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    PF-06463922 acetate

    CAS:
    PF-06463922 acetate: ALK/ROS1 inhibitor, brain- penetrable, active vs crizotinib-resistant mutants, in NSCLC trials.
    Formula:C23H23FN6O4
    Colore e forma:Solid
    Peso molecolare:466.46

    Ref: TM-T70060

  • Logo CymitQuimica
    Targetmol
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    EGFR-IN-62

    EGFR-IN-62: IC50 of 10-242 nM for various EGFR mutations, blocks A549/H1975 cell cycle, induces apoptosis, and inhibits cell motility and proliferation.
    Formula:C30H33N9O2
    Colore e forma:Solid
    Peso molecolare:551.64

    Ref: TM-T63895

  • PF-06263276
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    PF-06263276

    CAS:
    PF-06263276 selectively inhibits pan-JAK with IC50: JAK1 (2.2 nM), JAK2 (23.1 nM), JAK3 (59.9 nM), TYK2 (29.7 nM).
    Formula:C31H31FN8O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:566.63

    Ref: TM-T16488