PERK
Gli inibitori di PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) prendono di mira la via PERK, che è coinvolta nella risposta cellulare allo stress del reticolo endoplasmatico (ER) e nella regolazione dell'apoptosi. PERK svolge un ruolo cruciale nella risposta delle proteine mal ripiegate (UPR) bloccando la traduzione delle proteine e promuovendo la sopravvivenza cellulare in condizioni di stress. Tuttavia, una prolungata attivazione di PERK può portare all'apoptosi. L'inibizione di PERK può modulare queste risposte allo stress, rendendo questi inibitori preziosi nella ricerca su malattie neurodegenerative, cancro e disturbi metabolici. Presso CymitQuimica, offriamo una gamma di inibitori di PERK di alta qualità per supportare la tua ricerca in apoptosi, stress del RE e omeostasi cellulare.
Trovati 24 prodotti di "PERK"
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formula:C44H58N8O5SPurezza:98.24% - 99.96%Colore e forma:SolidPeso molecolare:811.05PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formula:C23H22N6OPurezza:99.62% - 99.92%Colore e forma:SolidPeso molecolare:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurezza:99.44% - 99.49%Colore e forma:SolidPeso molecolare:469.43Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurezza:98.68% - 99.85%Colore e forma:SolidPeso molecolare:490.31Ref: TM-T201081
50mgPrezzo su richiesta1mg66,00€5mg145,00€1mL*10mM (DMSO)172,00€10mg224,00€25mg354,00€EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Formula:C21H20F6N2O2Purezza:98.86%Colore e forma:SolidPeso molecolare:446.39Ref: TM-T62637
1mg58,00€5mg124,00€1mL*10mM (DMSO)136,00€10mg192,00€25mg360,00€50mg527,00€100mg757,00€200mg1.036,00€2BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFormula:C19H16ClF3N4O3Purezza:97.97% - 99.04%Colore e forma:SolidPeso molecolare:440.8Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurezza:98.27%Colore e forma:SolidPeso molecolare:547.99Ref: TM-T22436
1mg92,00€2mg128,00€5mg178,00€1mL*10mM (DMSO)243,00€10mg268,00€25mg439,00€50mg610,00€100mg820,00€200mg1.099,00€ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Formula:C25H28N2O5S2Purezza:97.82%Colore e forma:SolidPeso molecolare:500.63GSK621
CAS:GSK621 is a specific and potent AMPK activator.Formula:C26H20ClN3O5Purezza:97.02% - 97.05%Colore e forma:SolidPeso molecolare:489.91IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purezza:98.8%Colore e forma:SolidPeso molecolare:377.27GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Formula:C24H20F3N5OPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:451.44Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Formula:C26H36O6Purezza:99.45% - 99.91%Colore e forma:White To Off-White SolidPeso molecolare:444.56Ref: TM-T5A2461
1mg46,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg137,00€25mg224,00€50mg331,00€100mg489,00€500mg1.044,00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purezza:97.86% - 99.27%Colore e forma:SolidPeso molecolare:451.34GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurezza:98.59% - >99.99%Colore e forma:SolidPeso molecolare:416.45Ref: TM-T2654
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg135,00€50mg245,00€100mg442,00€200mg598,00€PERK/eIF2α activator 1
CAS:Compound V8 (PERK/eIF2α activator 1), a flavonoid, exhibits anti-tumor properties by inducing apoptosis and activating the PERK-eIF2α-ATF4 pathway. It effectively inhibits the proliferation of HepG2 cells, with an IC 50 value of 23 μM [1].Formula:C24H29NO7Peso molecolare:443.49DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Formula:C20H19ClF3N3O4Purezza:99.96%Colore e forma:SolidPeso molecolare:457.83eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.
Formula:C29H23BrClN5O2Purezza:99.49% - 99.89%Colore e forma:SolidPeso molecolare:588.88GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Formula:C19H12Cl2F2N4O3SPurezza:95.04% - 98%Colore e forma:SolidPeso molecolare:485.29eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formula:C31H33N3O5Colore e forma:SolidPeso molecolare:527.61HC-7366
CAS:HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Formula:C20H15ClF2N6O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:508.89
