PERK
Gli inibitori di PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) prendono di mira la via PERK, che è coinvolta nella risposta cellulare allo stress del reticolo endoplasmatico (ER) e nella regolazione dell'apoptosi. PERK svolge un ruolo cruciale nella risposta delle proteine mal ripiegate (UPR) bloccando la traduzione delle proteine e promuovendo la sopravvivenza cellulare in condizioni di stress. Tuttavia, una prolungata attivazione di PERK può portare all'apoptosi. L'inibizione di PERK può modulare queste risposte allo stress, rendendo questi inibitori preziosi nella ricerca su malattie neurodegenerative, cancro e disturbi metabolici. Presso CymitQuimica, offriamo una gamma di inibitori di PERK di alta qualità per supportare la tua ricerca in apoptosi, stress del RE e omeostasi cellulare.
Trovati 31 prodotti per "PERK".
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RAPT-37-Me
CAS:RAPT-37-Me is a GCN2 inhibitor, exhibiting IC50 values for GCN2, PERK, HRl, and PKR of 0.002 μM, >10 μM, 4.40 μM, and 1.31 μM, respectively.Formula:C22H21BrFN7OPeso molecolare:498.36HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Formula:C28H28F2N4O7Colore e forma:SolidPeso molecolare:570.54eIF4E-IN-4
CAS:eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.Formula:C20H19ClN5O5PColore e forma:SolidPeso molecolare:475.822HR-19011
CAS:HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Formula:C25H19F6N3O3Purezza:99.89%Colore e forma:Yellow SolidPeso molecolare:523.43Ref: TM-T63665
2mg79,00€5mg120,00€1mL*10mM (DMSO)138,00€10mg192,00€25mg385,00€50mg625,00€100mg982,00€200mg1.333,00€eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formula:C31H33N3O5Colore e forma:SolidPeso molecolare:527.61HC-7366
CAS:HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Formula:C20H15ClF2N6O4SPurezza:99.84%Colore e forma:White SolidPeso molecolare:508.89KRAS-IN-56
CAS:KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC50 of 33 μM. It disrupts the interaction between GTP-KRAS and SOS1, and reduces p-ERK levels. KRAS-IN-56 is applicable for research related to lung cancer.Formula:C19H19N3O2Peso molecolare:321.37NCATS-SM0225
CAS:NCATS-SM0225 is an ER-associated degradation (ERAD) inhibitor and a direct binder of VDAC1, VDAC2, and VDAC3. It has an IC50 of 1.02 μM for ERAD inhibition and a Kd of 3.13 μM for binding to human VDAC1. NCATS-SM0225 disrupts cellular calcium homeostasis, enhances VDAC1-IP3R coupling, and activates PERK. The compound selectively kills cancer cells and has shown tumor growth inhibition in melanoma xenograft models. It is useful for research into various cancers, including melanoma, as well as studies on ERAD and calcium homeostasis regulatory mechanisms.Formula:C23H28N2O4S2Peso molecolare:460.61ISR activator 3
CAS:ISR activator 3 (Compound cc81) is the active metabolite of A8. It activates the integrated stress response (ISR) by binding to RIG-I (KD≈ 0.55 μM) without inducing lipid droplet clearance. Additionally, ISR activator 3 enhances the interferon response under viral mimic signaling. This compound is applicable in studies of neurodegenerative diseases and immune stress.Formula:C23H21N3O3S2Peso molecolare:451.56APL-4098
CAS:APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. It reduces the phosphorylation levels of eIF2α and the expression of ATF4. APL-4098 impairs mitochondrial function and exhibits cytotoxicity against primary acute myeloid leukemia cells. It is applicable in studies related to acute myeloid leukemia.Formula:C17H12ClFN6O3SPeso molecolare:434.83HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formula:C24H24F2N4O3Purezza:99.33%Colore e forma:White SolidPeso molecolare:454.47
