PERK
Gli inibitori di PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) prendono di mira la via PERK, che è coinvolta nella risposta cellulare allo stress del reticolo endoplasmatico (ER) e nella regolazione dell'apoptosi. PERK svolge un ruolo cruciale nella risposta delle proteine mal ripiegate (UPR) bloccando la traduzione delle proteine e promuovendo la sopravvivenza cellulare in condizioni di stress. Tuttavia, una prolungata attivazione di PERK può portare all'apoptosi. L'inibizione di PERK può modulare queste risposte allo stress, rendendo questi inibitori preziosi nella ricerca su malattie neurodegenerative, cancro e disturbi metabolici. Presso CymitQuimica, offriamo una gamma di inibitori di PERK di alta qualità per supportare la tua ricerca in apoptosi, stress del RE e omeostasi cellulare.
Trovati 34 prodotti per "PERK".
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formula:C44H58N8O5SPurezza:98.24% - 99.98%Colore e forma:White SolidPeso molecolare:811.05ISR-IN-3
ISR-IN-3 (Compound 7a) is an eIF2B activator with a pEC50 value of 7.3. It also exhibits significant hERG inhibitory activity, with a pIC50 value of 5.7. ISR-IN-3 is applicable in research related to Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (als).eIF4E-IN-3
CAS:eIF4E-IN-3 is an eIF4E inhibitor that blocks cap-dependent translation and is used in cancer-related mechanism studies.Formula:C34H30ClF3N6O4SColore e forma:SolidPeso molecolare:711.16PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formula:C23H22N6OPurezza:99.62% - 99.97%Colore e forma:SolidPeso molecolare:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurezza:99.44% - 99.49%Colore e forma:SolidPeso molecolare:469.4342Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formula:C18H15Cl2F2N5O3SPurezza:98.68% - 99.85%Colore e forma:SolidPeso molecolare:490.31ML-291
CAS:ML-291 is a potent UPR inducer; activates PERK/eIF2α/CHOP apoptotic arm; cancer cell death research tool.Formula:C16H16ClN3O6SPurezza:99.79%Colore e forma:White SolidPeso molecolare:413.833EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Formula:C21H20F6N2O2Purezza:98.86%Colore e forma:White SolidPeso molecolare:446.39GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurezza:98.59% - >99.99%Colore e forma:SolidPeso molecolare:416.4508IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purezza:98.8%Colore e forma:SolidPeso molecolare:377.271GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Formula:C24H20F3N5OPurezza:98% - >99.99%Colore e forma:White SolidPeso molecolare:451.44Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Formula:C26H36O6Purezza:99.45% - 99.91%Colore e forma:SolidPeso molecolare:444.5604ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Formula:C25H28N2O5S2Purezza:97.82% - 98.94%Colore e forma:White SolidPeso molecolare:500.632BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFormula:C19H16ClF3N4O3Purezza:97.61% - 99.04%Colore e forma:SolidPeso molecolare:440.804GSK621
CAS:GSK621 is a specific and potent AMPK activator.Formula:C26H20ClN3O5Purezza:97.02% - 97.05%Colore e forma:SolidPeso molecolare:489.907ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purezza:97.86% - 99.27%Colore e forma:SolidPeso molecolare:451.34Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurezza:98.27%Colore e forma:Yellow SolidPeso molecolare:547.988PERK/eIF2α activator 1
CAS:Compound V8 (PERK/eIF2α activator 1), a flavonoid, exhibits anti-tumor properties by inducing apoptosis and activating the PERK-eIF2α-ATF4 pathway. It effectively inhibits the proliferation of HepG2 cells, with an IC 50 value of 23 μM [1].Formula:C24H29NO7Colore e forma:SolidPeso molecolare:443.49DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Formula:C20H19ClF3N3O4Purezza:99.96%Colore e forma:SolidPeso molecolare:457.83eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.Formula:C29H23BrClN5O2Purezza:99.49% - 99.89%Colore e forma:SolidPeso molecolare:588.882
