Caspasi
Gli inibitori delle caspasi sono composti che bloccano l'attività delle caspasi, una famiglia di proteasi che sono esecutori centrali dell'apoptosi. Le caspasi clivano substrati specifici all'interno della cellula per innescare il processo apoptotico, portando alla morte cellulare programmata. Gli inibitori delle caspasi sono utilizzati per studiare i meccanismi dell'apoptosi, nonché per prevenire la morte cellulare indesiderata in vari modelli di ricerca. Questi inibitori sono anche esplorati in contesti terapeutici per proteggere le cellule dall'apoptosi in malattie come la neurodegenerazione. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle caspasi di alta qualità per supportare la tua ricerca in apoptosi, morte cellulare e campi correlati.
Trovati 163 prodotti per "Caspasi".
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Ac-LEVD-CHO
CAS:Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formula:C22H36N4O9Colore e forma:SolidPeso molecolare:500.54Ac-DNLD-CHO
CAS:Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, exhibiting IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7Formula:C20H31N5O10Purezza:98%Colore e forma:SolidPeso molecolare:501.49IRF1-IN-1
CAS:IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Formula:C22H24N4O4SPurezza:99.88%Colore e forma:SolidPeso molecolare:440.52TD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Colore e forma:SolidPeso molecolare:987.19Topoisomerase I-IN-18
TopoisomeraseI-IN-18, a derivative of Thiosemicarbazide, functions as a Topoisomerase I inhibitor, disrupting DNA synthesis and transcription. It suppresses tumor cell proliferation by inducing S phase cell cycle arrest. Additionally, it enhances mitochondria-mediated apoptosis (apoptosis), evidenced by inhibited cell migration and increased intracellular reactive oxygen species (ROS). TopoisomeraseI-IN-18 upregulates p53 protein expression, γH2AX phosphorylation, Bax expression, downregulates Bcl-2 expression, and activates the caspase cascade. This compound is applicable for lung cancer research.Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Colore e forma:Odour SolidRef: TM-L9000
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaTNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Colore e forma:SolidPeso molecolare:711.729Ac-AAVALLPAVLLALLAPVAD-CHO TFA
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a complex of Ac-VAD-CHO. It acts as a non-selective caspase inhibitor and features a hydrophobic sequence derived from K-FGF that enables cell penetration.Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formula:C28H33N7O9Colore e forma:SolidPeso molecolare:611.6IRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formula:C18H20N2O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:360.43Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidRef: TM-L1100
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaMX1013
CAS:MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.Formula:C18H23FN2O6Colore e forma:SolidPeso molecolare:382.39Almorexant hydrochloride
CAS:Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.Formula:C29H32ClF3N2O3Purezza:99.85%Colore e forma:White SolidPeso molecolare:549.02J22352
CAS:J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects inFormula:C24H21N3O4Colore e forma:SolidPeso molecolare:415.44Tripeptide-32
CAS:Tripeptide-32 is a bioactive peptide recognized for its anti-aging properties, commonly utilized as an ingredient in cosmetics [1].Formula:C12H22N4O5Purezza:98%Colore e forma:SolidPeso molecolare:302.33Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purezza:98.07% - 99.18%Colore e forma:White SolidPeso molecolare:240.25Ref: TM-T16522
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg767,00€Chelidonic acid
CAS:Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Formula:C7H4O6Purezza:99.03%Colore e forma:SolidPeso molecolare:184.10Almorexant
CAS:Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.Formula:C29H31F3N2O3Purezza:97.75% - 98.02%Colore e forma:SolidPeso molecolare:512.56Asperosaponin VI
CAS:Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.Formula:C47H76O18Purezza:97.15% - 99.79%Colore e forma:White SolidPeso molecolare:929.10Z-IETD-FMK
CAS:Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.Formula:C30H43FN4O11Purezza:98% - 99.81%Colore e forma:White SolidPeso molecolare:654.68Ginsenoside Rh2
CAS:Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.Formula:C36H62O8Purezza:99.20% - 99.76%Colore e forma:White PowderPeso molecolare:622.872-HBA
CAS:2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.Formula:C17H14O3Purezza:99.76%Colore e forma:Red SolidPeso molecolare:266.29Ref: TM-T7374
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg137,00€50mg213,00€100mg340,00€200mg504,00€Ac-DEVD-AMC
CAS:Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .Formula:C30H37N5O13Purezza:99.89%Colore e forma:White PowderPeso molecolare:675.64KEA1-97
CAS:Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).Formula:C15H9Cl2FN4Purezza:97.07%Colore e forma:Yellow SolidPeso molecolare:335.16Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purezza:99.57% - 99.63%Colore e forma:SolidPeso molecolare:1031.18Z-VAD(OMe)-FMK
CAS:View and buy Z-VAD(OMe)-FMK from TargetMol.Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.Cited in 10 publications.Formula:C22H30FN3O7Purezza:95.92% - 99.71%Colore e forma:SolidPeso molecolare:467.49Ref: TM-T6013
1mg54,00€2mg84,00€5mg137,00€1mL*10mM (DMSO)138,00€10mg222,00€25mg331,00€50mg447,00€100mg623,00€200mg883,00€PHYTOSPHINGOSINE
CAS:Phytosphingosine: anticancer phospholipid; triggers apoptosis in cancer cells via caspase 8 activation and Bax translocation.Formula:C18H39NO3Purezza:99.74% - 99.81%Colore e forma:White SolidPeso molecolare:317.51TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFormula:C20H22N2O2Purezza:97.86%Colore e forma:Yellow SolidPeso molecolare:322.4Belnacasan
CAS:Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.Formula:C24H33ClN4O6Purezza:96.53% - 99.5%Colore e forma:SolidPeso molecolare:508.99Ref: TM-T6090
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg81,00€25mg161,00€50mg222,00€100mg396,00€200mg585,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purezza:97.47% - 99.95%Colore e forma:SolidPeso molecolare:178.14Ac-DEVD-pNA
CAS:Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.Formula:C26H34N6O13Purezza:>99.99%Colore e forma:WhitePeso molecolare:638.58Ref: TM-T7816
2mg34,00€5mg57,00€10mg75,00€1mL*10mM (DMSO)79,00€25mg160,00€50mg231,00€100mg335,00€200mg477,00€Z-YVAD-FMK
CAS:AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.Formula:C31H39FN4O9Purezza:98.00%Colore e forma:White SolidPeso molecolare:630.66Dihydrocapsaicin
CAS:Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.Formula:C18H29NO3Purezza:99.8% - ≥95%Colore e forma:White CrystalPeso molecolare:307.43Tauroursodeoxycholate
CAS:Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.Formula:C26H45NO6SPurezza:98.77% - 99.93%Colore e forma:White SolidPeso molecolare:499.7Diclofenac Potassium
CAS:Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.Formula:C14H10Cl2KNO2Purezza:99.93%Colore e forma:White SolidPeso molecolare:334.24CASP3 Activator 1541
CAS:CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.Formula:C24H17N3O4Purezza:98.84%Colore e forma:SolidPeso molecolare:411.41Ref: TM-T8652
1mg34,00€5mg71,00€1mL*10mM (DMSO)86,00€10mg105,00€25mg215,00€50mg344,00€100mg532,00€200mg740,00€5,7,4'-Trimethoxyflavone
CAS:5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.Formula:C18H16O5Purezza:97.53%Colore e forma:SolidPeso molecolare:312.32L67
CAS:L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).Formula:C16H14Br2N4O4Purezza:98.34% - 99.56%Colore e forma:SolidPeso molecolare:486.11AVN-944
CAS:AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.Formula:C25H27N5O5Purezza:99.07% - ≥95%Colore e forma:White SolidPeso molecolare:477.51Ref: TM-T1979
1mg56,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg130,00€25mg245,00€50mg358,00€100mg537,00€200mg763,00€Taurodeoxycholic acid sodium hydrate
CAS:Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.Formula:C26H46NNaO7SPurezza:99.95%Colore e forma:SolidPeso molecolare:539.70Ospemifene
CAS:Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.Formula:C24H23ClO2Purezza:99.95%Colore e forma:SolidPeso molecolare:378.895,7-Dihydroxychromone
CAS:1.Formula:C9H6O4Purezza:99.76% - ≥95%Colore e forma:Yellow SolidPeso molecolare:178.14Ref: TM-T5S1805
1mg44,00€1mL*10mM (DMSO)75,00€5mg84,00€10mg119,00€25mg197,00€50mg294,00€100mg437,00€500mg954,00€Boc-Asp(OMe)-fluoromethyl ketone
CAS:Boc-Asp(OMe)-FMK is a broad-spectrum caspase inhibitor that blocks Fas-mediated processes without affecting IL-8 chemotaxis.Formula:C11H18FNO5Purezza:≥98%Colore e forma:SolidPeso molecolare:263.26(E/Z)-Necrosulfonamide
CAS:(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.Formula:C18H15N5O6S2Purezza:97.62% - 98%Colore e forma:SolidPeso molecolare:461.47Lobaplatin
CAS:Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.Formula:C9H18N2O3PtPurezza:98.00% - 99.96%Colore e forma:White SolidPeso molecolare:397.33Ref: TM-T15771
1mgPrezzo su richiesta1mlPrezzo su richiesta2mgPrezzo su richiesta5mgPrezzo su richiesta10mgPrezzo su richiestaZ-DEVD-FMK
CAS:Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7,Formula:C30H41FN4O12Purezza:96.19% - 99.69%Colore e forma:SolidPeso molecolare:668.66Diethylnorspermine HBr
CAS:DENSPM is a potent polyamine analog that induces SSAT, arrests the cell cycle, and triggers apoptosis in various cancer cells.Formula:C13H36Br4N4Colore e forma:SolidPeso molecolare:568.075Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purezza:96.66% - 99.93%Colore e forma:White SolidPeso molecolare:332.39EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurezza:99.71%Colore e forma:SolidPeso molecolare:311.33Ref: TM-T27242
1mg38,00€5mg80,00€1mL*10mM (DMSO)88,00€10mg126,00€25mg222,00€50mg334,00€100mg505,00€500mg1.071,00€1g1.431,00€
