Chk
Gli inibitori delle chinasi di checkpoint (Chk) prendono di mira le chinasi Chk1 e Chk2, che sono regolatori chiave della risposta ai danni del DNA e dei punti di controllo del ciclo cellulare. Queste chinasi bloccano la progressione del ciclo cellulare in risposta ai danni al DNA, consentendo il tempo necessario per la riparazione. L'inibizione delle chinasi Chk può impedire l'arresto del ciclo cellulare, costringendo le cellule danneggiate a proseguire nel ciclo e a subire l'apoptosi. Gli inibitori di Chk sono particolarmente preziosi nella ricerca sul cancro, dove possono sensibilizzare le cellule tumorali agli agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una varietà di inibitori di Chk di alta qualità per supportare la tua ricerca sulla risposta ai danni del DNA, la regolazione del ciclo cellulare e l'oncologia.
Trovati 46 prodotti di "Chk"
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Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Purezza:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:147 kDa (average)CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purezza:99.29%Colore e forma:SoildPeso molecolare:480.75CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Colore e forma:SolidPeso molecolare:377.16002Zimistobart
CAS:Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:LiquidCCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formula:C23H29Cl2FN4O4Colore e forma:SolidPeso molecolare:515.41CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Formula:C68H119N21O25SColore e forma:SolidPeso molecolare:1662.86CHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Formula:C17H12N2O2SPurezza:98.40%Colore e forma:SolidPeso molecolare:308.35Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formula:C16H18F3N7Colore e forma:SolidPeso molecolare:365.364GDC-0425
CAS:<p>GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.</p>Formula:C18H19N5OColore e forma:SolidPeso molecolare:321.38PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purezza:98.02%Colore e forma:SolidPeso molecolare:328.32GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Formula:C16H22BrCl2N5OColore e forma:SolidPeso molecolare:451.19CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purezza:99.17%Colore e forma:SolidPeso molecolare:408.46GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Formula:C16H21BrClN5OPurezza:97.85%Colore e forma:SolidPeso molecolare:414.73CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurezza:98.28% - 99.93%Colore e forma:SolidPeso molecolare:379.34AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurezza:98.96% - 99.19%Colore e forma:SolidPeso molecolare:362.42M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurezza:99.02% - >99.99%Colore e forma:SolidPeso molecolare:404.48GDC-0575
CAS:<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Formula:C16H20BrN5OPurezza:≥95%Colore e forma:SolidPeso molecolare:378.27Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purezza:99.77%Colore e forma:SolidPeso molecolare:381.43
