Chk
Gli inibitori delle chinasi di checkpoint (Chk) prendono di mira le chinasi Chk1 e Chk2, che sono regolatori chiave della risposta ai danni del DNA e dei punti di controllo del ciclo cellulare. Queste chinasi bloccano la progressione del ciclo cellulare in risposta ai danni al DNA, consentendo il tempo necessario per la riparazione. L'inibizione delle chinasi Chk può impedire l'arresto del ciclo cellulare, costringendo le cellule danneggiate a proseguire nel ciclo e a subire l'apoptosi. Gli inibitori di Chk sono particolarmente preziosi nella ricerca sul cancro, dove possono sensibilizzare le cellule tumorali agli agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una varietà di inibitori di Chk di alta qualità per supportare la tua ricerca sulla risposta ai danni del DNA, la regolazione del ciclo cellulare e l'oncologia.
Trovati 49 prodotti per "Chk".
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CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purezza:99.29%Colore e forma:SolidPeso molecolare:480.75Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Purezza:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:Transparent LiquidPeso molecolare:147 kDaWAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFormula:C17H12N2O2SPurezza:98.40%Colore e forma:SolidPeso molecolare:308.35CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Formula:C68H119N21O25SColore e forma:SolidPeso molecolare:1662.86CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Colore e forma:SolidPeso molecolare:377.16002CHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.Colore e forma:Odour SolidFLT3/CHK1 ligand-1
FLT3/CHK1 ligand-1 is a PROTAC target protein ligand used in the synthesis of PROTACs, such as [PROTAC FLT3/CHK1 Degrader-1]. [PROTAC FLT3/CHK1 Degrader-1] functions as a potent FLT3/CHK1 PROTAC degrader with antitumor activity.CCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formula:C23H29Cl2FN4O4Colore e forma:SolidPeso molecolare:515.41PROTAC Chk1 degrader-1
CAS:Compound PROTAC-2, also known as PROTAC Chk1 degrader-1, is a potent degrader of Chk1, exhibiting a DC50 of 1.33 μM. It is utilized in cancer research [1].Formula:C43H44N14O9Colore e forma:SolidPeso molecolare:900.9CHK1-IN-15
CHK1-IN-15 (compound 9a) is an ATP-competitive inhibitor of checkpoint kinase 1 (CHK1), exhibiting a binding rate of 95% at a concentration of 1.0 µM. It also acts as a Chk1 target protein ligand of MA203 and is applicable for tumor-related research.Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.Formula:C16H18F3N7Colore e forma:SolidPeso molecolare:365.364PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purezza:98.02%Colore e forma:SolidPeso molecolare:328.32CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purezza:99.17%Colore e forma:SolidPeso molecolare:408.46GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Formula:C16H22BrCl2N5OColore e forma:SolidPeso molecolare:451.19LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purezza:99.77%Colore e forma:White SolidPeso molecolare:381.43GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurezza:97.85%Colore e forma:SolidPeso molecolare:414.73Ref: TM-T27407
1mg43,00€2mg55,00€5mg80,00€1mL*10mM (DMSO)93,00€10mg103,00€25mg177,00€50mg255,00€100mg356,00€200mg520,00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurezza:98.28% - 99.93%Colore e forma:SolidPeso molecolare:379.34Ref: TM-T7080
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg113,00€25mg213,00€50mg350,00€100mg523,00€AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurezza:98.96% - 99.19%Colore e forma:SolidPeso molecolare:362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formula:C16H20BrN5OPurezza:≥95%Colore e forma:SolidPeso molecolare:378.27M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurezza:99.02% - >99.99%Colore e forma:Red SolidPeso molecolare:404.48
