Ferroptosi
La ferroptosi è una forma di morte cellulare regolata caratterizzata dall'accumulo di perossidi lipidici e dallo stress ossidativo dipendente dal ferro. A differenza dell'apoptosi, la ferroptosi non è guidata dalle caspasi, ma piuttosto dal fallimento delle difese antiossidanti cellulari, che porta alla morte cellulare. Gli inibitori e gli induttori della ferroptosi sono fondamentali per studiare questa particolare via di morte cellulare, implicata in varie malattie, tra cui il cancro, la neurodegenerazione e il danno da ischemia-riperfusione. Presso CymitQuimica, offriamo una vasta gamma di modulatori della ferroptosi di alta qualità per supportare la tua ricerca sui meccanismi di morte cellulare, stress ossidativo e patologia delle malattie.
Trovati 226 prodotti di "Ferroptosi"
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FIN56
CAS:FIN56 is a specific inducer of ferroptosis.Formula:C25H31N3O5S2Purezza:99.72% - 99.78%Colore e forma:SolidPeso molecolare:517.66Ref: TM-T4066
2mg42,00€5mg63,00€10mg89,00€25mg192,00€50mg341,00€100mg535,00€200mg748,00€1mL*10mM (DMSO)72,00€Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purezza:97.43% - 98.4%Colore e forma:SolidPeso molecolare:374.34Ref: TM-TJS1159
1mg60,00€5mg127,00€10mg188,00€25mg348,00€50mg512,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)226,00€Pifithrin-α hydrobromide
CAS:Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.Formula:C16H18N2OS·HBrPurezza:97.71% - >99.99%Colore e forma:SolidPeso molecolare:367.3Pifithrin-β hydrobromide
CAS:Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis.Formula:C16H17BrN2SPurezza:99.24% - 99.74%Colore e forma:SolidPeso molecolare:349.29Liproxstatin-1 hydrochloride
CAS:Liproxstatin-1 hydrochloride is a high-potency ferroptosis inhibitor capable of effectively preventing ferroptotic cell death, with an IC50 value of 22 nM [1].Formula:C19H22Cl2N4Colore e forma:SolidPeso molecolare:377.31L-Buthionine-(S,R)-sulfoximine hydrochloride
L-Buthionine-(S,R)-sulfoximine hydrochloride is a fast, irreversible γ-GCS inhibitor that depletes glutathione. IC50: 1.9-29 μM in various tumors.Formula:C8H19ClN2O3SColore e forma:SolidPeso molecolare:258.77Levobupivacaine hydrochloride
CAS:Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.Formula:C18H28N2O·HClPurezza:99.74%Colore e forma:White Crystalline PowderPeso molecolare:324.89Ammonium iron(III) citrate
CAS:Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload and iron death.Formula:C24H32Fe3N3O28Purezza:98%Colore e forma:Ferric Ammonium Citrate Is A Yellowish Brown To Red Solid With A Faint Odor Of AmmoniaPeso molecolare:978.05Pioglitazone potassium
CAS:Pioglitazone potassium is an oral PPARγ agonist with EC50 of 0.93 μM (human) and 0.99 μM (mouse), used in diabetes research.Formula:C19H19KN2O3SColore e forma:SolidPeso molecolare:394.53CDDO-Im
CAS:CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).Formula:C34H43N3O3Purezza:98.3% - 99.61%Colore e forma:SolidPeso molecolare:541.72Ref: TM-TQ0120
1mg34,00€5mg74,00€10mg105,00€25mg200,00€50mg319,00€100mg485,00€500mg1.035,00€1mL*10mM (DMSO)89,00€U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Formula:C29H40N2O3Purezza:97.50%Colore e forma:Solid Off-WhitePeso molecolare:464.64(-)-Epicatechin
CAS:(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localizationFormula:C15H14O6Purezza:98.55% - 98.80%Colore e forma:SolidPeso molecolare:290.27CIL56
CAS:CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS).Formula:C23H27N3O5S2Purezza:99.46% - 99.91%Colore e forma:SolidPeso molecolare:489.61Ref: TM-T4309
1mg37,00€2mg52,00€5mg79,00€10mg115,00€25mg188,00€50mg299,00€100mg459,00€1mL*10mM (DMSO)86,00€Hemin
CAS:Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.Formula:C34H32ClFeN4O4Purezza:97.169% - 99.59%Colore e forma:Dark Purple Crystalline PowderPeso molecolare:651.94DihydroarteMisinic acid
CAS:DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinalFormula:C15H24O2Purezza:99.06% - 99.17%Colore e forma:SolidPeso molecolare:236.35Arteannuin B
CAS:1. Arteannuin B has potent antimalarial activity.Formula:C15H20O3Purezza:98% - 99.8%Colore e forma:SolidPeso molecolare:248.32UAMC-3203
CAS:UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).Formula:C25H37N5O2SPurezza:97.052% - 99.72%Colore e forma:SolidPeso molecolare:471.66Eprenetapopt
CAS:Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.Formula:C10H17NO3Purezza:98.75% - 99.57%Colore e forma:SolidPeso molecolare:199.25Ref: TM-T4414
5mg73,00€10mg105,00€25mg207,00€50mg368,00€100mg652,00€500mg1.320,00€1mL*10mM (DMSO)81,00€D-glutamine
CAS:D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.Formula:C5H10N2O3Purezza:99.99%Colore e forma:White Or Off-White PowderPeso molecolare:146.14RSL3
CAS:View and buy RSL3 from TargetMol.RSL3 is a VDAC-independent ferroptosis activator.Cited in 10 publications.Formula:C23H21ClN2O5Purezza:98% - 99.96%Colore e forma:SolidPeso molecolare:440.88Ref: TM-T3646
1g1.359,00€1mg39,00€2mg51,00€5mg79,00€10mg126,00€25mg258,00€50mg349,00€100mg459,00€500mg1.026,00€1mL*10mM (DMSO)74,00€Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purezza:97.03% - 99.90%Colore e forma:SolidPeso molecolare:317.34DL-α-Tocopherol
CAS:<p>DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.</p>Formula:C29H50O2Purezza:99.61% - 99.90%Colore e forma:Light Yellow Liquid ViscousPeso molecolare:430.71(E)-Ferulic acid
CAS:(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression ofFormula:C10H10O4Purezza:99.63%Colore e forma:SolidPeso molecolare:194.18SRS11-92
CAS:SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1Formula:C22H28N2O2Purezza:98.58%Colore e forma:SolidPeso molecolare:352.47Ref: TM-T8922
1mg46,00€5mg80,00€10mg116,00€25mg227,00€50mg359,00€100mg550,00€500mg1.159,00€1mL*10mM (DMSO)105,00€Deferitrin
CAS:Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.Formula:C11H11NO4SPurezza:98.71%Colore e forma:SolidPeso molecolare:253.27Ref: TM-T19692
1mg104,00€5mg235,00€10mg364,00€25mg582,00€50mg817,00€100mg1.121,00€1mL*10mM (DMSO)216,00€ML162
CAS:ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.Formula:C23H22Cl2N2O3SPurezza:98.42% - 99.55%Colore e forma:SolidPeso molecolare:477.4Ref: TM-T8970
1mg43,00€5mg85,00€10mg110,00€25mg215,00€50mg334,00€100mg467,00€200mg672,00€1mL*10mM (DMSO)92,00€1R,3S-RSL 3
CAS:1R,3S-RSL 3 is a harmala alkaloid.Formula:C23H21ClN2O5Purezza:99.51%Colore e forma:SolidPeso molecolare:440.88Ref: TM-T9561
1mg86,00€5mg177,00€10mg265,00€25mg427,00€50mg605,00€100mg800,00€200mg1.071,00€1mL*10mM (DMSO)207,00€Piperazine Erastin
CAS:<p>Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.</p>Formula:C35H41ClN6O4Purezza:99.52%Colore e forma:SolidPeso molecolare:645.19Ref: TM-T16540
1mg96,00€5mg168,00€10mg283,00€25mg567,00€50mg929,00€100mg1.225,00€200mg1.681,00€500mg2.498,00€PD146176
CAS:<p>PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.</p>Formula:C15H11NSPurezza:98.00%Colore e forma:SolidPeso molecolare:237.32Setanaxib
CAS:Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.Formula:C21H19ClN4O2Purezza:93.468% - 99.31%Colore e forma:SolidPeso molecolare:394.85Dp44mT
CAS:Dp44mT, a effective iron chelator, has selective antitumor activity.Formula:C14H15N5SPurezza:99% - 99.02%Colore e forma:SolidPeso molecolare:285.37Nordihydroguaiaretic acid
CAS:<p>Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.</p>Formula:C18H22O4Purezza:97.82% - 99.91%Colore e forma:SolidPeso molecolare:302.36FINO2
CAS:FINO2, a strong ferroptosis trigger, blocks GPX4, oxidizes Fe2+, stable in different pH, causes lipid peroxidation.Formula:C15H28O3Purezza:97.27%Colore e forma:SoildPeso molecolare:256.38Frataxin-IN-1
CAS:Frataxin-IN-1 inhibits the mitochondrial protein Frataxin with IC50 45 μM and is used in Friedreich’s ataxia research linked to mitochondrial defects.Formula:C20H23NO6Purezza:99.34%Peso molecolare:373.4Microtubule inhibitor 8
CAS:<p>Microtubule Inhibitor 8 (MP-HJ-1b) serves as a potent disruptor of microtubule function, inducing cell death via ferroptosis and demonstrating anti-tumor effects [1] [2].</p>Formula:C21H15N3O2SColore e forma:SolidPeso molecolare:373.43Anti-Mouse IL-1b Antibody (B122)
Anti-Mouse IL-1b Antibody (B122) is a mab inhibitor, blocks IL-1β signaling, reducing monocyte infiltration and alleviating T cell exhaustion.Colore e forma:Odour LiquidPioglitazone-d4
CAS:Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .Formula:C19H20N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:360.46IM-93
CAS:IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].Formula:C21H28N4O2Colore e forma:SolidPeso molecolare:368.47Anticancer agent 147
CAS:Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROSFormula:C32H40BrN3O2Purezza:98%Colore e forma:SolidPeso molecolare:578.58Ferroptosis-IN-4
CAS:Ferroptosis-IN-4 (compound 6k), an inhibitor of ferroptosis, exhibits an EC50 of 20 μM and lacks significant cytotoxicity. It demonstrates a protective role in glycerol-induced RM-AKI mice by alleviating kidney dysfunction [1].Formula:C17H24ClN3O2Peso molecolare:337.84W1131
CAS:W1131 is a potent STAT3 inhibitor and ferroptosis trigger, reducing cancer progression and 5-FU resistance.Formula:C23H19N5O4Colore e forma:SolidPeso molecolare:429.43Tubulin inhibitor 30
CAS:Tubulin Inhibitor 30, exhibiting an IC50 value of 0.52 μM, functions as an inhibitor of tubulin assembly. Additionally, it can induce ferroptosis.Formula:C22H19N3O5Colore e forma:SolidPeso molecolare:405.4CGP 65015
CAS:CGP 65015 is an oral iron chelator and can mobilize iron deposits.Formula:C14H15NO4Purezza:98%Colore e forma:SolidPeso molecolare:261.27Ferroptosis inducer-1
CAS:Ferroptosis inducer-1 is a Ferroptosis inducer with antitumor potential .Formula:C25H21ClN2O5Colore e forma:SolidPeso molecolare:464.9NPD4928
CAS:NPD4928 boosts cancer cell sensitivity to GPX4 inhibitors, hinting at therapeutic potential through ferroptosis.Formula:C29H32N2O6Colore e forma:SolidPeso molecolare:504.57CN128 hydrochloride
CAS:<p>CN128 hydrochloride is an oral, selective hydroxypyridone iron chelator for β-thalassemia research.</p>Formula:C15H18ClNO3Colore e forma:SolidPeso molecolare:295.76YL-939
YL-939 is a potent inhibitor of ferroptosis, targeting the PHB2/ferritin/iron axis to impede this form of cell death.Formula:C25H26N6OColore e forma:SolidPeso molecolare:426.51Erastin2
CAS:<p>Erastin2 is an iron death inducer that induces cell death by binding to the lipophilic free radical trapping antioxidant ferrostatin-1 or the iron chelator DFO.</p>Formula:C36H35ClN4O4Purezza:99.63%Colore e forma:SolidPeso molecolare:623.14HBED
CAS:HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.Formula:C20H24N2O6Purezza:97.35% - 98.58%Colore e forma:SolidPeso molecolare:388.41BCP-T.A
CAS:BCP-T.A is an iron death inducer that acts by binding to GPX4.Formula:C23H19Cl2N3OSPurezza:99.49%Colore e forma:SolidPeso molecolare:456.39
