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CDK

CDK

Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.

Trovati 522 prodotti di "CDK"

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  • BAY-958
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    BAY-958

    CAS:
    BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.
    Formula:C17H16FN5O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:389.4

    Ref: TM-T23775

  • Olomoucine II
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    Olomoucine II

    CAS:
    Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.
    Formula:C19H26N6O2
    Purezza:99.94%
    Colore e forma:Solid
    Peso molecolare:370.45

    Ref: TM-T35696

  • CDK5 inhibitor 20-223
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    CDK5 inhibitor 20-223

    CAS:
    CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.
    Formula:C19H19N3O
    Colore e forma:Solid
    Peso molecolare:305.37

    Ref: TM-T36742

  • P18IN003
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    P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purezza:98.77%
    Colore e forma:Solid
    Peso molecolare:296.32

    Ref: TM-T24580

  • β-catenin-IN-3
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    β-catenin-IN-3

    CAS:
    β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces the
    Formula:C19H20Br2N2OS
    Colore e forma:Solid
    Peso molecolare:484.25

    Ref: TM-T63212

  • CDK7-IN-12
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    CDK7-IN-12

    CAS:
    CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.
    Formula:C20H19F3N6
    Colore e forma:Solid
    Peso molecolare:400.4

    Ref: TM-T61922

  • GW8510
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    GW8510

    CAS:
    GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.
    Formula:C21H15N5O3S2
    Purezza:99.32%
    Colore e forma:Solid
    Peso molecolare:449.51

    Ref: TM-T24125

  • Crozbaciclib fumarate
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    Crozbaciclib fumarate

    CAS:
    Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.
    Formula:C32H34F2N6O4
    Colore e forma:Solid
    Peso molecolare:604.65

    Ref: TM-T72393

  • Cdc7-IN-17
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    Cdc7-IN-17

    CAS:
    Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].
    Formula:C13H15N5OS
    Colore e forma:Solid
    Peso molecolare:289.36

    Ref: TM-T60589

  • FN-1501
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    FN-1501

    CAS:
    <p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>
    Formula:C22H25N9O
    Purezza:97.4%
    Colore e forma:Solid
    Peso molecolare:431.49

    Ref: TM-T15335

  • BS-181
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    BS-181

    CAS:
    BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
    Formula:C22H32N6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:380.53

    Ref: TM-T1947

  • BRD7389
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    BRD7389

    CAS:
    BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
    Formula:C24H18N2O2
    Purezza:99.51%
    Colore e forma:Solid
    Peso molecolare:366.41

    Ref: TM-T14779

  • CLK-IN-T3
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    CLK-IN-T3

    CAS:
    CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.
    Formula:C28H30N6O2
    Purezza:99.61%
    Colore e forma:Solid
    Peso molecolare:482.58

    Ref: TM-T14980

  • 9-Isopropylolomoucine
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    9-Isopropylolomoucine

    CAS:
    9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.
    Formula:C17H22N6O
    Purezza:99.82%
    Colore e forma:Solid
    Peso molecolare:326.4

    Ref: TM-T23589

  • CDK8-IN-1
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    CDK8-IN-1

    CAS:
    CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
    Formula:C11H8F3N3O
    Purezza:98.48%
    Colore e forma:Solid
    Peso molecolare:255.2

    Ref: TM-T10740

  • CDK9-IN-10
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    CDK9-IN-10

    CAS:
    CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.
    Formula:C22H16O5
    Purezza:99.8%
    Colore e forma:Solid
    Peso molecolare:360.36

    Ref: TM-T10742

  • PS423
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    PS423

    CAS:
    PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.
    Formula:C25H23F3O9
    Purezza:98.81% - 99.26%
    Colore e forma:Solid
    Peso molecolare:524.44

    Ref: TM-T24676

  • SEL120-34A
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    SEL120-34A

    CAS:
    SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.
    Formula:C15H18Br2N4
    Purezza:99.764% - 99.84%
    Colore e forma:Solid
    Peso molecolare:414.14

    Ref: TM-T10744

  • hSMG-1 inhibitor 11e
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    hSMG-1 inhibitor 11e

    CAS:
    hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.
    Formula:C26H27N7O3S
    Purezza:99.89%
    Colore e forma:Solid
    Peso molecolare:517.6

    Ref: TM-T35529

  • HTH-01-091
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    HTH-01-091

    CAS:
    HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,
    Formula:C26H28Cl2N4O2
    Purezza:98.82%
    Colore e forma:Solid
    Peso molecolare:499.43

    Ref: TM-T24152