ROCK
Gli inibitori della chinasi associata a Rho (ROCK) prendono di mira le chinasi ROCK, che sono coinvolte nella regolazione del citoscheletro, della forma cellulare e della motilità. ROCK svolge un ruolo significativo nel controllo della divisione cellulare, in particolare in processi come la citodieresi. L'inibizione di ROCK può portare a cambiamenti nella dinamica del ciclo cellulare, nella motilità cellulare e nell'apoptosi, rendendo questi inibitori preziosi nella ricerca sul cancro, nella neurobiologia e negli studi cardiovascolari. Presso CymitQuimica, offriamo una selezione di inibitori ROCK di alta qualità per supportare la tua ricerca in biologia cellulare, dinamica del citoscheletro e meccanismi delle malattie.
Trovati 63 prodotti di "ROCK"
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Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formula:C16H18Cl2N4OPurezza:98.88% - 99.89%Colore e forma:SolidPeso molecolare:353.25Ref: TM-T13384L
1mg34,00€5mg66,00€10mg102,00€25mg192,00€50mg341,00€100mg510,00€200mg732,00€1mL*10mM (DMSO)78,00€Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formula:C28H29Cl2N3O3Purezza:99.94% - 99.98%Colore e forma:SolidPeso molecolare:526.45ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formula:C21H20N2O2Purezza:99.85%Colore e forma:SolidPeso molecolare:332.4Ref: TM-T12746
1mg66,00€5mg144,00€10mg216,00€25mg432,00€50mg645,00€100mg905,00€1mL*10mM (DMSO)106,00€CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurezza:99.01% - 99.04%Colore e forma:SolidPeso molecolare:466.46Akt/ROCK-IN-1
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively.Formula:C21H19BrF2N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:509.37Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Formula:C15H18FN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:323.39Ref: TM-T7492
1mg75,00€5mg150,00€10mg238,00€25mg530,00€50mg873,00€100mg1.459,00€1mL*10mM (DMSO)166,00€LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Formula:C23H29N7O3xHClPurezza:98.96%Colore e forma:SolidPeso molecolare:487.99ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formula:C28H30N8O2Colore e forma:SolidPeso molecolare:510.59Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurezza:99.79% - 99.84%Colore e forma:SolidPeso molecolare:291.37WAY-656935
CAS:WAY-656935 inhibits ROCK.Formula:C20H28ClN3O3SPurezza:97%Colore e forma:SolidPeso molecolare:425.97GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formula:C15H13Cl2N3Purezza:98.1%Colore e forma:SoildPeso molecolare:306.19Ref: TM-T11402L
1mg71,00€5mg154,00€10mg221,00€25mg354,00€50mg497,00€100mg705,00€200mg928,00€1mL*10mM (DMSO)167,00€GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formula:C29H31ClN8O5Colore e forma:SolidPeso molecolare:607.06Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formula:C27H28N6O5SPurezza:98.73%Colore e forma:SolidPeso molecolare:548.61Ref: TM-T39555
1mg35,00€2mg48,00€5mg74,00€10mg92,00€25mg163,00€50mg243,00€100mg373,00€200mg547,00€1mL*10mM (DMSO)89,00€Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formula:C17H17N3O2SPurezza:99.68%Colore e forma:SolidPeso molecolare:327.4Ref: TM-T60924
1mg55,00€5mg147,00€10mg231,00€25mg370,00€50mg522,00€100mg692,00€1mL*10mM (DMSO)161,00€Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formula:C16H21N3O2SPurezza:98.41%Colore e forma:SolidPeso molecolare:319.42Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formula:C14H13NO7Purezza:98.16% - 99.58%Colore e forma:SolidPeso molecolare:307.26Ref: TM-TQ0183
1mg90,00€5mg388,00€10mg575,00€25mgPrezzo su richiesta50mgPrezzo su richiesta1mL*10mM (DMSO)425,00€SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Formula:C14H16N2O2Purezza:99.42%Colore e forma:SolidPeso molecolare:244.29Ref: TM-T7391
2mg34,00€5mg50,00€10mg75,00€25mg128,00€50mg200,00€100mg319,00€200mg474,00€1mL*10mM (DMSO)55,00€SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Formula:C22H24N4O4Purezza:98.46%Colore e forma:SolidPeso molecolare:408.45SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormula:C14H17ClN2O2Purezza:99.15%Colore e forma:SolidPeso molecolare:280.75RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormula:C17H16N4O2SPurezza:99.53% - ≥95%Colore e forma:SolidPeso molecolare:340.4Ref: TM-T2011
1mg70,00€5mg142,00€10mg207,00€25mg369,00€50mg540,00€100mg772,00€500µg49,00€1mL*10mM (DMSO)160,00€
