ROCK
Gli inibitori della chinasi associata a Rho (ROCK) prendono di mira le chinasi ROCK, che sono coinvolte nella regolazione del citoscheletro, della forma cellulare e della motilità. ROCK svolge un ruolo significativo nel controllo della divisione cellulare, in particolare in processi come la citodieresi. L'inibizione di ROCK può portare a cambiamenti nella dinamica del ciclo cellulare, nella motilità cellulare e nell'apoptosi, rendendo questi inibitori preziosi nella ricerca sul cancro, nella neurobiologia e negli studi cardiovascolari. Presso CymitQuimica, offriamo una selezione di inibitori ROCK di alta qualità per supportare la tua ricerca in biologia cellulare, dinamica del citoscheletro e meccanismi delle malattie.
Trovati 66 prodotti per "ROCK".
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Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formula:C16H18Cl2N4OPurezza:98.88% - 99.89%Colore e forma:SolidPeso molecolare:353.246ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formula:C21H20N2O2Purezza:99.85%Colore e forma:SolidPeso molecolare:332.3957Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formula:C28H29Cl2N3O3Purezza:99.92% - 99.98%Colore e forma:White SolidPeso molecolare:526.454CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurezza:99.01% - 99.52%Colore e forma:SolidPeso molecolare:466.46ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formula:C28H30N8O2Colore e forma:SolidPeso molecolare:510.59WAY-656935
CAS:WAY-656935 inhibits ROCK.Formula:C20H28ClN3O3SPurezza:97%Colore e forma:SolidPeso molecolare:425.973Y-39983 hydrochloride
CAS:Y-39983 hydrochloride (SNJ-1656) is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor.Formula:C16H17ClN4OPeso molecolare:316.79Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Formula:C15H18FN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:323.386Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurezza:99.84% - 99.97%Colore e forma:White SolidPeso molecolare:291.369ROCK2-IN-11
ROCK2-IN-11 (Compound A20) is a selective ROCK2 inhibitor with an IC50 of 0.18 μM against ROCK2, demonstrating greater potency over ROCK1. It is applicable in the research of idiopathic pulmonary fibrosis and chronic graft-versus-host disease (cGVHD).S6(229-239), Amide, biotinalyted
S6(229-239), Amide, biotinylated, is a bioactive peptide known as a substrate for Rho-kinase II.Formula:C64H119N27O15SPeso molecolare:1537.90997GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formula:C15H13Cl2N3Purezza:98.1%Colore e forma:SolidPeso molecolare:306.19Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formula:C17H17N3O2SPurezza:99.68%Colore e forma:SolidPeso molecolare:327.401GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formula:C29H31ClN8O5Colore e forma:SolidPeso molecolare:607.06Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formula:C16H21N3O2SPurezza:98.41%Colore e forma:SolidPeso molecolare:319.422Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formula:C27H28N6O5SPurezza:99.36%Colore e forma:SolidPeso molecolare:548.61SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Formula:C14H16N2O2Purezza:99.42%Colore e forma:White SolidPeso molecolare:244.289RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormula:C17H16N4O2SPurezza:99.70% - ≥95%Colore e forma:White SolidPeso molecolare:340.4ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Formula:C18H13ClF2N6OPurezza:97.29%Colore e forma:SolidPeso molecolare:402.79SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormula:C14H17ClN2O2Purezza:99.15%Colore e forma:SolidPeso molecolare:280.75
