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HSP

HSP

Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.

Trovati 200 prodotti per "HSP".

prodotti per pagina.
  • GRP78-IN-3
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    GRP78-IN-3

    CAS:
    GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.
    Formula:C17H18N4O2S
    Purezza:99.49%
    Colore e forma:Solid
    Peso molecolare:342.415

    Ref: TM-T67897

  • Ethoxyquin
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    Ethoxyquin

    Prodotto controllato
    CAS:
    Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
    Formula:C14H19NO
    Purezza:97.15% - 98.73%
    Colore e forma:Yellow Liquid
    Peso molecolare:217.3068

    Ref: TM-T0756

  • IPI-493
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    IPI-493

    CAS:
    IPI-493 is a bioactive chemical.
    Formula:C28H39N3O8
    Purezza:99.86%
    Colore e forma:Solid
    Peso molecolare:545.62

    Ref: TM-T32188

  • Novobiocin Sodium
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    Novobiocin Sodium

    CAS:
    Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.
    Formula:C31H35N2NaO11
    Purezza:98.46% - 99.51%
    Colore e forma:Solid
    Peso molecolare:634.6062

    Ref: TM-T0974

  • CC-99677
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    CC-99677

    CAS:
    CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.
    Formula:C22H20ClN5O3S
    Purezza:99.59%
    Colore e forma:Solid
    Peso molecolare:469.944

    Ref: TM-T39321

  • Arimoclomol maleate
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    Arimoclomol maleate

    CAS:
    Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.
    Formula:C18H24ClN3O7
    Purezza:99.44% - 99.98%
    Colore e forma:Solid
    Peso molecolare:429.852

    Ref: TM-T13554

  • Col003
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    Col003

    CAS:
    Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).
    Formula:C14H11NO4
    Purezza:99.03% - 99.96%
    Colore e forma:Solid
    Peso molecolare:257.2414

    Ref: TM-T10860

  • Palmitic acid-13C2
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    Palmitic acid-13C2

    CAS:
    13C-labeled Palmitic acid is a saturated fatty acid in animals/plants influencing GRP78 and CHOP in mouse cells.
    Formula:C16H32O2
    Peso molecolare:258.415

    Ref: TM-T40980

  • Palmitic acid-D4
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    Palmitic acid-D4

    CAS:
    Palmitic acid-D4 is the deuterated form of Palmitic acid. This compound is a long-chain saturated fatty acid commonly found in animals and plants. Palmitic acid (T2908) is known to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in murine granulosa cells.
    Formula:C16H32O2
    Peso molecolare:260.45

    Ref: TM-TMID-0977

  • trans-Dehydrocurvularin
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    trans-Dehydrocurvularin

    CAS:
    trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.
    Formula:C16H18O5
    Colore e forma:Solid
    Peso molecolare:290.315

    Ref: TM-T125357

  • Logo CymitQuimica
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    Grp94-IN-3

    Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.

    Ref: TM-T214222

  • Grp94 Inhibitor-2
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    Grp94 Inhibitor-2

    Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.
    Formula:C26H25ClFNO4
    Peso molecolare:469.94

    Ref: TM-T89400

  • NMS-E973
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    NMS-E973

    CAS:
    NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
    Formula:C22H22N4O7
    Purezza:99.84%
    Colore e forma:Yellow Solid
    Peso molecolare:454.4327

    Ref: TM-T6609

  • Logo CymitQuimica
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    TBPH

    TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.

    Ref: TM-T211712

  • Palmitic acid-13C sodium
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    Palmitic acid-13C sodium

    CAS:
    13C-labeled Palmitic acid, a common long-chain fatty acid in flora/fauna, induces GRP78/CHOP in mouse cells.
    Formula:CC15H31NaO2
    Peso molecolare:279.4

    Ref: TM-T39423

  • HEMTAC WEE1 degrader-1
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    HEMTAC WEE1 degrader-1

    CAS:
    HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.
    Formula:C57H71N15O6
    Colore e forma:Solid
    Peso molecolare:1062.27

    Ref: TM-T207012

  • Shepherdin (79-87)
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    Shepherdin (79-87)

    CAS:
    Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.
    Formula:C41H64N12O12S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:949.09

    Ref: TM-T12896

  • [Au(TPP)]Cl
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    [Au(TPP)]Cl

    CAS:
    [Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'
    Formula:C44H28AuClN4
    Peso molecolare:845.14

    Ref: TM-T88478

  • Logo CymitQuimica
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    Hsp90β-IN-2

    Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.

    Ref: TM-T213425

  • JD-13
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    JD-13

    CAS:
    JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.
    Formula:C25H32N4O3
    Purezza:99.32% - 99.69%
    Colore e forma:White Solid
    Peso molecolare:436.56

    Ref: TM-T212638