Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2462 prodotti di "Cromatina/Epigenetica"
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PARP1-IN-5 dihydrochloride
CAS:PARP1-IN-5 dihydrochloride: oral, potent PARP-1 inhibitor (IC50=14.7 nM), for cancer research.Formula:C25H26Cl2N2O5SPurezza:98.01%Colore e forma:SolidPeso molecolare:537.46DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Formula:C6H9NO5Purezza:80.23% - 99.98%Colore e forma:SolidPeso molecolare:175.14KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formula:C16H16Cl4N2O4S4Purezza:98% - 99.11%Colore e forma:SolidPeso molecolare:570.38Fedratinib hydrochloride hydrate
CAS:Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formula:C27H40Cl2N6O4SPurezza:98.96% - 99.87%Colore e forma:SolidPeso molecolare:615.61WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formula:C16H14Br2ClN3O3Purezza:99.49%Colore e forma:SolidPeso molecolare:491.56Ref: TM-T4657L
2mg37,00€5mg50,00€10mg90,00€25mg145,00€50mg192,00€100mg276,00€200mg393,00€1mL*10mM (DMSO)77,00€PFI-3
CAS:PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.Formula:C19H19N3O2Purezza:99.58% - 99.94%Colore e forma:SolidPeso molecolare:321.37Rucaparib tartrate
CAS:Rucaparib tartrate: oral PARP-1/2/3 inhibitor, Ki=1.4 nM; also inhibits H6PD; for studying CRPC.Formula:C23H24FN3O7Colore e forma:SolidPeso molecolare:473.457Windorphen
CAS:Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.Formula:C17H15ClO3Purezza:99.66%Colore e forma:SolidPeso molecolare:302.75ME0328
CAS:ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.Formula:C19H19N3O2Purezza:99.22%Colore e forma:SolidPeso molecolare:321.37UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formula:C29H44F2N6O2Purezza:98.75% - 99.5%Colore e forma:SolidPeso molecolare:546.7Ref: TM-T4166
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg230,00€50mg378,00€100mg567,00€200mg825,00€1mL*10mM (DMSO)95,00€DL-α-Hydroxyglutaric acid disodium salt
CAS:DL-α-Hydroxyglutaric acid disodium salt (disodium 2-hydroxypentanedioate) is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuranFormula:C5H6Na2O5Purezza:≥98%Colore e forma:SolidPeso molecolare:192.08ARN-3236
CAS:ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nMFormula:C19H16N2O2SPurezza:98.89% - 99.7%Colore e forma:SolidPeso molecolare:336.41Ref: TM-T5993
1mg60,00€5mg97,00€10mg160,00€25mg264,00€50mg354,00€100mg540,00€200mg777,00€1mL*10mM (DMSO)150,00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purezza:99.32% - 99.98%Colore e forma:SolidPeso molecolare:421.54PIN1 inhibitor API-1
CAS:API-1 is a Pin1 inhibitor (IC50: 72.3 nM), enhancing anticancer miRNA biogenesis and inhibiting hepatocellular carcinoma.Formula:C15H13F3N6O2Purezza:98.48%Colore e forma:SolidPeso molecolare:366.3Ref: TM-T16538
1mg60,00€5mg127,00€10mg235,00€25mg344,00€50mg512,00€100mg645,00€200mg898,00€500mg1.311,00€1mL*10mM (DMSO)140,00€Nicotinamide Hydrochloride
CAS:Nicotinamide Hydrochloride, a vitamin B3 form, inhibits SIRT2 and melanoma growth, enhancing NAD+, ATP, ROS, and survival in melanoma mice.Formula:C6H7ClN2OColore e forma:SolidPeso molecolare:158.59OG-L002
CAS:OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.Formula:C15H15NOPurezza:97.05% - 98.62%Colore e forma:SolidPeso molecolare:225.29EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Formula:C24H18ClN3O3Purezza:99.20% - 99.36%Colore e forma:SolidPeso molecolare:431.87Ref: TM-TQ0028
1mg37,00€2mg52,00€5mg74,00€10mg111,00€25mg221,00€50mg376,00€100mg565,00€1mL*10mM (DMSO)85,00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purezza:97.88% - 98.79%Colore e forma:White PowderPeso molecolare:474.55SAR-20347
CAS:SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Formula:C21H18ClFN4O4Purezza:98.99% - 99.77%Colore e forma:SolidPeso molecolare:444.84Ref: TM-T4210
1mg35,00€5mg80,00€10mg116,00€25mg227,00€50mg354,00€100mg588,00€200mg818,00€1mL*10mM (DMSO)88,00€UNC 669
CAS:UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.Formula:C15H20BrN3OPurezza:97.38%Colore e forma:SolidPeso molecolare:338.24Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurezza:99.26% - >99.99%Colore e forma:SolidPeso molecolare:326.17NCGC00244536
CAS:NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM).Formula:C25H22N2O2Purezza:97.2% - 99.72%Colore e forma:SolidPeso molecolare:382.45Ref: TM-TQ0050
1mg90,00€5mg264,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€1mL*10mM (DMSO)227,00€MR837
CAS:MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Formula:C16H14N2OSPurezza:99.77% - 99.85%Colore e forma:SolidPeso molecolare:282.36Ref: TM-T8879
2mg40,00€5mg58,00€10mg96,00€25mg145,00€50mg255,00€100mg375,00€200mg530,00€1mL*10mM (DMSO)70,00€MM-102 TFA
CAS:MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 interaction, impeding H3K4 HMT activity.Formula:C37H50F5N7O6Purezza:99.4% - 99.78%Colore e forma:SolidPeso molecolare:783.83Ref: TM-T8768
1mg39,00€2mg51,00€5mg105,00€10mg168,00€25mg284,00€50mg420,00€100mg620,00€1mL*10mM (DMSO)149,00€G007-LK
CAS:<p>G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.</p>Formula:C25H16ClN7O3SPurezza:97.63% - 98.17%Colore e forma:SolidPeso molecolare:529.96MPT0G211 mesylate
CAS:MPT0G211 mesylate: potent, selective HDAC6 inhibitor (IC50=0.291nM), oral, BBB-penetrating, anti-tau and metastasis, potential anticancer.Formula:C18H19N3O5SColore e forma:SolidPeso molecolare:389.43Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formula:C21H23N5O3SPurezza:98.03% - ≥95%Colore e forma:SolidPeso molecolare:425.5DR2313
CAS:DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.Formula:C8H10N2OSPurezza:98.65%Colore e forma:SolidPeso molecolare:182.24GSK-J1
CAS:GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.Formula:C22H23N5O2Purezza:99.23% - 99.67%Colore e forma:SolidPeso molecolare:389.45PJ34 hydrochloride
CAS:PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.Formula:C17H18ClN3O2Purezza:98.87% - ≥95%Colore e forma:SolidPeso molecolare:331.8UPF 1069
CAS:UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.Formula:C17H13NO3Purezza:98.80% - 99.88%Colore e forma:SolidPeso molecolare:279.29Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formula:C28H32N4O3Purezza:99.25% - 99.49%Colore e forma:SolidPeso molecolare:472.58CPI203
CAS:CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurezza:99.13% - 99.77%Colore e forma:SolidPeso molecolare:399.9HJ-PI01
CAS:<p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>Formula:C14H11NO2Purezza:98.92%Colore e forma:SolidPeso molecolare:225.24ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purezza:99.11% - 99.59%Colore e forma:Pale Yellow SolidPeso molecolare:513.59JQKD82
CAS:JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.Formula:C27H40N4O5Purezza:100.00%Colore e forma:SolidPeso molecolare:500.63MK-3903
CAS:MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).Formula:C27H19ClN2O3Purezza:98.63% - 99.75%Colore e forma:SolidPeso molecolare:454.9Ref: TM-T5187
1mg35,00€5mg80,00€10mg120,00€25mg188,00€50mg354,00€100mg588,00€200mg833,00€1mL*10mM (DMSO)88,00€Niraparib hydrochloride
CAS:Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.Formula:C19H21ClN4OPurezza:99.26%Colore e forma:SolidPeso molecolare:356.85GSK484 hydrochloride
CAS:GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor.Cost-effective and quality-assured.Formula:C27H32ClN5O3Purezza:98.32% - 99.62%Colore e forma:SolidPeso molecolare:510.03Ref: TM-TQ0067
1mg71,00€5mg147,00€10mg215,00€25mg435,00€50mg622,00€100mg887,00€1mL*10mM (DMSO)164,00€AZ6102
CAS:AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.Formula:C25H28N6OPurezza:97.98% - 99.91%Colore e forma:SolidPeso molecolare:428.53VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formula:C24H20Cl2FN5O2Purezza:98.92% - ≥98%Colore e forma:SolidPeso molecolare:500.35Bisindolylmaleimide IV
CAS:<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Formula:C20H13N3O2Purezza:98.83%Colore e forma:Dark Red SolidPeso molecolare:327.34Ref: TM-T6S0071
2mg35,00€5mg52,00€10mg88,00€25mg160,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)86,00€Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Formula:C16H18O9Purezza:98.84% - 99.67%Colore e forma:SolidPeso molecolare:354.31JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Formula:C12H6ClF3N4O3Purezza:99.58% - ≥95%Colore e forma:SolidPeso molecolare:346.65Ref: TM-T3180
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg210,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€OAC1
CAS:OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.Formula:C14H11N3OPurezza:99.49% - 99.65%Colore e forma:SolidPeso molecolare:237.26Ref: TM-T2040
1mg37,00€2mg49,00€5mg70,00€10mg97,00€25mg167,00€50mg316,00€100mg570,00€1mL*10mM (DMSO)70,00€I-BRD9
CAS:I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.Formula:C22H22F3N3O3S2Purezza:98.16% - 99.51%Colore e forma:SolidPeso molecolare:497.55Ref: TM-T6859
1mg40,00€2mg51,00€5mg74,00€10mg113,00€25mg215,00€50mg411,00€100mg610,00€1mL*10mM (DMSO)84,00€Isoxazole
CAS:Isoxazole (1,2-oxazole) is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.Formula:C3H3NOPurezza:99.34%Colore e forma:Colorless LiquidPeso molecolare:69.06
