Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2486 prodotti di "Cromatina/Epigenetica"
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UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formula:C29H44F2N6O2Purezza:98.75% - 99.5%Colore e forma:SolidPeso molecolare:546.7Ref: TM-T4166
1mg38,00€2mg50,00€5mg82,00€10mg124,00€25mg219,00€50mg358,00€100mg537,00€200mg782,00€1mL*10mM (DMSO)89,00€SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formula:C16H18N4O2Purezza:99.75% - 99.89%Colore e forma:SolidPeso molecolare:298.34BI-7273
CAS:BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.Formula:C20H23N3O3Purezza:97.37% - 99.57%Colore e forma:SolidPeso molecolare:353.413-methyl-1,2-dihydroquinolin-2-one
CAS:3-methyl-1,2-dihydroquinolin-2-one is the first known micromolar inhibitors of the ATAD2 bromodomain.Formula:C10H9NOPurezza:99.62%Colore e forma:SolidPeso molecolare:159.18Ref: TM-T50035
1mg35,00€5mg77,00€10mg103,00€25mg170,00€50mg250,00€100mg354,00€200mg480,00€1mL*10mM (DMSO)62,00€N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Formula:C4H5NO5Purezza:99.23%Colore e forma:Colourless SolidPeso molecolare:147.09O-304
CAS:O-304 is a pan-activator of AMP-activated protein kinase (AMPK).Formula:C16H11Cl2N3O2SPurezza:99.84% - ≥98%Colore e forma:SolidPeso molecolare:380.25Ref: TM-T7362
1mg66,00€2mg96,00€5mg144,00€10mg216,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)159,00€Splitomicin
CAS:Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in aFormula:C13H10O2Purezza:97.09% - 99.11%Colore e forma:SolidPeso molecolare:198.22DL-α-Hydroxyglutaric acid disodium salt
CAS:DL-α-Hydroxyglutaric acid disodium salt (disodium 2-hydroxypentanedioate) is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuranFormula:C5H6Na2O5Purezza:≥98%Colore e forma:SolidPeso molecolare:192.08AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3PIN1 inhibitor API-1
CAS:API-1 is a Pin1 inhibitor (IC50: 72.3 nM), enhancing anticancer miRNA biogenesis and inhibiting hepatocellular carcinoma.Formula:C15H13F3N6O2Purezza:98.48%Colore e forma:SolidPeso molecolare:366.3Ref: TM-T16538
1mg60,00€5mg127,00€10mg235,00€25mg344,00€50mg512,00€100mg645,00€200mg898,00€500mg1.311,00€1mL*10mM (DMSO)140,00€OG-L002
CAS:OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.Formula:C15H15NOPurezza:97.05% - 98.62%Colore e forma:SolidPeso molecolare:225.29MLN8054 sodium
CAS:MLN8054 sodium is an Aurora A inhibitor.Formula:C25H14ClF2N4NaO2Colore e forma:SolidPeso molecolare:498.84UNC 669
CAS:UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.Formula:C15H20BrN3OPurezza:97.38%Colore e forma:SolidPeso molecolare:338.243-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purezza:99.16% - >99.99%Colore e forma:SolidPeso molecolare:146.15Ref: TM-T4108
2mg39,00€5mg52,00€10mg93,00€25mg166,00€50mg248,00€100mg393,00€200mg560,00€1mL*10mM (DMSO)52,00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purezza:97.88% - 98.79%Colore e forma:White PowderPeso molecolare:474.554-Phenylbutyric acid
CAS:4-Phenylbutyric acid (Benzenebutyric acid) is a HDAC inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. Cost-effective and quality-assured.Formula:C10H12O2Purezza:98.40% - 99.76%Colore e forma:SolidPeso molecolare:164.2HDAC8-IN-1
CAS:MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.Formula:C22H19NO3Purezza:97.13% - 99.19%Colore e forma:SolidPeso molecolare:345.39Ref: TM-T7082
1mg34,00€5mg63,00€10mg95,00€25mg172,00€50mg259,00€100mg330,00€200mg467,00€1mL*10mM (DMSO)70,00€MM-102 TFA
CAS:MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 interaction, impeding H3K4 HMT activity.Formula:C37H50F5N7O6Purezza:99.4% - 99.78%Colore e forma:SolidPeso molecolare:783.83Ref: TM-T8768
1mg39,00€2mg51,00€5mg105,00€10mg168,00€25mg284,00€50mg420,00€100mg620,00€1mL*10mM (DMSO)149,00€Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formula:C21H23N5O3SPurezza:98.03% - ≥95%Colore e forma:SolidPeso molecolare:425.5Methyl L-histidinate dihydrochloride
CAS:The inhibitory effect of Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) on histidine decarboxylase in Sprague-Dawley ratFormula:C7H13Cl2N3O2Purezza:99.74%Colore e forma:White To Off-White PowderPeso molecolare:242.14-(3-Chlorophenyl)-2(3H)-thiazolone
CAS:4-(3-chlorophenyl)-2,3-dihydro-1,3-thiazol-2-one: a thiazole used to make antifungals, antivirals, and anti-inflammatories.Formula:C9H6ClNOSPurezza:95.311%Colore e forma:SolidPeso molecolare:211.67ABBV-744
CAS:ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.Formula:C28H30FN3O4Purezza:97.03% - >99.99%Colore e forma:SolidPeso molecolare:491.55Ref: TM-T4697
1mg47,00€2mg59,00€5mg96,00€10mg150,00€25mg299,00€50mg432,00€100mg527,00€200mg758,00€1mL*10mM (DMSO)96,00€G007-LK
CAS:<p>G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.</p>Formula:C25H16ClN7O3SPurezza:97.63% - 98.17%Colore e forma:SolidPeso molecolare:529.96MPT0G211 mesylate
CAS:MPT0G211 mesylate: potent, selective HDAC6 inhibitor (IC50=0.291nM), oral, BBB-penetrating, anti-tau and metastasis, potential anticancer.Formula:C18H19N3O5SColore e forma:SolidPeso molecolare:389.43DR2313
CAS:DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.Formula:C8H10N2OSPurezza:98.65%Colore e forma:SolidPeso molecolare:182.24TFMB-(R)-2-HG
CAS:TFMB-(R)-2-HG, a carcinogen in AML, hinders SCF ER-Hoxb8 differentiation after estrogen loss.Formula:C13H11F3O4Purezza:97.15%Colore e forma:SolidPeso molecolare:288.22Ref: TM-T17065
1mg77,00€5mg166,00€10mg250,00€25mg452,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)140,00€A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFormula:C18H16Cl2N4Purezza:99.92%Colore e forma:SolidPeso molecolare:359.25CPI203
CAS:CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurezza:99.13% - 99.77%Colore e forma:SolidPeso molecolare:399.9JQKD82
CAS:JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.Formula:C27H40N4O5Purezza:100.00%Colore e forma:SolidPeso molecolare:500.63Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formula:C28H32N4O3Purezza:99.25% - 99.49%Colore e forma:SolidPeso molecolare:472.58ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purezza:99.11% - 99.59%Colore e forma:Pale Yellow SolidPeso molecolare:513.59AZ6102
CAS:AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.Formula:C25H28N6OPurezza:97.98% - 99.91%Colore e forma:SolidPeso molecolare:428.53Ref: TM-T6S0071
2mg35,00€5mg52,00€10mg88,00€25mg160,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)86,00€Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formula:C16H17N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:371.42Ref: TM-T2485
5mg50,00€10mg73,00€25mg90,00€50mg115,00€100mg144,00€200mg188,00€500mg311,00€1mL*10mM (DMSO)69,00€Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36Ref: TM-T3043
1g583,00€5mg49,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1mL*10mM (DMSO)56,00€AMPK activator 2
CAS:AMPK activator 2, a chloroformin derivative, may boost cancer treatment by enhancing AMPK and inhibiting mTOR pathways, and cancer cell growth.Formula:C13H18F3N5Purezza:99.86%Colore e forma:SolidPeso molecolare:301.31Bisindolylmaleimide IV
CAS:<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Formula:C20H13N3O2Purezza:98.83%Colore e forma:Dark Red SolidPeso molecolare:327.34I-BRD9
CAS:I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.Formula:C22H22F3N3O3S2Purezza:98.16% - 99.51%Colore e forma:SolidPeso molecolare:497.55Ref: TM-T6859
1mg40,00€2mg51,00€5mg74,00€10mg113,00€25mg215,00€50mg411,00€100mg610,00€1mL*10mM (DMSO)84,00€Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formula:C18H19F3N6OPurezza:99.28% - >99.99%Colore e forma:SolidPeso molecolare:392.38Ref: TM-T2636
1mg35,00€2mg50,00€5mg74,00€10mg104,00€25mg207,00€50mg311,00€100mg472,00€1mL*10mM (DMSO)84,00€OAC1
CAS:OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.Formula:C14H11N3OPurezza:99.49% - 99.65%Colore e forma:SolidPeso molecolare:237.26Ref: TM-T2040
1mg37,00€2mg49,00€5mg70,00€10mg97,00€25mg167,00€50mg316,00€100mg570,00€1mL*10mM (DMSO)70,00€MT-DADMe-ImmA
CAS:MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).Formula:C13H19N5OSPurezza:99.56%Colore e forma:SolidPeso molecolare:293.39Ref: TM-TQ0008
1mg70,00€5mg135,00€10mg225,00€25mg399,00€50mg560,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)169,00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€ORY1001
CAS:ORY1001: Oral LSD1/KDM1A inhibitor, highly selective, IC50 <20 nM.Formula:C15H22N2·2HClPurezza:99.85% - 99.96%Colore e forma:SolidPeso molecolare:303.27Ref: TM-T6922
1mg59,00€2mg84,00€5mg134,00€10mg234,00€25mg452,00€50mg660,00€100mg939,00€500mg1.882,00€1mL*10mM (DMSO)134,00€SGC-SMARCA-BRDVIII
CAS:SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,Formula:C19H25N5O3Purezza:99.54% - 99.92%Colore e forma:SolidPeso molecolare:371.43Ref: TM-T9568
1mg47,00€5mg70,00€10mg106,00€25mg235,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)57,00€Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formula:C16H12O6Purezza:98.53% - 99.87%Colore e forma:SolidPeso molecolare:300.26Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurezza:98.53% - 99.94%Colore e forma:SolidPeso molecolare:248.71Ref: TM-T6111
5mg50,00€10mg57,00€25mg93,00€50mg140,00€100mg235,00€200mg349,00€500mg565,00€1mL*10mM (DMSO)52,00€Senaparib hydrochloride
CAS:Senaparib hydrochloride is a potent and selective oral PARP1/2 inhibitor with strong antitumor activity.Formula:C24H21ClF2N6O3Colore e forma:SolidPeso molecolare:514.92Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Formula:C20H13N5OPurezza:97.03% - 98.69%Colore e forma:SolidPeso molecolare:339.35Ref: TM-T5093
1mg85,00€2mg124,00€5mg173,00€10mg263,00€25mg464,00€50mg672,00€100mg945,00€1mL*10mM (DMSO)192,00€RK-287107
CAS:RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).Formula:C22H26F2N4O2Purezza:99.64%Colore e forma:SolidPeso molecolare:416.46Iniparib
CAS:Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).Formula:C7H5IN2O3Purezza:98.93%Colore e forma:SolidPeso molecolare:292.03Ref: TM-T6224
5mg50,00€10mg77,00€25mg126,00€50mg229,00€100mg359,00€200mg570,00€500mg912,00€1mL*10mM (DMSO)55,00€
