Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2442 prodotti di "Cromatina/Epigenetica"
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NI-57
CAS:NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).Formula:C19H17N3O4SPurezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:383.42Menin-MLL inhibitor MI-2
CAS:Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.Formula:C18H25N5S2Purezza:97.46%Colore e forma:SolidPeso molecolare:375.55Ref: TM-T2649
2mg42,00€5mg62,00€10mg88,00€25mg169,00€50mg243,00€100mg376,00€200mg550,00€1mL*10mM (DMSO)67,00€Molibresib besylate
CAS:Molibresib besylate (GSK 525762C) is a BET protein family inhibitor used in the study of refractory hematologic malignant diseases.Formula:C28H28ClN5O5SPurezza:99.64% - 99.64%Colore e forma:SolidPeso molecolare:582.07Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purezza:98.72% - 99.55%Colore e forma:SolidPeso molecolare:284.26Ref: TM-T6S1315
1mg39,00€5mg74,00€10mg96,00€25mg156,00€50mg220,00€100mg325,00€200mg472,00€1mL*10mM (DMSO)88,00€Tofacitinib
CAS:Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.Formula:C16H20N6OPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:312.37GSK126
CAS:GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Formula:C31H38N6O2Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:526.67Ref: TM-T2079
2mg44,00€5mg65,00€10mg88,00€25mg152,00€50mg227,00€100mg349,00€200mg455,00€1mL*10mM (DMSO)74,00€Seclidemstat
CAS:Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.Formula:C20H23ClN4O4SPurezza:98.28% - 99.76%Colore e forma:SolidPeso molecolare:450.94Ref: TM-T4527
5mg48,00€10mg72,00€25mg120,00€50mg187,00€100mg354,00€200mg528,00€500mg852,00€1mL*10mM (DMSO)49,00€Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurezza:98% - 99.81%Colore e forma:SolidPeso molecolare:317.21Remodelin
CAS:Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.Formula:C15H14N4SPurezza:99.39% - 99.83%Colore e forma:SolidPeso molecolare:282.363Ref: TM-T3499
2mg39,00€5mg55,00€10mg77,00€25mg130,00€50mg185,00€100mg250,00€200mg373,00€1mL*10mM (DMSO)59,00€PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formula:C17H12F3NO4SPurezza:98.91% - 99.55%Colore e forma:SolidPeso molecolare:383.34Ref: TM-T7848
1mg66,00€2mg87,00€5mg153,00€10mg235,00€25mg399,00€50mg562,00€100mg782,00€200mg1.035,00€1mL*10mM (DMSO)126,00€Venadaparib
CAS:Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.Formula:C23H23FN4O2Purezza:99.86%Colore e forma:SolidPeso molecolare:406.45Ref: TM-T9430
1mg48,00€2mg63,00€5mg96,00€10mg144,00€25mg283,00€50mg464,00€100mg680,00€1mL*10mM (DMSO)96,00€RN-1 dihydrochloride
CAS:RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).Formula:C23H31Cl2N3O2Purezza:99.64%Colore e forma:SolidPeso molecolare:452.42Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Formula:C17H18N6Purezza:99.4% - >99.99%Colore e forma:SolidPeso molecolare:306.36GSK2801
CAS:GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.Formula:C20H21NO4SPurezza:97.78% - 99.45%Colore e forma:SolidPeso molecolare:371.455-Methyl-2'-deoxycytidine
CAS:5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.Formula:C10H15N3O4Purezza:99.18% - 99.69%Colore e forma:SolidPeso molecolare:241.242-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one
CAS:2-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is ligand of CBP.Formula:C10H11NOSPurezza:99.68%Colore e forma:SolidPeso molecolare:193.275-Fluoro-2'-deoxycytidine
CAS:5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .Formula:C9H12FN3O4Purezza:97.91%Colore e forma:Fine White PowderPeso molecolare:245.21Ref: TM-T7718
2mg35,00€5mg50,00€10mg67,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg525,00€1mL*10mM (DMSO)52,00€A-366
CAS:A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.Formula:C19H27N3O2Purezza:97.28% - 99.8%Colore e forma:SolidPeso molecolare:329.44Ref: TM-T3624
1mg35,00€2mg50,00€5mg74,00€10mg90,00€25mg208,00€50mg359,00€100mg530,00€1mL*10mM (DMSO)82,00€UNC3866 TFA(1872382-47-2 free base)
CAS:UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C45H67F3N6O10Purezza:98.43%Colore e forma:SolidPeso molecolare:909.046-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurezza:98.75% - >99.99%Colore e forma:Odorless Or Almost Odorless Pale Yellow Crystalline PowderPeso molecolare:167.19IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formula:C15H16N6O3Purezza:99.97%Colore e forma:SolidPeso molecolare:328.33NEO2734
CAS:NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).Formula:C22H24F3N3O3Purezza:98.72% - 98.8%Colore e forma:SolidPeso molecolare:435.44Ref: TM-T8658
1mg114,00€5mg274,00€10mg454,00€25mg750,00€50mg1.026,00€100mg1.406,00€500mg2.822,00€1mL*10mM (DMSO)303,00€GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormula:C31H39N7O2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:541.69Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:460.73XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurezza:99.07%Colore e forma:SolidPeso molecolare:437.54Ref: TM-T17267
1mg56,00€2mg78,00€5mg99,00€10mg149,00€25mg258,00€50mg393,00€100mg582,00€1mL*10mM (DMSO)110,00€Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurezza:99.99%Colore e forma:SolidPeso molecolare:464.591-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one
CAS:1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one is an inhibitor Bromodomain-containing protein 4 (human).Formula:C17H19NOPurezza:99.08%Colore e forma:SolidPeso molecolare:253.34Ref: TM-T8601
1mg62,00€5mg123,00€10mg180,00€25mg298,00€50mg419,00€100mg567,00€200mg752,00€1mL*10mM (DMSO)115,00€GSK620
CAS:<p>GSK620, a selective pan-BD2 inhibitor, has anti-inflammatory properties and favorable oral pharmacokinetics.</p>Formula:C18H19N3O3Purezza:99.42% - 99.88%Colore e forma:SolidPeso molecolare:325.36Talazoparib
CAS:Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).Formula:C19H14F2N6OPurezza:97.02% - 99.92%Colore e forma:SolidPeso molecolare:380.35Ref: TM-T6253
2mg42,00€5mg62,00€10mg88,00€25mg135,00€50mg187,00€100mg311,00€200mg429,00€500mg697,00€1mL*10mM (DMSO)67,00€Solcitinib
CAS:<p>Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.</p>Formula:C22H23N5O2Purezza:99.61% - 99.82%Colore e forma:SolidPeso molecolare:389.45Dbet57
CAS:dBET57: PROTAC-based BRD4BD1 degrader, DC50/5h at 500 nM, ineffective on BRD4BD2.Formula:C34H31ClN8O5SPurezza:99.36% - 99.52%Colore e forma:SolidPeso molecolare:699.18Ref: TM-T5440
1mg49,00€5mg97,00€10mg156,00€25mg279,00€50mg432,00€100mg625,00€500mg1.293,00€1mL*10mM (DMSO)170,00€MAT2A inhibitor 4
CAS:MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancerFormula:C16H15ClFNPurezza:99.17%Colore e forma:SolidPeso molecolare:275.75Ref: TM-T9262
1mg40,00€5mg90,00€10mg131,00€25mg220,00€50mg314,00€100mg426,00€200mg575,00€1mL*10mM (DMSO)89,00€Mivebresib
CAS:Mivebresib (ABBV-075) is a potent BET inhibitor with antitumor effects, disrupting gene expression and MYC, TMPRSS2-ETS proteins.Formula:C22H19F2N3O4SPurezza:98.74% - 99.32%Colore e forma:SolidPeso molecolare:459.47Ref: TM-T3712
1mg58,00€2mg82,00€5mg97,00€10mg159,00€25mg256,00€50mg462,00€100mg660,00€1mL*10mM (DMSO)99,00€PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formula:C28H35N7O2Purezza:98.2%Colore e forma:SolidPeso molecolare:501.623-Aminobenzamide
CAS:3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction duringFormula:C7H8N2OPurezza:98.4% - 99.5%Colore e forma:White To Off-White PowderPeso molecolare:136.15SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Formula:C19H17NO5SPurezza:99.1% - 99.51%Colore e forma:SolidPeso molecolare:371.41Ref: TM-T3986
1mg37,00€5mg79,00€10mg119,00€25mg274,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Formula:C22H23BrN6O2Purezza:98.86% - 99.98%Colore e forma:SolidPeso molecolare:483.36Ref: TM-T15624
1mg88,00€5mg170,00€10mg274,00€25mg567,00€50mg944,00€100mg1.659,00€1mL*10mM (DMSO)182,00€GeA-69
CAS:<p>GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).</p>Formula:C20H16N2OPurezza:99.85%Colore e forma:SolidPeso molecolare:300.35TTK21
CAS:<p>TTK21 is an activator of CBP/p300 histone acetyltransferase activity.</p>Formula:C17H15ClF3NO2Purezza:98.43%Colore e forma:SolidPeso molecolare:357.75PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formula:C13H20Cl4N2O3Purezza:97% - 99.79%Colore e forma:SolidPeso molecolare:394.12Ref: TM-T6961
1mg42,00€5mg88,00€10mg137,00€25mg205,00€50mg276,00€100mg434,00€200mg638,00€1mL*10mM (DMSO)88,00€LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formula:C26H29NO5Purezza:98.1% - 98.22%Colore e forma:SolidPeso molecolare:435.51Ref: TM-T3494
2mg47,00€5mg69,00€10mg89,00€25mg183,00€50mg298,00€100mg449,00€500mg938,00€1mL*10mM (DMSO)69,00€Ref: TM-T5S2358
1mg52,00€2mg72,00€5mg111,00€10mg144,00€25mg207,00€50mg311,00€100mg472,00€1mL*10mM (DMSO)123,00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formula:C17H12F3NO4SPurezza:99.34% - 99.88%Colore e forma:SolidPeso molecolare:383.34Ref: TM-T16679
1mg70,00€5mg153,00€10mg216,00€25mg411,00€50mg660,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)166,00€I-BET151
CAS:I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).Formula:C23H21N5O3Purezza:97.34% - 99.63%Colore e forma:SolidPeso molecolare:415.44Ref: TM-T2120
1mg48,00€2mg65,00€5mg96,00€10mg115,00€25mg202,00€50mg339,00€100mg507,00€500mg1.130,00€1mL*10mM (DMSO)105,00€Veliparib
CAS:Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.Formula:C13H16N4OPurezza:98.66% - 99%Colore e forma:SolidPeso molecolare:244.29Ref: TM-T2591
5mg57,00€10mg81,00€25mg127,00€50mg207,00€100mg331,00€200mg540,00€500mg852,00€1mL*10mM (DMSO)64,00€Tranylcypromine hemisulfate
CAS:Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset ofFormula:C9H11N1H2SO4Purezza:98% - 99.96%Colore e forma:SolidPeso molecolare:182.23SGI-1027
CAS:SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).Formula:C27H23N7OPurezza:99.45% - 99.78%Colore e forma:SolidPeso molecolare:461.52Ref: TM-T1904
5mg58,00€10mg94,00€25mg163,00€50mg296,00€100mg467,00€500mg1.035,00€1mL*10mM (DMSO)74,00€GSK467
CAS:GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).Formula:C17H13N5O2Purezza:99.55% - 99.85%Colore e forma:SolidPeso molecolare:319.32MG 149
CAS:MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).Formula:C22H28O3Purezza:98.69% - 99.86%Colore e forma:SolidPeso molecolare:340.46Ref: TM-T6584
1mg52,00€2mg74,00€5mg96,00€10mg170,00€25mg324,00€50mg518,00€100mg747,00€1mL*10mM (DMSO)114,00€UNC3866
CAS:UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C43H66N6O8Purezza:88.06% - 99.62%Colore e forma:SolidPeso molecolare:795.02
