Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2548 prodotti di "Cromatina/Epigenetica"
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SP-2-225
CAS:SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,Formula:C28H34N2O3Purezza:98%Colore e forma:SolidPeso molecolare:446.58MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formula:C18H18ClF2N5OSPurezza:98%Colore e forma:SolidPeso molecolare:425.88TC-AC28
CAS:TC-AC28 is a novel potent and selective Brd2(2) ligand.Formula:C23H21N5O3Purezza:98%Colore e forma:SolidPeso molecolare:415.44GSK4028
CAS:GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.Formula:C17H21BrN4OColore e forma:SolidPeso molecolare:377.28Bisegliptin
CAS:Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formula:C18H26FN3O3Purezza:98%Colore e forma:SolidPeso molecolare:351.42GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurezza:98%Colore e forma:SolidPeso molecolare:416.48SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Formula:C28H32ClN7O3SPurezza:99.77%Colore e forma:SolidPeso molecolare:582.12GNE-207
CAS:GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).Formula:C29H30N6O3Purezza:98%Colore e forma:SolidPeso molecolare:510.59FT895
CAS:FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.Formula:C16H15F3N4O2Purezza:98.95% - >99.99%Colore e forma:SolidPeso molecolare:352.31Ref: TM-T11329
1mg97,00€5mg230,00€10mg359,00€25mg602,00€50mg838,00€100mg1.169,00€1mL*10mM (DMSO)255,00€Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formula:C18H21N5O3Purezza:99.85%Colore e forma:SolidPeso molecolare:355.39Ref: TM-T78207
1mg50,00€5mg104,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€1mL*10mM (DMSO)114,00€AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formula:C25H24ClNO9Purezza:98%Colore e forma:SolidPeso molecolare:517.91GSK2646264
CAS:GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.
Formula:C24H26N2O2Colore e forma:SolidPeso molecolare:374.48KAT modulator-1
CAS:KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].Formula:C20H36O2Purezza:98%Colore e forma:SolidPeso molecolare:308.5PARP-2-IN-1
CAS:PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).Formula:C21H19F4N5O3Purezza:98%Colore e forma:SolidPeso molecolare:465.4PI3K/HDAC-IN-2
CAS:PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Formula:C23H23N7O4Colore e forma:SolidPeso molecolare:461.47F-Amidine TFA
CAS:F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Formula:C14H19FN4O2CF3COOHColore e forma:SolidPeso molecolare:408.4JH-131e-153
CAS:JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈Formula:C22H38O5Colore e forma:SolidPeso molecolare:382.53Bavarostat
CAS:Bavarostat: brain-penetrant HDAC6 inhibitor; IC50=60nM; >80x selective for HDAC6; modulates tubulin over histone acetylation.Formula:C20H27FN2O2Colore e forma:SolidPeso molecolare:346.44CW 008
CAS:CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.Formula:C21H14F2N6O2Purezza:97.39%Colore e forma:SolidPeso molecolare:420.37JBI-589
CAS:JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Formula:C29H28FN5OColore e forma:SolidPeso molecolare:481.56
