Cromatina/Epigenetica
Gli inibitori della cromatina/epigenetica sono composti che modulano la struttura e la funzione della cromatina o interferiscono con le modificazioni epigenetiche, come la metilazione del DNA e la modifica degli istoni. Questi inibitori sono strumenti essenziali per studiare la regolazione dell'espressione genica e il ruolo dell'epigenetica in malattie come il cancro, i disturbi neurologici e le anomalie dello sviluppo. Mirando ai processi epigenetici, questi inibitori possono alterare i modelli di espressione genica e offrire nuove opportunità terapeutiche. Presso CymitQuimica, offriamo un'ampia selezione di inibitori della cromatina/epigenetica di alta qualità per supportare le tue ricerche in biologia molecolare, genetica ed epigenetica.
Sottocategorie di "Cromatina/Epigenetica"
Trovati 2553 prodotti di "Cromatina/Epigenetica"
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Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS:Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.Formula:C88H138N20O34P2Purezza:98%Colore e forma:SolidPeso molecolare:2082.1GSK973
CAS:GSK973 is a selective oral BET inhibitor, 1600x more for BRD4 BD2 (pIC50 7.8, pKd 8.7) than BD1, effective against other BD2s.
Formula:C23H23FN2O4Colore e forma:SolidPeso molecolare:410.445Antitumor agent-170
Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.Formula:C59H69ClF3N11O9Peso molecolare:1167.49204BET-IN-25
BET-IN-25 (compound 7) is an orally bioactive inhibitor targeting the bromodomains BD1 and BD2, with IC50 values of 0.18 μM and 9.2 μM, respectively.Formula:C19H25N5O4SPeso molecolare:419.16273dBRD9
CAS:dBRD9 is a PROTAC.Formula:C40H45N7O10Purezza:99.81%Colore e forma:SolidPeso molecolare:783.83Ref: TM-T31221
1mg129,00€5mg311,00€10mg502,00€25mg874,00€50mg1.320,00€100mg1.833,00€1mL*10mM (DMSO)434,00€coumarin-SAHA
CAS:SAHA inhibits class I/II HDAC; c-SAHA, a fluorescent derivative, excites at 325 nm and emits at 400 nm.Formula:C18H22N2O5Colore e forma:SolidPeso molecolare:346.383AB3067
AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)Formula:C74H91ClFN11O17S2Colore e forma:SolidPeso molecolare:1525.16GSK023
GSK023 (compound 31) is a selective chemical probe that targets the BET BD1 domain.Formula:C29H39N5O2Peso molecolare:489.31038HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Formula:C20H39B12N4O2Peso molecolare:499.41897HDAC1/6-IN-2
HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.Formula:C22H17FN4O3Colore e forma:SolidPeso molecolare:404.39PROTAC BRD4 Degrader-9
CAS:PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formula:C59H71F2N9O15S4Colore e forma:SolidPeso molecolare:1312.5PROTAC BET Degrader-1
CAS:PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formula:C44H45N11O9Purezza:98%Colore e forma:SolidPeso molecolare:871.9Ref: TM-T13849
5mg410,00€10mg627,00€25mg1.378,00€50mgPrezzo su richiesta100mgPrezzo su richiesta1mL*10mM (DMSO)447,00€iRucaparib-AP6
CAS:iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.Formula:C46H55FN6O11Purezza:98%Colore e forma:SolidPeso molecolare:886.96ZXH-3-26
CAS:ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.
Formula:C38H37ClN8O7SPurezza:98.90% - 98.90%Colore e forma:SolidPeso molecolare:785.27PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Colore e forma:SolidPeso molecolare:544.696CDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Formula:C32H31ClN6O3Purezza:98.30%Colore e forma:SoildPeso molecolare:583.08PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formula:C27H30F3N7O6S2Purezza:98%Colore e forma:SolidPeso molecolare:669.7AU-24118
AU-24118 is an orally bioavailable chimeric degrader (PROTAC) that targets the proteolysis of mSWI/SNF ATPases (SMARCA2 and SMARCA4) and PBRM1.Formula:C37H40N6O4Peso molecolare:632.3111HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormula:C23H40O5Purezza:98%Colore e forma:SolidPeso molecolare:396.56BRD7-IN-3
BRD7-IN-3 (compound 1-78) functions as a dual inhibitor targeting the bromodomain-containing proteins BRD7 and BRD9, demonstrating half-maximal inhibitoryFormula:C18H18N2O2Purezza:98%Colore e forma:SolidPeso molecolare:294.35
