Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 126 prodotti per "Topoisomerasi".
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Gatifloxacin
CAS:Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.Formula:C19H22FN3O4Purezza:99.50% - 99.85%Colore e forma:SolidPeso molecolare:375.39Etoposide
CAS:Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).Formula:C29H32O13Purezza:99.19% - 99.94%Colore e forma:SolidPeso molecolare:588.56Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Formula:C27H29NO11·HClPurezza:98% - 99.99%Colore e forma:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecolare:579.99Mitoxantrone dihydrochloride
CAS:Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.Formula:C22H30Cl2N4O6Purezza:97.05% - >99.99%Colore e forma:SolidPeso molecolare:517.4Nalidixic acid
CAS:Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.Formula:C12H12N2O3Purezza:99.9% - 99.95%Colore e forma:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Peso molecolare:232.24DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.Formula:C22H21ClN2O6Purezza:99.85%Colore e forma:Yellow SolidPeso molecolare:444.87Topotecan hydrochloride
CAS:Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.Formula:C23H24ClN3O5Purezza:97.88% - 99.41%Colore e forma:SolidPeso molecolare:457.92Enoxacin hydrate
CAS:Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.Formula:C15H17FN4O3H2OPurezza:99.50%Colore e forma:White SolidPeso molecolare:347.34Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formula:C33H45ClN4O9Purezza:98.22% - 99.96%Colore e forma:Yellow SolidPeso molecolare:677.18Irinotecan Hydrochloride
CAS:Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Formula:C33H39ClN4O6Purezza:98% - 99.94%Colore e forma:Yellow SolidPeso molecolare:623.14Ref: TM-T0486L
10mg34,00€25mg49,00€50mg65,00€1mL*10mM (DMSO)71,00€100mg89,00€200mg129,00€500mg254,00€Ciprofloxacin monohydrochloride
CAS:Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.Formula:C17H18FN3O3·HClPurezza:99.5% - 99.73%Colore e forma:SolidPeso molecolare:367.80Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Formula:C15H17FN4O3Purezza:99.60% - 99.89%Colore e forma:White SolidPeso molecolare:320.32Berberine chloride
CAS:Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Formula:C20H18ClNO4Purezza:99.47% - 99.93%Colore e forma:Yellow Crystalline PowderPeso molecolare:371.80XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.Formula:C23H25ClN4O2Purezza:98.52%Colore e forma:SolidPeso molecolare:424.92Daunorubicin hydrochloride
CAS:Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFormula:C27H29NO10·HClPurezza:96.21% - 99.53%Colore e forma:Red SolidPeso molecolare:563.99Ref: TM-T1511
5mg34,00€10mg52,00€1mL*10mM (DMSO)59,00€25mg87,00€50mg113,00€100mg177,00€200mg281,00€500mg442,00€Nalidixic acid sodium salt
CAS:Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.Formula:C12H11N2NaO3Purezza:99.72% - 99.95%Colore e forma:White To Off-White PowderPeso molecolare:254.22Ciprofloxacin
CAS:Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!Formula:C17H18FN3O3Purezza:98.77% - 99.91%Colore e forma:White PowderPeso molecolare:331.34Teniposide
CAS:Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFormula:C32H32O13SPurezza:97.7% - 99.45%Colore e forma:SolidPeso molecolare:656.65Levofloxacin hydrate
CAS:Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formula:C18H20FN3O4H2OPurezza:98.26%Colore e forma:White SolidPeso molecolare:370.38Hycanthone
CAS:Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Formula:C20H24N2O2SPurezza:98.78%Colore e forma:Yellow-Orange Powder (Ntp 1992)Peso molecolare:356.48Lurtotecan
CAS:Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.Formula:C28H30N4O6Purezza:99.18%Colore e forma:Yellow SolidPeso molecolare:518.56Epirubicin hydrochloride
CAS:Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.Formula:C27H30ClNO11Purezza:98.13% - 99.79%Colore e forma:SolidPeso molecolare:579.98Ref: TM-T0125
2mg37,00€5mg52,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg142,00€50mg226,00€100mg308,00€500mg745,00€Flumequine
CAS:Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.Formula:C14H12FNO3Purezza:98.92% - 99.4%Colore e forma:White SolidPeso molecolare:261.25DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Colore e forma:Odour SolidTopoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.Purezza:98%Colore e forma:Odour SolidAntitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targetsFormula:C70H82N8O18SPurezza:98%Colore e forma:SolidPeso molecolare:1355.51Garenoxacin
CAS:Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Formula:C23H20F2N2O4Purezza:98%Colore e forma:SolidPeso molecolare:426.41AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.Purezza:98%Colore e forma:Odour SolidVoreloxin
CAS:Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formula:C18H19N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:401.44DTS-108
CAS:DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Formula:C145H233N43O33S2Colore e forma:SolidPeso molecolare:3170.8AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowPurezza:98%Colore e forma:Odour SolidCH-0793076
CAS:CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).Formula:C26H26N4O4Purezza:98%Colore e forma:SolidPeso molecolare:458.51Banoxantrone-D12
CAS:Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formula:C22H28N4O6Purezza:98%Colore e forma:SolidPeso molecolare:456.55CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formula:C169H240FN35O49S2Colore e forma:SolidPeso molecolare:3629.05Topoisomerase II inhibitor 13
CAS:WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Formula:C22H23N9Purezza:99.84%Colore e forma:SoildPeso molecolare:413.48Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formula:C53H83FN6O15Colore e forma:SolidPeso molecolare:1063.26Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H26ClN3O5Purezza:97.04%Colore e forma:SoildPeso molecolare:483.94Topo I/II-IN-1
Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.Formula:C15H13N3S2Colore e forma:SolidPeso molecolare:299.414TAK1 inhibitor
CAS:TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.Formula:C22H19ClN6O2SPurezza:98%Colore e forma:SolidPeso molecolare:466.94Chimmitecan
CAS:Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.Formula:C23H20N2O5Purezza:98.35%Colore e forma:Yellow SolidPeso molecolare:404.42Banoxantrone-D12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formula:C22H30Cl2N4O6Purezza:98%Colore e forma:SolidPeso molecolare:529.48Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Colore e forma:SolidPeso molecolare:347.41Topoisomerase II inhibitor 19
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and a topoisomerase II inhibitor with an IC50 of 0.34 μM. It induces damage in ctDNA.Formula:C27H16ClN3OSPeso molecolare:465.07026AuL1
AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.Formula:C29H50AuCl2N5Colore e forma:SolidPeso molecolare:736.61Topoisomerase IIα-IN-9
CAS:Topoisomerase IIα-IN-9 ,with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Topoisomerase IIα-IN-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColore e forma:SolidPeso molecolare:278.32Merbarone
CAS:Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.Formula:C11H9N3O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:263.27Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formula:C22H21N3O5Purezza:97.49%Colore e forma:SolidPeso molecolare:407.42EIDD-1931
CAS:EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.Formula:C9H13N3O6Purezza:99.14% - 99.73%Colore e forma:SolidPeso molecolare:259.22Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formula:C22H14O9Purezza:85% - 97.1%Colore e forma:Deep Red Coarse Crystalline PowderPeso molecolare:422.34Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formula:C30H48O3Purezza:98.22% - 99.7%Colore e forma:White SolidPeso molecolare:456.70
