Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 126 prodotti di "Topoisomerasi"
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Exatecan mesylate dihydrate
CAS:Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].Formula:C25H30FN3O9SPurezza:98%Colore e forma:SolidPeso molecolare:567.58Daniquidone
CAS:Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasmsFormula:C15H11N3OPurezza:98.39% - 99.52%Colore e forma:SolidPeso molecolare:249.27BNS-22
CAS:BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.Formula:C24H25NO5Purezza:99.62%Colore e forma:SolidPeso molecolare:407.46T638
CAS:T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.Formula:C18H16N4OSColore e forma:SolidPeso molecolare:336.41Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurezza:99.2% - 99.34%Colore e forma:Yellow Crystalline Powder SolidPeso molecolare:393.46Pyrazoloacridine
CAS:Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Formula:C19H21N5O3Purezza:99.72%Colore e forma:SolidPeso molecolare:367.4Pegamotecan
CAS:Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cellFormula:C52H48N6O14Purezza:96.40% - 97.83%Colore e forma:SolidPeso molecolare:980.984ARN-21934
CAS:ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formula:C21H24N6Purezza:99.8%Colore e forma:SolidPeso molecolare:360.46Ref: TM-T36968
1mg58,00€2mg85,00€5mg128,00€1mL*10mM (DMSO)141,00€10mg200,00€25mg353,00€50mg482,00€100mg665,00€200mg893,00€SDOX
CAS:SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formula:C69H97NO20S2Purezza:98%Colore e forma:SolidPeso molecolare:1324.63Topoisomerase inhibitor 2
CAS:Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].Formula:C23H23N5O4Purezza:98%Colore e forma:SolidPeso molecolare:433.46Anticancer agent 216
CAS:Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formula:C23H21N3O6Colore e forma:SolidPeso molecolare:435.43Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormula:C23H15Br2FN2Purezza:98%Colore e forma:SolidPeso molecolare:498.19LMP744 hydrochloride
CAS:LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
Formula:C24H25ClN2O7Purezza:99.59% - 99.85%Colore e forma:SolidPeso molecolare:488.92Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurezza:99.18%Colore e forma:SolidPeso molecolare:512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormula:C22H18ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:428.84Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formula:C23H22FN3O4Colore e forma:SolidPeso molecolare:423.44LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formula:C22H19FN2O5Colore e forma:SolidPeso molecolare:410.4Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formula:C29H28N4O11Purezza:98%Colore e forma:SolidPeso molecolare:608.55Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.Formula:C25H28N2O4SiPurezza:98%Colore e forma:SolidPeso molecolare:448.59Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Formula:C25H27N3O7Colore e forma:SolidPeso molecolare:481.498
