Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 126 prodotti di "Topoisomerasi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formula:C22H21N3O5Purezza:97.49%Colore e forma:SolidPeso molecolare:407.42Gatifloxacin hydrochloride
CAS:Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Formula:C19H23ClFN3O4Purezza:99.85% - 99.89%Colore e forma:SolidPeso molecolare:411.86Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purezza:98.07% - 99.18%Colore e forma:SolidPeso molecolare:240.25Ref: TM-T16522
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg767,00€Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formula:C30H48O3Purezza:98.22% - 99.7%Colore e forma:White Crystalline PowderPeso molecolare:456.70Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formula:C26H27NO9·HClPurezza:98.91% - 99.96%Colore e forma:SolidPeso molecolare:533.95Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formula:C18H20ClN5O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:437.9SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purezza:98% - 99.97%Colore e forma:Light-Yellow SolidPeso molecolare:392.4Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formula:C25H27N5O10Purezza:98.70% - 99.11%Colore e forma:SolidPeso molecolare:557.21Topotecan
CAS:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formula:C23H23N3O5Purezza:96.14% - 98.23%Colore e forma:Light Yellow Needle Crystal Or Crystalline PowderPeso molecolare:421.45Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purezza:97.47% - 99.97%Colore e forma:WhitePeso molecolare:1429.15(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purezza:99.09% - 99.81%Colore e forma:SolidPeso molecolare:364.35Bisantrene
CAS:Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formula:C22H22N8Purezza:96.07% - 98.57%Colore e forma:SolidPeso molecolare:398.46Rubitecan
CAS:Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.Formula:C20H15N3O6Purezza:97.54%Colore e forma:Yellow Amorphous PowderPeso molecolare:393.35IndiMitecan
CAS:IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
Formula:C25H21N3O6Purezza:98.53%Colore e forma:SoildPeso molecolare:459.45(±)-10-Hydroxycamptothecin
CAS:(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.
Formula:C20H16N2O5Purezza:98% - 99.06%Colore e forma:SolidPeso molecolare:364.35Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formula:C27H29NO11Purezza:99.31%Colore e forma:Red Crystalline Solid SolidPeso molecolare:543.52PNU-159682
CAS:PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Formula:C32H35NO13Purezza:98.24%Colore e forma:SolidPeso molecolare:641.62Ref: TM-T16557
1mg87,00€5mg178,00€1mL*10mM (DMSO)263,00€10mg326,00€25mg537,00€50mg735,00€100mg964,00€Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Formula:C20H16N2O4Purezza:99.52% - 99.88%Colore e forma:Solid PowderPeso molecolare:348.35Ellipticine
CAS:Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Formula:C17H14N2Purezza:97.26% - 99.88%Colore e forma:SolidPeso molecolare:246.31PluriSIn #2
CAS:PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Formula:C11H8FN3O3Purezza:98% - 99.79%Colore e forma:SolidPeso molecolare:249.2
